Patents by Inventor Giannoula Klement

Giannoula Klement has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NORMALIZATION OF PLATELET BIOMARKERS
    Publication number: 20130177928
    Abstract: Described herein are methods useful for normalizing any biomarker in platelets. This has application in any method in which one wishes to ascertain or compare the level of a biomarker, e.g., for diagnostic or prognostic methods relating to a biomarker of interest. Using such an approach can permit the assessment of disease status (e.g., angiogenic status) of an individual with less error than an expression value that is not normalized or that is normalized to total protein levels. Also provided are methods for selecting a normalizing protein for normalizing biomarkers in a sample, e.g., a platelet sample.
    Type: Application
    Filed: November 23, 2010
    Publication date: July 11, 2013
    Applicants: THE NEWMAN-LAKKA CANCER FOUNDATION, THE BRIGHAM AND WOMEN'S HOSPITAL, INC., ORTHO-CLINICAL DIAGNOSTICS, INC.
    Inventors: Jon Peterson, Giannoula Klement, Joseph Italiano, Sean Downing
  • Platelet biomarkers for cancer
    Patent number: 8173433
    Abstract: The present invention relates to the fields of immunology and biochemistry. Particularly, the present invention describes methods, devices and kits for early detection of clinical conditions having associated changes in systemic angiogenic activity, particularly cancers, inflammatory conditions, infections, and events associated with pregnancy and abortion.
    Type: Grant
    Filed: April 22, 2005
    Date of Patent: May 8, 2012
    Assignee: Vermillion, Inc.
    Inventors: Judah M. Folkman, Giannoula Klement, Tai-Tung Yip, William E. Rich, Vladimir N. Podust
  • PLATELET BIOMARKERS FOR CANCER
    Publication number: 20090042229
    Abstract: The present invention relates to the fields of immunology and biochemistry. Particularly, the present invention describes methods, devices and kits for early detection of clinical conditions having associated changes in systemic angiogenic activity, particularly cancers, inflammatory conditions, infections, and events associated with pregnancy and abortion.
    Type: Application
    Filed: April 22, 2005
    Publication date: February 12, 2009
    Applicants: CIPHERGEN BIOSYSTEMS, INC., CHILDRENS MEDICAL CENTER CORPORATION
    Inventors: Judah M. Folkman, Giannoula Klement, Tai-Tung Yip, William E. Rich, Vladimir N. Podust
  • Platelet biomarkers for the detection of disease
    Publication number: 20060204951
    Abstract: The present inventors have surprisingly discovered that platelets sequester angiogenic regulators and prevent their degradation. Thus, by analyzing levels of angiogenic regulators in platelets, it is now possible to detect angiogenic activity, even at an early stage. By monitoring for changes in angiogenic activity, the presence of cancer or other angiogenic diseases or disorders can be predicted.
    Type: Application
    Filed: April 26, 2005
    Publication date: September 14, 2006
    Inventors: Judah Folkman, Giannoula Klement
  • Platelet biomarkers for the detection of disease
    Publication number: 20060134605
    Abstract: The present inventors have surprisingly discovered that platelets sequester angiogenic regulators and prevent their degradation. Thus, by analyzing levels of angiogenic regulators in platelets, it is now possible to detect angiogenic activity, even at an early stage. By monitoring for changes in angiogenic activity, the presence of cancer or other angiogenic diseases or disorders can be predicted.
    Type: Application
    Filed: December 15, 2005
    Publication date: June 22, 2006
    Applicant: Children's Medical Center Corporation
    Inventors: Judah Folkman, Giannoula Klement