Patents by Inventor Gilberto De Nucci

Gilberto De Nucci has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10822333
    Abstract: The present invention describes new pyridopyrimidine derivatives compounds with structure represented by General Formula (I): or pharmaceutically acceptable salts thereof, or their mixtures (in any ratio), a pharmaceutical composition containing them, a method for using the new pyridopyrimidine derivatives compounds as inhibitor of the cyclic nucleotide synthesis or as inhibitor of the cAMP and cGMP synthesis, and their uses in the prophylactic and/or curative treatment of diarrhea, colitis and irritable bowel syndrome.
    Type: Grant
    Filed: March 25, 2019
    Date of Patent: November 3, 2020
    Assignee: Biolab Sanus Farmaceutica LTDA
    Inventor: Gilberto De Nucci
  • Publication number: 20190218216
    Abstract: The present invention describes new pyridopyrimidine derivatives compounds with structure represented by General Formula (I): or pharmaceutically acceptable salts thereof, or their mixtures (in any ratio), a pharmaceutical composition containing them, a method for using the new pyridopyrimidine derivatives compounds as inhibitor of the cyclic nucleotide synthesis or as inhibitor of the cAMP and cGMP synthesis, and their uses in the prophylactic and/or curative treatment of diarrhea, colitis and irritable bowel syndrome.
    Type: Application
    Filed: March 25, 2019
    Publication date: July 18, 2019
    Inventor: Gilberto De Nucci
  • Patent number: 10280162
    Abstract: The present invention describes new pyridopyrimidine derivatives compounds with structure represented by General Formula (I): or pharmaceutically acceptable salts thereof, or their mixtures (in any ratio), a pharmaceutical composition containing them, a method for using the new pyridopyrimidine derivatives compounds as inhibitor of the cyclic nucleotide synthesis or as inhibitor of the cAMP and cGMP synthesis, and their uses in the prophylactic and/or curative treatment of diarrhea, colitis and irritable bowel syndrome.
    Type: Grant
    Filed: September 11, 2015
    Date of Patent: May 7, 2019
    Assignee: BIOLAB SANUS FARMACEUTICA LTDA
    Inventor: Gilberto De Nucci
  • Publication number: 20180111926
    Abstract: The present invention describes new pyridopyrimidine derivatives compounds with structure represented by General Formula (I): or pharmaceutically acceptable salts thereof, or their mixtures (in any ratio), a pharmaceutical composition containing them, a method for using the new pyridopyrimidine derivatives compounds as inhibitor of the cyclic nucleotide synthesis or as inhibitor of the cAMP and cGMP synthesis, and their uses in the prophylactic and/or curative treatment of diarrhea, colitis and irritable bowel syndrome.
    Type: Application
    Filed: September 11, 2015
    Publication date: April 26, 2018
    Inventor: Gilberto De Nucci
  • Publication number: 20170112859
    Abstract: The present invention relates to a method of treatment comprising administering an association of an antihypertensive agent and antiplatelet agent, wherein the antihypertensive agent is administered daily and the antiplatelet agent is administered every three days. The invention further comprises a kit comprising the association of the antihypertensive agent and the antiplatelet agent, packed so as to facilitate the compliance and the correct administration of the dosage of treatment by the patient.
    Type: Application
    Filed: January 5, 2017
    Publication date: April 27, 2017
    Inventor: Gilberto De Nucci
  • Publication number: 20160175330
    Abstract: The present invention relates to a method of treatment comprising administering an association of an antihypertensive agent and antiplatelet agent, wherein the antihypertensive agent is administered daily and the antiplatelet agent is administered every three days. The invention further comprises a kit comprising the association of the antihypertensive agent and the antiplatelet agent, packed so as to facilitate the compliance and the correct administration of the dosage of treatment by the patient.
    Type: Application
    Filed: December 17, 2014
    Publication date: June 23, 2016
    Inventor: Gilberto De Nucci
  • Publication number: 20160075702
    Abstract: The present invention describes new pyridopyrimidine derivatives compounds with structure represented by General Formula (I): or pharmaceutically acceptable salts thereof, or their mixtures (in any ratio), a pharmaceutical composition containing them, a method for using the new pyridopyrimidine derivatives compounds as inhibitor of the cyclic nucleotide synthesis or as inhibitor of the cAMP and cGMP synthesis, and their uses in the prophylactic and/or curative treatment of diarrhea, colitis and irritable bowel syndrome.
    Type: Application
    Filed: September 11, 2015
    Publication date: March 17, 2016
    Inventor: Gilberto De Nucci
  • Patent number: 8338432
    Abstract: A series of derivatives of 6,7-dihydro-3H-oxazolo[3,4-a]pyrazine-5,8-dione, mixtures thereof, their pharmaceutically acceptable salts, which are inhibitors of PDE-5, possessing vasodilatator properties and relaxing effects. In particular, compounds of formula (I), where R1, R2, R3, and R4 are defined herein, processes for the preparation of said compounds, pharmaceutical compositions containing them, as well as uses as inhibitors of the enzyme phosphodiesterase type 5 (PDE-5) in the treatment of the erectile dysfunction and PDE-5 inhibitor treatable disorders.
    Type: Grant
    Filed: August 2, 2011
    Date of Patent: December 25, 2012
    Assignee: Biolab Sanus Farmaceutica Ltda.
    Inventors: Sérgio Luiz Sacurai, Márcio Henrique Zaim, Carlos Eduardo da Costa Touzarim, Artur Franz Keppler, Gilberto De Nucci
  • Publication number: 20120040988
    Abstract: The present invention describes a series of derivatives of 6,7-dihydro-3H-oxazolo[3,4-a]pyrazine-5,8-dione, mixtures thereof, their pharmaceutically acceptable salts, which are inhibitors of PDE-5, possessing vasodilatator properties and relaxing effects. In particular, the derivative (R)-3-(1,3-benzodioxol-5-yl)-1-(1H-indol-3-yl)-7-methyl-6,7-dihydro[1,3]oxazolo[3,4-a]pyrazine-5,8-dione, its enantiomer (S)-3-(1,3-benzodioxol-5-yl)-1-(1H-indol-3-yl)-7-methyl-6,7-dihydro[1,3]oxazolo[3,4-a]pyrazine-5,8-dione. The present invention describes, additionally, processes for the preparation of said compounds, pharmaceutical compositions containing them, thereof, as well as uses as inhibitors of the enzyme phosphodiesterase type 5 (PDE-5) in the treatment of the erectile dysfunction and PDE-5 inhibitor treatable disorders.
    Type: Application
    Filed: August 2, 2011
    Publication date: February 16, 2012
    Applicant: BIOLAB SANUS FARMACEUTICA LTDA.
    Inventors: Sérgio Luiz SACURAI, Márcio Henrique Zaim, Carlos Eduardo da Costa Touzarim, Artur Franz Keppler, Gilberto De Nucci
  • Publication number: 20060034824
    Abstract: The present patent application refers to a new product composition comprising: BROMELINE . . . more than 0.01%.
    Type: Application
    Filed: September 19, 2002
    Publication date: February 16, 2006
    Inventors: Cristiano Santana, Gilberto De Nucci
  • Publication number: 20030108541
    Abstract: The present invention refers to a new composition of a carrier substance for products to be aggregated comprising in its formulation more than 0.01% of papayne.
    Type: Application
    Filed: October 2, 2002
    Publication date: June 12, 2003
    Inventors: Cristiano A. R. Santana, Gilberto De Nucci, Mqarcio Falci
  • Publication number: 20030103955
    Abstract: The present application refers to a new pharmaceutical composition of diclofenac comprising the following formulation: PAPAIN . . . 0.1 to 15%, HYALURONIDASE . . . 50 to 900 utr/mg, VITAMIN E . . . 10 to 2000 mg.
    Type: Application
    Filed: November 14, 2002
    Publication date: June 5, 2003
    Inventors: Cristiano A.R. Santana, Gilberto De Nucci, Marcio Falci
  • Publication number: 20030049247
    Abstract: the present invention application refers to a new pharmaceutical composition comprising carriers for products to be aggregated to the base of vitamin-E, papain and hyaluronidase, in the following quantities: 1 PAPAIN- 0.
    Type: Application
    Filed: September 24, 2002
    Publication date: March 13, 2003
    Inventors: Cristiano A.R. Santana, Gilberto De Nucci, Mqarcio Falci