Patents by Inventor Gili Hart

Gili Hart has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • LONG-ACTING COAGULATION FACTORS AND METHODS OF PRODUCING SAME
    Publication number: 20220170005
    Abstract: Polypeptides comprising at least one carboxy-terminal peptide (CTP) of chorionic gonadotrophin attached to the carboxy terminus but not to the amino terminus of a coagulation factor and polynucleotides encoding the same are disclosed. Pharmaceutical compositions comprising the polypeptides and polynucleotides of the invention and methods of using and producing same are also disclosed.
    Type: Application
    Filed: July 19, 2021
    Publication date: June 2, 2022
    Applicant: OPKO BIOLOGICS LTD.
    Inventors: Udi Eyal FIMA, Gili HART
  • LONG-ACTING COAGULATION FACTORS AND METHODS OF PRODUCING SAME
    Publication number: 20220000990
    Abstract: Polypeptides comprising at least one carboxy-terminal peptide (CTP) of chorionic gonadotropin attached to the carboxy terminus but not to the amino terminus of a coagulation factor and polynucleotides encoding the same are disclosed. Pharmaceutical compositions and pharmaceutical formulations comprising the polypeptides and polynucleotides of the disclosure and methods of using and producing same are also disclosed.
    Type: Application
    Filed: March 2, 2021
    Publication date: January 6, 2022
    Applicant: OPKO BIOLOGICS LTD.
    Inventors: Udi Eyal FIMA, Gili Hart
  • Long-acting coagulation factors and methods of producing same
    Patent number: 11066658
    Abstract: Polypeptides comprising at least one carboxy-terminal peptide (CTP) of chorionic gonadotrophin attached to the carboxy terminus but not to the amino terminus of a coagulation factor and polynucleotides encoding the same are disclosed. Pharmaceutical compositions comprising the polypeptides and polynucleotides of the invention and methods of using and producing same are also disclosed.
    Type: Grant
    Filed: May 1, 2020
    Date of Patent: July 20, 2021
    Assignee: OPKO BIOLOGICS LTD.
    Inventors: Udi Eyal Fima, Gili Hart
  • Long-acting coagulation factors and methods of producing same
    Patent number: 10960058
    Abstract: Polypeptides comprising at least one carboxy-terminal peptide (CTP) of chorionic gonadotropin attached to the carboxy terminus but not to the amino terminus of a coagulation factor and polynucleotides encoding the same are disclosed. Pharmaceutical compositions and pharmaceutical formulations comprising the polypeptides and polynucleotides of the disclosure and methods of using and producing same are also disclosed.
    Type: Grant
    Filed: June 19, 2016
    Date of Patent: March 30, 2021
    Assignee: OPKO BIOLOGICS LTD.
    Inventors: Udi Eyal Fima, Gili Hart
  • LONG-ACTING COAGULATION FACTORS AND METHODS OF PRODUCING SAME
    Publication number: 20200255816
    Abstract: Polypeptides comprising at least one carboxy-terminal peptide (CTP) of chorionic gonadotrophin attached to the carboxy terminus but not to the amino terminus of a coagulation factor and polynucleotides encoding the same are disclosed. Pharmaceutical compositions comprising the polypeptides and polynucleotides of the invention and methods of using and producing same are also disclosed.
    Type: Application
    Filed: May 1, 2020
    Publication date: August 13, 2020
    Applicant: OPKO Biologics Ltd.
    Inventors: UDI EYAL FIMA, GILI HART
  • Long-acting coagulation factors and methods of producing same
    Patent number: 10640758
    Abstract: Polypeptides comprising at least one carboxy-terminal peptide (CTP) of chorionic gonadotrophin attached to the carboxy terminus but not to the amino terminus of a coagulation factor and polynucleotides encoding the same are disclosed. Pharmaceutical compositions comprising the polypeptides and polynucleotides of the invention and methods of using and producing same are also disclosed.
    Type: Grant
    Filed: October 15, 2018
    Date of Patent: May 5, 2020
    Assignee: OPKO Biologics Ltd.
    Inventors: Udi Eyal Fima, Gili Hart
  • Long-acting coagulation factors and methods of producing same
    Patent number: 10538755
    Abstract: Polypeptides comprising at least one carboxy-terminal peptide (CTP) of chorionic gonadotropin attached to the carboxy terminus but not to the amino terminus of a coagulation factor and polynucleotides encoding the same are disclosed. Pharmaceutical compositions comprising the polypeptides and polynucleotides of the invention and methods of using and producing same are also disclosed.
    Type: Grant
    Filed: April 11, 2017
    Date of Patent: January 21, 2020
    Assignee: OPKO Biologics Ltd.
    Inventors: Udi Eyal Fima, Gili Hart
  • Long-acting coagulation factors and methods of producing same
    Patent number: 10144921
    Abstract: Polypeptides comprising at least one carboxy-terminal peptide (CTP) of chorionic gonadotrophin attached to the carboxy terminus but not to the amino terminus of a coagulation factor and polynucleotides encoding the same are disclosed. Pharmaceutical compositions comprising the polypeptides and polynucleotides of the invention and methods of using and producing same are also disclosed.
    Type: Grant
    Filed: May 19, 2016
    Date of Patent: December 4, 2018
    Assignee: OPKO Biologics Ltd.
    Inventors: Udi Eyal Fima, Gili Hart
  • Long-acting coagulation factors and methods of producing same
    Patent number: 10119132
    Abstract: Polypeptides comprising at least one carboxy-terminal peptide (CTP) of chorionic gonadotrophin attached to the carboxy terminus but not to the amino terminus of a coagulation factor and polynucleotides encoding the same are disclosed. Pharmaceutical compositions comprising the polypeptides and polynucleotides of the invention and methods of using and producing same are also disclosed.
    Type: Grant
    Filed: November 23, 2015
    Date of Patent: November 6, 2018
    Assignee: OPKO Biologics Ltd.
    Inventors: Udi Eyal Fima, Gili Hart
  • LONG-ACTING COAGULATION FACTORS AND METHODS OF PRODUCING SAME
    Publication number: 20180087042
    Abstract: Polypeptides comprising at least one carboxy-terminal peptide (CTP) of chorionic gonadotropin attached to the carboxy terminus but not to the amino terminus of a coagulation factor and polynucleotides encoding the same are disclosed. Pharmaceutical compositions comprising the polypeptides and polynucleotides of the invention and methods of using and producing same are also disclosed.
    Type: Application
    Filed: April 11, 2017
    Publication date: March 29, 2018
    Inventors: Udi Eyal FIMA, Gili HART
  • Long-acting polypeptides and methods of producing and administering same
    Patent number: 9828417
    Abstract: A polypeptide and polynucleotides comprising at least two carboxy-terminal peptides (CTP) of chorionic gonadotrophin attached to a non-human peptide-of-interest are disclosed. Pharmaceutical compositions comprising the non-human polypeptides and polynucleotides of the invention and methods of using both human and non-human polypeptides and polynucleotides are also disclosed.
    Type: Grant
    Filed: November 26, 2014
    Date of Patent: November 28, 2017
    Assignee: OPKO Biologics Ltd.
    Inventors: Udi Eyal Fima, Gili Hart
  • Long-acting coagulation factors and methods of producing same
    Patent number: 9663778
    Abstract: Polypeptides comprising at least one carboxy-terminal peptide (CTP) of chorionic gonadotropin attached to the carboxy terminus but not to the amino terminus of a coagulation factor and polynucleotides encoding the same are disclosed. Pharmaceutical compositions comprising the polypeptides and polynucleotides of the invention and methods of using and producing same are also disclosed.
    Type: Grant
    Filed: May 9, 2014
    Date of Patent: May 30, 2017
    Assignee: OPKO Biologies Ltd.
    Inventors: Udi Eyal Fima, Gili Hart
  • Long-acting coagulation factors and methods of producing same
    Patent number: 9458444
    Abstract: Polypeptides comprising at least one carboxy-terminal peptide (CTP) of chorionic gonadotrophin attached to the carboxy terminus but not to the amino terminus of a coagulation factor and polynucleotides encoding the same are disclosed. Pharmaceutical compositions comprising the polypeptides and polynucleotides of the invention and methods of using and producing same are also disclosed.
    Type: Grant
    Filed: February 5, 2013
    Date of Patent: October 4, 2016
    Assignee: OPKO BIOLOGICS LTD.
    Inventors: Udi Eyal Fima, Gili Hart
  • LONG-ACTING COAGULATION FACTORS AND METHODS OF PRODUCING SAME
    Publication number: 20160250301
    Abstract: Polypeptides comprising at least one carboxy-terminal peptide (CTP) of chorionic gonadotrophin attached to the carboxy terminus but not to the amino terminus of a coagulation factor and polynucleotides encoding the same are disclosed. Pharmaceutical compositions comprising the polypeptides and polynucleotides of the invention and methods of using and producing same are also disclosed.
    Type: Application
    Filed: May 19, 2016
    Publication date: September 1, 2016
    Applicant: OPKO Biologics Ltd.
    Inventors: Udi Eyal FIMA, Gili HART
  • LONG-ACTING COAGULATION FACTORS AND METHODS OF PRODUCING SAME
    Publication number: 20160076018
    Abstract: Polypeptides comprising at least one carboxy-terminal peptide (CTP) of chorionic gonadotrophin attached to the carboxy terminus but not to the amino terminus of a coagulation factor and polynucleotides encoding the same are disclosed. Pharmaceutical compositions comprising the polypeptides and polynucleotides of the invention and methods of using and producing same are also disclosed.
    Type: Application
    Filed: November 23, 2015
    Publication date: March 17, 2016
    Applicant: OPKO Biologics Ltd.
    Inventors: Udi Eyal FIMA, Gili Hart
  • Long-acting coagulation factors and methods of producing same
    Patent number: 9249407
    Abstract: Polypeptides comprising at least one carboxy-terminal peptide (CTP) of chorionic gonadotrophin attached to the carboxy terminus but not to the amino terminus of a coagulation factor and polynucleotides encoding the same are disclosed. Pharmaceutical compositions comprising the polypeptides and polynucleotides of the invention and methods of using and producing same are also disclosed.
    Type: Grant
    Filed: July 1, 2013
    Date of Patent: February 2, 2016
    Assignee: OPKO BIOLOGICS LTD.
    Inventors: Udi Eyal Fima, Gili Hart
  • LONG-ACTING COAGULATION FACTORS AND METHODS OF PRODUCING SAME
    Publication number: 20150368630
    Abstract: Polypeptides comprising at least one carboxy-terminal peptide (CTP) of chorionic gonadotrophin attached to the carboxy terminus but not to the amino terminus of a coagulation factor and polynucleotides encoding the same are disclosed. Pharmaceutical compositions comprising the polypeptides and polynucleotides of the invention and methods of using and producing same are also disclosed.
    Type: Application
    Filed: February 5, 2013
    Publication date: December 24, 2015
    Applicant: PROLOR BIOTECH INC.
    Inventors: Udi Eyal FIMA, Gili Hart
  • LONG-ACTING POLYPEPTIDES AND METHODS OF PRODUCING AND ADMINISTERING SAME
    Publication number: 20150148291
    Abstract: A polypeptide and polynucleotides comprising at least two carboxy-terminal peptides (CTP) of chorionic gonadotrophin attached to a non-human peptide-of-interest are disclosed. Pharmaceutical compositions comprising the non-human polypeptides and polynucleotides of the invention and methods of using both human and non-human polypeptides and polynucleotides are also disclosed.
    Type: Application
    Filed: November 26, 2014
    Publication date: May 28, 2015
    Inventors: UDI EYAL FIMA, GILI HART
  • LONG-ACTING COAGULATION FACTORS AND METHODS OF PRODUCING SAME
    Publication number: 20150079063
    Abstract: Polypeptides comprising at least one carboxy-terminal peptide (CTP) of chorionic gonadotropin attached to the carboxy terminus but not to the amino terminus of a coagulation factor and polynucleotides encoding the same are disclosed. Pharmaceutical compositions comprising the polypeptides and polynucleotides of the invention and methods of using and producing same are also disclosed.
    Type: Application
    Filed: May 9, 2014
    Publication date: March 19, 2015
    Applicant: OPKO Biologics Ltd.
    Inventors: Udi Eyal FIMA, Gili Hart
  • Long-acting coagulation factors and methods of producing same
    Patent number: 8759292
    Abstract: Polypeptides comprising at least one carboxy-terminal peptide (CTP) of chorionic gonadotrophin attached to the carboxy terminus but not to the amino terminus of a coagulation factor and polynucleotides encoding the same are disclosed. Pharmaceutical compositions comprising the polypeptides and polynucleotides of the invention and methods of using and producing same are also disclosed.
    Type: Grant
    Filed: February 14, 2012
    Date of Patent: June 24, 2014
    Assignee: Prolor Biotech, LLC
    Inventors: Udi Eyal Fima, Gili Hart