Abstract: The use of some glycosaminoglycans like sulodexide, low molecular weight heparin and low molecular weight dermatan sulfate and of the medicines by parenteral use that contain them in the treatment of patients suffering from chronic renal insufficiency subjected to peritoneal dialysis is described. The effectiveness of this use has been shown both by pharmacological studies carried out in nephrectomized rats to whom a peritoneal damage has been caused and by clinical studies carried out in patients suffering from chronic renal insufficiency subjected to CAPD and treated by intraperitoneal route (i.p.) with 2 ml vials of VESSEL DUE F.RTM. containing 50 mg of sulodexide. A significant increase of the peritoneal transports of urea and of creatinine joined to a significant decrease of the protein-loss in the peritoneal effluent has been observed. Significant changes of the ultrafiltration capacity and of haemorrhagic-coagulative complications have not been observed during the study.

Abstract: A method and apparatus for ambulatory intraperitoneal dialysis, comprising at least two containers one filled with unused dialysis fluid and one empty, each container being provided with flow regulating means and with a connecting tube ending in a Y-shaped junction whose common branch is connected to a third tube, provided at its free end with a sterile needle. The needle is inserted in a second Y-shaped junction having two branches each containing two membranes which form therebetween a sterilizing liquid chamber. The common channel of the second Y-shaped junction is connected to an external portion of an intraperitoneal catheter. By appropriate positioning of the containers and operation of the regulating means, used solution may be drained and fresh solution introduced.