Patents by Inventor Giovanni Gaviraghi
Giovanni Gaviraghi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8865704Abstract: The present invention relates to known and novel compounds of formula (I) as herein described and pharmaceutical compositions thereof. The compounds of formula (I) have inhibitory effect on the Wnt pathway and are therefore useful in the preparation of a medicament, in particular for the treatment of cancer.Type: GrantFiled: October 6, 2010Date of Patent: October 21, 2014Assignee: Siena Biotech S.p.A.Inventors: Maurizio Varrone, Arianna Nencini, Joanna Margaret Quinn, Andrea Caricasole, Annette Cornelia Bakker, Giovanni Gaviraghi, Massimilano Salerno
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Publication number: 20120196851Abstract: The present invention relates to known and novel compounds of formula (I) as herein described and pharmaceutical compositions thereof. The compounds of formula (I) have inhibitory effect on the Wnt pathway and are therefore useful in the preparation of a medicament, in particular for the treatment of cancer.Type: ApplicationFiled: October 6, 2010Publication date: August 2, 2012Applicant: SIENA BIOTECH S.P.A.Inventors: Maurizio Varrone, Arianna Nencini, Joanna Margaret Quinn, Andrea Caricasole, Annette Cornelia Bakker, Giovanni Gaviraghi, Massimilano Salerno
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Publication number: 20080275028Abstract: The present invention relates to compounds with ?7 nAChR agonistic activity, processes for their preparation, pharmaceutical compositions containing the same and the use thereof for the treatment of neurological, psychiatric, cognitive, immunological and inflammatory disorders.Type: ApplicationFiled: July 19, 2005Publication date: November 6, 2008Inventors: Giovanni Gaviraghi, Chiara Ghiron, Hendrik Bothmann, Renza Roncarati, Georg Christian Terstappenn
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Patent number: 6531466Abstract: A compound of formula (I), salts and metabolically labile esters thereof, wherein R represents optionally substituted aryl or heteroaryl group; A represents a propylene chain or A is a chain of 3 members one of which is selected from an oxygen or sulphur atom or the group NH or a substituted derivative thereof and the other two members are methylene groups, having antibacterial activity, processes for their preparation and to their use in medicine.Type: GrantFiled: February 13, 2001Date of Patent: March 11, 2003Assignee: GlaxoSmithKline SpAInventors: Tino Rossi, Daniele Andreotti, Giovanna Tedesco, Luca Tarsi, Emiliangelo Ratti, Aldo Feriani, Domenica Antonia Pizzi, Giovanni Gaviraghi, Stefano Biondi, Gabriella Finizia
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Patent number: 6413930Abstract: The use of CCK-B antagonists for the treatment of sleep disorders.Type: GrantFiled: April 10, 1997Date of Patent: July 2, 2002Assignee: Glaxo Wellcome SpaInventors: Emiliangelo Ratti, David Gordon Trist, Giovanni Gaviraghi, Francesco Crespi, Angelo Mario Reggiani
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Patent number: 6071939Abstract: A composition comprising diethyl (E)-4-[2-[(tert-butyloxycarbonyl)vinyl]phenyl-1,4-dihydro-2,6-dimethylpyri dine-3,5-dicarboxylate (lacidipine) and 4'-[[2-n-propyl-4-methyl-6 -(1-methylbenziimidazol-2-yl)-benzimidazol-1-yl]-methyl]-biphenyl-2 -carboxylic acid (telmisartan) or a physiologically functional derivative thereof.Type: GrantFiled: May 4, 1999Date of Patent: June 6, 2000Assignees: Glaxo Group Limited, Boehringer Ingelheim GmbHInventors: Giovanni Gaviraghi, Mauro Quartaroli
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Patent number: 5686461Abstract: The invention relates to compounds of formula (I). ##STR1## or a salt, or metabolically labile ester thereof wherein R.sub.1 represents a group selected from halogen, alkyl, alkoxy, amino, alkylamino, dialkylamino, hydroxy, trifluoromethyl, trifluoromethoxy, nitro, cyano, SO.sub.2 R.sub.3 or COR.sub.3 wherein R.sub.3 represents hydroxy, methoxy, or amino; m is zero or an integer 1 or 2;A represents an ethynyl group or an optionally substituted ethenyl group;X represents a bond or a C.sub.1-4 alkylene chain;R.sub.2 represents a bridged cycloalkyl or bridged heterocyclic group; which are antagonists of excitatory amino acids, to processes for their preparation and to their use in medicine.Type: GrantFiled: September 18, 1995Date of Patent: November 11, 1997Assignee: Glaxo Wellcome S.p.A.Inventors: Alfredo Cugola, Giovanni Gaviraghi, Fabrizio Micheli
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Patent number: 5587374Abstract: A compound of the formula 1-cyclohexyloxycarbonyloxethyl (4S, 8S, 9R 10S, 12R)-4-methoxy-10-(1-hydroxyethyl)-11-oxo-1-azatricyclo[7.2.0.0..sup.3,8 ]undec-2-ene-2-carboxylate which is useful as a pharmaceutical composition to treat bacterial infection.Type: GrantFiled: February 14, 1995Date of Patent: December 24, 1996Assignee: Glaxo SpAInventors: Alcide Perboni, Tino Rossi, Giovanni Gaviraghi, Giorgio Tarzia, Antonella Ursini
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Patent number: 5510367Abstract: The invention relates to the compound of formula (I) ##STR1## wherein A represents an unsubstituted ethenyl group in the trans (E) configuration or a physiologically acceptable salt or metabilically labile ester thereof which are antagonists of excitatory amino acids, to processes for their preparation and to their use in medicine.Type: GrantFiled: December 8, 1994Date of Patent: April 23, 1996Assignee: Glaxo SpAInventors: Alfredo Cugola, Giovanni Gaviraghi
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Patent number: 5455257Abstract: The invention relates to a method for the treatment of arteriosclerosis in a mammal which comprises administering to said mammal an effective amount of (E)-4-[2-[3-(1,1-dimethylethoxy)-3-oxo-1-propenyl]phenyl]-1,4-dihydro-2,6- dimethyl-3,5-pyridinedicarboxylic acid diethyl ester, lacidipine, as well as methods of treatment of arteriosclerosis which comprise administering to a mammal, especially a human, in need thereof, a pharmaceutical composition comprising lacidipine and a pharmaceutically acceptable carrier or excipient.Type: GrantFiled: August 11, 1993Date of Patent: October 3, 1995Assignee: Glaxo SpAInventor: Giovanni Gaviraghi
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Patent number: 5407931Abstract: The invention relates to heterocyclic derivatives having antibacterial activity, to processes for their preparation, to compositions containing them, and to their medicinal uses.Type: GrantFiled: September 7, 1990Date of Patent: April 18, 1995Assignee: Glaxo S.p.A.Inventors: Bruno Tamburini, Alcide Perboni, Tino Rossi, Daniele Donati, Daniele Andreotti, Giovanni Gaviraghi, Roberto Carlesso, Claudio Bismara
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Patent number: 5374648Abstract: The invention relates to compounds of formula (I). ##STR1## or a salt, or metabolically labile ester thereof wherein R represents a group selected from halogen, alkyl, alkoxy, amino, alkylamino, dialkylamino, hydroxy, trifluoromethyl, trifluoromethoxy, nitro, cyano, SO.sub.2 R.sub.1 or COR.sub.1 wherein R.sub.1 represents hydroxy, methoxy, or amino; m is zero or an integer 1 or 2;A represents an ethynyl group or an optionally substituted ethenyl, orcyclopropyl group or a substituted ethenyl group;X represents --O-- or NH;R.sub.2 represents an aryl group and when X represents an oxygen atom R.sub.2 may also represent a hydrogen atom or an alkyl group; which are antagonists of excitatory amino acids, to processes for their preparation and to their use in medicine.Type: GrantFiled: April 15, 1993Date of Patent: December 20, 1994Assignee: Glaxo S.p.A.Inventors: Alfredo Cugola, Giovanni Gaviraghi, Simone Giacobbe
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Patent number: 5374649Abstract: The invention relates to compounds of formula I. ##STR1## or a salt, or metabolically labile ester thereof wherein A represents an unsubstituted ethenyl, group in the trans configuration, R.sub.1 represents a substituted phenyl group which are antagonists of excitatory amino acids, to processes for their preparation and to their use in medicine.Type: GrantFiled: April 15, 1993Date of Patent: December 20, 1994Assignee: Glaxo S.p.A.Inventors: Alfredo Cugola, Giovanni Gaviraghi
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Patent number: 5373018Abstract: The invention relates to the compound of formula (I) ##STR1## wherein A represents an unsubstituted ethenyl group in the trans (E) configuration or a physiologically acceptable salt or metabilically labile ester thereof which are antagonists of excitatory amino acids, to processes for their preparation and to their use in medicine.Type: GrantFiled: April 15, 1993Date of Patent: December 13, 1994Assignee: Glaxo S.p.A.Inventors: Alfredo Cugola, Giovanni Gaviraghi
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Patent number: 5162345Abstract: Compounds are described of the formula: ##STR1## and physiologically acceptable salts thereof, in which R.sub.1 -R.sub.7 are defined hereinafter.The compounds represented by formula (I) reduce intracellular calcium ion concentration by limiting transmembranal calcium ion concentration and thus may be useful for the treatment of cardiovascular disorders such as hypertension.Type: GrantFiled: August 20, 1990Date of Patent: November 10, 1992Assignee: Glaxo, S.p.A.Inventors: Claudio Semeraro, Dino Micheli, Daniele Pieraccioli, Giovanni Gaviraghi, Alan D. Borthwick
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Patent number: 5138048Abstract: Compounds of the general formula (I) ##STR1## in which: R.sub.1 represents a hydroxyl protecting group; andR.sub.2 represents a hydrogen or halogen atom, an azido group, a C.sub.1-3 alkyl group, a group (CH.sub.2).sub.m OR.sub.3 wherein m is zero or one and R.sub.3 represents a hydrogen atom or a hydroxyl protecting group, an azidoethoxy group, a protected hydroxyethoxy group or a group XR.sub.4 in which X is an oxygen atom or the group S(O).sub.n in which n is zero, 1 or 2 and R.sub.4 represents a C.sub.1-5 alkyl, C.sub.3-7 cycloalkyl or phenyl group or when X is oxygen or sulphur then R.sub.4 may also represent the group AlkNR.sub.5 R.sub.6 in which Alk represents a C.sub.2-6 straight or branched alkylene chain and R.sub.5 and R.sub.6 independently represent a hydrogen atom or C.sub.1-4 alkyl group or R.sub.5 and R.sub.6 together with the nitrogen atom to which they are attached form a pyrrolidino or piperidino ring or the group NR.sub.5 R.sub.6 represents a protected amino group, or R.sub.Type: GrantFiled: September 7, 1990Date of Patent: August 11, 1992Assignee: Glaxo S.p.A.Inventors: Bruno Tamburini, Alcide Perboni, Tino Rossi, Daniele Donati, Daniele Andreotti, Giovanni Gaviraghi, Stefano Biondi, Claudio Bismara
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Patent number: 5091395Abstract: Compounds are described of the formula ##STR1## wherein R.sub.1 and R.sub.4 independently represent a C.sub.1-4 alkyl group;R.sub.2 and R.sub.3 independently represent a C.sub.1-6 straight or branched alkyl chain or alkoxy group;R.sub.5 represents a straight or branched chain C.sub.1-13 alkyl group or a C.sub.5-8 cycloalkyl group which may be substituted by a C.sub.1-3 alkyl substituent;R.sub.6 represents a halogen atom or a straight or branched C.sub.1-3 alkyl group.The compounds represented by formula (I) reduce intracellular calcium ion concentration by limiting transmembranal calcium ion reflux and thus may be useful for the treatment of cardiovascular disorders such as hypertension.Type: GrantFiled: November 4, 1988Date of Patent: February 25, 1992Assignee: Glaxo S.p.A.Inventors: Claudio Semeraro, Dino Micheli, Daniele Pieraccioli, Giovanni Gaviraghi, Alan D. Borthwick
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Patent number: 5051432Abstract: Compounds are described of the formula ##STR1## wherein R.sub.1 and R.sub.4 independently represent a C.sub.1-4 alkyl group:R.sub.2 represents a group ##STR2## (where A is a bond or a methylene group and R.sub.7 is phenyl C.sub.1-4 alkyl; or R.sub.2 represents a group CH.sub.2 CH.sub.2 NR.sub.8 R.sub.9 (where R.sub.8 is hydrogen or C.sub.1-4 alkyl and R.sub.9 is C.sub.1-4 alkyl, phenyl C.sub.1-4 alkyl or benzoyl C.sub.1-4 alkyl); or R.sub.2 represents a C.sub.1-4 alkyl group substituted by nitrile.R.sub.3 represents a C.sub.1-6 straight or brached alkyl chain or alkoxy group;R.sub.5 represents a straight or branched chain C.sub.1-13 alkyl group or a C.sub.5-8 cycloalkyl group which may be substituted by a C.sub.1-3 alkyl substituent;R.sub.6 represents a halogen atom or a straight or branched C.sub.1-3 alkyl group.Type: GrantFiled: September 19, 1990Date of Patent: September 24, 1991Assignee: Glaxo, S.p.A.Inventors: Claudio Semeraro, Dino Micheli, Daniele Pieraccioli, Giovanni Gaviraghi, Alan D. Borthwick
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Patent number: 5011848Abstract: Compounds are described of the formula ##STR1## wherein R.sub.1 and R.sub.4 independently represent a C.sub.1-4 alkyl group;R.sub.2 and R.sub.3 independently represent a C.sub.1-6 straight or branched alkyl chain which may be interrupted by an oxygen atom;R.sub.5 represents a straight or branched chain C.sub.1-13 alkyl group or a C.sub.5-8 cycloalkyl group which may be substituted by a C.sub.1-3 alkyl substitutent;The compounds represented by formula (I) reduce intracellular calcium ion concentration by limiting transmembranal calcium ion influx and thus may be useful for the treatment of cardiovascular disorders such as hypertension.Type: GrantFiled: January 23, 1989Date of Patent: April 30, 1991Assignee: Glaxo, S.p.A.Inventors: Claudio Semeraro, Dino Micheli, Daniele Pieraccioli, Giovanni Gaviraghi, Allan D. Borthwick
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Patent number: 4963571Abstract: Compounds are described of the formula ##STR1## wherein R.sub.1 and R.sub.4 independently represent a C.sub.1-4 alkyl group;R.sub.2 and R.sub.3 independently represent a C.sub.1-6 straight or branched alkyl chain or alkoxy group;R.sub.5 represents a straight or branched chain C.sub.1-13 alkyl group or a C.sub.5-8 cycloalkyl group which may be substituted by a C.sub.1-3 alkyl substituent;R.sub.6 represents a halogen atom or a straight or branched C.sub.1-3 alkyl group.R.sub.7 represents a C.sub.1-4 alkyl group [optionally substituted by hydroxy, C.sub.1-3 alkoxy or trifluoromethyl or by a group NR.sub.8 R.sub.9 where NR.sub.8 R.sub.9 forms a saturated 5 to 7 membered ring optionally containing an additional heleroatom which is oxygen]; or R.sub.7 represents a phenylC.sub.1-2 alkyl group in which the portion is optionally substituted by 1 to 3 C.sub.1-3 alkyl or C.sub.1-3 alkoxy groups or halogen atoms.Type: GrantFiled: November 16, 1988Date of Patent: October 16, 1990Assignee: Glaxo S.p.A.Inventors: Claudio Semeraro, Dino Micheli, Daniele Pieraccioli, Giovanni Gaviraghi, Alan D. Borthwick