Abstract: The invention relates to hDHODH inhibitors, in particular 2-hydroxypyrazolo[1,5-a]pyridine derivatives, for use as antiviral agents. The hDHODH inhibitors for use according to the invention are effective as inhibitors of the replication of a wide spectrum of both DNA and RNA viruses, including, i.a., Herpes simplex virus 1 (HSV-1), Herpes simplex virus 2 (HSV-2), Influenza A virus, Influenza B virus, Respiratory syncytial virus (RSV), Severe acute respiratory syndrome coronavirus 1 (SARS-CoV-1), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and Middle East respiratory syndrome-related coronavirus (MERS-CoV).

Abstract: The present invention refers to a method to identify a genetic fusion associated with a subject affected by a disease, preferably B-cell acute lymphoblastic leukemia (B-ALL). A method to classify a subject affected by a disease into a known subtype of said disease and methods to select a suitable therapeutic treatment involving the identification of genetic fusions in said subject are also disclosed.

Abstract: Compounds of formulae (I) and (II) which are novel inhibitors of human dihydroorotate dehydrogenase (hDHODH) and pharmaceutical compositions containing the compounds of formulae (I) and (II) are provided. A method for treating tumor diseases, including acute myelogenous leukemia (AML), triple-negative breast cancer, PTEN-mutant tumors, and KRAS-driven tumors by administering pharmaceutical compositions containing the compounds of formulae (I) and (II) is also provided.

Abstract: The embodiments disclosed herein provide fast recovery of a network signal path by, in the event of a failure or unacceptable degradation in a signal in the original network path, diverting the optical signal passing through the network to a preselected bypass optical path which is maintained in a warm or operational state. The optical elements on the bypass optical path are available network resources which may, during part or all of the time the bypass path is designated for a node in the primary optical path, be in use to transmit other optical signals in the network. By maintaining the resources in the designated bypass path in a warm or operating state, fast rerouting and recovery of an interrupted signal is possible.

Abstract: The embodiments disclosed herein provide fast recovery of a network signal path by, in the event of a failure or unacceptable degradation in a signal in the original network path, diverting the optical signal passing through the network to a preselected bypass optical path which is maintained in a warm or operational state. The optical elements on the bypass optical path are available network resources which may, during part or all of the time the bypass path is designated for a node in the primary optical path, be in use to transmit other optical signals in the network. By maintaining the resources in the designated bypass path in a warm or operating state, fast rerouting and recovery of an interrupted signal is possible.

Abstract: The embodiments disclosed herein provide fast recovery of a network signal path by, in the event of a failure or unacceptable degradation in a signal in the original network path, diverting the optical signal passing through the network to a preselected bypass optical path which is maintained in a warm or operational state. The optical elements on the bypass optical path are available network resources which may, during part or all of the time the bypass path is designated for a node in the primary optical path, be in use to transmit other optical signals in the network. By maintaining the resources in the designated bypass path in a warm or operating state, fast rerouting and recovery of an interrupted signal is possible.

Abstract: The embodiments disclosed herein provide fast recovery of a network signal path by, in the event of a failure or unacceptable degradation in a signal in the original network path, diverting the optical signal passing through the network to a preselected bypass optical path which is maintained in a warm or operational state. The optical elements on the bypass optical path are available network resources which may, during part or all of the time the bypass path is designated for a node in the primary optical path, be in use to transmit other optical signals in the network. By maintaining the resources in the designated bypass path in a warm or operating state, fast rerouting and recovery of an interrupted signal is possible.

Abstract: Techniques are presented herein to setup a wavelength on a path from a source node to a destination node. Cross-talk margin information already computed for one or more installed wavelengths is obtained between the source node and destination node. A total margin as a function of the cross-talk margin information is computed. A determination is then made as to whether to perform non-linear impairment validation of the wavelength based on the total margin. These techniques may be generalized to account for coherent and non-coherent portions of a network.

Abstract: Techniques are provided for using light path priority of service information in an optical network. At a node in the optical network, priority of service information is stored for a plurality of light paths used in the optical network. The node serves traffic in the optical network using the plurality of light paths based on the priority of service information. These techniques provide for prioritizing light paths (wavelengths) for scenarios such as restoration, congestion and resource contention.

Abstract: Techniques are presented herein to setup a wavelength on a path from a source node to a destination node. Cross-talk margin information already computed for one or more installed wavelengths is obtained between the source node and destination node. A total margin as a function of the cross-talk margin information is computed. A determination is then made as to whether to perform non-linear impairment validation of the wavelength based on the total margin. These techniques may be generalized to account for coherent and non-coherent portions of a network.

Abstract: Techniques are provided for receiving a connection request at a first network node configured to request a connection from the first network node to a second network node. At the first network node, it is determined if a path to the second network node without an optical regenerator is available for the connection. In response to determining that a path without an optical regenerator is not available, a path to the second network node is determined that has a minimum number of optical regenerators. The connection is set up using the path with the minimum number of optical regenerators.

Abstract: Techniques are provided for using light path priority of service information in an optical network. At a node in the optical network, priority of service information is stored for a plurality of light paths used in the optical network. The node serves traffic in the optical network using the plurality of light paths based on the priority of service information. These techniques provide for prioritizing light paths (wavelengths) for scenarios such as restoration, congestion and resource contention.

Abstract: Methods and apparatus for efficiently utilizing an optical control plane distinct from an electronic control plane to facilitate the setup of paths in a dense wave division multiplexing network are disclosed. According to one aspect of the present invention, a method includes receiving a probe arranged determine the optical feasibility of a first path, and determining a probability of success associated with the probe. The probability of success indicates a likelihood that the probe will be successfully routed on the first path to the destination, and is associated with a particular wavelength. A second path on which to route the probe is dynamically identified if the probability indicates a low likelihood of successful routing on the first path. Finally, the method includes determining if a notification associated with the probe has been received, and altering the probability of success based on the notification if the notification has been received.

Abstract: Techniques are provided for receiving a connection request at a first network node configured to request a connection from the first network node to a second network node. At the first network node, it is determined if a path to the second network node without an optical regenerator is available for the connection. In response to determining that a path without an optical regenerator is not available, a path to the second network node is determined that has a minimum number of optical regenerators. The connection is set up using the path with the minimum number of optical regenerators.

Abstract: Techniques are provided for detecting at a controller associated with a physical layer of a network an occurrence of a failure within the physical layer of the network. In response to detecting the failure, the controller sends messages to at least first and second nodes in a transport layer of the network, where the messages are configured to indicate normal operations in the physical layer so as to prevent execution of transport layer protection processes for a period of time.

Abstract: An optical control plane (OCP) distinct from an electronic control plane helps the setup of path routes in a DWDM network. The OCP determines the optical feasibility of any path route selected by the electronic control plane, such as operated under GMPLS protocol, and asks the electronic control plane for another path route if the optical feasibility is determined to be negative. The OCP can be set in a server or distributed across the nodes of the network.

Abstract: Techniques are provided for detecting at a controller associated with a physical layer of a network an occurrence of a failure within the physical layer of the network. In response to detecting the failure, the controller sends messages to at least first and second nodes in a transport layer of the network, where the messages are configured to indicate normal operations in the physical layer so as to prevent execution of transport layer protection processes for a period of time.

Abstract: Methods and apparatus for efficiently utilizing an optical control plane distinct from an electronic control plane to facilitate the setup of paths in a dense wave division multiplexing network are disclosed. According to one aspect of the present invention, a method includes receiving a probe arranged determine the optical feasibility of a first path, and determining a probability of success associated with the probe. The probability of success indicates a likelihood that the probe will be successfully routed on the first path to the destination, and is associated with a particular wavelength. A second path on which to route the probe is dynamically identified if the probability indicates a low likelihood of successful routing on the first path. Finally, the method includes determining if a notification associated with the probe has been received, and altering the probability of success based on the notification if the notification has been received.