Abstract: The present invention relates to the field of optical imaging. More particularly, it relates to compounds of the cyanine family with near-infrared emission characterized by improved physico-chemical and biological properties and to conjugates with biological ligands thereof. The invention also relates to the use of these compounds as optical diagnostic agents in imaging or therapy of solid tumors, to the methods for their preparation and to the compositions comprising them.

Abstract: The present invention relates to the field of optical imaging. More particularly, it relates to compounds of the cyanine family with near-infrared emission characterized by improved physico-chemical and biological properties and to conjugates with biological ligands thereof. The invention also relates to the use of these compounds as optical diagnostic agents in imaging or therapy of solid tumors, to the methods for their preparation and to the compositions comprising them.

Abstract: The present invention relates to the field of optical imaging. More particularly, it relates to compounds of the cyanine family with near- infrared emission characterized by improved physico-chemical and biological properties and to conjugates with biological ligands thereof. The invention also relates to the use of these compounds as optical diagnostic agents in imaging or therapy of solid tumors, to the methods for their preparation and to the compositions comprising them.

Abstract: A solution is proposed for imaging a field of view (103) comprising a target (115) containing a luminescence substance. A corresponding method (500) comprises setting (512-552) an analysis region (225;260) to a portion of a luminescence image 5(205;205F) surrounding a suspected representation of the target (115) and segmenting (554-556) the analysis region (225;260) into a detection segment (230d;265d) and a non-detection segment (230n;265n) of the luminescence substance; the luminescence image (205;205F) is then displayed (558-586) with the detection segment (230d;265d) that is highlighted according to a verification indicator based on a quality of the 0segmentation. A computer program (400) and a corresponding computer program product for implementing the method (500) are also proposed. Moreover, a corresponding system (100) is proposed. A surgical method, a diagnostic method and a therapeutic method based on the same solution are further proposed.

Abstract: A solution is proposed for assisting a medical procedure. A corresponding method comprises acquiring a luminescence image (205F), based on a luminescence light, and an auxiliary image (205R), based on an auxiliary light different from this luminescence light, of a field of view (103); the field of view (103) contains a region of interest comprising a target body of the medical procedure (containing a luminescence substance) and one or more foreign objects. An auxiliary informative region (210Ri) representative of the region of interest without the foreign objects is identified in the auxiliary image (205R) according to its content, and a luminescence informative region (210Fi) is identified in the luminescence image (205F) according to the auxiliary informative region (210Ri). The luminescence image (205F) is processed limited to the luminescence informative region (210Fi) for facilitating an identification of a representation of the target body therein.

Abstract: The present invention relates to the field of optical imaging More particularly, it relates to compounds of the cyanine family characterized by improved physico-chemical and biological properties and to their conjugates with biological ligands thereof. The invention also relates to the use of these compounds as optical diagnostic agents in imaging or therapy of solid tumors, to the methods for their preparation and to the compositions comprising them.

Abstract: The present invention relates to the use of a NIR fluorescent probe comprising an aza-bicycloalkane based cyclic peptide labelled with a Cy5.5 dye moiety in the fluorescence-guided surgery of pathologic regions and to an optical imaging method that comprises using this fluorescent probe for the identification and demarcation of tumor margins during the surgical resection.

Abstract: The present invention generally relates to paramagnetic contrast agents and a Dynamic Contrast Enhanced-MRI method for the non-invasive estimation of the delivery of a macromolecular anticancer drug or pro-drug within pathological tissues and, especially, in solid tumors and for the optimization of anticancer therapies.

Abstract: The present invention relates to the use of a NIR fluorescent probe comprising an aza-bicycloalkane based cyclic peptide labelled with a Cy5.5 dye moiety in the fluorescence- guided surgery of pathologic regions and to an optical imaging method that comprises using this fluorescent probe for the identification and demarcation of tumor margins during the surgical resection.

Abstract: The present invention generally relates to paramagnetic contrast agents and a Dynamic Contrast Enhanced-MRI method for the non-invasive estimation of the delivery of a macromolecular anticancer drug or pro-drug within pathological tissues and, especially, in solid tumors and for the optimization of anticancer therapies.