Patents by Inventor Gordon V. L. Wang

Gordon V. L. Wang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8198079
    Abstract: The present invention is directed at optimized expression vectors for the expression of native-like heterologous proteins in insect cells. Compositions of the invention are nucleotide sequences representing elements of an expression vector that when combined results in enhanced expression and secretion of heterologous proteins. The elements include sequences that define transcriptional activators, core promoters, secretion signals, and 3? untranslated regions that are functional in insect cells. The elements contained in the optimized vectors are all synthetically derived or are modified variants of naturally occurring insect sequences. The expression vectors are useful for the expression of native-like proteins when protein encoding nucleotide sequences are operatively linked to the vectors. These vectors can be used to transform insect cells, which can then be cultured to produce the desired protein product.
    Type: Grant
    Filed: April 28, 2008
    Date of Patent: June 12, 2012
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: David Edward Clements, Gordon V. L. Wang, Carolyn Weeks-Levy
  • Publication number: 20100167389
    Abstract: The present invention is directed at optimized expression vectors for the expression of native-like heterologous proteins in insect cells. Compositions of the invention are nucleotide sequences representing elements of an expression vector that when combined results in enhanced expression and secretion of heterologous proteins. The elements include sequences that define transcriptional activators, core promoters, secretion signals, and 3? untranslated regions that are functional in insect cells. The elements contained in the optimized vectors are all synthetically derived or are modified variants of naturally occurring insect sequences. The expression vectors are useful for the expression of native-like proteins when protein encoding nucleotide sequences are operatively linked to the vectors. These vectors can be used to transform insect cells, which can then be cultured to produce the desired protein product.
    Type: Application
    Filed: April 28, 2008
    Publication date: July 1, 2010
    Applicant: Hawaii Biotech, Inc.
    Inventors: David Edward Clements, Gordon V. L. Wang, Carolyn Weeks-Levy