Patents by Inventor Goutam Palui

Goutam Palui has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10294213
    Abstract: A series of multicoordinating and multifunctional ligands optimized for the surface-functionalization of luminescent quantum dots (QDs) and gold nanoparticles (AuNPs) alike is disclosed. An L-aspartic acid precursor is modified with functionality, through simple peptide coupling chemistry, one or two lipoic acid (LA) groups and poly(ethylene glycol) (PEG) moieties in the same ligand. These ligands were combined with a new photoligation strategy to yield hydrophilic and reactive QDs that are colloidally stable over a broad range of conditions, including storage at nanomolar concentration and under ambient conditions.
    Type: Grant
    Filed: December 1, 2016
    Date of Patent: May 21, 2019
    Assignee: The Florida State University Research Foundation, Inc.
    Inventors: Hedi Mattoussi, Naiqian Zhan, Goutam Palui
  • Patent number: 9790329
    Abstract: The disclosure is directed to multi-coordinating polymers as ligands that combine two distinct metal-chelating groups, lipoic acid and imidazole, for the surface functionalization of QDs. These ligands combine the benefits of thiol and imidazole coordination to reduce issues of thiol oxidation and weak binding affinity of imidazole. The ligand design relies on the introduction of controllable numbers of lipoic acid and histamine anchors, along with hydrophilic moieties and reactive functionalities, onto a poly(isobutylene-alt-maleic anhydride) chain via a one-step nucleophilic addition reaction. We further demonstrate that this design is fully compatible with a novel and mild photoligation strategy to promote the in-situ ligand exchange and phase transfer of hydrophobic QDs to aqueous media under borohydride-free conditions. Ligation with these polymers provides highly fluorescent QDs that exhibit great long-term colloidal stability over a wide range of conditions.
    Type: Grant
    Filed: March 30, 2015
    Date of Patent: October 17, 2017
    Assignee: The Florida State University Research Foundation, Inc.
    Inventors: Hedi Mattoussi, Wentao Wang, Goutam Palui
  • Publication number: 20170168042
    Abstract: A series of multicoordinating and multifunctional ligands optimized for the surface-functionalization of luminescent quantum dots (QDs) and gold nanoparticles (AuNPs) alike is disclosed. An L-aspartic acid precursor is modified with functionality, through simple peptide coupling chemistry, one or two lipoic acid (LA) groups and poly(ethylene glycol) (PEG) moieties in the same ligand. These ligands were combined with a new photoligation strategy to yield hydrophilic and reactive QDs that are colloidally stable over a broad range of conditions, including storage at nanomolar concentration and under ambient conditions.
    Type: Application
    Filed: December 1, 2016
    Publication date: June 15, 2017
    Inventors: Hedi Mattoussi, Naiqian Zhan, Goutam Palui
  • Patent number: 9598635
    Abstract: A method for the photo-mediated phase transfer of inorganic nanocrystals, such as luminescent quantum dots, QDs, is provided. Irradiation, specifically UV excitation (?ex<400 nm), promotes the in-situ ligand exchange of hydrophobic quantum dots with hydrophilic ligands and their facile transfer to polar solvents and buffer media. The technique enables transfer of quantum dots and other nanocrystal materials from hydrophobic to polar and hydrophilic solutions.
    Type: Grant
    Filed: May 7, 2013
    Date of Patent: March 21, 2017
    Assignee: The Florida State University Research Foundation, Inc.
    Inventors: Hedi Mattoussi, Igor Alabugin, Goutam Palui, Tommaso Avellini
  • Patent number: 9580560
    Abstract: The disclosure is directed to polymer ligands that are optimally suited for surface-functionalizing magnetic nanoparticles. The amphiphilic polymers are prepared by coupling several amine-terminated anchoring groups, polyethylene glycol moieties, and reactive groups onto a poly(isobutylene-alt-maleic anhydride) (PIMA) chain. The reaction of maleic anhydride groups with amine-containing molecules is highly-efficient and occurs in one-step. The availability of several dopamine groups in the same ligand greatly enhances the ligand affinity, via multiple-coordination, to the magnetic NPs, while the hydrophilic and reactive groups promote colloidal stability in buffer media and allow subsequent conjugation with target biomolecules. Nanoparticles ligated with terminally reactive polymers have been easily coupled to target dyes and tested in live cell imaging with no measurable cytotoxicity.
    Type: Grant
    Filed: March 30, 2015
    Date of Patent: February 28, 2017
    Assignee: The Florida State University Research Foundation, Inc.
    Inventors: Hedi Mattoussi, Wentao Wang, Goutam Palui
  • Patent number: 9446152
    Abstract: In a composition aspect of the invention, a nanoparticle coating comprises repeating polyacrylic acid monomers covalently bound together in an aliphatic chain having a plurality of carboxylic acid functional groups and modified carboxylic acid functional groups extending therefrom. A first portion of the modified carboxylic acid functional groups are modified by a PEG oligomer having a terminal methoxy functional group and a second portion of the modified carboxylic acid functional groups are modified by a PEG oligomer having at least one terminal sulfur moiety.
    Type: Grant
    Filed: August 28, 2015
    Date of Patent: September 20, 2016
    Assignee: The Florida State University Research Foundation, Inc.
    Inventors: Hedi Mattoussi, Goutam Palui, Hyon Bin Na
  • Patent number: 9446153
    Abstract: In a composition aspect of the invention, a nanoparticle coating comprises repeating polyacrylic acid monomers covalently bound together in an aliphatic chain having a plurality of carboxylic acid functional groups and modified carboxylic acid functional groups extending therefrom. A first portion of the modified carboxylic acid functional groups are modified by a PEG oligomer having a terminal methoxy functional group and a second portion of the modified carboxylic acid functional groups are modified by a PEG oligomer having at least one terminal catechol group.
    Type: Grant
    Filed: August 28, 2015
    Date of Patent: September 20, 2016
    Assignee: The Florida State University Research Foundation, Inc.
    Inventors: Hedi Mattoussi, Goutam Palui, Hyon Bin Na
  • Publication number: 20160136302
    Abstract: In a composition aspect of the invention, a nanoparticle coating comprises repeating polyacrylic acid monomers covalently bound together in an aliphatic chain having a plurality of carboxylic acid functional groups and modified carboxylic acid functional groups extending therefrom. A first portion of the modified carboxylic acid functional groups are modified by a PEG oligomer having a terminal methoxy functional group and a second portion of the modified carboxylic acid functional groups are modified by a PEG oligomer having at least one terminal sulfur moiety.
    Type: Application
    Filed: August 28, 2015
    Publication date: May 19, 2016
    Inventors: Hedi Mattoussi, Goutam Palui, Hyon Bin Na
  • Patent number: 9309432
    Abstract: In a composition aspect of the invention, a nanoparticle coating comprises repeating polyacrylic acid monomers covalently bound together in an aliphatic chain having a plurality of carboxylic acid functional groups and modified carboxylic acid functional groups extending therefrom. A first portion of the modified carboxylic acid functional groups are modified by a PEG oligomer having a terminal methoxy functional group and a second portion of the modified carboxylic acid functional groups are modified by a PEG oligomer having at least one terminal catechol group.
    Type: Grant
    Filed: February 21, 2013
    Date of Patent: April 12, 2016
    Assignee: The Florida State University Research Foundation, Inc.
    Inventors: Hedi Mattoussi, Goutam Palui, Hyon Bin Na
  • Publication number: 20160055946
    Abstract: In a composition aspect of the invention, a nanoparticle coating comprises repeating polyacrylic acid monomers covalently bound together in an aliphatic chain having a plurality of carboxylic acid functional groups and modified carboxylic acid functional groups extending therefrom. A first portion of the modified carboxylic acid functional groups are modified by a PEG oligomer having a terminal methoxy functional group and a second portion of the modified carboxylic acid functional groups are modified by a PEG oligomer having at least one terminal catechol group.
    Type: Application
    Filed: August 28, 2015
    Publication date: February 25, 2016
    Inventors: Hedi Mattoussi, Goutam Palui, Hyon Bin Na
  • Publication number: 20150284493
    Abstract: The disclosure is directed to multi-coordinating polymers as ligands that combine two distinct metal-chelating groups, lipoic acid and imidazole, for the surface functionalization of QDs. These ligands combine the benefits of thiol and imidazole coordination to reduce issues of thiol oxidation and weak binding affinity of imidazole. The ligand design relies on the introduction of controllable numbers of lipoic acid and histamine anchors, along with hydrophilic moieties and reactive functionalities, onto a poly(isobutylene-alt-maleic anhydride) chain via a one-step nucleophilic addition reaction. We further demonstrate that this design is fully compatible with a novel and mild photoligation strategy to promote the in-situ ligand exchange and phase transfer of hydrophobic QDs to aqueous media under borohydride-free conditions. Ligation with these polymers provides highly fluorescent QDs that exhibit great long-term colloidal stability over a wide range of conditions.
    Type: Application
    Filed: March 30, 2015
    Publication date: October 8, 2015
    Inventors: Hedi Mattoussi, Wentao Wang, Goutam Palui
  • Publication number: 20150284517
    Abstract: The disclosure is directed to polymer ligands that are optimally suited for surface-functionalizing magnetic nanoparticles. The amphiphilic polymers are prepared by coupling several amine-terminated anchoring groups, polyethylene glycol moieties, and reactive groups onto a poly(isobutylene-alt-maleic anhydride) (PIMA) chain. The reaction of maleic anhydride groups with amine-containing molecules is highly-efficient and occurs in one-step. The availability of several dopamine groups in the same ligand greatly enhances the ligand affinity, via multiple-coordination, to the magnetic NPs, while the hydrophilic and reactive groups promote colloidal stability in buffer media and allow subsequent conjugation with target biomolecules. Nanoparticles ligated with terminally reactive polymers have been easily coupled to target dyes and tested in live cell imaging with no measurable cytotoxicity.
    Type: Application
    Filed: March 30, 2015
    Publication date: October 8, 2015
    Inventors: Hedi Mattoussi, Wentao Wang, Goutam Palui
  • Patent number: 9150748
    Abstract: In a composition aspect of the invention, a nanoparticle coating comprises repeating polyacrylic acid monomers covalently bound together to form an aliphatic chain having a plurality of carboxylic acid functional groups and modified carboxylic acid functional groups extending therefrom. A first portion of the modified carboxylic acid functional groups are modified by a PEG oligomer having a terminal methoxy functional group and a second portion of the modified carboxylic acid functional groups are modified by a PEG oligomer having at least one terminal sulfur moiety.
    Type: Grant
    Filed: February 21, 2013
    Date of Patent: October 6, 2015
    Assignee: The Florida State University Research Foundation, Inc.
    Inventors: Hedi Mattoussi, Goutam Palui, Hyon Bin Na
  • Publication number: 20130299745
    Abstract: A method for the photo-mediated phase transfer of inorganic nanocrystals, such as luminescent quantum dots, QDs, is provided. Irradiation, specifically UV excitation (?ex<400 nm), promotes the in-situ ligand exchange of hydrophobic quantum dots with hydrophilic ligands and their facile transfer to polar solvents and buffer media. The technique enables transfer of quantum dots and other nanocrystal materials from hydrophobic to polar and hydrophilic solutions.
    Type: Application
    Filed: May 7, 2013
    Publication date: November 14, 2013
    Applicant: The Florida State University Research Foundation Inc.
    Inventors: Hedi Mattoussi, Igor Alabugin, Goutam Palui, Tommaso Avellini