Abstract: Compounds of Formula (I) or (II) useful for the treatment of spinal muscular atrophy or other uses, as well as methods of using such compounds to increase SMN expression, increase EAAT2 expression, or increase the expression of a nucleic acid that encodes a translational stop codon introduced by mutation or frameshift.

Abstract: Compounds of Formula (I) or (II) useful for the treatment of spinal muscular atrophy or other uses, as well as methods of using such compounds to increase SMN expression, increase EAAT2 expression, or increase the expression of a nucleic acid that encodes a translational stop codon introduced by mutation or frameshift.

Abstract: A fluid compressor 10 comprising a stator 22, having a bore shaped first chamber 26 and an annular second chamber 30, and a piston 18 comprising a central piston rod 36 having a first piston head 44 and a concentrically arranged cylindrical piston sleeve 38 having a second piston head 48. The stator 22 and piston 18 together define a first compression chamber 12, a second compression chamber 14 provided concentrically around the first chamber 12, and a third compression chamber 16 provided concentrically around the first chamber 12 and linearly with the second chamber 14. The compression chambers 12, 14, 16 are interconnected via intercooling conduits 72, 74. A hydraulic actuator 20 is coupled to the piston 18 by a hydraulic ram 82. During left to right movement of the piston 18 fluid enters the third chamber 16 and fluid is compressed in the second chamber 14.

Abstract: The present invention relates to a controllable polymeric surface coating including a macromolecule, which is covalently bound to the surface of a substrate, the macromolecule including a plurality of polymerisation initiators and a plurality of surface binding groups; and pendant polymers grafted from at least some of the polymerisation initiators.

Abstract: A flow control arrangement 10 for controlling the flow of lubricant discharged from a bearing 12 includes a flow control member 24 locatable, in use, adjacent to the bearing 12. The flow control member 24 defines a generally circumferential outer edge 26a and is rotatable to direct lubricant discharged onto the flow control member 24 radially outwardly towards the outer edge 26a for ejection therefrom.

Abstract: A contact of a component is electrically connected to an associated contact of an electrical circuit, typically formed on a substrate, by depositing material between the contacts, the material forming or being processed to form an electrical connection between the contacts. The invention also provides apparatus for this purpose and a resulting circuit.

Abstract: A method for manufacturing a structured optical device (1) starts with a substrate (2), on which is coated an alignment layer (3) and a liquid crystal polymer network layer (4). One of these layers can be created as a coating using a conventional technique. The other layer, either in a first step the alignment layer or in a second step the liquid crystal polymer network layer, is jet printed. The invention advantageously enables the making of a patterned liquid crystal polymer network which can be personalized upon manufacturing.

Abstract: A method of identifying a source of a marking fluid applied to a person or an object comprises applying a marking fluid including one or more security markers to a person or an object and illuminating the applied marking fluid to excite the security markers. Photoluminescent emission from the security markers in response to the excitation is measured and compared with one or more pre-defined photoluminescent signatures associated with the source of the marking fluid. The source of the marking fluid is identified based on a match between the detected photoluminescent emission and at least one of the pre-defined photoluminescent signatures.

Abstract: A method of allowing access to a secure area comprises illuminating an access control token incorporating one or more security markers. Emission from the security markers in response to the illumination is detected and processed to generate an access signature. Access to the secure area is allowed if the generated access signature matches one or more pre-defined access profiles.

Abstract: The present invention relates to apparatus for influencing fluid flow over a surface, and more particularly, but not exclusively, to turbulent boundary layer flow drag reduction for an aircraft. The present invention provides such apparatus including a plasma generator comprising a first electrode and a signal generator, the apparatus being operable to drive the first electrode with a pulsed signal generated by the signal generator thereby to cause a change in direction of the flow of the fluid over the surface.

Abstract: A method of determining a component of a medium comprises illuminating the medium to excite a marker associated with the component. Detected photoluminescent emission from the marker in response to the excitation is compared with one or more emission profiles. The component is identified based on a match between the detected photoluminescent emission and at least one of the emission profiles.

Abstract: A method of controlling operation of one or more functions performed by an item comprises illuminating a token including one or more luminescent markers and detecting emission from the markers in response to the illumination. A spectral signature from the detected emission is generated and compared with one or more pre-defined spectral signatures associated with authorization to perform, access, or use the functions. Operation of one or more of the functions is allowed when the generated spectral signature matches one or more of the pre-defined spectral signatures.

Abstract: A method of marking pharmaceuticals comprises providing a luminescent marker having a spectral signature associated with information associated with the pharmaceutical. Providing the luminescent marker includes incorporating the luminescent marker into the pharmaceutical, incorporating the luminescent marker into a coating on the pharmaceutical, incorporating the luminescent marker into packaging for the pharmaceutical, and the like.

Abstract: A method of ascertaining navigational information comprises illuminating a region of a surface incorporating one or more luminescent markers. Emission from the luminescent markers in response to the illumination is detected and processed to ascertain navigational information associated with the processed emission.

Abstract: A method of indicating the condition of an item comprises illuminating the item to excite one or more photoluminescent markers incorporated within the item. Photoluminescent emission from the markers in response to the excitation is compared to one or more pre-defined photoluminescent signatures indicating different conditions of the item.

Abstract: The present invention relates to apparatus for influencing fluid flow over a surface, and more particularly, but not exclusively, to turbulent boundary layer flow drag reduction for an aircraft. The present invention provides such apparatus including a plasma generator comprising first and second spaced-apart independently controllable electrodes operable to cause a change in direction of the flow of the fluid over the surface.

Abstract: A system for tagging articles. A glass is fabricated from (1) a combination of oxides and (2) one or more rare earth elements. The glass is divided into particles or fragments, which are attached to the article. When the particles are excited by specific radiation, they emit a characteristic signature, in terms of a collection of frequencies, each frequency having a characteristic amplitude and decay time. However, the particles cannot be counterfeited, or reverse-engineered, because, at present, no systematic data is available which correlates a particle's characteristic signature with the composition and processing of the particle itself. Thus, at best, a trial-and-error approach must be taken in attempts at counterfeiting, which is considered impossible.

Abstract: A method for manufacturing a structured optical device (1) starts with a substrate (2), on which is coated an alignment layer (3) and a liquid crystal polymer network layer (4). One of these layers can be created as a coating using a conventional technique. The other layer, either in a first step the alignment layer or in a second step the liquid crystal polymer network layer, is jet printed. The invention advantageously enables the making of a patterned liquid crystal polymer network which can be personalized upon manufacturing.

Abstract: The present invention relates to apparatus for influencing fluid flow over a surface, and more particularly, but not exclusively, to turbulent boundary layer flow drag reduction for an aircraft. The present invention provides such apparatus including a plasma generator comprising first and second spaced-apart independently controllable electrodes operable to cause a change in direction of the flow of the fluid over the surface.

Abstract: The present invention relates to apparatus for influencing fluid flow over a surface, and more particularly, but not exclusively, to turbulent boundary layer flow drag reduction for an aircraft. The present invention provides such apparatus including a plasma generator comprising a first electrode (7) and a signal generator (18), the apparatus being operable to drive the first electrode (7) with a pulsed signal generated by the signal generator (18) thereby to cause a change in direction of the flow of the fluid over the surface.