Patents by Inventor Graham R. Moran

Graham R. Moran has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Treatment of microbial infections with compounds that inhibit 4-hydroxyphenylpyruvate dioxygenase
    Patent number: 8354451
    Abstract: Methods of inhibiting phagolysosomal fusion in patients infected with a microorganism involve the administration of a 4-hydroxyphenylpyruvate dioxygenase (HPPD)-inhibiting compound, such as 2-(2-nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione (NTBC) to the patient. A HPPD-inhibiting compound administered in an amount effective to enhance phagolysosomal fusion in the macrophages or neutrophils of the patient reduces or treats the infection. Methods for treating bacterial infections by administering a HPPD-inhibiting compound and reducing the production of pyomelanin or melanin in microorganisms are disclosed.
    Type: Grant
    Filed: March 9, 2010
    Date of Patent: January 15, 2013
    Assignee: The UWM Research Foundation, Inc.
    Inventors: Graham R. Moran, Panqing He
  • TREATMENT OF MICROBIAL INFECTIONS WITH COMPOUNDS THAT INHIBIT 4-HYDROXYPHENYLPYRUVATE DIOXYGENASE
    Publication number: 20100227936
    Abstract: Methods of inhibiting phagolysosomal fusion in patients infected with a microorganism involve the administration of a 4-hydroxyphenylpyruvate dioxygenase (HPPD)-inhibiting compound, such as 2-(2-nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione (NTBC) to the patient. A HPPD-inhibiting compound administered in an amount effective to enhance phagolysosomal fusion in the macrophages or neutrophils of the patient reduces or treats the infection. Methods for treating bacterial infections by administering a HPPD-inhibiting compound and reducing the production of pyomelanin or melanin in microorganisms are disclosed.
    Type: Application
    Filed: March 9, 2010
    Publication date: September 9, 2010
    Inventors: Graham R. Moran, Panqing He