Patents by Inventor Graham Ruecroft
Graham Ruecroft has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10143991Abstract: A process for preparing crystalline particles of an active principal in the presence of ultrasonic irradiation that comprises contacting a solution of a solute in a solvent in a first flowing stream with an anti-solvent in a second flowing stream causing the mixing thereof, wherein the flow rate ratio of the anti-solvent: solvent is higher than 20:1, and collecting crystals that are generated.Type: GrantFiled: September 15, 2015Date of Patent: December 4, 2018Assignee: Circassia LimitedInventors: James Robinson, Graham Ruecroft
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Publication number: 20170275781Abstract: This invention provides a process for increasing the crystallinity of at least one solid material which is less than 100% crystalline, comprising contacting said solid material with solvent in which the solid material is insoluble or poorly soluble (a non-solvent); and applying ultrasound to the solid material when in contact with said non-solvent.Type: ApplicationFiled: April 18, 2017Publication date: September 28, 2017Inventors: Graham Ruecroft, Dipesh Parikh, David Hipkiss
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Patent number: 9637840Abstract: This invention provides a process for increasing the crystallinity of at least one solid material which is less than 100% crystalline, comprising contacting said solid material with solvent in which the solid material is insoluble or poorly soluble (a non-solvent); and applying ultrasound to the solid material when in contact with said non-solvent.Type: GrantFiled: July 20, 2009Date of Patent: May 2, 2017Assignee: Prosonix LimitedInventors: Graham Ruecroft, Dipesh Parikh, David Hipkiss
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Publication number: 20160081924Abstract: This invention provides a pharmaceutical composition comprising a eutectic composition of two pharmacologically active ingredients for delivery to the lung by inhalation. This invention also provides a pharmaceutical composition comprising a eutectic composition of two pharmacologically active ingredients for the treatment of respiratory disease.Type: ApplicationFiled: November 25, 2015Publication date: March 24, 2016Inventors: Graham Ruecroft, Dipesh Parikh
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Patent number: 9278323Abstract: A process for preparing an emulsion or a dispersion comprising crystalline particles of at least one active principal that comprises contacting a solution of at least one solute in a solvent or mixture of solvents in a first flowing stream with a non-solvent in a second flowing stream wherein the non-solvent and solvent are not miscible with each other, so as to form an emulsion or a dispersion. Super saturation is brought about by suitable means, and the emulsion or dispersion is subjected to ultrasonic irradiation to mediate crystal nucleation.Type: GrantFiled: June 17, 2008Date of Patent: March 8, 2016Assignee: Prosonix LimitedInventors: Graham Ruecroft, James Robinson, Dipesh Parikh
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Publication number: 20160001252Abstract: A process for preparing crystalline particles of an active principal in the presence of ultrasonic irradiation that comprises contacting a solution of a solute in a solvent in a first flowing stream with an anti-solvent in a second flowing stream causing the mixing thereof, wherein the flow rate ratio of the anti-solvent: solvent is higher than 20:1, and collecting crystals that are generated.Type: ApplicationFiled: September 15, 2015Publication date: January 7, 2016Applicant: PROSONIX LIMITEDInventors: James Robinson, Graham Ruecroft
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Patent number: 9220708Abstract: This invention provides a pharmaceutical composition comprising a eutectic composition of two pharmacologically active ingredients for delivery to the lung by inhalation. This invention also provides a pharmaceutical composition comprising a eutectic composition of two pharmacologically active ingredients for the treatment of respiratory disease.Type: GrantFiled: August 8, 2012Date of Patent: December 29, 2015Assignee: Prosonix LimitedInventors: Graham Ruecroft, Dipesh Parikh
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Patent number: 9162160Abstract: A process for preparing crystalline particles of an active principal in the presence of ultrasonic irradiation that comprises contacting a solution of a solute in a solvent in a first flowing stream with an anti-solvent in a second flowing stream causing the mixing thereof, wherein the flow rate ratio of the anti-solvent: solvent is higher than 20:1, and collecting crystals that are generated.Type: GrantFiled: March 18, 2008Date of Patent: October 20, 2015Assignee: Prosonix LimitedInventors: James Robinson, Graham Ruecroft
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Publication number: 20140228330Abstract: This invention provides a pharmaceutical composition comprising a eutectic composition of two pharmacologically active ingredients for delivery to the lung by inhalation. This invention also provides a pharmaceutical composition comprising a eutectic composition of two pharmacologically active ingredients for the treatment of respiratory disease.Type: ApplicationFiled: August 8, 2012Publication date: August 14, 2014Inventors: Graham Ruecroft, Dipesh Parikh
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Patent number: 8771744Abstract: The invention provides a process for increasing the crystallinity of at least one solid material which is less than 100% crystalline, comprising applying ultrasound to the substantially dry solid material.Type: GrantFiled: October 20, 2010Date of Patent: July 8, 2014Assignee: Prosonix LimitedInventors: Graham Ruecroft, Dipesh Parikh
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Publication number: 20120309729Abstract: The invention provides a process for increasing the crystallinity of at least one solid material which is less than 100% crystalline, comprising applying ultrasound to the substantially dry solid material.Type: ApplicationFiled: October 20, 2010Publication date: December 6, 2012Inventors: Graham Ruecroft, Dipesh Parikh
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Publication number: 20110288060Abstract: This invention provides an oscillating baffled reactor apparatus for preparing crystalline particles of at least one substance comprising: a reactor vessel; means for supplying a first flowing stream; means for oscillating fluid within the reactor vessel; a plurality of baffles; source of ultrasonic radiation; and means for collecting said particles.Type: ApplicationFiled: January 5, 2010Publication date: November 24, 2011Applicant: PROSONIX LIMITEDInventors: Graham Ruecroft, John Burns
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Publication number: 20110146678Abstract: This invention provides a process for increasing the crystallinity of at least one solid material which is less than 100% crystalline, comprising contacting said solid material with solvent in which the solid material is insoluble or poorly soluble (a non-solvent); and applying ultrasound to the solid material when in contact with said non-solvent.Type: ApplicationFiled: July 20, 2009Publication date: June 23, 2011Inventors: Graham Ruecroft, Dipesh Parikh
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Publication number: 20100269825Abstract: Crystalline particles wherein each particle comprises a combination of a pharmaceutically acceptable salt of 8-hydroxy-5-[(1R)-1-hydroxy-2-[[(1R)-2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]-2(1H)-quinolinone (carmoterol), and a corticosteroid in a pre-determined and constant ratio are effective for the prevention and treatment of inflammatory or obstructive airways diseases.Type: ApplicationFiled: February 25, 2010Publication date: October 28, 2010Applicant: Chiesi Farmaceutici S.p.A.Inventors: Daniela COCCONI, Rossella MUSA, Gaetano BRAMBILLA, Dipesh PARIKH, Graham RUECROFT
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Publication number: 20100190760Abstract: A process for preparing an emulsion or a dispersion comprising crystalline particles of at least one active principal that comprises contacting a solution of at least one solute in a solvent or mixture of solvents in a first flowing stream with a non-solvent in a second flowing stream wherein the non-solvent and solvent are not miscible with each other, so as to form an emulsion or a dispersion. Super saturation is brought about by suitable means, and the emulsion or dispersion is subjected to ultrasonic irradiation to mediate crystal nucleation.Type: ApplicationFiled: June 17, 2008Publication date: July 29, 2010Applicant: PROSONIX LIMITEDInventors: Graham Ruecroft, James Robinson, Dipesh Parikh
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Publication number: 20100018853Abstract: A process for preparing crystalline particles of an active principal in the presence of ultrasonic irradiation that comprises contacting a solution of a solute in a solvent in a first flowing stream with an anti-solvent in a second flowing stream causing the mixing thereof, wherein the flow rate ratio of the anti-solvent: solvent is higher than 20:1, and collecting crystals that are generated.Type: ApplicationFiled: March 18, 2008Publication date: January 28, 2010Applicant: PROSONIX LIMITEDInventors: James Robinson, Graham Ruecroft
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Patent number: 5777138Abstract: A process for amidating a 2-azabicyclo?2.2.1!heptan-3-one or a 2-azabicyclo?2.2.1!hept-5-en-3-one by reaction with an amine, to form the corresponding ring-opened amide, is modified by the addition of an additive that accelerates the rate of reaction to an extent that the reaction can be carried out at atmospheric pressure.Type: GrantFiled: March 12, 1997Date of Patent: July 7, 1998Assignee: Chriroscience LimitedInventors: Robin Mark Bannister, Neil Henderson, Graham Ruecroft
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Patent number: 5739332Abstract: A process for the product of a 2,3-cis-dihydroxycycloalkane-1-carboxamide, comprises dihydroxylation of the corresponding cycloalkene-1-carboxamide. Some products are new. The stereoselective dihydroxylation is surprising.Type: GrantFiled: June 4, 1996Date of Patent: April 14, 1998Assignee: Chiroscience LimitedInventors: Raymond McCague, Graham Ruecroft, Christopher Palmer
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Patent number: 5663356Abstract: Patients susceptible to or suffering from central nervous system are treated by administering an effective amount of an aryl substituted olefinic amine compound, such as (E)-metanicotine. (E)-metanicotine is provided from nicotine. Nicotine is reacted with ethyl chloroformate to produce ethyl N-methyl-N-[4-chloro-4-(3-pyridyl)butyl]carbamate, which then is reacted in the presence of potassium tert-butoxide, tetrahydrofuran and dimethylformamide to produce (E)-metanicotine N-ethyl carbamate, which then is subjected to hydrolysis using hydrochloric acid to produce a reaction mixture containing (E)-metanicotine. The reaction mixture containing (E)-metanicotine is adjusted to a slightly basic pH, and then contacted with dichloromethane. The resulting water immiscible phase then is separated from the aqueous phase. The aqueous phase, then is adjusted to a very basic pH, and then contacted with methyl tert-butyl ether.Type: GrantFiled: April 23, 1996Date of Patent: September 2, 1997Inventors: Graham Ruecroft, Martin Woods