Patents by Inventor Graham Sandford

Graham Sandford has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200095207
    Abstract: The present invention relates to a method of manufacturing a fluorocytosine-based compound of Formula I. The invention also relates to a compound obtained by such a method, a pharmaceutical drug substance and a method for its manufacture, a pharmaceutical composition, and also various uses in therapy of the compounds, pharmaceutical drug substances, and pharmaceutical compositions of the invention.
    Type: Application
    Filed: August 19, 2019
    Publication date: March 26, 2020
    Inventors: Graham Sandford, Antal Harsanyi
  • Publication number: 20200028213
    Abstract: a secondary battery is provided. The secondary battery includes a cathode; an anode; and an electrolytic solution including a carbonyl compound.
    Type: Application
    Filed: September 30, 2019
    Publication date: January 23, 2020
    Inventors: Qiaoshu HU, Takumi HIASA, Kazumasa TAKESHI, Graham SANDFORD, Joshua WALTON, Nadejda KRASTEVA, Silvia ROSSELLI, Gabriele NELLES, David DANNER, Vitor DEICHMANN, Dennis CHERCKA, William FORD, Clemens WALL
  • Patent number: 10040819
    Abstract: A method for chemically modifying a peptide, derivative or analogue thereof is described. The method comprises contacting a peptide, derivative or analogue thereof with a fluoro-heteroaromatic compound to activate the peptide, derivative or analogue thereof. The activated peptide, derivative or analogue thereof is then contacted with a nucleophile or base to create a chemically modified peptide, derivative or analogue thereof.
    Type: Grant
    Filed: May 28, 2015
    Date of Patent: August 7, 2018
    Assignee: The University of Durham
    Inventors: Steven Cobb, Christopher Coxon, Graham Sandford
  • Publication number: 20170298028
    Abstract: The present invention relates to a method of manufacturing a fluorocytosine-based compound of Formula I. The invention also relates to a compound obtained by such a method, a pharmaceutical drug substance and a method for its manufacture, a pharmaceutical composition, and also various uses in therapy of the compounds, pharmaceutical drug substances, and pharmaceutical compositions of the invention.
    Type: Application
    Filed: August 13, 2015
    Publication date: October 19, 2017
    Applicant: University of Durham
    Inventors: Graham SANDFORD, Antal HARSANYI
  • Publication number: 20170204134
    Abstract: A method for preparing a cyclic peptide, derivative or analogue thereof is described. The method comprises contacting a peptide, derivative or analogue thereof with a fluoro-heteroaromatic compound to cyclise the peptide, derivative or analogue thereof.
    Type: Application
    Filed: May 28, 2015
    Publication date: July 20, 2017
    Inventors: Steven Cobb, Christopher Coxon, Graham Sandford
  • Patent number: 9701684
    Abstract: This invention relates to fluorinating agents and, more particularly, to chiral non-racemic fluorinating agents useful for enantioselective fluorination, as well as to their synthesis and use and other subject matter. The fluorinating agents are based on a substituted 1,4-diazabicyclo[2.2.2]octane (DABCO) skeleton and provide electrophillic fluorine enantioselectively.
    Type: Grant
    Filed: November 5, 2013
    Date of Patent: July 11, 2017
    Assignee: OXFORD UNIVERSITY INNOVATION LIMITED
    Inventors: Veronique Gouverneur, Graham Sandford
  • Publication number: 20170081360
    Abstract: A method for chemically modifying a peptide, derivative or analogue thereof is described. The method comprises contacting a peptide, derivative or analogue thereof with a fluoro-heteroaromatic compound to activate the peptide, derivative or analogue thereof. The activated peptide, derivative or analogue thereof is then contacted with a nucleophile or base to create a chemically modified peptide, derivative or analogue thereof.
    Type: Application
    Filed: May 28, 2015
    Publication date: March 23, 2017
    Inventors: Steven Cobb, Christopher Coxon, Graham Sandford
  • Publication number: 20150284401
    Abstract: This invention relates to fluorinating agents and, more particularly, to chiral non-racemic fluorinating agents useful for enantioselective fluorination, as well as to their synthesis and use and other subject matter. The fluorinating agents are based on a substituted 1,4-diazabicyclo[2.2.2]octane (DABCO) skeleton and provide electrophillic fluorine enantioselectively.
    Type: Application
    Filed: November 5, 2013
    Publication date: October 8, 2015
    Inventors: Veronique Gouverneur, Graham Sandford
  • Patent number: 8609873
    Abstract: The invention relates to a process for making HOF.RCN and using it to oxidise organic substrates in a quick and safe way. The process comprises passing diluted fluorine through a conduit and RCN in water through another conduit into a microreactor to form HOF.RCN and reacting this with an organic substrates.
    Type: Grant
    Filed: September 5, 2008
    Date of Patent: December 17, 2013
    Assignee: The Secretary of State for Defense in Her Britannic Majesty's Government of the United Kingdom of Great Britain and Northern Ireland
    Inventors: Christopher Murray, Graham Sandford
  • Patent number: 8038902
    Abstract: The present invention relates to a composition comprising at least one type of liquid crystal, to a liquid crystal cell and liquid crystal display device comprising such composition and to a method of preparing such a composition and/or such a liquid crystal cell.
    Type: Grant
    Filed: March 30, 2007
    Date of Patent: October 18, 2011
    Assignee: Sony Deutschland GmbH
    Inventors: Pinar Kilickiran, Akira Masutani, Anthony Roberts, Gabriele Nelles, Akio Yasuda, Andrzej Tadeusiak, Graham Sandford
  • Publication number: 20110040092
    Abstract: The invention relates to a process for making HOF.RCN and using it to oxidise organic substrates in a quick and safe way. The process comprises passing diluted fluorine through a conduit and RCN in water through another conduit into a microreactor to form HOF.RCN and reacting this with an organic substrates.
    Type: Application
    Filed: September 5, 2008
    Publication date: February 17, 2011
    Applicant: THE SECRETARY OF STATE FOR DEFENSE
    Inventors: Christopher Murray, Graham Sandford
  • Publication number: 20090244443
    Abstract: The present invention relates to a composition comprising at least one type of liquid crystal, to a liquid crystal cell and liquid crystal display device comprising such composition and to a method of preparing such a composition and/or such a liquid crystal cell.
    Type: Application
    Filed: March 30, 2007
    Publication date: October 1, 2009
    Applicant: SONY DEUTSCHLAND GMBH
    Inventors: Pinar Kilickiran, Akira Masutani, Anthony Roberts, Gabriele Nelles, Akio Yasuda, Andrzej Tadeusiak, Graham Sandford
  • Patent number: 7541008
    Abstract: A reactor for carrying out a reaction between at least two fluids comprises a reactor plate (20) with a plurality of grooves or through slots (22) in which the fluids mix and react and a separable overlying reservoir plate (2) for supplying the fluids to slots (22) from reservoirs (4, 6) via slots (10) a, (10) b, with a collecting conduit or reservoir (8) and slots (10) c for the product of the reaction. Reservoir plate (2) may lie between two reactor plates, or a single reactor plate (20) may lie between two reservoir plates. Third or further reservoirs may or may not be spaced from the second reservoir (6) depending on whether more than two fluids need to be present simultaneously, or whether a second reaction is required after the first two fluids have had time to react. Means may be provided for controlling the pressure in slots (22), the pressure differential (and flow rate) along slot (22), and/or the temperature in the reservoirs (4, 6) or slots (22).
    Type: Grant
    Filed: May 9, 2003
    Date of Patent: June 2, 2009
    Assignee: University of Durham of University Office
    Inventors: Richard Dickinson Chambers, Darren Holling, Graham Sandford
  • Publication number: 20050214184
    Abstract: A reactor for carrying out a reaction between at least two fluids comprises a reactor plate (20) with a plurality of grooves or through slots (22) in which the fluids mix and react and a separable overlying reservoir plate (2) for supplying the fluids to slots (22) from reservoirs (4, 6) via slots (10) a, (10) b, with a collecting conduit or reservoir (8) and slots (10) c for the product of the reaction. Reservoir plate (2) may lie between two reactor plates, or a single reactor plate (20) may lie between two reservoir plates. Third or further reservoirs may or may not be spaced from the second reservoir (6) depending on whether more than two fluids need to be present simultaneously, or whether a second reaction is required after the first two fluids have had time to react. Means may be provided for controlling the pressure in slots (22), the pressure differential (and flow rate) along slot (22), and/or the temperature in the reservoirs (4, 6) or slots (22).
    Type: Application
    Filed: May 9, 2003
    Publication date: September 29, 2005
    Inventors: Richard Chambers, Darren Holling, Graham Sandford
  • Patent number: 6441232
    Abstract: There is provided a method of selectively replacing a carbon-hydrogen bond at an unactivated saturated sp3 hybridised carbon atom in an organic compound by a carbon-nitrogen bond, the method comprising reacting the compound with a fluorinating agent in a solvent reaction medium comprising a nitrile compound and providing a Lewis acid whereby the carbon-hydrogen bond is replaced by a carbon-nitrogen bond. Advantageously, the reaction may be performed in one stage and/or in one vessel. Advantageously, the method may be carried out at or just below ambient or room temperature.
    Type: Grant
    Filed: January 1, 2002
    Date of Patent: August 27, 2002
    Assignee: F2 Chemicals Ltd.
    Inventors: Richard Dickinson Chambers, Mandy Parsons, Graham Sandford
  • Patent number: 5859255
    Abstract: A method of fluorinating a heterocyclic organic compound comprises the step of reacting a heterocyclic compound with elemental fluorine in the presence of another halogen. The reaction may be conducted in the presence of a base.
    Type: Grant
    Filed: June 20, 1997
    Date of Patent: January 12, 1999
    Assignee: F2 Chemicals Ltd.
    Inventors: Richard Dickinson Chambers, Graham Sandford
  • Patent number: 5789580
    Abstract: A process for the preparation of a selectively fluorinated organic compound, which process includes reaction of a precursor of said organic compound, the precursor containing at least one Group VI element selected from sulfur, selenium and tellurium, with a fluorinating agent and another halogenating agent and characterized in that the fluorinating agent is elemental fluorine.
    Type: Grant
    Filed: April 25, 1996
    Date of Patent: August 4, 1998
    Assignee: British Nuclear Fuels plc
    Inventors: Richard Dickinson Chambers, Graham Sandford