Abstract: The present invention relates to methods of modulating (e.g., reducing) the mannose content, particularly high-mannose content of recombinant glycoproteins.

Abstract: The present invention relates to methods of modulating (e.g., reducing) the mannose content, particularly high-mannose content of recombinant glycoproteins.

Abstract: A composite insulating and cladding panel has a backing sheet, a plurality of cladding parts, and a support grid between the backing sheet and the cladding parts. The cladding parts are mounted to the support grid and a body of insulating material such as insulating foam. The cladding parts are spaced-apart to provide gaps. The cladding parts may have any desired surface finish. The cladding parts provide a finished façade. The panel incorporates a support grid that transfers load directly to a building structural framework. The panels also have interengagable features that facilitate joining between a plurality of panels to form a finished façade.

Abstract: A clip assembly is configured to securely connect a first structural component to a second structural component. The clip assembly may include an arc attachment member and an arc-receiving member. The arc attachment member may include a securing arc having a semi-circular rim. The arc attachment member is configured to be secured to one of the first or second structural components. The arc-receiving member may include an arc-receiving portion configured to receive the securing arc through multiple directions. The arc-receiving member is configured to be secured to the other of the first or second structural components. The securing arc is configured to be pivotally adjusted with respect to the arc-receiving portion.

Abstract: The present invention relates to methods of modulating (e.g., reducing) the mannose content, particularly high-mannose content of recombinant glycoproteins.

Abstract: The present invention relates to methods of modulating (e.g., reducing) the mannose content, particularly high-mannose content of recombinant glycoproteins.

Abstract: A method for manufacturing a composite insulated panel (1) comprising the steps of: providing a first sheet (2); cutting a hole (7) in the first sheet (2) to accommodate a photovoltaic solar collector module (8); inserting the solar collector module (8) into the cut-out hole; sealing the solar collector module to the first sheet (2); providing a second sheet (3), the second sheet having an opening therein to receive a connector housing (22); leading electrical connections from the solar collector module through the connector housing; and providing a body (4) of insulating material between the inner face of the second sheet and the inner face of the first sheet and the inner face of the photovoltaic solar collector module.

Abstract: A composite insulating and cladding panel has a backing sheet, a plurality of cladding parts, and a support grid between the backing sheet and the cladding parts. The cladding parts are mounted to the support grid and a body of insulating material such as insulating foam. The cladding parts are spaced-apart to provide gaps. The cladding parts may have any desired surface finish. The cladding parts provide a finished façade. The panel incorporates a support grid that transfers load directly to a building structural framework. The panels also have interengagable features that facilitate joining between a plurality of panels to form a finished façade.

Abstract: A manufactured composite insulating panel comprises an external sheet having an outer face and an inner face, an internal sheet having an outer face and an inner face, and an insulating body between the inner face of the external sheet and the inner face of the internal sheet. The external sheet has a portion that extends beyond the internal sheet and the insulating body to define an overlap part for overlapping with part of an adjacent panel, on assembly and a seal is applied to the inner face of the overlap part of the external sheet. The panel has a side overlap part to which a side seal is factory applied. An end seal is also factory applied to an end overlap part of the panel.

Abstract: A clip assembly is configured to securely connect a first structural component to a second structural component. The clip assembly may include an arc attachment member and an arc-receiving member. The arc attachment member may include a securing arc having a semi-circular rim. The arc attachment member is configured to be secured to one of the first or second structural components. The arc-receiving member may include an arc-receiving portion configured to receive the securing arc through multiple directions. The arc-receiving member is configured to be secured to the other of the first or second structural components. The securing arc is configured to be pivotally adjusted with respect to the arc-receiving portion.

Abstract: A composite insulating panel comprises an external sheet, an internal sheet, and an insulating body between the external sheet and the internal sheet. There is a photovoltaic solar collector module on the external surface of the external sheet and a connector for interconnecting between the photovoltaic solar collector module and another photovoltaic solar collector module. The panel has a through hole for receiving a housing, of the connector.

Abstract: A facade/wall system comprises a number of modules. Each module comprises a plurality of insulating panels which have connection means on opposite sides thereof for interengaging the panels together at joints between the panels. Reinforcing elements in the form of top hat sections bridge the joints between adjacent panels. The top hat reinforcement elements used to interconnect adjacent panels in a module ensure that the composite panels act together as monolithic structure that creates a diaphragm while providing a surface to which cladding can be fixed and also providing a cavity between the panels and the cladding attached to the modules. They stiffen the panels and thereby enhance resistance to deflection. The system is cost effective and relatively easy and quick to install.

Abstract: A method for manufacturing a composite insulated panel (1) comprising the steps of: providing a first sheet (2); cutting a hole (7) in the first sheet (2) to accommodate a photovoltaic solar collector module (8); inserting the solar collector module (8) into the cut-out hole; sealing the solar collector module to the first sheet (2); providing a second sheet (3), the second sheet having an opening therein to receive a connector housing (22); leading electrical connections from the solar collector module through the connector housing; and providing a body (4) of insulating material between the inner face of the second sheet and the inner face of the first sheet and the inner face of the photovoltaic solar collector module.

Abstract: A manufactured composite insulating panel comprises an external sheet having an outer face and an inner face, an internal sheet having an outer face and an inner face, and an insulating body between the inner face of the external sheet and the inner face of the internal sheet. The external sheet has a portion that extends beyond the internal sheet and the insulating body to define an overlap part for overlapping with part of an adjacent panel, on assembly and a seal is applied to the inner face of the overlap part of the external sheet. The panel has a side overlap part to which a side seal is factory applied. An end seal is also factory applied to an end overlap part of the panel.

Abstract: A composite insulating panel comprises an external sheet, an internal sheet, and an insulating body between the sheets. The external sheet has a first longitudinally extending raised side underlap projection at one side and a side overlap projection on the opposite side of the panel with a substantially flat portion extending between the projections. A photovoltaic solar collector is mounted to the flat portion of external sheet. The solar collector comprises a photovoltaic sheet and a protective translucent cover for the photovoltaic sheet. A first adhesive layer is provided between the photovoltaic sheet and the translucent cover. A second adhesive layer is provided between the underside of the photovoltaic sheet and the external surface of the composite panel upper or external sheet.

Abstract: A system, method, and apparatus for performing surgery within the epidural space of a patient includes at least two high-power light generators. The epidural space is filled with a fluid to maintain patency and to absorb excess light power. The light energy from the high-power light generators is directed into a first end of a bundle of fiber optics and the second end of the bundle is maneuvered within the epidural space of the patient. When the second end of the fiber optics is aimed at unwanted tissue of a first type, the appropriate high-power light generator is operated to vaporize that tissue. When the second end of the fiber optics is aimed at unwanted tissue of a second type, the appropriate high-power light generator is operated to vaporize that tissue.

Abstract: The present invention relates to methods of modulating (e.g., reducing) the mannose content, particularly high-mannose content of recombinant glycoproteins.

Abstract: A facade/wall system comprises a number of modules. Each module comprises a plurality of insulating panels which have connection means on opposite sides thereof for interengaging the panels together at joints between the panels. Reinforcing elements in the form of top hat sections bridge the joints between adjacent panels. The top hat reinforcement elements used to interconnect adjacent panels in a module ensure that the composite panels act together as monolithic structure that creates a diaphragm whilst providing a surface to which cladding can be fixed and also providing a cavity between the panels and the cladding attached to the modules. They stiffen the panels and thereby enhance resistance to deflection. The system is cost effective and relatively easy and quick to install.

Abstract: A translucent wall panel (1) comprises a single body of translucent polycarbonate material comprising skin wall means and a multiwall support (4) extending between the skin wall means. The skin wall means comprises an outer weather wall (2), an inner liner wall (3), a longitudinally extending first side (5) and a longitudinally extending second side (6) opposite to the first side. The first side (5) has outer projecting and recess parts and the second side (6) has outer projecting and recess parts. The projecting and recess parts of the first side (5) are of mating form with corresponding recess and projecting parts respectively of the second side 6 for engagement between the first side (5) of one panel A and the second side of another like panel B. The sides (5, 6) have additional spacer recesses (51, 52) which are aligned so that when two similar panels (50) are aligned adjacent to one another as illustrated in FIG.

Abstract: The present invention relates to methods of modulating (e.g., reducing) the mannose content, particularly high-mannose content of recombinant glycoproteins.