Abstract: Systems and methods are provided for controlling robotic movement of a tool based on one or more virtual boundaries. The system comprises a tool and a manipulator to support the tool. A control system controls operation of the manipulator and movement of the tool based on a relationship between the tool and the one or more virtual boundaries associated with a target site. The control system includes a boundary handler to determine whether the tool is in compliance with the one or more virtual boundaries or is in violation of the one or more virtual boundaries.

Abstract: A system and method for detecting and preventing ransomware includes creating a number of watch files in a filesystem and adding a location and a timestamp of each to an ingest log. A number of native files are found in the filesystem and cataloged, adding the location and the timestamp of each to the ingest log. Periodically, each timestamp of each entry in the ingest log is compared to a current timestamp of a corresponding file in the filesystem and a count of watch files that have change and a count of native files that have changed is made. If the count of watch and native files that have changed indicate that a ransomware program is running on the computer, the ransomware program is suspended and reported. If a command indicates that the ransomware program is not ransomware, execution of the program is resumed.

Abstract: The invention provides sample cartridges for processing samples. The sample cartridges comprise at least one fluidic channel. Each fluidic channel comprises a sample chamber, a lysis chamber, a binding chamber, a pre-amplification region, and an amplification region. The sample cartridges also comprise a waste line that is in fluidic connectivity with each fluidic channel. The sample cartridges can interface with a plurality of plungers that are capable of occluding at least one fluidic channel, waste line, and/or optional assay line to limit the transport of fluids into, out of, and/or along at least one fluidic channel by plunging. The invention also provides multi-channel sample cartridges, which are sample cartridges that comprise at least two fluidic channels. In addition, the sample cartridges can house fluids on the cartridge, off the cartridge, or some on the cartridge and some fluids off the cartridge.

Abstract: A system and method for detecting and preventing ransomware includes creating a number of watch files in a filesystem and adding a location and a timestamp of each to an ingest log. A number of native files are found in the filesystem and cataloged, adding the location and the timestamp of each to the ingest log. Periodically, each timestamp of each entry in the ingest log is compared to a current timestamp of a corresponding file in the filesystem and a count of watch files that have change and a count of native files that have changed is made. If the count of watch and native files that have changed indicate that a ransomware program is running on the computer, the ransomware program is suspended and reported. If a command indicates that the ransomware program is not ransomware, execution of the program is resumed.

Abstract: The invention includes low-volume systems for sample identification. The systems are designed to use multi-use consumables including but not limited to fluid containers containing large volumes of fluids. In some embodiments, the low-volume systems identify nucleic acids in samples using polymerase chain reaction (PCR).

Abstract: A compact particle accelerator can include two or more cavities disposed along an axis of the particle accelerator, each of which is coupled to two or more drivers. The accelerator can also include a power supply coupled to the two or more drivers such that a particle beam traveling along the axis is accelerated. The power supply can be an interface with a commercial power outlet, battery power, or a combination thereof depending upon the use case. Example configurations of the accelerator include hand held or mobile devices that are capable of delivering up to and greater than a 1 MeV electron beam.

Abstract: A road clearing apparatus that is configured to dislodge snow and ice from a surface of a roadway. The road clearing apparatus includes a housing that is operably secured to a rear of a motor vehicle. The housing is manufactured from a rigid material and includes a first end and a second end. The housing has a plurality of apertures that are formed in the top wall and bottom wall, wherein the plurality of apertures are axially aligned. Operably coupled with the plurality of apertures are rod members. The rod members are movable intermediate a first position and a second position wherein in the second position the rod members are extended downward from the housing so as to engage a roadway surface. Actuators are operably coupled to the rod members and are configured to provide movement thereof. A controller is present to provide an operational interface.

Abstract: The present invention teaches a method for quickly and easily nesting and un-nesting bulk seed boxed. A first lower box is engaged with forks extending from a forklift truck, and the stacked boxes are elevated to a target height. Next, the forklift truck is advanced forward until the stacked boxes are in position in a box inverter apparatus, wherein the stacked boxes are positioned between opposing box engaging surfaces of rotary clamp pads. The rotary clamp pads engage the stacked boxes at a clamping location below the center of mass of the second, upper box unit. The forks of the fork truck carrying the first, lower box unit are then lowered until the first lower box unit is separated from the second, upper box unit, thereby affecting rotation of the second, upper box unit and rotary clamp pads until the second, upper box unit rotates a full 180 degrees to an inverted position.

Abstract: A road clearing apparatus that is configured to dislodge snow and ice from a surface of a roadway. The road clearing apparatus includes a housing that is operably secured to a rear of a motor vehicle. The housing is manufactured from a rigid material and includes a first end and a second end. The housing has a plurality of apertures that are formed in the top wall and bottom wall, wherein the plurality of apertures are axially aligned. Operably coupled with the plurality of apertures are rod members. The rod members are movable intermediate a first position and a second position wherein in the second position the rod members are extended downward from the housing so as to engage a roadway surface. Actuators are operably coupled to the rod members and are configured to provide movement thereof. A controller is present to provide an operational interface.

Abstract: At least one exemplary embodiment of the invention is directed to a molecular diagnostic device that comprises a cartridge configured to eject samples comprising genomic material into a microfluidic chip that comprises an amplification area, a detection area, and a matrix analysis area.

Abstract: The present invention teaches a method used in connection with a forklift truck for quickly and easily nesting and un-nesting bulk seed boxes. A lower surface of the first lower box unit is engaged with forks extending from a forklift truck. The stacked first and second box units are then elevated to a target height. Next, the forklift truck is advanced forward until the stacked first and second box units are in a predetermined horizontal position in a box inverter apparatus, wherein the stacked first and second box units are positioned between opposing box engaging surfaces of first and second rotary clamp pads associated with the box inverter apparatus. The rotary clamp pads are then moved toward the stacked first and second box units until the opposing box engaging surfaces engage opposing outer surfaces of the second, upper box unit at a clamping location below the center of mass of the second, upper box unit.

Abstract: A subsea production system and method for installing the same are provided. The subsea production system includes a high pressure subsea wellhead, a tubing hanger landed proximate the wellhead, a production tree disposed above the wellhead downstream of the tubing hanger, a riser, a subsea flowline system coupled between the production tree and the riser, at least one barrier located downstream of the tubing hanger, and a secondary barrier valve disposed within the tubing hanger or in line with and upstream of the tubing hanger. The at least one barrier provides a pressure barrier that controls pressure of fluid flowing from components of the subsea production system located upstream of the barrier to components of the subsea production system located downstream of the barrier, and the secondary barrier valve is remotely actuable between a closed position and an open position.

Abstract: An apparatus for performing a thermocyclic process, such as amplifying DNA, includes a microfluidic chip with a channel formed therein and one or more thermal distribution elements disposed over portions of the chip. Each thermal distribution element is configured to distribute thermal energy from an external thermal energy source substantially uniformly over the portion of the chip covered by the thermal distribution element. The portion of the chip covered by the thermal distribution element thereby comprises a discrete temperature zone. Other temperature zones can be defined by other thermal distribution elements or by portions of the chip not covered by a thermal distribution element. The channel is configured so that a fluid flowing through the channel would enter and exit the different temperature zones a plurality of times, thereby alternately exposing the fluid to the temperature of each zone for a period of time required for the fluid to traverse the zone.

Abstract: The present invention teaches an apparatus and method used in connection with a forklift truck for quickly and easily nesting and un-nesting bulk seed boxes. A box inverter apparatus includes first and second rotary clamp pads, each clamp pad having a box engaging surface and an opposing rear surface. The first and second rotary clamp pads are positioned such that the box engaging surfaces thereof face one another in a spaced apart relationship. First and second spindle and bearing assemblies are associated with and extend radially outwardly from the opposing rear surfaces of the first and second rotary clamp pads, respectively. Each of the spindle and bearing assemblies has a first end attached to the rear surface of the rotary clamp pad and a second end attached to a frame such that each spindle and bearing assembly permits rotation of the rotary clamp pad relative to the frame.

Abstract: The present invention relates to methods for amplifying nucleic acids in micro-channels. More specifically, the present invention relates to methods for performing a real-time polymerase chain reaction (PCR) in a continuous-flow microfluidic system and to methods for monitoring real-time PCR in such systems.

Abstract: A compact particle accelerator can include two or more cavities disposed along an axis of the particle accelerator, each of which is coupled to two or more drivers. The accelerator can also include a power supply coupled to the two or more drivers such that a particle beam traveling along the axis is accelerated. The power supply can be an interface with a commercial power outlet, battery power, or a combination thereof depending upon the use case. Example configurations of the accelerator include hand held or mobile devices that are capable of delivering up to and greater than a 1 MeV electron beam.

Abstract: A subsea production system and method for installing the same are provided. The subsea production system includes a high pressure subsea wellhead, a tubing hanger landed proximate the wellhead, a production tree disposed above the wellhead downstream of the tubing hanger, a riser, a subsea flowline system coupled between the production tree and the riser, at least one barrier located downstream of the tubing hanger, and a secondary barrier valve disposed within the tubing hanger or in line with and upstream of the tubing hanger. The at least one barrier provides a pressure barrier that controls pressure of fluid flowing from components of the subsea production system located upstream of the barrier to components of the subsea production system located downstream of the barrier, and the secondary barrier valve is remotely actuable between a closed position and an open position.

Abstract: In accordance with the present disclosure, a full top-to-bottom subsea system and method used to drill, complete, produce, and perform interventions on HPHT subsea wells is provided. The disclosed systems and methods involve the use of a controlled multiple barrier system, such as a high integrity pipeline protection system (HIPPS), incorporated into the subsea system to divide the system into two sections. The sections on either side of the barrier may be rated for different pressures, temperatures, and/or flow rates. For example, the first section (upstream of the barrier) is rated for operating at pressures/temperatures/flow rates up to a first (higher) threshold. The second section (downstream of the barrier) is rated for operating at pressures/temperatures/flow rates up to a second (lower) threshold. The disclosed subsea production system methodology, which uses barriers to divide the system components between two pressure ratings, may allow for enhanced development of HPHT reservoirs.

Abstract: The invention relates to systems and methods including a combination of thermal generating device technologies to achieve more efficiency and accuracy in PCR temperature cycling of nucleic samples undergoing amplification.

Abstract: At least one exemplary embodiment of the invention is directed to a molecular diagnostic device that comprises a cartridge configured to eject samples comprising genomic material into a microfluidic chip that comprises an amplification area, a detection area, and a matrix analysis area.