Patents by Inventor Gregory H. Owen
Gregory H. Owen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10363558Abstract: The present invention relates to systems and methods for the real time processing of nucleic acid during polymerase chain reaction (PCR) and thermal melt applications. According to an aspect of the invention, a system for the rapid serial processing of multiple nucleic acid assays is provided. In one embodiment, the system includes, but is not limited to: a microfluidic cartridge having microfluidic (flow-through) channels, a fluorescence imaging system, a temperature measurement and control system; a pressure measurement and control system for applying variable pneumatic pressures to the microfluidic cartridge; a storage device for holding multiple reagents (e.g., a well-plate); a liquid handling system comprising at least one robotic pipettor for aspirating, mixing, and dispensing reagent mixtures to the microfluidic cartridge; systems for data storage, processing, and output; and a system controller to coordinate the various devices and functions.Type: GrantFiled: August 24, 2015Date of Patent: July 30, 2019Assignee: Canon U.S. Life Sciences, Inc.Inventors: Ivor T. Knight, Kenton C. Hasson, Johnathan S. Coursey, Hongye Liang, Sami Kanderian, Gregory H. Owen, Weidong Cao, Ying-Xin Wang, Scott Corey, Ben Lane, Conrad Laskowski, Alex Flamm, Brian Murphy, Eric Schneider, Takayoshi Hanagata, Hiroshi Inoue, Shulin Zeng, Brian Bean, Franklin Regan
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Publication number: 20180193839Abstract: The present invention, in one aspect, provides methods and systems for controlling slugs using temperature dependent fluorescent dyes. In some embodiments, the present invention uses one or more techniques to enhance the visibility of slugs, enhance a system's ability to differentiate between slugs, and enhance a system's ability to identify the positions of slugs.Type: ApplicationFiled: January 5, 2018Publication date: July 12, 2018Applicant: Canon U.S. Life Sciences, Inc.Inventors: Johnathan S. Coursey, Kenton C. Hasson, Sami Kanderian, Gregory H. Owen, Hongye Liang, Scott Corey, Brian Bean
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Patent number: 9939336Abstract: The invention relates to systems and methods for calibrating and using resistance temperature detectors. In one embodiment, the system includes a calibration circuit comprising a resistance temperature detector in a bridge circuit with at least one potentiometer, and a programmable gain amplifier coupled to the bridge circuit. Embodiments of the invention further comprise methods for calibrating the bridge circuit and the programmable gain amplifier for use with the resistance temperature detector and methods for determining the self heating voltage of the bridge circuit.Type: GrantFiled: August 4, 2014Date of Patent: April 10, 2018Assignee: Canon U.S. Life Sciences, Inc.Inventors: Johnathan S. Coursey, Kenton C. Hasson, Gregory H. Owen
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Patent number: 9861985Abstract: The present invention, in one aspect, provides methods and systems for controlling slugs using temperature dependent fluorescent dyes. In some embodiments, the present invention uses one or more techniques to enhance the visibility of slugs, enhance a system's ability to differentiate between slugs, and enhance a system's ability to identify the positions of slugs.Type: GrantFiled: August 31, 2011Date of Patent: January 9, 2018Assignee: Canon U.S. Life Sciences, Inc.Inventors: Johnathan S. Coursey, Kenton C. Hasson, Sami Kanderian, Gregory H. Owen, Hongye Liang, Scott Corey, Brian Bean
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Patent number: 9829389Abstract: The invention relates to methods and devices for control of an integrated thin-film device with a plurality of microfluidic channels. In one embodiment, a microfluidic device is provided that includes a microfluidic chip having a plurality of microfluidic channels and a plurality of multiplexed heater electrodes, wherein the heater electrodes are part of a multiplex circuit including a common lead connecting the heater electrodes to a power supply, each of the heater electrodes being associated with one of the microfluidic channels. The microfluidic device also includes a control system configured to regulate power applied to each heater electrode by varying a duty cycle, the control system being further configured to determine the temperature of each heater electrode by determining the resistance of each heater electrode.Type: GrantFiled: February 22, 2016Date of Patent: November 28, 2017Assignee: Canon U.S. Life Sciences, Inc.Inventors: Johnathan S. Coursey, Kenton C. Hasson, Gregory H. Owen, Gregory A. Dale
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Patent number: 9823135Abstract: The invention relates to methods and devices for control of an integrated thin-film device with a plurality of microfluidic channels. In one aspect, the present invention provides a method for controlling the temperature of a heater electrode associated with a microfluidic channel of a microfluidic device, wherein power applied to the heater electrode is regulated by varying the duty cycle of a pulse width modulation (PWM). In another aspect, the present invention a controller configured to compute the temperature of the heater electrode during the power-on portion of the duty cycle and the during the power-off portion of the duty cycle and to adjust the duty cycle as necessary to achieve a desired temperature in the heater electrode.Type: GrantFiled: December 28, 2015Date of Patent: November 21, 2017Assignee: Canon U.S. Life Sciences, Inc.Inventors: Gregory H. Owen, Gregory A. Dale, Kenton C. Hasson
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Publication number: 20170108384Abstract: The invention relates to methods and devices for control of an integrated thin-film device with a plurality of microfluidic channels. In one embodiment, a microfluidic device is provided that includes a microfluidic chip having a plurality of microfluidic channels and a plurality of multiplexed heater electrodes, wherein the heater electrodes are part of a multiplex circuit including a common lead connecting the heater electrodes to a power supply, each of the heater electrodes being associated with one of the microfluidic channels. The microfluidic device also includes a control system configured to regulate power applied to each heater electrode by varying a duty cycle, the control system being further configured to determine the temperature each heater electrode by determining the resistance of each heater electrode.Type: ApplicationFiled: December 23, 2016Publication date: April 20, 2017Applicant: Canon U.S. Life Sciences, Inc.Inventors: Kenton C. Hasson, Johnathan S. Coursey, Gregory H. Owen, Gregory A. Dale
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Publication number: 20170067784Abstract: The invention relates to methods and devices for control of an integrated thin-film device with a plurality of microfluidic channels. In one embodiment, a microfluidic device is provided that includes a microfluidic chip having a plurality of microfluidic channels and a plurality of multiplexed heater electrodes, wherein the heater electrodes are part of a multiplex circuit including a common lead connecting the heater electrodes to a power supply, each of the heater electrodes being associated with one of the microfluidic channels. The microfluidic device also includes a control system configured to regulate power applied to each heater electrode by varying a duty cycle, the control system being further configured to determine the temperature each heater electrode by determining the resistance of each heater electrode.Type: ApplicationFiled: November 18, 2016Publication date: March 9, 2017Applicant: Canon U.S. Life Sciences, Inc.Inventors: Kenton C. Hasson, Johnathan S. Coursey, Gregory H. Owen, Gregory A. Dale
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Patent number: 9527083Abstract: The invention relates to methods and devices for control of an integrated thin-film device with a plurality of microfluidic channels. In one embodiment, a microfluidic device is provided that includes a microfluidic chip having a plurality of microfluidic channels and a plurality of multiplexed heater electrodes, wherein the heater electrodes are part of a multiplex circuit including a common lead connecting the heater electrodes to a power supply, each of the heater electrodes being associated with one of the microfluidic channels. The microfluidic device also includes a control system configured to regulate power applied to each heater electrode by varying a duty cycle, the control system being further configured to determine the temperature each heater electrode by determining the resistance of each heater electrode.Type: GrantFiled: June 30, 2008Date of Patent: December 27, 2016Assignee: Canon U.S. Life Sciences, Inc.Inventors: Kenton C. Hasson, Johnathan S. Coursey, Gregory H. Owen, Gregory A. Dale
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Publication number: 20160362722Abstract: In one aspect, the present invention provides a systems and methods for the real-time amplification and analysis of a sample of DNA.Type: ApplicationFiled: March 14, 2016Publication date: December 15, 2016Applicant: Canon U.S. Life sciences, Inc.Inventors: Gregory H. Owen, Gregory A. Dale, Kenton C. Hasson, Shulin Zeng, Dwayne Warren Warfield
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Publication number: 20160341605Abstract: The invention relates to methods and devices for control of an integrated thin-film device with a plurality of microfluidic channels. In one embodiment, a microfluidic device is provided that includes a microfluidic chip having a plurality of microfluidic channels and a plurality of multiplexed heater electrodes, wherein the heater electrodes are part of a multiplex circuit including a common lead connecting the heater electrodes to a power supply, each of the heater electrodes being associated with one of the microfluidic channels. The microfluidic device also includes a control system configured to regulate power applied to each heater electrode by varying a duty cycle, the control system being further configured to determine the temperature of each heater electrode by determining the resistance of each heater electrode.Type: ApplicationFiled: February 22, 2016Publication date: November 24, 2016Applicant: Canon U.S. Life Sciences, Inc.Inventors: Johnathan S. Coursey, Kenton C. Hasson, Gregory H. Owen, Gregory A. Dale
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Publication number: 20160129446Abstract: The invention relates to methods and devices for control of an integrated thin-film device with a plurality of microfluidic channels. In one aspect, the present invention provides a method for controlling the temperature of a heater electrode associated with a microfluidic channel of a microfluidic device, wherein power applied to the heater electrode is regulated by varying the duty cycle of a pulse width modulation (PWM). In another aspect, the present invention a controller configured to compute the temperature of the heater electrode during the power-on portion of the duty cycle and the during the power-off portion of the duty cycle and to adjust the duty cycle as necessary to achieve a desired temperature in the heater electrode.Type: ApplicationFiled: December 28, 2015Publication date: May 12, 2016Applicant: Canon U.S. Life Sciences, Inc.Inventors: Gregory H. Owen, Gregory A. Dale, Kenton C. Hasson
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Patent number: 9283563Abstract: In one aspect, the present invention provides a systems and methods for the real-time amplification and analysis of a sample of DNA.Type: GrantFiled: October 28, 2008Date of Patent: March 15, 2016Assignee: Canon U.S. Life Sciences, Inc.Inventors: Gregory H. Owen, Gregory A. Dale, Kenton C. Hasson, Shulin Zeng, Dwayne W. Warfield, Sarah Warfield
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Publication number: 20160051985Abstract: The present invention relates to systems and methods for the real time processing of nucleic acid during polymerase chain reaction (PCR) and thermal melt applications. According to an aspect of the invention, a system for the rapid serial processing of multiple nucleic acid assays is provided. In one embodiment, the system includes, but is not limited to: a microfluidic cartridge having microfluidic (flow-through) channels, a fluorescence imaging system, a temperature measurement and control system; a pressure measurement and control system for applying variable pneumatic pressures to the microfluidic cartridge; a storage device for holding multiple reagents (e.g., a well-plate); a liquid handling system comprising at least one robotic pipettor for aspirating, mixing, and dispensing reagent mixtures to the microfluidic cartridge; systems for data storage, processing, and output; and a system controller to coordinate the various devices and functions.Type: ApplicationFiled: August 24, 2015Publication date: February 25, 2016Applicant: Canon U.S. Life Sciences, Inc.Inventors: Ivor T. KNIGHT, Kenton C. Hasson, Johnathan S. Coursey, Hongye Liang, Sami Kanderian, Gregory H. Owen, Weidong Cao, Ying-Xin Wang, Scott Corey, Ben Lane, Conrad Laskowski, Alex Flamm, Brian Murphy, Eric Schneider, Takayoshi Hanagata, Hiroshi Inoue, Shulin Zeng, Brian Bean, Franklin Regan
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Patent number: 9267852Abstract: The invention relates to methods and devices for control of an integrated thin-film device with a plurality of microfluidic channels. In one embodiment, a microfluidic device is provided that includes a microfluidic chip having a plurality of microfluidic channels and a plurality of multiplexed heater electrodes, wherein the heater electrodes are part of a multiplex circuit including a common lead connecting the heater electrodes to a power supply, each of the heater electrodes being associated with one of the microfluidic channels. The microfluidic device also includes a control system configured to regulate power applied to each heater electrode by varying a duty cycle, the control system being further configured to determine the temperature of each heater electrode by determining the resistance of each heater electrode.Type: GrantFiled: November 5, 2012Date of Patent: February 23, 2016Assignee: Canon U.S. Life Sciences, Inc.Inventors: Johnathan S. Coursey, Kenton C. Hasson, Gregory H. Owen, Gregory A Dale
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Patent number: 9221056Abstract: The invention relates to methods and devices for control of an integrated thin-film device with a plurality of microfluidic channels. In one aspect, the present invention provides a method for controlling the temperature of a heater electrode associated with a microfluidic channel of a microfluidic device, wherein power applied to the heater electrode is regulated by varying the duty cycle of a pulse width modulation (PWM). In another aspect, the present invention a controller configured to compute the temperature of the heater electrode during the power-on portion of the duty cycle and the during the power-off portion of the duty cycle and to adjust the duty cycle as necessary to achieve a desired temperature in the heater electrode.Type: GrantFiled: June 30, 2008Date of Patent: December 29, 2015Assignee: Canon U.S. Life Sciences, Inc.Inventors: Gregory H. Owen, Gregory A. Dale, Kenton C. Hasson
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Publication number: 20150283547Abstract: The invention relates to methods and devices for control of an integrated thin-film device with a plurality of microfluidic channels. In one embodiment, a microfluidic device is provided that includes a microfluidic chip having a plurality of microfluidic channels and a plurality of multiplexed resistive thermal detectors (RTDs). Each of the RTDs is associated with one of the microfluidic channels. The RTDs are connected to a power supply through individual electrodes and pairs of common electrodes. Adjacent RTDs may be driven with alternating polarities, and the current in the common electrodes may be minimized using a virtual ground circuit. The compact microfluidic device is capable of fast heating and highly precise thermal control. The compact microfluidic device is also capable using the RTDs to sense temperature without their heating capability.Type: ApplicationFiled: June 22, 2015Publication date: October 8, 2015Applicant: Canon U.S. Life Sciences, Inc.Inventors: Kenton C. Hasson, Johnathan S. Coursey, Gregory H. Owen, Hiroshi Inoue
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Publication number: 20150253214Abstract: Systems and methods for testing a fluidic device comprising fluidic features are disclosed. In some embodiments, the systems and methods may perform testing and burn-in of one or more fluidic features of the fluidic device. In some embodiments, the systems and methods may subject one or more of the fluidic features to a differential pressure, measure a pressure response of one or more of the fluidic features to the differential pressure, and detecting whether an abnormality is present in the pressure response. In some embodiments, the systems and methods may perform proof testing one or more fluidic features. The proof testing may include subjecting a fluidic feature to a proof pressure and monitoring the pressure of the fluidic feature for a period of time. A change in pressure at one or more of the waste and vent wells may be indicative of a leak in the fluidic feature.Type: ApplicationFiled: March 6, 2015Publication date: September 10, 2015Applicant: Canon U.S. Life Sciences, Inc.Inventors: Kenton C. Hasson, Johnathan S. Coursey, Gregory H. Owen
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Patent number: 9114399Abstract: The present invention relates to systems and methods for the real time processing of nucleic acid during polymerase chain reaction (PCR) and thermal melt applications. According to an aspect of the invention, a system for the rapid serial processing of multiple nucleic acid assays is provided. In one embodiment, the system includes, but is not limited to: a microfluidic cartridge having microfluidic (flow-through) channels, a fluorescence imaging system, a temperature measurement and control system; a pressure measurement and control system for applying variable pneumatic pressures to the microfluidic cartridge; a storage device for holding multiple reagents (e.g., a well-plate); a liquid handling system comprising at least one robotic pipettor for aspirating, mixing, and dispensing reagent mixtures to the microfluidic cartridge; systems for data storage, processing, and output; and a system controller to coordinate the various devices and functions.Type: GrantFiled: August 31, 2011Date of Patent: August 25, 2015Assignee: Canon U.S. Life Sciences, Inc.Inventors: Ivor T. Knight, Kenton C. Hasson, Johnathan S. Coursey, Hongye Liang, Sami Kanderian, Gregory H. Owen, Weidong Cao, Ying-Xin Wang, Scott Corey, Ben Lane, Conrad Laskowski, Alex Flamm, Brian Murphy, Eric Schneider, Takayoshi Hanagata, Hiroshi Inoue, Shulin Zeng, Brian Bean, Franklin Regan
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Patent number: 9061278Abstract: The invention relates to methods and devices for control of an integrated thin-film device with a plurality of microfluidic channels. In one embodiment, a microfluidic device is provided that includes a microfluidic chip having a plurality of microfluidic channels and a plurality of multiplexed resistive thermal detectors (RTDs). Each of the RTDs is associated with one of the microfluidic channels. The RTDs are connected to a power supply through individual electrodes and pairs of common electrodes. Adjacent RTDs may be driven with alternating polarities, and the current in the common electrodes may be minimized using a virtual ground circuit. The compact microfluidic device is capable of fast heating and highly precise thermal control. The compact microfluidic device is also capable using the RTDs to sense temperature without their heating capability.Type: GrantFiled: June 29, 2010Date of Patent: June 23, 2015Assignee: Canon U.S. Life Sciences, Inc.Inventors: Kenton C. Hasson, Johnathan S. Coursey, Gregory H. Owen, Hiroshi Inoue