Patents by Inventor Gregory P. Pogue

Gregory P. Pogue has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190093117
    Abstract: The present disclosure provides compositions and methods for editing a target site of a plant genome by delivery of functional editing components using modified tobacco mosaic virus (mTMV). The methods disclosed herein can be used to deliver a gene editing system, such as a DNA endonuclease, to a tobacco plant cell for modification of a target site of the plant genome. Further, the methods and compositions disclosed herein provide for production of a RNA molecule encoding a meganuclease in vitro prior to delivery of the RNA to a plant cell. After introduction of the nucleic acid molecule encoding a functional editing component and subsequent expression of the functional editing components, the plant can be cultured and allowed to produce seeds having an edit at a genomic target site. The seeds can then undergo embryo rescue and be cultured to produce a modified plant without heterologous genetic material.
    Type: Application
    Filed: July 30, 2018
    Publication date: March 28, 2019
    Inventors: Xingpeng Li, Yijian He, Gregory P. Pogue, Emmett Ernest Hiatt, Darlene Madeline Lawson
  • Patent number: 7939318
    Abstract: Herein-described are various methods for making a vaccine that are made of re-assembled virus like particles (VLP). First, the VLPs are disassembled into encapsidation intermediate populations. Each encapsidation intermediate population undergoes, for instance, chemical conjugation of unique peptide or nucleic moieties to form separate populations. Thereafter, a predetermined amount of each of the several (one or more) different encapsidation intermediates from the different populations is mixed and joined, forming intact VLPs, surrounding a nucleic acid core, that are composed of different encapsidation intermediate such that the reassembled VLP displays more than one peptide or nucleic acid. The nucleic acid can function either as a scaffold alone or can be engineered for the expression of an immunomodulatory protein in a eukaryotic cell.
    Type: Grant
    Filed: April 24, 2006
    Date of Patent: May 10, 2011
    Assignee: Kentucky Bioprocessing, LLC
    Inventors: Alison A. McCormick, Mark L. Smith, Kenneth E. Palmer, John A. Lindbo, Long V. Nguyen, Gregory P. Pogue
  • Patent number: 7915483
    Abstract: The invention described herein provides a C-terminally truncated interferon having a deletion of 7, 8, or 9 amino acids and having enhanced biological activity, and the polynucleotides encoding such an interferon. Also provided are methods for producing and using such truncated interferon. In some embodiments, the truncated interferon is produced in a plant.
    Type: Grant
    Filed: October 18, 2007
    Date of Patent: March 29, 2011
    Assignee: Biolex Therapeutics, Inc.
    Inventors: Stephen J. Reinl, Gregory P. Pogue
  • Publication number: 20090208522
    Abstract: The invention provides a fusion protein comprising a plant virus coat protein and a GDF8 peptide domain, or antigenic fragment of the GDF8 peptide domain. Plant virus vectors expressing the fusion protein and methods of using these vectors are also provided.
    Type: Application
    Filed: August 22, 2008
    Publication date: August 20, 2009
    Inventors: David E. Junker, Mark D. Cochran, Mark L. Smith, Kenneth E. Palmer, Gregory P. Pogue
  • Publication number: 20090025106
    Abstract: The invention described herein provides a C-terminally truncated interferon having enhanced biological activity and the polynucleotides encoding such interferon. Also provided are methods for producing and using such truncated interferon.
    Type: Application
    Filed: October 18, 2007
    Publication date: January 22, 2009
    Applicant: Large Scale Biology Corporation
    Inventors: Stephen J. Reinl, Gregory P. Pogue
  • Patent number: 7432079
    Abstract: The invention provides a fusion protein comprising a plant virus coat protein and a GDF8 peptide domain, or antigenic fragment of the GDF8 peptide domain. Plant virus vectors expressing the fusion protein and methods of using these vectors are also provided.
    Type: Grant
    Filed: December 21, 2005
    Date of Patent: October 7, 2008
    Assignee: Schering-Plough Animal Health Corporation
    Inventors: David E. Junker, Mark D. Cochran, Mark L. Smith, Kenneth E. Palmer, Gregory P. Pogue
  • Publication number: 20080213293
    Abstract: Juvenile-onset recurrent respiratory papillomatosis is treated using active vaccination or passive immune therapy of neutralizing antibodies against HPV L2 neutralizing epitopes.
    Type: Application
    Filed: December 4, 2007
    Publication date: September 4, 2008
    Applicant: LARGE SCALE BIOLOGY CORPORATION
    Inventors: Kenneth E. Palmer, Daniel Tuse, Stephen J. Reinl, Mark L. Smith, Gregory P. Pogue
  • Patent number: 7413889
    Abstract: The present invention relates to foreign peptide sequences fused to recombinant plant viral structural proteins and a method of their production. Fusion proteins are economically synthesized in plants at high levels by biologically contained tobamoviruses. The fusion proteins of the invention have are useful as antigens for inducing the production of antibodies having desired binding properties, e.g., protective antibodies, or for use as vaccine antigens for the induction of protective immunity against the parvovirus. Feline parvovirus epitopes were fused to the N-terminus of the TMV coat protein, expressed in Nicotiana plants, extracted, purified, characterized and administered to animals, resulting in protective immunity.
    Type: Grant
    Filed: February 4, 2002
    Date of Patent: August 19, 2008
    Assignee: Kentucky Bioprocessing, LLC
    Inventors: Gregory P. Pogue, John A. Lindbo, Michael J. McCulloch, Jonathan E. Lawrence, Cynthia S. Gross, Stephen J. Garger
  • Patent number: 7291767
    Abstract: This invention relates to putative known and unknown deoxyribonucleic acid (DNA) and amino acid sequences identified in one or more metabolic pathways that lead to dwarfism and stunting in plants and the use of these sequences in agriculture to create dwarf varieties of any plant species. This invention also relates to nucleic acids sequences and polypeptides that produce altered metabolism phenotypes in plants.
    Type: Grant
    Filed: July 20, 2001
    Date of Patent: November 6, 2007
    Assignee: The Dow Chemical Company
    Inventors: J. Vincent B. Oriedo, David McCrery, Philip Savickas, Barbara A. Miller, Randy Pell, Ignacio M. Larrinua, Ted Weglarz, Daniel Gachotte, Avutu S. Reddy, Max Ruegger, Beth Blakeslee, Gregory P. Pogue, Rodney Crosley, Wenjin Zheng, Guy R. Della-Cioppa, Gerson Wolfe
  • Patent number: 7270825
    Abstract: The present invention relates to foreign peptide sequences fused to recombinant plant viral structural proteins and a method of their production. Fusion proteins are economically synthesized in plants at high levels by biologically contained tobamoviruses. The fusion proteins of the invention have are useful as antigens for inducing the production of antibodies having desired binding properties, e.g., protective antibodies, or for use as vaccine antigens for the induction of protective immunity against the parvovirus. Feline parvovirus epitopes were fused to the N-terminus of the TMV coat protein, expressed in Nicotiana plants, extracted, purified, characterized and administered to animals, resulting in protective immunity.
    Type: Grant
    Filed: July 12, 2002
    Date of Patent: September 18, 2007
    Assignee: Large Scale Biology Corporation
    Inventors: Gregory P. Pogue, John A. Lindbo, Michael J. McCulloch, Jonathan E. Lawrence, Cynthia S. Gross, Stephen J. Garger
  • Patent number: 7132588
    Abstract: The present invention provides nucleic acid sequences having an altered viral movement protein and 126/183 kDa replicase proteins further characterized in its ability tostabilize a transgene contained in a virus that expresses the altered movement protein. The present invention also provides viral vectors expressing the altered movement protein, cells transformed with the vectors, and host plants infected by the viral vectors.
    Type: Grant
    Filed: July 21, 2003
    Date of Patent: November 7, 2006
    Assignee: Large Scale Biology Corporation
    Inventors: Wayne P. Fitzmaurice, Gregory P. Pogue, John A. Lindbo
  • Patent number: 7049134
    Abstract: A rolling circle DNA replicon which replicates in a host eukaryotic cell is disclosed which has a truncated replication cycle. The rolling circle DNA replicon comprises the following elements present on the same DNA molecule. It contains a Rep gene open reading frame from a virus belonging to the viral taxonomic families Geminiviridae, Circoviridae or genus Nanovirus. The Rep gene open reading frame is placed under transcriptional control of a promoter, which is placed 5? of the gene. Any sequences that are required to be present in cis on the rolling circle DNA replicon in order that the Rep protein might promote replication of the rolling circle DNA replicon are included. An expression cassette for expression of an ancillary protein that is capable of creating a cellular environment permissive for replication of the rolling circle DNA replicon in the host cell of interest is also included.
    Type: Grant
    Filed: November 1, 2002
    Date of Patent: May 23, 2006
    Assignee: Large Scale Biology Corporation
    Inventors: Kenneth E. Palmer, Gregory P. Pogue
  • Patent number: 6855522
    Abstract: The present invention relates to a polymerase chain reaction (PCR) assay for the diagnosis of leishmaniasis using specific oligonucleotide primers for the identification of Leishmania donovani parasites in clinical samples.
    Type: Grant
    Filed: February 27, 2002
    Date of Patent: February 15, 2005
    Assignee: Indian Council of Medical Research
    Inventors: Poonam Salotra, Gannavaran Sreenivas, Gregory P. Pogue, Hiralal Nakhasi
  • Patent number: 6846968
    Abstract: The invention relates to the production of enzymatically active recombinant human and animal lysosomal enzymes involving construction and expression of recombinant expression constructs comprising coding sequences of human or animal lysosomal enzymes in a plant expression system. The plant expression system provides for post-translational modification and processing to produce a recombinant gene product exhibiting enzymatic activity. The invention is demonstrated by working examples in which transgenic tobacco plants express recombinant expression constructs comprising human glucocerebrosidase nucleotide sequences. The invention is also demonstrated by working examples in which transfected tobacco plants express recombinant viral expression constructs comprising human ? galactosidase nucleotide sequences.
    Type: Grant
    Filed: July 26, 2000
    Date of Patent: January 25, 2005
    Assignee: Large Scale Biology Corporation
    Inventors: Robert L. Erwin, Laurence K. Grill, Gregory P. Pogue, Thomas H. Turpen, Monto H. Kumagai
  • Publication number: 20040253687
    Abstract: A plurality of proteins of interest, or peptides of interest, or other genetically expressed materials, are screened and subsequently produced using any of a variety of expression systems. The plurality of proteins are extracted from a plurality of separate, processed green juices, each green juice containing one of the proteins of interest. A multi-channel apparatus processes the various green juices, one green juice per channel. The apparatus is computer controlled such that the various valves in each channel and pump are controlled in an automated manner to extract each protein of interest and deliver each protein of interest into its own storage vessel.
    Type: Application
    Filed: June 29, 2004
    Publication date: December 16, 2004
    Inventors: Mark L. Smith, Kenneth E. Palmer, Gregory P. Pogue, John A. Lindbo, Kathleen M. Hanley, David P. Mannion, Gershon M. Wolfe
  • Publication number: 20040214318
    Abstract: The present invention provides a method for enhancing the production of RNAs or proteins in a plant host using either non-native 5′ untranslated sequences or artificial leader sequences. Preferably, commercially useful proteins, polypeptides, or fusion products thereof are produced, such as, enzymes, antibodies, hormones, pharmaceuticals, vaccines, pigments, anti-microbial polypeptides, and the like. The non-native 5′ untranslated enhancers may also be effective in many different types of transcription or translation systems, such as bacterial and animal systems.
    Type: Application
    Filed: June 1, 2004
    Publication date: October 28, 2004
    Inventors: Sean Chapman, William O. Dawson, Jonothan Donson, Monto H. Kumagai, Dennis J. Lewandowski, John A. Lindbo, Gregory P. Pogue, Shailaja Shivprasad
  • Patent number: 6800748
    Abstract: The present invention relates to recombinant viral vectors encoding a transcriptional unit, that encodes a fusion protein, or a foreign protein or a gene of interest to be silenced, which can be expressed in a host. The present invention also relates to the use of these recombinant viral vectors to express a fusion protein, a foreign protein, to silence a gene of interest in a host. The present invention also relates to the use of these recombinant viral vectors to screen a CDNA or genomic library in order to correlate a nucleotide sequence with a phenotypic or biochemical change.
    Type: Grant
    Filed: January 25, 2001
    Date of Patent: October 5, 2004
    Assignee: Large Scale Biology Corporation
    Inventors: Steven P. Holzberg, Gregory P. Pogue
  • Publication number: 20040170606
    Abstract: Vaccines and diagnostic composition are made and used for preventing, treating and detecting antigens from a papilloma virus, ebola virus, HIV virus, Rift Valley Fever virus or a parvovirus. The epitopes of these viruses are produced as genetically engineered fusion peptides in plants by infection with a recombinant tobamovirus vectors to express fusion proteins containing the epitope peptides.
    Type: Application
    Filed: September 3, 2003
    Publication date: September 2, 2004
    Inventors: Kenneth E. Palmer, Long V. Nguyen, Rachel L. Toth, Michael Jones, Sean Chapman, Lisa Smolenska, Alison A. McCormick, Gregory P. Pogue
  • Publication number: 20040093646
    Abstract: The invention relates to the production of enzymatically active recombinant human and animal lysosomal enzymes involving construction and expression of recombinant expression constructs comprising coding sequences of human or animal lysosomal enzymes in a plant expression system. The plant expression system provides for post-translational modification and processing to produce a recombinant gene product exhibiting enzymatic activity. The invention is demonstrated by working examples in which transgenic tobacco plants express recombinant expression constructs comprising human glucocerebrosidase nucleotide sequences. The invention is also demonstrated by working examples in which transfected tobacco plants express recombinant viral expression constructs comprising human &agr; galactosidase nucleotide sequences.
    Type: Application
    Filed: October 9, 2003
    Publication date: May 13, 2004
    Inventors: Robert L. Erwin, Laurence K. Grill, Gregory P. Pogue, Thomas H. Turpen, Monto H. Kumagai
  • Publication number: 20040088762
    Abstract: This invention relates to putative known and unknown deoxyribonucleic acid (DNA) and amino acid sequences identified in one or more metabolic pathways that lead to dwarfism and stunting in plants and the use of these sequences in agriculture to create dwarf varieties of any plant species. This invention also relates to nucleic acids sequences and polypeptides that produce altered metabolism phenotypes in plants.
    Type: Application
    Filed: October 10, 2003
    Publication date: May 6, 2004
    Inventors: J. Vincent B. Oriedo, David McCrery, Philip Savickas, Barbara A. Miller, Randy Pell, Ignacio M. Larrinua, Ted Weglarz, Daniel Gachotte, Avutu S. Reddy, Max Ruegger, Beth Blakeslee, Gregory P. Pogue, Rodney Crosley, Wenjin Zheng, Guy R. Della-Cioppa, Wolfe D.W. Gershon