Patents by Inventor Guadalupe A. Limjuco

Guadalupe A. Limjuco has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Purification of human interleukin-1 species
    Patent number: 4770781
    Abstract: Human interleukin-1 (IL-1) charged species (pI 6.8, 6.0, 5.4 and 5.2) are separated and purified by a rapid and efficient two or three stage chromatographic process. Interleukin-1 species present in concentrated culture fluid from stimulated human mononuclear cells are separated and partially purified by anion exchange high performance liquid chromatography. The pI 5.4 and 5.2 species in addition are partially purified by HPLC gel filtration chromatography. Each of the individual IL-1 species are then finally purified by reverse phase high performance liquid chromatography. This process results in homogenously pure pI 6.8, pI 5.4 and pI 5.2 species while the pI 6.0 species is isolated in a substantially pure form.
    Type: Grant
    Filed: July 29, 1987
    Date of Patent: September 13, 1988
    Assignee: Merck & Co., Inc.
    Inventors: Jack A. Schmidt, Patricia M. Cameron, Guadalupe A. Limjuco
  • E. coli enterotoxin vaccine for veterinary and human use
    Patent number: 4285931
    Abstract: A vaccine against E. coli caused diarrhea is prepared from an isolate of the homogeneous heat-labile enterotoxin of human strain MB3353 of Escherichia coli, ATCC 31361, or of the porcine strain MB3708, ATCC 31362. The toxin, which is a protein, is a low molecular weight species of 10,000-13,000.
    Type: Grant
    Filed: February 15, 1980
    Date of Patent: August 25, 1981
    Assignee: Merck & Co., Inc.
    Inventors: Guadalupe A. Limjuco, Yashwant D. Karkhanis, Dennis J. Carlo
  • E. coli enterotoxin vaccine for veterinary and human use
    Patent number: 4220584
    Abstract: A vaccine against E. coli caused diarrhea is prepared from an isolate of the homogeneous heat-labile enterotoxin of human strain MB3353 of Escherichia coli, ATCC 31361, or of the porcine strain MB3708, ATCC 31362. The toxin, which is a protein, is a low molecular weight species of 10,000-13,000.
    Type: Grant
    Filed: January 30, 1978
    Date of Patent: September 2, 1980
    Assignee: Merck & Co., Inc.
    Inventors: Guadalupe A. Limjuco, Yashwant D. Karkhanis, Dennis J. Carlo
  • Endotoxin free meningococcus polysaccharides
    Patent number: 3978209
    Abstract: Endotoxin contaminant in meningococcus group A and group C polysaccharide is removed by means of a phosphate containing adsorbent.
    Type: Grant
    Filed: March 24, 1975
    Date of Patent: August 31, 1976
    Assignee: Merck & Co., Inc.
    Inventors: Guadalupe A. Limjuco, Dennis J. Carlo