Abstract: This application relates to apparatus and methods for automatically determining query corrections based on prior interactions of users with a search query. In some examples, a computing device receives a search query from a user, and returns a query correction to the user in response to the search query. The computing device obtains engagement data corresponding to the query correction from the user. The computing device also updates one of a query-correction database and a typo-candidate database based at least in part on the engagement data. When the computing device receives the search query from another user, it corrects the search query from the another user using the query-correction database and the typo-candidate database.

Abstract: Provided herein are bifunctional compounds with a moiety (e.g., lenalidomide, thalidomide) that is a binder of an E3 ubiquitin ligase (e.g., Cereblon) and another moiety that is a binder of a kinase (e.g., HCK, BTK) to induce degradation of the kinase (e.g., HCK, BTK). Also provided are pharmaceutical compositions comprising the bifunctional compounds, and methods of treating and/or preventing diseases (e.g., proliferative diseases (e.g., non-Hodgkin's lymphoma, Burkitt's lymphoma, Waldenstrom macroglobulinemia, MYD88-mutated Waldenstrom macroglobulinemia, activated B-cell diffuse large B-cell lymphoma, leukemia)), inflammatory disease, or other diseases associated with MYD88 mutations). Provided also are methods of inducing the degradation of a kinase (e.g., HCK, BTK) in a cell in a biological sample or subject by administering the bifunctional compound or composition described herein.

Abstract: The present invention relates to recombinant cyanobacterial cells for the production of a chemical compound of interest. In particular, the present invention relates to genetic modifications that introduce one or more heterologous phosphopantetheinyl transferases (PPTases) into a cyanobacterial cell. These cells can, optionally, further comprise heterologous carrier protein and nucleic acid constructs that provide the cyanobacterial cells with the capability of producing chemicals of interest or compounds of interest, such secondary metabolites polyketides, nonribosomal peptides and their hybrids, the three major families of bioactive natural products, of cyanobacteria and other bacterial phyla, secondary metabolites analogs, and unnatural compounds.

Abstract: An permissionless blockchain consensus method with adjusting block weight, comprising: setting weights of all blocks in the permissionless blockchain to the same initial value; determining parent edges(forward reference-edges) of any one of blocks in the permissionless blockchain according to the blockchain topology; detecting whether a first judgment block x is in blocks contained by the parent edge of a block b; if yes, determining that the block b is an unstable block and transferring to next step, otherwise, determining the block b is a stable block and transferring to a pivot chain consensus step; and detecting whether a second judgment blocky is in the stable block contained by the parent edge of the block b; if yes, determining the block b is a readjusted block and transferring to a weight adjustment step, otherwise, determining the block b is a stable block and transferring to the pivot chain consensus step.

Abstract: The present application provides a pixel driving circuit and a liquid crystal display panel. The pixel driving circuit comprises a main pixel electrode driving module, a sub-pixel electrode driving module, a first potential regulation module, and a second potential regulation module.

Abstract: An association handling method and device are provided. The method includes: determining one or more TNL addresses of a CU; and establishing multiple TNL associations between a DU and the CU according to the one or more TNL addresses.

Abstract: Provided are amino acid sequences capable of binding to and inhibiting a Cas protein's ability to bind to a nucleic acid molecule, thereby inhibiting the Cas protein's function in genome editing. Such Cas protein inhibitors, which can be comprised of a major coat protein (G8P), an extracellular region of the G8P (G8PEX), or a biological equivalent, are useful in improving the specificity of Cas protein-based genome editing procedures.

Abstract: A disassemblable anastomosis clamp, at least comprising a clamp frame and a first clasping part and a second clasping part connected to the clamp frame. The first clasping part and/or the second clasping part is detachably connected to the clamp frame. At least one clasping part is designed to be detachable from the clamp frame, and thus when removing the anastomosis clamp, the detachable clasping part can be separated from the clamp frame first and then moved away, allowing the anastomosis clamp to be removed safely and conveniently.

Abstract: A method, apparatus and system for transmitting data. The system includes: the load balance gate wall translating a virtual MAC address of the virtual server in a destination address of a data packet from a client to a real MAC address of the real server according to a pre-configured address mapping relationship between a real server and a virtual server; the load balance gate wall sending a modified data packet to the virtual switch; the virtual switch determining a data packet flowing into the real server after receiving the data packet from the load balance gate wall, then translating a virtual IP and a virtual port of the virtual server in the destination address in the determined data packet to a real IP and a real port of the real server; and the virtual switch sending the modified data packet to the real server.

Abstract: An access method, a network device, and a mobile communication terminal are provided. The access method applied to the network device includes transmitting frequency information of a downlink frequency range and at least two uplink frequency ranges and a physical random access channel parameter.

Abstract: Provided are anti-CXCR2 antibodies and antigen-binding fragments thereof. The antibodies or fragments thereof specifically bind to N-terminal, extracellular domain of the CXCR2 protein. In various example, the antibodies or fragments thereof include a VH CDR1 of SEQ ID NO: 1, a VH CDR2 of SEQ ID NO: 2, a VH CDR3 of SEQ ID NO: 3, or any one of SQ ID NO: 7-14, a VL CDR1 of SEQ ID NO: 4, a VL CDR2 of SEQ ID NO: 5, and a VL CDR3 of SEQ ID NO: 6, or variants of each thereof. Methods of using the antibodies or fragments thereof for treating and diagnosing diseases such as cancer and inflammatory diseases are also provided.

Abstract: An electronic circuit for detecting a change in a property of interest, the circuit comprising a voltage detector having an input and a device for providing a bias current to the input of the voltage detector, wherein the circuit is arranged such that a change in the property of interest modifies the current received at the input of the voltage detector. A change in the property of interest may modify the current by adding or subtracting a current to the bias current. The property of interest may be a signal which is combined with the bias current thereby to alter the current at the input of the voltage detector. The signal may be capacitively coupled into the bias current. The signal may be provided by a sensor, which may be a voltage generating sensor and could be an antenna, rectenna, microphone or any other suitable sensor.

Abstract: A battery includes a cathode, an anode comprising Si, an electrolyte comprising glyme, and a lithium salt having at least one fluorine or boron atom in the anion. The glyme can have the formula CH3(OCH2CH2)nOCH3, where 1?n?4. The glyme can have the formula CnH2nOm, where 8?n?4 and 4?m?1. The electrolyte can further include an additive, wherein the additive has low solubility for the lithium salts such that the additive does not change the coordination of the ions in the glyme, has a viscosity<1 cP at 25° C., and is miscible with the glyme. An electrolyte for a battery and a method of making a battery are also discussed.

Abstract: A gas meter reading system based on national cryptographic algorithm and gas data transmission method thereof. The system includes: an information acquisition device, central information processor, national cryptographic algorithm module, receiving terminal. The method includes: collecting gas data; generating meter reading data; encrypting meter reading data; generating first ciphertext; encrypting first abstract of first ciphertext; generating first abstract ciphertext; sending first ciphertext and first abstract ciphertext to receiving terminal; decrypting first abstract ciphertext to obtain first abstract, recalculating abstract of first ciphertext to obtain second abstract, decrypting first ciphertext to obtain meter reading data after second abstract matches with first abstract.

Abstract: A 5G-based Internet of Things device access method and system, and storage medium. Method includes steps that IoT access platform generates authentication identification of to-be-accessed IoT device according to device identification of to-be-accessed IoT device, and carries out identity authentication of to-be-accessed IoT device through authentication identification, and identity authentication result is sent to to-be-accessed IoT device so when identity authentication result received by to-be-accessed IoT device is that identity authentication is passed, to-be-accessed IoT device accesses IoT access platform and performs encrypted data communication. Method is advantaged in that legal identity of to-be-accessed IoT equipment is verified by taking equipment fingerprint as authentication identifier, and data integrity of to-be-accessed IoT equipment is ensured through access authentication, so illegal terminal is prevented from accessing IoT access platform, and security of data transmission is improved.

Abstract: A portable blowing device includes a body and fans arranged in the body. Air channels are arranged in the body and extend in the length direction of the body to allow airflow to pass through. Wind shields are arranged in the air channels, and a periphery of the wind shield is closely connected with a side wall of the air channel so that a sub-air channel is formed between the wind shield and the side wall of the air channel. Air outlets are formed in the side wall for communicating with outside and the sub-air channel, and airflow generated by the fan can enter the sub-air channel and then exits the air outlets. Because of the reduced volume of the sub-air channel, the airflow is concentrated after entering the sub-air channel, and airflow exiting the air outlets is strengthened, so that the cooling effect and the user experience are improved.

Abstract: The invention provides a semiconductor testkey pattern, the semiconductor testkey pattern includes a high density device region and a plurality of resistor pairs surrounding the high density device region, wherein each resistor pair includes two mutually symmetrical resistor patterns.

Abstract: The present technology relates generally to compositions and methods of preventing or treating diseases associated with mutantleptin receptors, leptin deficiency or leptin dysfunction. The present technology also relates to administering the anti-leptin receptor antibodies in effective amounts to treat a subject suffering from, or predisposed to, a disease associated with mutant leptin receptors, obesity, leptin deficiency, leptin resistance, and/or hypoleptinemia.

Abstract: The present technology relates generally to compositions and methods of preventing or treating diseases associated with mutant Cx26, Cx32, and/or Cx30 hemichannels. The present technology also relates to administering the anti-Cx26 hemichannel antibodies in effective amounts to treat a subject suffering from, or predisposed to, ectodermal dysplasia 2, Clouston type (OMIM No. 129500), Keratitis-ichthyosis-deafness syndrome (KIDS; OMIM No. 148210), and/or type X Charcot-Marie-Tooth neuropathy (CMTXl; OMIM No. 302800).