Patents by Inventor Guido Guglielmi

Guido Guglielmi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5916235
    Abstract: The retention of free coils or GDC coils within body cavities or aneurysms in the human vascular system is achieved through the use of a GDC cage. The GDC cage is comprised of an expandable cage coupled to the wire, which cage and wire are disposed within a catheter. The cage has a memory so that it normally assumes an expanded configuration when unconfined, but is capable of assuming a collapsed configuration when disposed and confined within the catheter. In the illustrated embodiments a detachable joint is provided between the cage and wire so that the cage may be selectively detached from the wire and left in place within the body lumen in its selected position in the expanded configuration. The cage may thus be placed and detached in aneurysms to retain the coils disposed therein or placed in front of aneurysm openings to prevent the escape of free coils from the aneurysm. The cage may be used as a fishing tool to capture escaped free coils in the vessel, which may have escaped from the aneurysm.
    Type: Grant
    Filed: August 13, 1997
    Date of Patent: June 29, 1999
    Assignee: The Regents of the University of California
    Inventor: Guido Guglielmi
  • Patent number: 5895385
    Abstract: An artery, vein, aneurysms vascular malformation or arterial fistula is occluded through endovascular occlusion by the endovascular insertion of a platinum wire and/or tip into the vascular cavity. The vascular cavity is packed with the tip to obstruct blood flow or access of blood in the cavity such that the blood clots in the cavity and an occlusion if formed. The tip may be elongate and flexible so that it packs the cavity by being folded upon itself a multiple number of times, or may pack the cavity by virtue of a filamentary or fuzzy structure of the tip. The tip is then separated from the wire mechanically or by electrolytic separation of the tip from the wire. The wire and the microcatheter are thereafter removed leaving the tip embedded in the thrombus formed within the vascular cavity. Movement of wire in the microcatheter is more easily tracked by providing a radioopaque proximal marker on the microcatheter and a corresponding indicator marker on the wire.
    Type: Grant
    Filed: November 6, 1997
    Date of Patent: April 20, 1999
    Assignee: The Regents of the University of California
    Inventors: Guido Guglielmi, Ivan Sepetka
  • Patent number: 5894022
    Abstract: The present invention is an endovascular embolic composition. The embolic composition comprises a hydrophilic insoluble matrix having a microscopic mesh-like structure. The voids or intricacies of the matrix enclose droplets of aqueous solution as well as liquid oil. This structure is essentially equivalent to a "gel" structure with the insoluble matrix including both aqueous and oil droplets within its mesh. In creating the matrix a liquid oil base is mixed with an aqueous solution of a matrix base. The matrix base comprises an organic polymer such as a protein like albumin or its equivalent dissolved in an aqueous solution which may contain additional solutes. The matrix base solution is mixed and emulsified with the liquid oil base at a volume ratio ranging between about 1-to-1 and 1-to-5 respectively.
    Type: Grant
    Filed: October 7, 1997
    Date of Patent: April 13, 1999
    Assignee: The Regents of the University of California
    Inventors: Cheng Ji, Guido Guglielmi
  • Patent number: 5888546
    Abstract: A multipurpose ointment (MPOc) in a semisolid-semiliquid form and a multipurpose particle (MPPc) in a solid soft particulate form are prepared by combining a matrix base in a aqueous solution with a liquid oil base and added modifiers and medications to form either an ointment or suspension of particles for endovascular disposition for embolizing abnormal microvascular beds or nidi. The ointment or particles are formed from a albumin (human serum or chicken egg) matrix or equivalent material or combination of the same in an aqueous solution, typically contrast-medium solution, which has been emulsified with a radiopaque oil base such as ETHIODOL, and then heated to modify the mobility, viscosity, deformability, elasticity, surface tension and friction along with the inclusion of medications and modifiers for the desired physical characteristics and biological end effects.
    Type: Grant
    Filed: August 28, 1995
    Date of Patent: March 30, 1999
    Assignee: The Regents of the University of California
    Inventors: Cheng Ji, Guido Guglielmi
  • Patent number: 5855578
    Abstract: An artery, vein, aneurysm, vascular malformation or arterial fistula is occluded through endovascular occlusion by the endovascular insertion of a platinum wire and/or tip into the vascular cavity. The vascular cavity is packed with the tip to obstruct blood flow or access of blood in the cavity such that the blood clots in the cavity and an occlusion if formed. The tip may be elongate and flexible so that it packs the cavity by being folded upon itself a multiple number of times, or may pack the cavity by virtue of a filamentary or fuzzy structure of the tip. The tip is then separated from the wire mechanically or by electrolytic separation of the tip from the wire. The wire and the microcatheter are thereafter removed leaving the tip embedded in the thrombus formed within the vascular cavity. Movement of wire in the microcatheter is more easily tracked by providing a radioopaque proximal marker on the microcatheter and a corresponding indicator marker on the wire.
    Type: Grant
    Filed: February 14, 1997
    Date of Patent: January 5, 1999
    Assignee: The Regents of the University of California
    Inventors: Guido Guglielmi, Ivan Sepetka
  • Patent number: 5851206
    Abstract: A trombus is generated in an aneurysm, arteriovenous malformation or fistula by means of a catheter having an insulated heating coil coupled to an insulated delivery wire. In one embodiment, two delivery wires are coupled to heating coils to provide a closed circuit. The heating coils may be in the form of a double helix or a single helix in combination with a straight heating coil. The heating coils may be electrolytically or mechanically detached therefrom. Alternatively, a single insulated heating coil may be attached to a single insulated delivery wire with a uninsulated coil attached to the tip of the insulated heating coil. The electrical circuit is then made through the heating coil and non-insulated electrode coil into the vascular system and to a body electrode. A catheter may also be used for heating blood within the vascular system which is directly flowed into a tumoral mass for the purposes of thermal treatment of cancer.
    Type: Grant
    Filed: June 30, 1995
    Date of Patent: December 22, 1998
    Assignee: The Regents of the University of California
    Inventors: Guido Guglielmi, Cheng Ji
  • Patent number: 5743905
    Abstract: This is a device used in the occlusion of various lumen and other cavities in the body. In particular, it may be used to form an endovascular occlusion through the application of a radio-frequency modulated voltage to the device after its placement in the body. The elongated device is distally insulated to optimize its occlusive activity without harm to the body.
    Type: Grant
    Filed: February 27, 1996
    Date of Patent: April 28, 1998
    Assignee: Target Therapeutics, Inc.
    Inventors: Joseph Eder, Guido Guglielmi, Cheng Ji
  • Patent number: 5569245
    Abstract: An apparatus is provided for electrocoagulating blood and tissue at an occlusion site by means of application of an alternating signal or current through a detachable coil on the end of a microcatheter. A Guglielmi Detachable Coil (GDC) is preferably used in the combination with radio frequency energy to cause local heating at the coil. Once carbonization of blood at the detachment zone of the GDC coil occurs, the impedance of the entire system increases. The impedance increase is detected to automatically turn off the alternating current and then to apply a direct current to electrolytically detach the GDC coil from the microcatheter.
    Type: Grant
    Filed: October 17, 1994
    Date of Patent: October 29, 1996
    Assignee: The Regents of the University of California
    Inventors: Guido Guglielmi, Cheng Ji
  • Patent number: 5540680
    Abstract: An artery, vein, aneurysm, vascular malformation or arterial fistula is occluded through endovascular occlusion by the endovascular insertion of a platinum wire and/or tip into the vascular cavity. The vascular cavity is packed with the tip to obstruct blood flow or access of blood in the cavity such that the blood clots in the cavity and an occlusion if formed. The tip may be elongate and flexible so that it packs the cavity by being folded upon itself a multiple number of times, or may pack the cavity by virtue of a filamentary or fuzzy structure of the tip. The tip is then separated from the wire mechanically or by electrolytic separation of the tip from the wire. The wire and the microcatheter are thereafter removed leaving the tip embedded in the thrombus formed within the vascular cavity. Movement of wire in the microcatheter is more easily tracked by providing a radioopaque proximal marker on the microcatheter and a corresponding indicator marker on the wire.
    Type: Grant
    Filed: September 23, 1994
    Date of Patent: July 30, 1996
    Assignees: The Regents of the University of California, Target Therapeutics, Inc.
    Inventors: Guido Guglielmi, Ivan Sepetka
  • Patent number: 5354295
    Abstract: An artery, vein, aneurysm, vascular malformation or arterial fistula is occluded through endovascular occlusion by the endovascular insertion of a platinum wire and/or tip into the vascular cavity. The vascular cavity is packed with the tip to obstruct blood flow or access of blood in the cavity such that the blood clots in the cavity and an occlusion if formed. The tip may be elongate and flexible so that it packs the cavity by being folded upon itself a multiple number of times, or may pack the cavity by virtue of a filamentary or fuzzy structure of the tip. The tip is then separated from the wire mechanically or by electrolytic separation of the tip from the wire. The wire and the microcatheter are thereafter removed leaving the tip embedded in the thrombus formed within the vascular cavity. Movement of wire in the microcatheter is more easily tracked by providing a radioopaque proximal marker on the microcatheter and a corresponding indicator marker on the wire.
    Type: Grant
    Filed: February 24, 1992
    Date of Patent: October 11, 1994
    Assignees: Target Therapeutics, Inc., The Regents of the University of California
    Inventors: Guido Guglielmi, Ivan Sepetka
  • Patent number: 5122136
    Abstract: An artery, vein, aneurysm, vascular malformation or arterial fistula is occluded through endovascular electrothrombosis by the endovascular insertion of a platinum guidewire tip into the vascular cavity followed by application of a positive current. The guidewire tip is then separated from the guidewire by electrolytic separation of the tip from the guidewire. A portion of the guidewire connected between the tip and the body of the guidewire is comprised of stainless steel and exposed to the bloodstream so that upon continued application of a positive current to the exposed portion, the exposed portion is corroded away at least at one location and the tip is separated from the body of the guidewire. The guidewire and the microcatheter are thereafter removed leaving the guidewire tip embedded in the thrombus formed within the vascular cavity.
    Type: Grant
    Filed: March 13, 1990
    Date of Patent: June 16, 1992
    Assignee: The Regents of the University of California
    Inventors: Guido Guglielmi, Ivan Sepetka