Abstract: A method performed in a control unit for opening a contactor device. The contactor device includes a carrier being movable between a closed position in which a current is allowed to flow in a current path and an open position in which the current path is broken. The control unit is configured to enable the movement of the carrier between the closed position and the open position by energizing a coil of an electromagnetic circuit. The method includes: initiating the opening of the contactor device by de-energizing the coil, wherein the de-energizing includes using a demagnetization circuit including a discharge element, the discharge element being arranged to consume energy in the coil; bypassing, at a first point of time, the discharge element; and re-energizing the coil.

Abstract: A method in a control unit for closing a contactor device. The control unit is configured to enable the movement between the closed and opened position by energizing a coil of an electromagnetic circuit. The method includes applying a voltage over the coil; determining, during a first period of time, current through the coil and voltage over the coil and estimating based thereon model parameters for a model predicting the behavior of the current through the coil if the contactor device were to stay in an open position, and measuring, after the ending of the first period of time, current through the coil and determining a difference between, on the one hand the measured current and, on the other hand a predicted current of the model, and repeating the measuring and determining until a state change from open position to closed position is detected by the difference in current.

Abstract: A method performed in a control unit for opening a contactor device. The contactor device includes a carrier being movable between a closed position in which a current is allowed to flow in a current path and an open position in which the current path is broken. The control unit is configured to enable the movement of the carrier between the closed position and the open position by energizing a coil of an electromagnetic circuit. The method includes: initiating the opening of the contactor device by de-energizing the coil, wherein the de-energizing includes using a demagnetization circuit including a discharge element, the discharge element being arranged to consume energy in the coil; bypassing, at a first point of time, the discharge element; and re-energizing the coil.

Abstract: A low voltage contactor for connecting and disconnecting a three-phase load to an electric power including a coil, main contacts operated by the coil and an electronic control circuit for controlling voltage supplied to the coil. The electronic control circuit includes a pre-arranged time point selection scheme and is further adapted to select a time point from the pre-arranged time point selection scheme as a time delay, and initiate an instant opening command based on the selected time point.

Abstract: A feeder movement compensation algorithm for use within a processor controlled sewing machine. The sewing machine configured with a reciprocating needle and thread, and including a stitch plate upon which fabric to be sewn is positioned beneath the needle and thread. The machine also includes a feeder mechanism driving a feed dog thru a movement. The feed dog movement pushes the fabric along the stitch plate and the reciprocating needle and thread form stitches in the fabric. During the stitch cycle, the feed dog movement completes at least one feeder stroke. The feeder stroke includes a portion of the feed dog extending above the stitch plate and moving along the direction of feed. The feeder stroke thus pushes the fabric along the stitch plate. The compensation algorithm calculates a theoretical feeder stroke length based upon a desired stitch.

Abstract: The instant disclosure relates to compositions that may be useful as therapeutic agents for the treatment of disorders associated or caused by Ras deregulation or dysregulation, for example, disorders associated with alterations in the NF1 gene such as neurofibromatosis type I, fungal infections such as those caused by Candida albicans, and proliferative disorders such as glioblastoma.

Abstract: The instant disclosure relates to compositions that may be useful as therapeutic agents for the treatment of disorders associated or caused by Ras deregulation or dysregulation, for example, disorders associated with alterations in the NF1 gene such as neurofibromatosis type I, fungal infections such as those caused by Candida albicans, and proliferative disorders such as glioblastoma.

Abstract: Methods and novel intermediates for the preparation of and the treatment with acyclic nucleoside derivatives of the formula: where one of R1 and R2 is an amino acid acyl group and the other of R1 and R2 is a —C(O)C3—C21 saturated or monounsaturated, optionally substituted alkyl and R3 is OH or H.

Abstract: 4-Amino-1-((2R,3S,4S,5R)-5-azido-4-hydroxy-5-hydroxymethyl-3-methyl-tetrahydrofuran-2-yl)-1H-pyrimidin-2-one (22) and prodrugs thereof are hepatitis C (HCV) polymerase inhibitors. Also disclosed are compositions and methods for inhibiting HCV and treating HCV-mediated diseases, processes for making the compounds and synthetic intermediates employed in the process.

Abstract: Methods and novel intermediates for the preparation of and the treatment with acyclic nucleoside derivatives of the formula: where one of R1 and R2 is an amino acid acyl group and the other of R1 and R2 is a —C(O)C3-C21 saturated or monounsaturated, optionally substituted alkyl and R3 is OH or H.

Abstract: A feeder movement compensation algorithm for use within a processor controlled sewing machine. The sewing machine configured with a reciprocating needle and thread, and including a stitch plate upon which fabric to be sewn is positioned beneath the needle and thread. The machine also includes a feeder mechanism driving a feed dog thru a movement. The feed dog movement pushes the fabric along the stitch plate and the reciprocating needle and thread form stitches in the fabric. During the stitch cycle, the feed dog movement completes at least one feeder stroke. The feeder stroke includes a portion of the feed dog extending above the stitch plate and moving along the direction of feed. The feeder stroke thus pushes the fabric along the stitch plate. The compensation algorithm calculates a theoretical feeder stroke length based upon a desired stitch.

Abstract: A method of controlling a current of a three-phase electric motor with a three-phase controller. The firing angles are adjusted so as to leave a range of firing angles in which DC components appear.

Abstract: A method for reducing the influence of a DC component in a load current of an asynchronous three-phase motor, in which the voltages of two of the three phases are controlled by adjusting firing angles of semiconductor devices of the type turning-off at zero-crossing of the current therethrough comprises the steps carried out for each said controlled phase: detecting turn-off times of the semiconductor devices, calculating a value of a change of firing angle of the semiconductor devices needed for changing the length of the time period between two subsequent turn-off times for compensating for the influence of a DC component, and determining the firing angle of said semiconductor devices in dependence of the result of this calculation.

Abstract: Deoxyuridine derivatives of the formula where R1 is H or various substituents; D is —NHCO—, —CONH—, —O—, —C(?O)—, —CH?CH, —C?C—, —NR5—; R4 is hydrogen or various substituents; R5 is H, C1-C4 alkyl, C1-C4 alkanoyl; E is Si or C; R6, R7 and R8 are independently selected from C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl or a stable monocyclic, bicyclic or tricyclic ring system; G is —O—, —S—, —CHR10—, —C(?O)—; J is —CH2—, or when G is CHR10 may also be —O— or —NH—; R10 is H, F, —CH3, —CH2NH2, —CH2OH, —OH; R11 is H, F, —CH3, —CH2NH2, —CH2OH, CH(OH)CH3, CH(NH2)CH3; or R10 and R11 together define an olefinic bond, or together form a —CH2-group, thereby defining a cis or trans cyclopropyl group; have utility in the prophylaxis or treatment of protozoal diseases such as malaria.

Abstract: 4-Amino-1-((2R,3S,4S,5R)-5-azido-4-hydroxy-5-hydroxymethyl-3-methyl-tetrahydro-furan-2-yl)-1H-pyrimidin-2-one (22) and prodrugs thereof are hepatitis C(HCV) polymerase inhibitors. Also disclosed are compositions and methods for inhibiting HCV and treating HCV-mediated diseases, processes for making the compounds and synthetic intermediates employed in the process.

Abstract: 4-Amino-1-((2R,3S,4S,5R)-5-azido-4-hydroxy-5-hydroxymethyl-3-methyl-tetrahydro-furan-2-yl)-1H-pyrimidin-2-one (22) and prodrugs thereof are hepatitis C (HCV) polymerase inhibitors. Also disclosed are compositions and methods for inhibiting HCV and treating HCV-mediated diseases, processes for making the compounds and synthetic intermediates employed in the process.

Abstract: Deoxyuridine derivatives of the formula where R1 is H or various substituents; D is —NHCO—, —CONH—, —O—, —C(?O)—, —CH?CH, —C?C—, —NR5—; R4 is hydrogen or various substituents; R5 is H, C1-C4 alkyl, C1-C4 alkanoyl; E is Si or C; R6, R7 and R8 are independently selected from C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl or a stable monocyclic, bicyclic or tricyclic ring system; G is —O—, —S—, —CHR10—, —C(?O)—; J is —CH2—, or when G is CHR10 may also be —O— or —NH—; R10 is H, F, —CH3, —CH2NH2, —CH2OH, —OH; R11 is H, F, —CH3, —CH2NH2, —CH2OH, CH(OH)CH3, CH(NH2)CH3; or R10 and R11 together define an olefinic bond, or together form a —CH2-group, thereby defining a cis or trans cyclopropyl group; have utility in the prophylaxis or treatment of protozoal diseases such as malaria.

Abstract: 4-Amino-1-((2R,3S,4S,5R)-5-azido-4-hydroxy-5-hydroxymethyl-3-methyl-tetrahydro-furan-2-yl)-1H-pyrimidin-2-one (22) and prodrugs thereof are hepatitis C (HCV) polymerase inhibitors. Also disclosed are compositions and methods for inhibiting HCV and treating HCV-mediated diseases, processes for making the compounds and synthetic intermediates employed in the process.