Patents by Inventor Gunnar Kvalheim

Gunnar Kvalheim has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190071640
    Abstract: Methods are disclosed for the generation of immunosuppressive regulatory T cells. The methods can include contacting a population of CD4+CD25? T cells with a T cell receptor (TCR)/CD3 activator, a TCR co-stimulator activator, and rapamycin. Kits for the generation of immunosuppressive regulatory T cells, methods of use, and cell populations are also disclosed.
    Type: Application
    Filed: August 7, 2018
    Publication date: March 7, 2019
    Inventors: Tanja AARVAK, Anne-Marie RASMUSSEN, Gunnar KVALHEIM, Walter Gabriell Borelli PIEDRAS, Anne BRUNSVIG
  • Publication number: 20190048061
    Abstract: The present invention relates to nucleic acid molecules encoding chimeric antigen receptors (CARs) against the antigen CD37. The CARs disclosed herein have complementarity-determining regions (CDRs) derived from the potent monoclonal anti-CD37 antibody HH1, and may be used in immunotherapy to target cells expressing CD37. Such immunotherapy has a particular use in the treatment of B-cell cancers. The CARs of the present invention are highly functional in the redirection of immune cells to kill CD37+ cells, and include humanised CARs of particular use in medical therapy. The present invention also includes vectors comprising the above-described nucleic acid molecules, immune effector cells expressing the aforementioned CARs and the use of such immune effector cells in therapy, particularly adoptive transfer therapy, for cancer, including B-cell malignancies.
    Type: Application
    Filed: January 6, 2017
    Publication date: February 14, 2019
    Inventors: Erlend SMELAND, Sebastien WALCHLI, Gunnar KVALHEIM, Harald HOLTE, June Helen MYKLEBUST, Steinar FUNDERUD, Else Marit INDERBERG
  • Publication number: 20180010097
    Abstract: The present invention relates to a modified natural killer (NK) cell and its use in personalised medicine. The modified NK cells of the present invention are non-immunogenic, meaning that they are able to be administered to any recipient subject without being rejected by the host immune system (they are “universal”). In a first embodiment the non-immunogenic NK cells are modified to express CD3 to allow a T-cell Receptor (TcR) to be expressed. In a further embodiment the non-immunogenic NK cells are further modified to express a TcR together with the CD3 co-receptor. Co-expression of CD3 with a specific TcR results in the modified NK cells showing antigen-specific cytotoxicity towards target cells. Universal NK cells can thus be targeted against specific antigens, and may thus be used in personalised medicine, particularly in the field of oncology.
    Type: Application
    Filed: January 22, 2016
    Publication date: January 11, 2018
    Inventors: Sébastien WÄLCHLI, Else Marit Inderberg SUSO, Gustav GAUDERNACK, Gunnar KVALHEIM
  • Publication number: 20170106066
    Abstract: The present invention relates to peptides presented on the cell surface of cells in the MHC class I (MHC I) context in which the invariant chain has been engineered to favor loading of specific antigens and generate CD8+ T-cell activation
    Type: Application
    Filed: June 10, 2015
    Publication date: April 20, 2017
    Applicant: UNIVERSITETET I OSLO
    Inventors: Sebastien P. WÄLCHLI, Tone Fredsvik GREGERS, Else Marit Suso INDERBERG, Gustav GAUDERNACK, Gunnar KVALHEIM, Oddmund BAKKE
  • Publication number: 20160024470
    Abstract: Methods are disclosed for the generation of immunosuppressive regulatory T cells. The methods can include contacting a population of CD4+CD25? T cells with a T cell receptor (TCR)/CD3 activator, a TCR co-stimulator activator, and rapamycin. Kits for the generation of immunosuppressive regulatory T cells, methods of use, and cell populations are also disclosed.
    Type: Application
    Filed: July 22, 2015
    Publication date: January 28, 2016
    Inventors: Tanja AARVAK, Anne-Marie RASMUSSEN, Gunnar KVALHEIM, Walter Gabriell Borelli PIEDRAS, Anne BRUNSVIG
  • Patent number: 9119807
    Abstract: Methods are disclosed for the generation of immunosuppressive regulatory T cells. The methods can include contacting a population of CD4+CD25? T cells with a T cell receptor (TCR)/CD3 activator, a TCR co-stimulator activator, and rapamycin. Kits for the generation of immunosuppressive regulatory T cells, methods of use, and cell populations are also disclosed.
    Type: Grant
    Filed: November 29, 2012
    Date of Patent: September 1, 2015
    Assignee: Life Technologies AS
    Inventors: Tanja Aarvak, Anne-Marie Rasmussen, Gunnar Kvalheim, Walter Gabriell Borelli Piedras, Anne Brunsvig
  • Publication number: 20100129340
    Abstract: Methods are disclosed for the generation of immunosuppressive regulatory T cells. The methods can include contacting a population of CD4+CD25? T cells with a T cell receptor (TCR)/CD3 activator, a TCR co-stimulator activator, and rapamycin. Kits for the generation of immunosuppressive regulatory T cells, methods of use, and cell populations are also disclosed.
    Type: Application
    Filed: October 22, 2009
    Publication date: May 27, 2010
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Anne-Marie RASMUSSEN, Tanja Arvak, Gunnar Kvalheim, Walter Gabriell Borelli Piedras, Anne Brunsvig
  • Publication number: 20100068193
    Abstract: Methods are disclosed for the generation of immunosuppressive regulatory T cells. The methods can include contacting a population of CD4+CD25? T cells with a T cell receptor (TCR)/CD3 activator, a TCR co-stimulator activator, and rapamycin. Kits for the generation of immunosuppressive regulatory T cells, methods of use, and cell populations are also disclosed.
    Type: Application
    Filed: February 15, 2007
    Publication date: March 18, 2010
    Applicant: INVITROGEN DYNAL AS
    Inventors: Anne Brunsvig, Anne-Marie Rasmussen, Borelli Piedras, Gunnar Kvalheim, Tanja Aarvak
  • Patent number: 6893881
    Abstract: The invention relates to a method for detecting specific target-cells in a simple and time saving way, using paramagnetic particles, antibodies recognizing the Fc portions of target-cell associating antibodies and target-cell associating antibodies directed to specific antigen determinants in the target-cell membranes. Incubation of the cell suspension with a mild detergent and/or second set of antibodies or antibody fragments, prelabeled or not with fluorescent agents, metallocolloids, radioisotopes, biotincomplexes or certain enzymes allowing visualization, with dramatically increase the specificity of the method. The method can further be used for isolation of the target-cells by magnetic field application and kit for performing the method according to the invention is described.
    Type: Grant
    Filed: September 10, 1993
    Date of Patent: May 17, 2005
    Assignee: Abbott Laboratories, Inc.
    Inventors: Øystein Fodstad, Gunnar Kvalheim
  • Patent number: 6184043
    Abstract: The invention relates to a method for detecting specific target-cells in a simple and time saving way, using paramagnetic particles, antibodies recognizing the Fc portions of target-cell associating antibodies and target-cell associating antibodies directed to specific antigen determinants in the target-cell membranes. Incubation of the cell suspension with a mild detergent and/or second set of antibodies or antibody fragments, prelabeled or not with fluorescent agents, metallocolloids, radioisotopes, biotincomplexes or certain enzymes allowing visualization, with dramatically increase the specificity of the method. The method can further be used for isolation of the target-cells by magnetic field application and kit for performing the method according to the invention is described.
    Type: Grant
    Filed: June 24, 1997
    Date of Patent: February 6, 2001
    Inventors: Øystein Fodstad, Gunnar Kvalheim
  • Patent number: 4910148
    Abstract: A method and device are provided for separating magnetized particles from biological fluids. Cells such as cancer cells coated with magnetized particles can be separated from uncoated healthy cells. A fluid mixture of cancer cells, healthy cells and magnetizable particles is introduced into a container such as a disposable blood bag which is attached in a cassette on an underlying plane magnetic plane that provides a magnetic field. Incubation is carried out during which the cancer cells become coated with the magnetizable particles. The magnetic field pulls the coated cells down towards the bottom of the bag and anchors them, and uncoated healthy cells are removed from the bag. The separated uncoated healthy cells may be advanced through a final separation unit where any loose magnetizable particles are removed. There is provided means for adjusting vertical distance between the cassette and the magnetic plane and for agitating fluid within the container attached to the cassette.
    Type: Grant
    Filed: December 10, 1987
    Date of Patent: March 20, 1990
    Assignee: Dynal A. S.
    Inventors: Otto Sorensen, Gunnar Kvalheim, Eivind Siem
  • Patent number: RE43979
    Abstract: The invention relates to a method for detecting specific target-cells in a simple and time saving way, using paramagnetic particles, antibodies recognizing the Fc portions of target-cell associating antibodies and target-cell associating antibodies directed to specific antigen determinants in the target-cell membranes. Incubation of the cell suspension with a mild detergent and/or second set of antibodies or antibody fragments, prelabeled or not with fluorescent agents, metallocolloids, radioisotopes, biotincomplexes or certain enzymes allowing visualization, with dramatically increase the specificity of the method. The method can further be used for isolation of the target-cells by magnetic field application and kit for performing the method according to the invention is described.
    Type: Grant
    Filed: February 5, 2003
    Date of Patent: February 5, 2013
    Assignee: Abbott Laboratories
    Inventors: Oystein Fodstad, Gunnar Kvalheim