Abstract: The disclosure relates to a system for tracking the position of a target object. A marker arranged on the target object and an additional control marker are tracked by a tracking device secured to the robot arm. The control marker is arranged in a known specified three-dimensional positional relationship with the tracking device. During the tracking of the position of the target object, the specified three-dimensional positional relationship between the tracking device and the control marker is measured. In the event of a difference between the measured and the real specified three-dimensional positional relationship, a corresponding signal is generated depending on the difference.

Abstract: The present invention relates to an enteric coated pharmaceutical composition comprising a solid dispersion comprising regorafenib and at least one stabilizing agent outside of the solid dispersion, its process of preparation and its use for treating disorders.

Abstract: A method for recording image data of a moving, (e.g., cyclically moving), region of interest of a patient by a medical imaging system with an X-ray source and an X-ray detector, wherein a robotic device with a kinematic chain of moving components has a tactile connection with the patient, and wherein, the tactile connection is maintained at least for a prespecified period. The method includes acquiring measured values by sensors of the robotic device, evaluating the measured values and forwarding to the medical imaging system, wherein the evaluated measured values include information on the movement and/or position of the region of interest, and irradiation of the region of interest by the radiation source and recording of image data of the irradiated region of interest by the X-ray detector, and wherein the evaluated measured values are used to actuate the imaging system.

Abstract: In an embodiment, a method includes acquiring a first image data set of the patient, via an X-ray apparatus, at a first time point during the operative intervention, the first image data set including the reference structure, the anatomical structure and the reference system between the reference structure and the anatomical structure; acquiring a second image data set of the patient at a second time point, the second image data set including at least the reference structure; registering the second image data set to the first image data set. As a result of the registering of the second image data set to the first image data set, a registered second image data set is determined. Finally, an embodiment of the method includes determining the validity of the reference system by a comparison of the registered second image data set with the first image data set.

Abstract: A method is provided for controlling a robotic device, of which the end effector arranged on a kinematic chain interacts with an object, and including an ultrasound apparatus registered to the robotic device for movement capture of the object. Ultrasound image data of the object is captured. The relative movement of the object is determined on the basis of the ultrasound image data using a mathematical method. The absolute movement is determined through registration to a planning data set. Movements of the object are compensated for in the context of the interaction of the end effector of the robotic device with the object. Future movements of the object and a positioning of the end effector of the robotic device adapted thereto are predicted and the robotic device is controlled accordingly. In the calculation of the adapted positioning of the end effector of the robotic device, a temporal delay relative to the movement of the object is included.

Abstract: A method for calibrating a medical imaging device in terms of an image acquisition geometry, a method for performing a two-dimensional-three-dimensional registration based on corresponding calibration data, and a corresponding system are provided. Multiple images of a phantom are acquired using the imaging device in different positions of the phantom. A corresponding motion of the phantom from one position to a respective next position is tracked by a tracking device to keep continuous track of a spatial relation between the phantom and the imaging device. The medical imaging device is then calibrated based on the acquired images, corresponding recorded poses of the imaging device, and the tracked motion of the phantom.

Abstract: The disclosure relates to a system for tracking the position of a target object. A marker arranged on the target object and an additional control marker are tracked by a tracking device secured to the robot arm. The control marker is arranged in a known specified three-dimensional positional relationship with the tracking device. During the tracking of the position of the target object, the specified three-dimensional positional relationship between the tracking device and the control marker is measured. In the event of a difference between the measured and the real specified three-dimensional positional relationship, a corresponding signal is generated depending on the difference.

Abstract: A method for recording image data of a moving, (e.g., cyclically moving), region of interest of a patient by a medical imaging system with an X-ray source and an X-ray detector, wherein a robotic device with a kinematic chain of moving components has a tactile connection with the patient, and wherein, the tactile connection is maintained at least for a prespecified period. The method includes acquiring measured values by sensors of the robotic device, evaluating the measured values and forwarding to the medical imaging system, wherein the evaluated measured values include information on the movement and/or position of the region of interest, and irradiation of the region of interest by the radiation source and recording of image data of the irradiated region of interest by the X-ray detector, and wherein the evaluated measured values are used to actuate the imaging system.

Abstract: In an embodiment, a method includes acquiring a first image data set of the patient, via an X-ray apparatus, at a first time point during the operative intervention, the first image data set including the reference structure, the anatomical structure and the reference system between the reference structure and the anatomical structure; acquiring a second image data set of the patient at a second time point, the second image data set including at least the reference structure; registering the second image data set to the first image data set. As a result of the registering of the second image data set to the first image data set, a registered second image data set is determined. Finally, an embodiment of the method includes determining the validity of the reference system by a comparison of the registered second image data set with the first image data set.

Abstract: A method for calibrating a medical imaging device in terms of an image acquisition geometry, a method for performing a two-dimensional-three-dimensional registration based on corresponding calibration data, and a corresponding system are provided. Multiple images of a phantom are acquired using the imaging device in different positions of the phantom. A corresponding motion of the phantom from one position to a respective next position is tracked by a tracking device to keep continuous track of a spatial relation between the phantom and the imaging device. The medical imaging device is then calibrated based on the acquired images, corresponding recorded poses of the imaging device, and the tracked motion of the phantom.

Abstract: A method is provided for controlling a robotic device, of which the end effector arranged on a kinematic chain interacts with an object, and including an ultrasound apparatus registered to the robotic device for movement capture of the object. Ultrasound image data of the object is captured. The relative movement of the object is determined on the basis of the ultrasound image data using a mathematical method. The absolute movement is determined through registration to a planning data set. Movements of the object are compensated for in the context of the interaction of the end effector of the robotic device with the object. Future movements of the object and a positioning of the end effector of the robotic device adapted thereto are predicted and the robotic device is controlled accordingly. In the calculation of the adapted positioning of the end effector of the robotic device, a temporal delay relative to the movement of the object is included.

Abstract: The present invention relates to 5-oxoisoxazole derivatives of the formula I, the pharmaceutically usable salts thereof and the use thereof as medicinal substances.

Abstract: The present invention relates to a process to prepare a dried vegetable product comprising the steps of —subjecting a vegetable to a hypertonic heat shock by contacting (preferably submerging) the vegetable with (in) a hypertonic heat shock solution comprising at least one edible salt, at a temperature of 101 to 112 degrees C.; —coating the hypertonically heat shocked vegetable with a coating mix and —drying the coated hypertonically heat shocked vegetable.

Abstract: The present invention relates to imidazolidinecarboxamide derivatives of the general formula I, wherein R, R1, R2, X and Y are as defined herein, or pharmaceutically usable salts thereof and the use thereof as medicinal substances.

Abstract: A substrate support unit adapted for a system for testing or processing of a substrate is provided. The substrate support unit includes a support table having at least one substrate carrier structure adapted to support a substrate, wherein the substrate carrier structure is electrically floating with respect to ground.

Abstract: The present invention relates to a test system for measuring MEST activity, a method for screening for a ligand for MEST and the use of the test system for the identification of a MEST ligand, particularly a MEST inhibitor.

Abstract: The present invention relates to a device for testing an optoelectronic module, comprising a first source for generating an electromagnetic beam or particle beam, a second source for illuminating the optoelectronic module; and a detector. In addition, a method for testing an optoelectronic module is provided comprising illuminating the optoelectronic module, directing an electromagnetic beam or particle beam and detecting defects in the optoelectronic module. The illumination additional to the electromagnetic beam or particle beam makes defects visible which otherwise would not be detected.

Abstract: The present invention relates to a process to prepare a dried vegetable product comprising the steps of—subjecting a vegetable to a hypertonic heat shock by contacting (preferably submerging) the vegetable with (in) a hypertonic heat shock solution comprising at least one edible salt, at a temperature of 101 to 112 degrees C.;—coating the hypertonically heat shocked vegetable with a coating mix and—drying the coated hypertonically heat shocked vegetable.

Abstract: A platform for industrial installations, in particular for high-pressure descalers (3a) or other machines (3) with optionally bundled supply, discharge, and/or distribution conduits (11) which in operational position, are connectable with fixed conduits of a respective machine (3), can be provided as a central installation for connecting media and power lines that can be monitored and easily inspected, with an arrangement being carried out in an immediate proximity with predetermined distance, lateral position and height with regard to a connectable machine (3) with control units (4), devices (4), drives (5) and drive consoles (5a), distribution blocks (6), valve units (7), control elements and the like being distributed over a horizontal, polygonal platform foundation surface (2) according to their functions with regard to the machine (3).

Abstract: The present invention is directed to a device for quantitative analysis of an analyte in a liquid sample by detecting a magnetic label, an instrument for controlling the analysis process and displaying the results and a method for performing said analysis with said device and said instrument.