Patents by Inventor Guoan Zheng

Guoan Zheng has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10477097
    Abstract: Instruments, assemblies and methods are provided for undertaking imaging techniques (e.g., microscopic imaging techniques). The present disclosure provides improved imaging techniques, equipment and systems. More particularly, the present disclosure provides advantageous microscopy/imaging assemblies with single-frame sample autofocusing using multi-LED illumination. The present disclosure provides for assemblies and methods for single-frame rapid sample autofocusing without a z-scan. Potential applications for the disclosed assemblies/methods include, without limitation, whole slide imaging, optical metrology, wafer inspection, DNA sequencing and other high-throughput imaging applications where the sample may need to be scanned over a large field of view. The assemblies/methods advantageously utilize multiple LEDs for sample illumination. A captured image includes multiple copies of the sample, and one can recover the distance between these copies. The distance is directly related to the defocus distance.
    Type: Grant
    Filed: January 2, 2018
    Date of Patent: November 12, 2019
    Assignee: University of Connecticut
    Inventor: Guoan Zheng
  • Patent number: 10419665
    Abstract: Certain aspects pertain to Fourier ptychographic imaging systems, devices, and methods such as, for example, high NA Fourier ptychographic imaging systems and reflective-mode NA Fourier ptychographic imaging systems.
    Type: Grant
    Filed: April 26, 2018
    Date of Patent: September 17, 2019
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Xiaoze Ou, Roarke W. Horstmeyer, Guoan Zheng, Changhuei Yang
  • Patent number: 10401609
    Abstract: Certain aspects pertain to Fourier ptychographic imaging systems, devices, and methods that implement an embedded pupil function recovery.
    Type: Grant
    Filed: November 21, 2017
    Date of Patent: September 3, 2019
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Xiaoze Ou, Jaebum Chung, Roarke Horstmeyer, Guoan Zheng, Changhuei Yang
  • Patent number: 10330906
    Abstract: Advantageous instruments, assemblies and methods are provided for undertaking imaging techniques (e.g., microscopic imaging techniques). The present disclosure provides improved imaging techniques, equipment and systems. More particularly, the present disclosure provides advantageous microscopy/imaging assemblies with rapid sample auto-focusing (e.g., microscopy/imaging assemblies having instant focusing for rapid sample imaging with auto-focusing). The present disclosure provides for high-throughput whole slide imaging with instant focal plane detection. A whole slide imaging platform/assembly that uses instant focusing systems/methods for high-speed sample autofocusing is provided. Such exemplary platforms/assemblies can be used for digital pathology or the like, and can provide improved, faster and cheaper diagnosis/prognosis of ailments/diseases.
    Type: Grant
    Filed: July 27, 2016
    Date of Patent: June 25, 2019
    Assignee: University of Connecticut
    Inventor: Guoan Zheng
  • Publication number: 20180316855
    Abstract: Certain aspects pertain to Fourier ptychographic imaging systems, devices, and methods such as, for example, high NA Fourier ptychographic imaging systems and reflective-mode NA Fourier ptychographic imaging systems.
    Type: Application
    Filed: April 26, 2018
    Publication date: November 1, 2018
    Inventors: Xiaoze Ou, Roarke W. Horstmeyer, Guoan Zheng, Changhuei Yang
  • Publication number: 20180307017
    Abstract: Certain aspects pertain to aperture-scanning Fourier ptychographic imaging devices comprising an aperture scanner that can generate an aperture at different locations at an intermediate plane of an optical arrangement, and a detector that can acquire lower resolution intensity images for different aperture locations, and wherein a higher resolution complex image may be constructed by iteratively updating regions in Fourier space with the acquired lower resolution images.
    Type: Application
    Filed: April 20, 2018
    Publication date: October 25, 2018
    Inventors: Roarke W. Horstmeyer, Guoan Zheng, Xiaoze Ou, Changhuei Yang
  • Publication number: 20180191948
    Abstract: Instruments, assemblies and methods are provided for undertaking imaging techniques (e.g., microscopic imaging techniques). The present disclosure provides improved imaging techniques, equipment and systems. More particularly, the present disclosure provides advantageous microscopy/imaging assemblies with single-frame sample autofocusing using multi-LED illumination. The present disclosure provides for assemblies and methods for single-frame rapid sample autofocusing without a z-scan. Potential applications for the disclosed assemblies/methods include, without limitation, whole slide imaging, optical metrology, wafer inspection, DNA sequencing and other high-throughput imaging applications where the sample may need to be scanned over a large field of view. The assemblies/methods advantageously utilize multiple LEDs for sample illumination. A captured image includes multiple copies of the sample, and one can recover the distance between these copies. The distance is directly related to the defocus distance.
    Type: Application
    Filed: January 2, 2018
    Publication date: July 5, 2018
    Applicant: University of Connecticut
    Inventor: Guoan Zheng
  • Patent number: 9998658
    Abstract: Certain aspects pertain to Fourier ptychographic imaging systems, devices, and methods such as, for example, high NA Fourier ptychographic imaging systems and reflective-mode NA Fourier ptychographic imaging systems.
    Type: Grant
    Filed: July 13, 2016
    Date of Patent: June 12, 2018
    Assignee: California Institute of Technology
    Inventors: Xiaoze Ou, Roarke W. Horstmeyer, Guoan Zheng, Changhuei Yang
  • Patent number: 9983397
    Abstract: Certain aspects pertain to aperture-scanning Fourier ptychographic imaging devices comprising an aperture scanner that can generate an aperture at different locations at an intermediate plane of an optical arrangement, and a detector that can acquire lower resolution intensity images for different aperture locations, and wherein a higher resolution complex image may be constructed by iteratively updating regions in Fourier space with the acquired lower resolution images.
    Type: Grant
    Filed: July 11, 2016
    Date of Patent: May 29, 2018
    Assignee: California Institute of Technology
    Inventors: Roarke W. Horstmeyer, Guoan Zheng, Xiaoze Ou, Changhuei Yang
  • Publication number: 20180088309
    Abstract: Certain aspects pertain to Fourier ptychographic imaging systems, devices, and methods that implement an embedded pupil function recovery
    Type: Application
    Filed: November 21, 2017
    Publication date: March 29, 2018
    Inventors: Xiaoze Ou, Jaebum Chung, Roarke Horstmeyer, Guoan Zheng, Changhuei Yang
  • Patent number: 9892812
    Abstract: Methods, systems, and devices of Fourier ptychographic X-ray imaging by capturing a plurality of variably-illuminated, low-resolution intensity X-ray images of a specimen and computationally reconstructing a high-resolution X-ray image of the specimen by iteratively updating overlapping regions in Fourier space with the variably-illuminated, low-resolution intensity X-ray images.
    Type: Grant
    Filed: October 28, 2013
    Date of Patent: February 13, 2018
    Assignee: California Institute of Technology
    Inventors: Guoan Zheng, Changhuei Yang, Roarke Horstmeyer
  • Patent number: 9864184
    Abstract: Certain aspects pertain to Fourier ptychographic imaging systems, devices, and methods that implement an embedded pupil function recovery.
    Type: Grant
    Filed: December 16, 2014
    Date of Patent: January 9, 2018
    Assignee: California Institute of Technology
    Inventors: Xiaoze Ou, Jaebum Chung, Roarke Horstmeyer, Guoan Zheng, Changhuei Yang
  • Patent number: 9817224
    Abstract: In one aspect, the present disclosure provides a system for Fourier ptychographic microscopy, the system comprising (i) an image capture apparatus including an objective lens, (ii) at least one processor, and (iii) data storage including program instructions stored thereon that when executed by the at least one processor, cause the system to: (a) capture, via the image capture apparatus, a plurality of initial images of an object, wherein each of the plurality of initial images of the object have a first resolution, and (b) process each of the plurality of initial images in Fourier space to generate a final image of the object having a second resolution, wherein the second resolution is greater than the first resolution.
    Type: Grant
    Filed: April 30, 2015
    Date of Patent: November 14, 2017
    Assignee: University of Connecticut
    Inventors: Guoan Zheng, Siyuan Dong
  • Patent number: 9743020
    Abstract: A super resolution optofluidic microscope device comprises a body defining a fluid channel having a longitudinal axis and includes a surface layer proximal the fluid channel. The surface layer has a two-dimensional light detector array configured to receive light passing through the fluid channel and sample a sequence of subpixel shifted projection frames as an object moves through the fluid channel. The super resolution optofluidic microscope device further comprises a processor in electronic communication with the two-dimensional light detector array. The processor is configured to generate a high resolution image of the object using a super resolution algorithm, and based on the sequence of subpixel shifted projection frames and a motion vector of the object.
    Type: Grant
    Filed: March 23, 2011
    Date of Patent: August 22, 2017
    Assignee: California Institute of Technology
    Inventors: Guoan Zheng, Changhuei Yang, Samuel Yang, Seung Ah Lee
  • Patent number: 9643184
    Abstract: An e-Petri dish comprising a transparent layer having a specimen surface and a light detector configured to sample a sequence of sub-pixel shifted projection images of a specimen located on the specimen surface. The sub-pixel shifted projection images associated with light from a plurality of illumination angles provided by an illumination source.
    Type: Grant
    Filed: March 2, 2012
    Date of Patent: May 9, 2017
    Assignee: California Institute of Technology
    Inventors: Guoan Zheng, Samuel Yang, Seung Ah Lee, Shuo Pang, Changhuei Yang
  • Patent number: 9569664
    Abstract: Methods of rapid distinction between growing cells and debris, which determine a time-lapse movie of specimen images, track features of each entity, and categorize each entity as growing cells or debris.
    Type: Grant
    Filed: November 5, 2013
    Date of Patent: February 14, 2017
    Assignee: California Institute of Technology
    Inventors: Benjamin Judkewitz, Guoan Zheng, Samuel Yang, Seung Ah Lee, Shuo Pang, Changhuei Yang, Ying Min Wang
  • Publication number: 20170031146
    Abstract: Advantageous instruments, assemblies and methods are provided for undertaking imaging techniques (e.g., microscopic imaging techniques). The present disclosure provides improved imaging techniques, equipment and systems. More particularly, the present disclosure provides advantageous microscopy/imaging assemblies with rapid sample auto-focusing (e.g., microscopy/imaging assemblies having instant focusing for rapid sample imaging with auto-focusing). The present disclosure provides for high-throughput whole slide imaging with instant focal plane detection. A whole slide imaging platform/assembly that uses instant focusing systems/methods for high-speed sample autofocusing is provided. Such exemplary platforms/assemblies can be used for digital pathology or the like, and can provide improved, faster and cheaper diagnosis/prognosis of ailments/diseases.
    Type: Application
    Filed: July 27, 2016
    Publication date: February 2, 2017
    Applicant: University of Connecticut
    Inventor: Guoan Zheng
  • Patent number: 9497379
    Abstract: Certain aspects pertain to Fourier ptychographic imaging systems, devices, and methods such as, for example, high NA Fourier ptychographic imaging systems and reflective-mode NA Fourier ptychographic imaging systems.
    Type: Grant
    Filed: August 22, 2014
    Date of Patent: November 15, 2016
    Assignee: California Institute of Technology
    Inventors: Xiaoze Ou, Roarke Horstmeyer, Guoan Zheng, Changhuei Yang
  • Publication number: 20160320595
    Abstract: Certain aspects pertain to aperture-scanning Fourier ptychographic imaging devices comprising an aperture scanner that can generate an aperture at different locations at an intermediate plane of an optical arrangement, and a detector that can acquire lower resolution intensity images for different aperture locations, and wherein a higher resolution complex image may be constructed by iteratively updating regions in Fourier space with the acquired lower resolution images.
    Type: Application
    Filed: July 11, 2016
    Publication date: November 3, 2016
    Inventors: Roarke W. Horstmeyer, Guoan Zheng, Xiaoze Ou, Changhuei Yang
  • Publication number: 20160320605
    Abstract: Certain aspects pertain to Fourier ptychographic imaging systems, devices, and methods such as, for example, high NA Fourier ptychographic imaging systems and reflective-mode NA Fourier ptychographic imaging systems.
    Type: Application
    Filed: July 13, 2016
    Publication date: November 3, 2016
    Inventors: Xiaoze Ou, Roarke W. Horstmeyer, Guoan Zheng, Changhuei Yang