Patents by Inventor Guofeng Guan

Guofeng Guan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190344273
    Abstract: A microfluidic device comprises at least one inlet for receiving a sample comprising target cells and non-target cells; a first spiral channel portion having an upstream end in a central region and a downstream end in a peripheral region, the upstream end being coupled to the inlet, the first spiral channel portion being configured such that the target cells and the non-target cells occupy different streams at the downstream end; a first waste outlet arranged to couple with streams of non-target cells at the downstream end of the first spiral channel portion; a link channel portion arranged to couple with streams of target cells at the downstream end of the first spiral channel portion; a second spiral channel portion having an upstream end in a peripheral region and a downstream end in a central region, the upstream end of the second channel portion being coupled to the link channel portion, the second spiral channel portion being configured such that the target cells and the non-target cells occupy differen
    Type: Application
    Filed: January 28, 2016
    Publication date: November 14, 2019
    Inventors: Ali Asgar S. Bhagat, Guofeng Guan
  • Publication number: 20190151847
    Abstract: A system for enriching target cells in a sample is disclosed.
    Type: Application
    Filed: May 4, 2016
    Publication date: May 23, 2019
    Inventors: Ali Asgar S. Bhagat, Andrew En-Tzu Wu, Junquan Huang, Guofeng Guan, Shuzhe Chao, Yau Luong Koh, Yifang Lee, Man Chun Leong
  • Patent number: 10144009
    Abstract: A microfluidic device is disclosed. The device comprises at least one inlet for receiving circulating tumor cells and other cells in a sample; at least one curvilinear and/or spiral channel through which the sample is caused to undergo partial or complete Dean cycles to isolate the circulating tumor cells from the other cells; and at least one outlet configured to communicate with the channel for providing the isolated circulating tumor cells. The channel is configured to provide a predetermined Force ratio based on a desired threshold cell size of the circulating tumor cells. A corresponding method of manufacturing of the device, and a related diagnostic system are also disclosed.
    Type: Grant
    Filed: October 16, 2013
    Date of Patent: December 4, 2018
    Assignee: CLEARBRIDGE BIOMEDICS PTE LTD
    Inventors: Ali Asgar Bhagat, Guofeng Guan
  • Publication number: 20170296732
    Abstract: A system for intra-operative blood salvage autotransfusion is provided. The system comprises at least one inlet configured to receive whole blood of a patient; at least one curvilinear microchannel in fluid flow connection with the at least one inlet, the at least one curvilinear microchannel being adapted to isolate circulating tumor cells in the whole blood, based on cell size, along at least one portion of a cross-section of the at least one curvilinear microchannel; and at least two outlets in fluid flow connection with the at least one curvilinear microchannel, at least one outlet of the at least two outlets being configured to flow the circulating tumor cells isolated from the whole blood, and at least one other outlet of the at least two outlets being configured to flow at least a portion of a remainder of the whole blood, cleansed of the isolated circulating tumor cells, for return to the patient.
    Type: Application
    Filed: September 17, 2015
    Publication date: October 19, 2017
    Inventors: Majid Ebrahimi Warkiani, Guofeng Guan, Kah Ping Andy Tay, Lidan Wu, Jongyoon Han, Chwee Teck Lim
  • Patent number: 9789485
    Abstract: A micro-fluidic device includes at least one inlet and a curvilinear microchannel having a trapezoidal cross section defined by a radially inner side, a radially outer side, a bottom side, and a top side, the cross section having a) the radially inner side and the radially outer side unequal in height, or b) the radially inner side equal in height to the radially outer side, and wherein the top side has at least two continuous straight sections, each unequal in width to the bottom side.
    Type: Grant
    Filed: September 20, 2013
    Date of Patent: October 17, 2017
    Assignees: Massachusetts Institute of Technology, National University of Singapore
    Inventors: Jongyoon Han, Chao Yu Peter Chen, Chong Jin Ong, Guofeng Guan, Ali Asgar Bhagat, Lidan Wu
  • Publication number: 20170292104
    Abstract: A microfluidic system for cell retention for a perfusion bioreactor is provided. The system comprises at least one inlet configured to receive a bioreaction mixture to be processed. At least one curvilinear microchannel is in fluid flow connection with the at least one inlet, the at least one curvilinear microchannel being adapted to isolate cells in the bioreaction mixture, based on cell size, along at least one portion of a cross-section of the at least one curvilinear microchannel. At least two outlets are in fluid flow connection with the at least one curvilinear microchannel. At least one outlet of the at least two outlets is configured to flow the isolated cells to be recycled to the perfusion bioreactor.
    Type: Application
    Filed: September 17, 2015
    Publication date: October 12, 2017
    Applicants: MASSACHUSETTS INSTITUTE OF TECHNOLOGY, NATIONAL UNIVERSITY OF SINGAPORE
    Inventors: Majid EBRAHIMI WARKIANI, Jongyoon HAN, Kah Ping Andy TAY, Guofeng GUAN
  • Publication number: 20160303565
    Abstract: A microfluidic device is disclosed. The device comprises at least one inlet for receiving circulating tumor cells and other cells in a sample; at least one curvilinear and/or spiral channel through which the sample is caused to undergo partial or complete Dean cycles to isolate the circulating tumor cells from the other cells; and at least one outlet configured to communicate with the channel for providing the isolated circulating tumor cells. The channel is configured to provide a predetermined Force ratio based on a desired threshold cell size of the circulating tumor cells. A corresponding method of manufacturing of the device, and a related diagnostic system are also disclosed.
    Type: Application
    Filed: October 16, 2013
    Publication date: October 20, 2016
    Applicant: Clearbridge BioMedics Pte Ltd
    Inventors: Ali Asgar Bhagat, Guofeng Guan
  • Publication number: 20160243548
    Abstract: An interface comprising: a plurality of external ports configured to fluidically communicate with a plurality of ports of a fluidic delivery platform; and a plurality of engaging conduits configured to fluidically communicate with a plurality of ports of a microfluidic biochip, wherein a tolerance of both the plurality of external ports and/or the plurality of engaging conduits is significantly tighter than a tolerance of the plurality of ports of the microfluidic biochip.
    Type: Application
    Filed: October 16, 2014
    Publication date: August 25, 2016
    Applicant: Clearbridge BioMedics Pte Ltd
    Inventors: Ali Asgar Bhagat, Guofeng Guan
  • Publication number: 20150238963
    Abstract: A micro-fluidic device includes at least one inlet and a curvilinear microchannel having a trapezoidal cross section defined by a radially inner side, a radially outer side, a bottom side, and a top side, the cross section having a) the radially inner side and the radially outer side unequal in height, or b) the radially inner side equal in height to the radially outer side, and wherein the top side has at least two continuous straight sections, each unequal in width to the bottom side.
    Type: Application
    Filed: September 20, 2013
    Publication date: August 27, 2015
    Inventors: Jongyoon Han, Chao Yu Peter Chen, Chong Jin Ong, Guofeng Guan, Ali Asgar Bhagat, Lidan Wu