Patents by Inventor Gustavo F. Doncel
Gustavo F. Doncel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20210379089Abstract: A pharmaceutical composition and methods for using the pharmaceutical composition are disclosed. The pharmaceutical composition may include a therapeutically effective amount of one or more antiviral active pharmaceutical ingredients and a pharmaceutically acceptable excipient. The pharmaceutical composition may be a solid dosage form, wherein the solid dosage form provides sustained release of the antiviral active pharmaceutical ingredient when administered as a vaginal or rectal insert.Type: ApplicationFiled: October 23, 2019Publication date: December 9, 2021Inventors: Onkar N. SINGH, Timothy J. MCCORMICK, Vivek AGRAHARI, Melissa PEET, Meredith Roberts CLARK, Jill SCHWARTZ, Gustavo F. DONCEL
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Publication number: 20190328749Abstract: An improved long-acting injectable depot suspension formulation of LB displaying progestational effects which overcomes the aggregation and physical instability of LB injectable depot products, and also provides a longer duration of action of at least 4 months. Potential uses of this formulation include but are not limited to contraception and treatment or prevention of progestin/progesterone-sensitive reproductive tract dysfunctions and disorders.Type: ApplicationFiled: February 23, 2017Publication date: October 31, 2019Inventors: Timothy J. MCCORMICK, Gustavo F. DONCEL, Meredith Roberts CLARK, Jill SCHWARTZ
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Patent number: 9738678Abstract: The present invention relates to fatty acid and fatty alcohol substituted nucleoside derivatives and nucleoside and nucleoside derivatives substituted on multivalent scaffolds (e.g., polymers, peptides, polycarboxylic acid substituted compounds, compounds containing polycycloSaligenyl groups) that display potent anti-HIV activity. Furthermore, they show enhanced activity against multi-drug resistant, R5, and cell-associated virus. Some of them also display activity against other sexually transmitted pathogens and sperm. The present invention provides their methods of synthesis, composition of matter, and methods of use. Emphasis is placed on their application as topical microbicides to treat or prevent sexual transmission of disease, especially HIV/AIDS.Type: GrantFiled: March 24, 2016Date of Patent: August 22, 2017Assignees: Eastern Virginia Medical School, Board of Governors for Higher Education, State of Rhode Island and Providence PlantationsInventors: Gustavo F. Doncel, Keykavous Parang, Hitesh Kumar Agarwal
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Publication number: 20160311843Abstract: The present invention relates to fatty acid and fatty alcohol substituted nucleoside derivatives and nucleoside and nucleoside derivatives substituted on multivalent scaffolds (e.g., polymers, peptides, polycarboxylic acid substituted compounds, compounds containing polycycloSaligenyl groups) that display potent anti-HIV activity. Furthermore, they show enhanced activity against multi-drug resistant, R5, and cell-associated virus. Some of them also display activity against other sexually transmitted pathogens and sperm. The present invention provides their methods of synthesis, composition of matter, and methods of use. Emphasis is placed on their application as topical microbicides to treat or prevent sexual transmission of disease, especially HIV/AIDS.Type: ApplicationFiled: March 24, 2016Publication date: October 27, 2016Applicants: Eastern Virginia Medical School, Board of Governors for Higher Education, State of Rhode Island and Providence PlantationsInventors: Gustavo F. DONCEL, Keykavous PARANG, Hitesh Kumar AGARWAL
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Patent number: 9296776Abstract: The present invention relates to fatty acid and fatty alcohol substituted nucleoside derivatives and nucleoside and nucleoside derivatives substituted on multivalent scaffolds (e.g., polymers, peptides, polycarboxylic acid substituted compounds, compounds containing polycycloSaligenyl groups) that display potent anti-HIV activity. Furthermore, they show enhanced activity against multi-drug resistant, R5, and cell-associated virus. Some of them also display activity against other sexually transmitted pathogens and sperm. The present invention provides their methods of synthesis, composition of matter, and methods of use. Emphasis is placed on their application as topical microbicides to treat or prevent sexual transmission of disease, especially HIV/AIDS.Type: GrantFiled: July 9, 2008Date of Patent: March 29, 2016Assignees: Eastern Virginia Medical School, Board of Governors for Higher Education, State of Rhode Island and Providence PlantationsInventors: Gustavo F. Doncel, Keykavous Parang, Hitesh Kumar Agarwal
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Patent number: 8552064Abstract: The present invention is directed to methods of inhibiting STDs by topically administering suramin or a derivative thereof to actual or potential sites of infection, and methods of preventing pregnancy by topically applying suramin or a derivative thereof intravaginally. Suramin compositions that include an antimicrobial agent and/or a sperm-function inhibitor are also provided and may advantageously be used in the methods of the invention. A method of simultaneously inhibiting STDs and preventing pregnancy is also provided. Devices impregnated or coated with the topical suramin compositions are further disclosed and may be used to apply the compositions described herein.Type: GrantFiled: December 19, 2008Date of Patent: October 8, 2013Assignee: Eastern Virginia Medical SchoolInventor: Gustavo F. Doncel
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Publication number: 20110223239Abstract: A method for inactivating spermatozoa, neutralizing or inactivating a virus, and neutralizing or inactivating HIV using sophorolipids having spermicidal and/or antiviral properties produced by synthesizing the sophorolipid by fermentation of Candida bombicola in a fermentation media to form a natural mixture of lactonic sophorolipids compounds and non-lactonic sophorolipids compounds and utilizing the natural mixture as a spermicidal and/or antiviral agent, and/or separating the lactonic sophorolipids from the natural mixture to form a lactonic fraction and mixing all remaining fractions to form a non-lactonic fraction and utilizing the lactonic fraction and/or the non-lactonic fraction as an spermicidal and/or antiviral agent, and sophorolipid compounds for use as spermicidal and/or antiviral agents.Type: ApplicationFiled: May 20, 2011Publication date: September 15, 2011Inventors: Richard A. Gross, Vishal Shah, Gustavo F. Doncel
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Publication number: 20110217344Abstract: Sophorolipid compounds having spermicidal and/or antiviral properties prepared by synthesizing the sophorolipid by fermentation of Candida bombicola in a fermentation media to form a natural mixture of lactonic sophorolipids compounds and non-lactonic sophorolipids compounds and utilizing the natural mixture as a spermicidal and/or antiviral agent, and/or separating the lactonic sophorolipids from the natural mixture to form a lactonic fraction and mixing all remaining fractions to form a non-lactonic fraction and utilizing the lactonic fraction and/or the non-lactonic fraction as an spermicidal and/or antiviral agent, and sophorolipid compounds for use as spermicidal and/or antiviral agents.Type: ApplicationFiled: May 20, 2011Publication date: September 8, 2011Inventors: Richard A. Gross, Vishal Shah, Gustavo F. Doncel
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Publication number: 20110039798Abstract: The present invention relates to fatty acid and fatty alcohol substituted nucleoside derivatives and nucleoside and nucleoside derivatives substituted on multivalent scaffolds (e.g., polymers, peptides, polycarboxylic acid substituted compounds, compounds containing polycycloSaligenyl groups) that display potent anti-HIV activity. Furthermore, they show enhanced activity against multi-drug resistant, R5, and cell-associated virus. Some of them also display activity against other sexually transmitted pathogens and sperm. The present invention provides their methods of synthesis, composition of matter, and methods of use. Emphasis is placed on their application as topical microbicides to treat or prevent sexual transmission of disease, especially HIV/AIDS.Type: ApplicationFiled: July 9, 2008Publication date: February 17, 2011Applicant: EASTERN VIRGINIA MEDICAL SCHOOLInventors: Gustavo F. Doncel, Keykavous Parang, Hitesh Kumar Agarwal
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Publication number: 20090220574Abstract: The present invention is directed to methods of inhibiting STDs by topically administering suramin or a derivative thereof to actual or potential sites of infection, and methods of preventing pregnancy by topically applying suramin or a derivative thereof intravaginally. Suramin compositions that include an antimicrobial agent and/or a sperm-function inhibitor are also provided and may advantageously be used in the methods of the invention. A method of simultaneously inhibiting STDs and preventing pregnancy is also provided. Devices impregnated or coated with the topical suramin compositions are further disclosed and may be used to apply the compositions described herein.Type: ApplicationFiled: December 19, 2008Publication date: September 3, 2009Applicant: EASTERN VIRGINIA MEDICAL SCHOOLInventor: Gustavo F. Doncel
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Patent number: 7476693Abstract: The present invention is directed to methods of inhibiting STDs by topically administering suramin or a derivative thereof to actual or potential sites of infection, and methods of preventing pregnancy by topically applying suramin or a derivative thereof intravaginally. Suramin compositions that include an antimicrobial agent and/or a sperm-function inhibitor are also provided and may advantageously be used in the methods of the invention. A method of simultaneously inhibiting STDs and preventing pregnancy is also provided. Devices impregnated or coated with the topical suramin compositions are further disclosed and may be used to apply the compositions described herein.Type: GrantFiled: March 26, 2003Date of Patent: January 13, 2009Assignee: Eastern Virginia Medical SchoolInventor: Gustavo F. Doncel
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Publication number: 20040242501Abstract: A method for producing sophorolipids having spermicidal and/or antiviral properties by synthesizing the sophorolipid by fermentation of Candida bombicola in a fermentation media to form a natural mixture of lactonic sophorolipids compounds and non-lactonic sophorolipids compounds and utilizing the natural mixture as a spermicidal and/or antiviral agent, and/or separating the lactonic sophorolipids from the natural mixture to form a lactonic fraction and mixing all remaining fractions to form a non-lactonic fraction and utilizing the lactonic fraction and/or the non-lactonic fraction as an spermicidal and/or antiviral agent, and sophorolipid compounds for use as spermicidal and/or antiviral agents.Type: ApplicationFiled: March 19, 2004Publication date: December 2, 2004Inventors: Richard A. Gross, Vishal Shah, Gustavo F. Doncel
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Patent number: 6656936Abstract: Acylcarnitine analogues having alkyl side chains of 10 to 30 carbon atoms display excellent spermicidal and anti-HIV activity, a well as being potent inhibitors of the growth of Candida albicans.Type: GrantFiled: July 5, 2002Date of Patent: December 2, 2003Assignee: Virginia Tech Intellectual Properties, Inc.Inventors: Prashant S. Savle, Richard D. Gandour, Gustavo F. Doncel
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Patent number: 5595980Abstract: Improved contraceptive compositions are disclosed which comprise a spermicide or virucide, a polymeric delivery component and optionally a cosmetic ingredient. The improvement is directed to the use of certain hydrophobically modified polysaccharides as the polymeric delivery component. Quite advantageously, the hydrophobically modified polysaccharides of the present invention can alter sperm motility. Moreover, the hydrophobically modified polysaccharides can provide reduced irritation potential when used in combination with spermicides such as, for example, nonoxynol-9, which may reduce the potential for infection of sexually transmitted diseases such as HIV and herpes.Type: GrantFiled: April 7, 1995Date of Patent: January 21, 1997Assignees: Medical College of Hampton Roads, Biomaterials CorporationInventors: George L. Brode, Gustavo F. Doncel, Henry L. Gabelnick, Russell L. Kreeger, George A. Salensky