Patents by Inventor H. Michael Shepard

H. Michael Shepard has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11066656
    Abstract: Modified PH20 hyaluronidase polypeptides, including modified polypeptides that exhibit increased stability and/or increased activity, are provided. Also provided are compositions and formulations and uses thereof.
    Type: Grant
    Filed: June 25, 2020
    Date of Patent: July 20, 2021
    Assignee: Halozyme, Inc.
    Inventors: Ge Wei, H. Michael Shepard, Qiping Zhao, Robert James Connor
  • Patent number: 11041149
    Abstract: Modified PH20 hyaluronidase polypeptides, including modified polypeptides that exhibit increased stability and/or increased activity, are provided. Also provided are compositions and formulations and uses thereof.
    Type: Grant
    Filed: March 19, 2020
    Date of Patent: June 22, 2021
    Assignee: Halozyme, Inc.
    Inventors: Ge Wei, H. Michael Shepard, Qiping Zhao, Robert James Connor
  • Patent number: 10865400
    Abstract: Modified PH20 hyaluronidase polypeptides, including modified polypeptides that exhibit increased stability and/or increased activity, are provided. Also provided are compositions and formulations and uses thereof.
    Type: Grant
    Filed: August 2, 2016
    Date of Patent: December 15, 2020
    Assignee: Halozyme, Inc.
    Inventors: Ge Wei, H. Michael Shepard, Qiping Zhao, Robert James Connor
  • Publication number: 20200318091
    Abstract: Modified PH20 hyaluronidase polypeptides, including modified polypeptides that exhibit increased stability and/or increased activity, are provided. Also provided are compositions and formulations and uses thereof.
    Type: Application
    Filed: June 25, 2020
    Publication date: October 8, 2020
    Inventors: GE WEI, H. MICHAEL SHEPARD, QIPING ZHAO, ROBERT JAMES CONNOR
  • Publication number: 20200255814
    Abstract: Modified PH20 hyaluronidase polypeptides, including modified polypeptides that exhibit increased stability and/or increased activity, are provided. Also provided are compositions and formulations and uses thereof.
    Type: Application
    Filed: March 19, 2020
    Publication date: August 13, 2020
    Inventors: Ge WEI, H. Michael Shepard, Qiping Zhao, Robert James Connor
  • Publication number: 20190083449
    Abstract: Provided herein is combination cancer therapy effected by administering a polymer-conjugated hyaluronidase, and a tumor-targeted taxane, and optionally a further chemotherapeutic agent such as a nucleoside analog. The combination therapy can be used in methods of treating cancers, and in particular solid tumor cancers.
    Type: Application
    Filed: October 18, 2018
    Publication date: March 21, 2019
    Inventors: Daniel C. Maneval, H. Michael Shepard, Curtis B. Thompson
  • Patent number: 10137104
    Abstract: Provided herein is combination cancer therapy effected by administering a polymer-conjugated hyaluronidase, and a tumor-targeted taxane, and optionally a further chemotherapeutic agent such as a nucleoside analog. The combination therapy can be used in methods of treating cancers, and in particular solid tumor cancers.
    Type: Grant
    Filed: June 16, 2017
    Date of Patent: November 27, 2018
    Assignee: Halozyme, Inc.
    Inventors: Daniel C. Maneval, H. Michael Shepard, Curtis B. Thompson
  • Publication number: 20180216095
    Abstract: Provided are variant adenosine deaminase 2 (ADA2) proteins, conjugates thereof and compositions containing the proteins and/or conjugates. Also provided are methods and uses of the ADA2 proteins or conjugates for treating diseases and conditions, such as a tumor or cancer, and in particular any disease or condition associated with elevated adenosine or other associated marker.
    Type: Application
    Filed: March 29, 2018
    Publication date: August 2, 2018
    Inventors: Christopher D. THANOS, Lin Wang, H. Michael Shepard
  • Patent number: 9969998
    Abstract: Provided are variant adenosine deaminase 2 (ADA2) proteins, conjugates thereof and compositions containing the proteins and/or conjugates. Also provided are methods and uses of the ADA2 proteins or conjugates for treating diseases and conditions, such as a tumor or cancer, and in particular any disease or condition associated with elevated adenosine or other associated marker.
    Type: Grant
    Filed: April 8, 2016
    Date of Patent: May 15, 2018
    Assignee: Halozyme, Inc.
    Inventors: Christopher D. Thanos, Lin Wang, H. Michael Shepard
  • Patent number: 9913822
    Abstract: Provided herein is combination therapy containing an anti-hyaluronan agent, such as a polymer-conjugated hyaluronan-degrading enzyme, and a tumor-targeted taxane, and optionally a further chemotherapeutic agent such as a nucleoside analog. The combination therapy can be used in methods of treating cancers, and in particular solid tumor cancers.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: March 13, 2018
    Assignee: Halozyme, Inc.
    Inventors: Daniel C. Maneval, H. Michael Shepard, Curtis B. Thompson
  • Publication number: 20180044419
    Abstract: Provided are methods of treatments with combinations or compositions containing a soluble hyaluronidase, such as a polymer-modified hyaluronidase, and an immune checkpoint inhibitor treating cancers, including solid and non-solid tumors. The combinations and compositions also are provided.
    Type: Application
    Filed: February 27, 2017
    Publication date: February 15, 2018
    Inventors: Sanna ROSENGREN, H. Michael Shepard, Curtis B. Thompson
  • Publication number: 20170290796
    Abstract: Provided herein is combination cancer therapy effected by administering a polymer-conjugated hyaluronidase, and a tumor-targeted taxane, and optionally a further chemotherapeutic agent such as a nucleoside analog. The combination therapy can be used in methods of treating cancers, and in particular solid tumor cancers.
    Type: Application
    Filed: June 16, 2017
    Publication date: October 12, 2017
    Inventors: Daniel C. Maneval, H. Michael Shepard, Curtis B. Thompson
  • Publication number: 20170218069
    Abstract: Provided are methods of treatments with combinations or compositions containing a soluble hyaluronidase, such as a polymer-modified hyaluronidase, and an immune checkpoint inhibitor treating cancers, including solid and non-solid tumors. The combinations and compositions also are provided.
    Type: Application
    Filed: February 27, 2017
    Publication date: August 3, 2017
    Inventors: Sanna ROSENGREN, H. Michael Shepard, Curtis B. Thompson
  • Publication number: 20170166878
    Abstract: Provided are variant adenosine deaminase 2 (ADA2) proteins, conjugates thereof and compositions containing the proteins and/or conjugates. Also provided are methods and uses of the ADA2 proteins or conjugates for treating diseases and conditions, such as a tumor or cancer, and in particular any disease or condition associated with elevated adenosine or other associated marker.
    Type: Application
    Filed: April 8, 2016
    Publication date: June 15, 2017
    Inventors: Christopher D. Thanos, Lin Wang, H. Michael Shepard
  • Publication number: 20160362670
    Abstract: Modified PH20 hyaluronidase polypeptides, including modified polypeptides that exhibit increased stability and/or increased activity, are provided. Also provided are compositions and formulations and uses thereof.
    Type: Application
    Filed: August 2, 2016
    Publication date: December 15, 2016
    Inventors: Ge Wei, H. Michael Shepard, Qiping Zhao, Robert James Connor
  • Patent number: 9458442
    Abstract: Methods and diagnostic agents for identification of subjects for cancer treatment with an anti-hyaluronan agent, such as a hyaluronan-degrading enzyme, are provided. Diagnostic agents for the detection and quantification of hyaluronan in a biological sample and monitoring cancer treatment with an anti-hyaluronan agent, for example a hyaluronan-degrading enzyme, are provided. Combinations and kits for use in practicing the methods also are provided.
    Type: Grant
    Filed: August 14, 2014
    Date of Patent: October 4, 2016
    Assignee: Halozyme, Inc.
    Inventors: Ping Jiang, H. Michael Shepard, Lei Huang
  • Publication number: 20160272960
    Abstract: Provided are variant adenosine deaminase 2 (ADA2) proteins, conjugates thereof and compositions containing the proteins and/or conjugates. Also provided are methods and uses of the ADA2 proteins or conjugates for treating diseases and conditions, such as a tumor or cancer, and in particular any disease or condition associated with elevated adenosine or other associated marker.
    Type: Application
    Filed: April 8, 2016
    Publication date: September 22, 2016
    Inventors: Christopher D. Thanos, Lin Wang, H. Michael Shepard
  • Patent number: 9447401
    Abstract: Modified PH20 hyaluronidase polypeptides, including modified polypeptides that exhibit increased stability and/or increased activity, are provided. Also provided are compositions and formulations and uses thereof.
    Type: Grant
    Filed: December 28, 2012
    Date of Patent: September 20, 2016
    Assignee: Halozyme, Inc.
    Inventors: Ge Wei, H. Michael Shepard, Qiping Zhao, Robert James Connor
  • Patent number: 9278124
    Abstract: Provided herein are diagnostic methods for identifying subjects susceptible to treatment with a hypoxia-activated agent, and related methods. Also provided herein are methods of monitoring treatments with anti-hyaluronan agents, and related methods.
    Type: Grant
    Filed: October 16, 2013
    Date of Patent: March 8, 2016
    Assignee: Halozyme, Inc.
    Inventors: H. Michael Shepard, Xiaoming Li, Curtis Thompson
  • Publication number: 20150218544
    Abstract: Methods and diagnostic agents for identification of subjects for cancer treatment with an anti-hyaluronan agent, such as a hyaluronan-degrading enzyme, are provided. Diagnostic agents for the detection and quantification of hyaluronan in a biological sample and monitoring cancer treatment with an anti-hyaluronan agent, for example a hyaluronan-degrading enzyme, are provided. Combinations and kits for use in practicing the methods also are provided.
    Type: Application
    Filed: August 14, 2014
    Publication date: August 6, 2015
    Inventors: Ping Jiang, H. Michael Shepard, Lei Huang