Abstract: A diabetic foot management system according to one aspect includes a diabetic foot monitoring apparatus configured to measure user's foot condition information; and a diabetic foot analysis apparatus configured to determine a degree of progression of user's diabetic foot ulcer from the measured foot condition information using a machine learning-based diabetic foot determination model.

Abstract: Described are anti-doppel antibody-drug conjugates, compositions comprising them, and related methods of treating doppel-associated diseases and conditions, including cancer.

Abstract: The present disclosure relates to a method and apparatus for diagnosing urinary disturbances by simultaneously measuring a urinary flow rate and residual urine. The method for diagnosing urinary disturbances according to the present disclosure includes obtaining at least one ultrasonic image of a bladder for each unit time from a patient who is urinating, obtaining at least one urine region image for each unit time from the at least one ultrasonic image for each unit time, calculating at least one estimated urine volume for each unit time based on an area of the at least one urine region image for each unit time, calculating at least one parameter value with respect to urinary disturbances based on the at least one estimated urine volume for each unit time, and outputting the at least one parameter value.

Abstract: Disclosed herein is a kit for diagnosing spinal muscular atrophy (SMA) in a human subject based on the copy numbers of exons 7 and 8 of SMN1 gene and the copy numbers of exons 7 and 8 of SMN2 gene in a DNA sample isolated from the human subject. Also disclosed herein are methods of diagnosing SMA by use of the present kit, and methods of treating SMA based on the diagnostic result.

Abstract: An air intake system for a combustion engine includes an air intake duct in fluid communication with an engine intake manifold and a conduit component inserted into the air intake duct along a first assembly direction. The air intake system also includes a hydrocarbon (HC) trap secured to the conduit component within the air intake duct. The conduit component defines at least one retention feature to maintain a position of the HC trap such that removal of the HC trap from the air intake duct results in structural compromise of the at least one retention feature. The air intake duct is also configured to shield the at least one retention feature from user access to inhibit user removal of the HC trap.

Abstract: Disclosed herein is a method of performing polymerase chain reaction (PCR) to determine a repeating number of CGG sequence in fragile X mental retardation 1 (FMR1) gene. Also disclosed herein are a kit, and uses thereof in making a diagnosis of Fragile X syndrome (FXS) in a human subject based on the repeating number of the CGG sequence in a DNA sample isolated from the human subject. According to embodiments of the present disclosure, the kit comprises four primers, in which the first primer comprises a first polynucleotide sequence of SEQ ID NO: 1; the second primer comprises a second polynucleotide sequence of SEQ ID NO: 2; the third primer comprises a third polynucleotide sequence of SEQ ID NO: 3, and a non-human sequence disposed at and connected to the 5?-end of the third polynucleotide sequence; and the fourth primer comprises the non-human sequence.

Abstract: This application relates to a vehicle and method for generating a map corresponding to a three-dimensional space. In one aspect, the vehicle includes a sensor unit configured to sense a three-dimensional space by using at least one sensor and output spatial information in a plurality of frames and a memory storing computer executable instructions. The vehicle may also include a processor configured to execute the computer-executable instructions to predict a position of an object corresponding to a current frame by using an object movement model based on the plurality of frames, remove the object from the current frame based on the predicted position of the object, update a map database, which includes a predetermined number of previous frames, with the current frame from which the object is removed, and generate a map corresponding to the three-dimensional space based on the updated map database.

Abstract: An air intake system for a combustion engine includes an air intake duct in fluid communication with an engine intake manifold and a conduit component inserted into the air intake duct along a first assembly direction. The air intake system also includes a hydrocarbon (HC) trap secured to the conduit component within the air intake duct. The conduit component defines at least one retention feature to maintain a position of the HC trap such that removal of the HC trap from the air intake duct results in structural compromise of the at least one retention feature. The air intake duct is also configured to shield the at least one retention feature from user access to inhibit user removal of the HC trap.

Abstract: The present disclosure relates to a method and apparatus for diagnosing urinary disturbances by simultaneously measuring a urinary flow rate and residual urine. The method for diagnosing urinary disturbances according to the present disclosure includes obtaining at least one ultrasonic image of a bladder for each unit time from a patient who is urinating, obtaining at least one urine region image for each unit time from the at least one ultrasonic image for each unit time, calculating at least one estimated urine volume for each unit time based on an area of the at least one urine region image for each unit time, calculating at least one parameter value with respect to urinary disturbances based on the at least one estimated urine volume for each unit time, and outputting the at least one parameter value.

Abstract: Disclosed herein is a kit for diagnosing spinal muscular atrophy (SMA) in a human subject based on the copy numbers of exons 7 and 8 of SMN1 gene and the copy numbers of exons 7 and 8 of SMN2 gene in a DNA sample isolated from the human subject. Also disclosed herein are methods of diagnosing SMA by use of the present kit, and methods of treating SMA based on the diagnostic result.

Abstract: The disclosed tarpaulin comprises: a fabric layer, and a resin layer bonded to at least one surface of the fabric layer. The fabric layer comprises: high-density polyethylene (HDPE) multifilament yarns; polypropylene (PP) multifilament yams arranged to cross the HDPE multifilament yarns; and polyethylene terephthalate (PET) ground yarns binding the HDPE multifilament yarns and the PP multifilament yarns. The resin layer comprises PP and low-density polyethylene (LDPE).

Abstract: Disclosed herein is a method of performing polymerase chain reaction (PCR) to determine a repeating number of CGG sequence in fragile X mental retardation 1 (FMR1) gene. Also disclosed herein are a kit, and uses thereof in making a diagnosis of Fragile X syndrome (FXS) in a human subject based on the repeating number of the CGG sequence in a DNA sample isolated from the human subject. According to embodiments of the present disclosure, the kit comprises four primers, in which the first primer comprises a first polynucleotide sequence of SEQ ID NO: 1; the second primer comprises a second polynucleotide sequence of SEQ ID NO: 2; the third primer comprises a third polynucleotide sequence of SEQ ID NO: 3, and a non-human sequence disposed at and connected to the 5?-end of the third polynucleotide sequence; and the fourth primer comprises the non-human sequence.

Abstract: The present invention relates to a mesenchymal stem cell having immunomodulatory activity and a preparation method therefor and, more specifically, to: a rapamycin-treated mesenchymal stem cell having immunomodulatory activity, which expresses any one or more cell surface factors selected from the group consisting of CCR1, CCR2, CCR3, CCR4, CCR7, CCR9 and CXCR4; a cell therapy composition comprising the mesenchymal stem cell, for preventing or treating immune disorders; and a preparation method for the mesenchymal stem cell having immunomodulatory activity. The rapamycin-treated mesenchymal stem cell having immunomodulatory activity, according to the present invention, has increased expression of IDO, TGF-? and IL-10 which are factors having immunomodulatory activity, has decreased expression of Phospho-mTOR, Rictor and Ractor which are signal transduction factors of mTOR, and has increased expression, in the cell, of autophagic inducer Beclin1, ATG5, ATG7, LC3I or LCII.

Abstract: The present invention relates to a composition for preventing or treating mitochondrial diseases caused by immunosuppressants, and immune diseases, containing metformin and, more specifically, to a composition for treating mitochondrial diseases caused by immunosuppressants, containing metformin; a pharmaceutical composition for preventing or treating immune diseases, containing, as active ingredients, metformin and an immunosuppressant, which is a target of rapamycin inhibitor (mTOR inhibitor); and a pharmaceutical composite formulation for preventing or treating immune diseases, containing, as ingredients, metformin and a mammalian target of rapamycin inhibitor, wherein the metformin and mammalian target of rapamycin inhibitor are administered simultaneously or separately, or administered in a predetermined sequence.

Abstract: The present invention relates to a composite sheet, to a substrate for a display element including same, and to a display device including same. More specifically, the composite sheet comprises: a reinforcement-impregnated matrix; a coating layer formed on at least one surface of the matrix; and a barrier layer formed on at least one surface of the coating layer, wherein, if an elastic modulus of the matrix is E2 at a temperature of 25° C. and an elastic modulus of the coating layer is E3 at a temperature of 25° C., the ratio of the elastic modulus, i.e. E3/E2, is approximately 5×104 or less.

Abstract: The present invention relates to a mesenchymal stem cell having immunomodulatory activity and a preparation method therefor and, more specifically, to: a rapamycin-treated mesenchymal stem cell having immunomodulatory activity, which expresses any one or more cell surface factors selected from the group consisting of CCR1, CCR2, CCR3, CCR4, CCR7, CCR9 and CXCR4; a cell therapy composition comprising the mesenchymal stem cell, for preventing or treating immune disorders; and a preparation method for the mesenchymal stem cell having immunomodulatory activity. The rapamycin-treated mesenchymal stem cell having immunomodulatory activity, according to the present invention, has increased expression of IDO, TGF-? and IL-10 which are factors having immunomodulatory activity, has decreased expression of Phospho-mTOR, Rictor and Ractor which are signal transduction factors of mTOR, and has increased expression, in the cell, of autophagic inducer Beclin1, ATG5, ATG7, LC3I or LCII.

Abstract: A text-to-speech method for simulating a plurality of different voice characteristics includes dividing inputted text into a sequence of acoustic units; selecting voice characteristics for the inputted text; converting the sequence of acoustic units to a sequence of speech vectors using an acoustic model having a plurality of model parameters provided in clusters each having at least one sub-cluster and describing probability distributions which relate an acoustic unit to a speech vector; and outputting the sequence of speech vectors as audio with the selected voice characteristics. A parameter of a predetermined type of each probability distribution is expressed as a weighted sum of parameters of the same type using voice characteristic dependent weighting. In converting the sequence of acoustic units to a sequence of speech vectors, the voice characteristic dependent weights for the selected voice characteristics are retrieved for each cluster such that there is one weight per sub-cluster.

Abstract: The present invention relates to a method and a kit for monitoring an immune status after transplant. The kit for monitoring an immune status after transplant and the method for monitoring an immune status of an individual after transplant as provided in the present invention make it easy and accurate to determine an immune status in the individual after transplant and thus have an effect of reducing overuse of an immunosuppressive agent prescribed after transplant and also have an effect of conveniently managing an immune status of each patient.

Abstract: A hydrocarbon trap assembly for use in an intake system of a motor vehicle engine includes a first duct having an interior recess adjacent an end thereof, the recess having a blind end; a second duct overlapping the first duct's end and closing off a second end of the recess; and a thermoformed hydrocarbon-adsorbing sleeve inside the recess and having a first edge adjacent the blind end and a second edge adjacent the second end of the recess. One or both ends of the sleeve may engage a hook formed on the respective first and/or second ducts. The second end of the sleeve may have a flange that fits into a gap between the ducts.

Abstract: The present invention relates to a compound having a blocking effect against sodium ion channels, particularly Nav1.7, a preparation method thereof and the use thereof. A compound represented by formula 1 according to the invention, or a pharmaceutically acceptable salt, hydrate, solvate or isomer thereof may be effectively used for the prevention or treatment of pain, for example, acute pain, chronic pain, neuropathic pain, post-surgery pain, migraine, arthralgia, neuropathy, nerve injury, diabetic neuropathy, neuropathic disease, epilepsy, arrhythmia, myotonia, ataxia, multiple sclerosis, irritable bowel syndrome, urinary incontinence, visceral pain, depression, erythromelalgia, or paroxysmal extreme pain disorder (PEPD).