Patents by Inventor Hagop Kantarjian
Hagop Kantarjian has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8124351Abstract: The present invention concerns the detection of gene products resulting from chromosomal translocations, including fusion proteins comprising a first and second region. In particular, the fusion proteins are identified following subjecting a sample comprising the proteins to a bead comprising an antibody to a first region, followed by subjecting the bead-antibody-fusion complex to a second antibody directed against the second region, thereby detecting the fusion protein. In particular aspects, the invention is employed to provide prognosis for an individual with cancer, to identify suitability for a particular cancer therapy, and/or to monitor response of a patient to a therapy, for example.Type: GrantFiled: November 14, 2006Date of Patent: February 28, 2012Assignees: Board of Regents, The University of Texas System, Quest Diagnostics IncorporatedInventors: Maher Albitar, Hagop Kantarjian, Francis Giles, Iman Jilani
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Patent number: 7619000Abstract: Arsenic trioxide, an inorganic compound, is commercially available anti-cancer agent but it carries significant toxicity. Organic arsenicals, on the other hand, are much less toxic, to the extent that the methylation of inorganic arsenic in vivo into organic arsenicals has been considered a detoxification reaction. New organic arsenic derivatives have been synthesized, including S-dimethylarsino-glutathione, S-dimethylarsino-thiosuccinic acid and S-dimethylarsino-thiobenzoic acid, and established its potent in vitro cytotoxic activity against numerous human tumor cell lines, both of solid and hematological origin, as well as against malignant blood cells from patients with leukemia. Results form a basis for the development of S-dimethylarsino-glutathione, S-dimethylarsino-thiosuccinic acid, S-dimethylarsino-thiobenzoic acid, and other organic arsenicals as an anti-cancer therapy, combining high efficacy with very low, if any, toxicity.Type: GrantFiled: February 6, 2006Date of Patent: November 17, 2009Assignees: The Texas A&M University System, Board of Regents, The University of Texas SystemInventors: Ralph A. Zingaro, Emil J. Freireich, Hatice Duzkale, Hagop Kantarjian, Srdan Verstovsek, Merida Sotelo-Lerma
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Publication number: 20090226933Abstract: The present invention concerns the detection of gene products resulting from chromosomal translocations, including fusion proteins comprising a first and second region. In particular, the fusion proteins are identified following subjecting a sample comprising the proteins to a bead comprising an antibody to a first region, followed by subjecting the bead-antibody-fusion complex to a second antibody directed against the second region, thereby detecting the fusion protein. In particular aspects, the invention is employed to provide prognosis for an individual with cancer, to identify suitability for a particular cancer therapy, and/or to monitor response of a patient to a therapy, for example.Type: ApplicationFiled: November 14, 2006Publication date: September 10, 2009Inventors: Maher Albitar, Hagop Kantarjian, Francis Giles, Iman Jilani
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Patent number: 7405314Abstract: The present invention provides organic arsenicals. Many of these compounds have potent in vitro cytotoxic activity against numerous human tumor cell lines, both of solid and hematological origin, as well as against malignant blood cells from patients with leukemia.Type: GrantFiled: October 17, 2005Date of Patent: July 29, 2008Assignees: The Texas A&M University System, Board of Regents, The University of Texas SystemInventors: Ralph A. Zingaro, Hatice Duzkale, Emil J. Freireich, Hagop Kantarjian, Merida Sotelo-Lerma, Srdan Verstovsek, Mingzhang Gao
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Publication number: 20080090793Abstract: The present invention provides organic arsenicals. Many of these compounds have potent in vitro cytotoxic activity against numerous human tumor cell lines, both of solid and hematological origin, as well as against malignant blood cells from patients with leukemia.Type: ApplicationFiled: August 20, 2007Publication date: April 17, 2008Applicants: The Texas A&M University System, Board of Regents, The University of Texas SystemInventors: Ralph Zingaro, Hatice Duzkale, Emil Freireich, Hagop Kantarjian, Merida Sotelo-Lerma, Srdan Verstovsek, Mingzhang Gao
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Publication number: 20080090904Abstract: Arsenic trioxide, an inorganic compound, is commercially available anti-cancer agent but it carries significant toxicity. Organic arsenicals, on the other hand, are much less toxic, to the extent that the methylation of inorganic arsenic in vivo into organic arsenicals has been considered a detoxification reaction. New organic arsenic derivatives have been synthesized, including S-dimethylarsino-glutathione, S-dimethylarsino-thiosuccinic acid and S-dimethylarsino-thiobenzoic acid, and established its potent in vitro cytotoxic activity against numerous human tumor cell lines, both of solid and hematological origin, as well as against malignant blood cells from patients with leukemia. Results form a basis for the development of S-dimethylarsino-glutathione, S-dimethylarsino-thiosuccinic acid, S-dimethylarsino-thiobenzoic acid, and other organic arsenicals as an anti-cancer therapy, combining high efficacy with very low, if any, toxicity.Type: ApplicationFiled: August 20, 2007Publication date: April 17, 2008Applicants: The Texas A&M University System, Board of Regents, The University of Texas SystemInventors: Ralph Zingaro, Emil Freireich, Hatice Duzkale, Hagop Kantarjian, Srdan Verstovsek, Merida Sotelo-Lerma
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Publication number: 20060189687Abstract: Arsenic trioxide, an inorganic compound, is commercially available anti-cancer agent but it carries significant toxicity. Organic arsenicals, on the other hand, are much less toxic, to the extent that the methylation of inorganic arsenic in vivo into organic arsenicals has been considered a detoxification reaction. New organic arsenic derivatives have been synthesized, including S-dimethylarsino-glutathione, S-dimethylarsino-thiosuccinic acid and S-dimethylarsino-thiobenzoic acid, and established its potent in vitro cytotoxic activity against numerous human tumor cell lines, both of solid and hematological origin, as well as against malignant blood cells from patients with leukemia. Results form a basis for the development of S-dimethylarsino-glutathione, S-dimethylarsino-thiosuccinic acid, S-dimethylarsino-thiobenzoic acid, and other organic arsenicals as an anti-cancer therapy, combining high efficacy with very low, if any, toxicity.Type: ApplicationFiled: February 6, 2006Publication date: August 24, 2006Applicants: The Texas A&M University System, Board of Regents, The University of Texas SystemInventors: Ralph Zingaro, Emil Freireich, Hatice Duzkale, Hagop Kantarjian, Srdan Verstovsek, Merida Sotelo-Lerma
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Publication number: 20060128682Abstract: The present invention provides organic arsenicals. Many of these compounds have potent in vitro cytotoxic activity against numerous human tumor cell lines, both of solid and hematological origin, as well as against malignant blood cells from patients with leukemia.Type: ApplicationFiled: October 17, 2005Publication date: June 15, 2006Applicants: The Texas A&M University System, Board of Regents, The University of Texas SystemInventors: Ralph Zingaro, Hatice Duzkale, Emil Freireich, Hagop Kantarjian, Merida Sotelo-Lerma, Srdan Verstovsek, Mingzhang Gao
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Publication number: 20060073527Abstract: The present invention demonstrates that the diagnosis and prediction of clinical behavior in patients with hematologic malignancies, such as leukemia, can be accomplished by analysis of proteins present in a plasma sample. Thus, in particular embodiments the present invention uses plasma to create a diagnostic or prognostic protein profile of a hematologic malignancy comprising collecting plasma samples from a population of patients with hematologic malignancies; generating protein spectra from the plasma samples with or without fractionation; comparing the protein spectra with clinical data; and identifying protein markers in the plasma samples that correlate with the clinical data. Protein markers identified by this approach can then be used to create a protein profile that can be used to diagnose the hematologic malignancy or determine the prognosis of the hematologic malignancy. Potentially these specific proteins can be identified and targeted in the therapy of these malignancies.Type: ApplicationFiled: April 20, 2005Publication date: April 6, 2006Inventors: Maher Albitar, Elihu Estey, Hagop Kantarjian, Francis Giles, Michael Keating
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Publication number: 20060029574Abstract: The present invention provides methods and compositions for identifying cancer cells that are either sensitive or resistant to a particular anti-cancer therapy. Accordingly, the present invention allows for more accurate diagnosis, prognosis, and monitoring of a subject's condition. Furthermore, the ability to assess a subject's resistance or sensitivity to a particular treatment regimen will permit more informed treatment decisions to be made prior to beginning therapy. The present invention also overcomes deficiencies in the prior art concerning the treatment of cancers by providing methods and compositions for treating cancer and improving the effectiveness of other cancer therapies.Type: ApplicationFiled: August 6, 2004Publication date: February 9, 2006Inventors: Maher Albitar, Hagop Kantarjian, Ira Goldknopf, Essam Sheta
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Patent number: 6995188Abstract: Arsenic trioxide, an inorganic compound, is commercially available anti-cancer agent but it carries significant toxicity. Organic arsenicals, on the other hand, are much less toxic, to the extent that the methylation of inorganic arsenic in vivo into organic arsenicals has been considered a detoxification reaction. New organic arsenic derivatives have been synthesized, including S-dimethylarsino-glutathione, S-dimethylarsino-thiosuccinic acid and S-dimethylarsino-thiobenzoic acid, and established its potent in vitro cytotoxic activity against numerous human tumor cell lines, both of solid and hematological origin, as well as against malignant blood cells from patients with leukemia. Results form a basis for the development of S-dimethylarsino-glutathione, S-dimethylarsino-thiosuccinic acid, S-dimethylarsino-thiobenzoic acid, and other organic arsenicals as an anti-cancer therapy, combining high efficacy with very low, if any, toxicity.Type: GrantFiled: January 13, 2005Date of Patent: February 7, 2006Assignees: Board of Regents, The University of Texas System, The Texas A&M University SystemInventors: Ralph A. Zingaro, Emil J. Freireich, Hatice Duzkale, Hagop Kantarjian, Srdan Verstovsek, Merida Sotelo-Lerma
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Patent number: 6911471Abstract: Arsenic trioxide, an inorganic compound, is commercially available anti-cancer agent but it carries significant toxicity. Organic arsenicals, on the other hand, are much less toxic, to the extent that the methylation of inorganic arsenic in vivo into organic arsenicals has been considered a detoxification reaction. New organic arsenic derivatives have been synthesized, including S-dimethylarsino-glutathione, S-dimethylarsino-thiosuccinic acid and S-dimethylarsino-thiobenzoic acid, and established its potent in vitro cytotoxic activity against numerous human tumor cell lines, both of solid and hematological origin, as well as against malignant blood cells from patients with leukemia. Results form a basis for the development of S-dimethylarsino-glutathione, S-dimethylarsino-thiosuccinic acid, S-dimethylarsino-thiobenzoic acid, and other organic arsenicals as an anti-cancer therapy, combining high efficacy with very low, if any, toxicity.Type: GrantFiled: January 7, 2003Date of Patent: June 28, 2005Assignees: The Texas A&M University System, Board of Regents, The University of Texas SystemInventors: Ralph A. Zingaro, Emil J. Freireich, Hatice Duzkale, Hagop Kantarjian, Srdan Verstovsek, Merida Sotelo-Lerma
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Publication number: 20050131062Abstract: Arsenic trioxide, an inorganic compound, is commercially available anti-cancer agent but it carries significant toxicity. Organic arsenicals, on the other hand, are much less toxic, to the extent that the methylation of inorganic arsenic in vivo into organic arsenicals has been considered a detoxification reaction. New organic arsenic derivatives have been synthesized, including S-dimethylarsino-glutathione, S-dimethylarsino-thiosuccinic acid and S-dimethylarsino-thiobenzoic acid, and established its potent in vitro cytotoxic activity against numerous human tumor cell lines, both of solid and hematological origin, as well as against malignant blood cells from patients with leukemia. Results form a basis for the development of S-dimethylarsino-glutathione, S-dimethylarsino-thiosuccinic acid, S-dimethylarsino-thiobenzoic acid, and other organic arsenicals as an anti-cancer therapy, combining high efficacy with very low, if any, toxicity.Type: ApplicationFiled: January 13, 2005Publication date: June 16, 2005Applicants: The Texas A&M University System, Board of Regents, The University of Texas SystemInventors: Ralph Zingaro, Emil Freireich, Hatice Duzkale, Hagop Kantarjian, Srdan Verstovsek, Merida Sotelo-Lerma
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Publication number: 20040034095Abstract: Arsenic trioxide, an inorganic compound, is commercially available anti-cancer agent but it carries significant toxicity. Organic arsenicals, on the other hand, are much less toxic, to the extent that the methylation of inorganic arsenic in vivo into organic arsenicals has been considered a detoxification reaction. New organic arsenic derivatives have been synthesized, including S-dimethylarsino-glutathione, S-dimethylarsino-thiosuccinic acid and S-dimethylarsino-thiobenzoic acid, and established its potent in vitro cytotoxic activity against numerous human tumor cell lines, both of solid and hematological origin, as well as against malignant blood cells from patients with leukemia. Results form a basis for the development of S-dimethylarsino-glutathione, S-dimethylarsino-thiosuccinic acid, S-dimethylarsino-thiobenzoic acid, and other organic arsenicals as an anti-cancer therapy, combining high efficacy with very low, if any, toxicity.Type: ApplicationFiled: January 7, 2003Publication date: February 19, 2004Inventors: Ralph A. Zingaro, Emil J. Freireich, Hatice Duzkale, Hagop Kantarjian, Srdan Verstovsek, Merida Sotelo-Lerma
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Patent number: 6645972Abstract: The present invention provides a novel method for treating leukemia in a host that has been previously treated with a Bcr-Abl tyrosine kinase inhibitor comprising administering to the host a therapeutically effective amount of a compound having the formula I: wherein B is cytosine or 5-fluorocytosine and R is selected from H, monophosphate, diphosphate, triphosphate, carbonyl substituted with a C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C6-10 aryl, and and where in each Rc is independently selected from the group comprising H, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl an hydroxy protecting group.Type: GrantFiled: November 4, 2002Date of Patent: November 11, 2003Assignee: Shire BioChem Inc.Inventors: Jacques Jolivet, Francis Giles, Hagop Kantarjian
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Publication number: 20030125305Abstract: The present invention provides a novel method for treating leukemia in a host that has been previously treated with a Brc-Abl tyrosine kinase inhibitor comprising administering to the host a therapeutically effective amount of a compound having the formula I: 1Type: ApplicationFiled: November 4, 2002Publication date: July 3, 2003Applicant: Shire BioChem Inc.Inventors: Jacques Jolivet, Francis Giles, Hagop Kantarjian