Patents by Inventor Haim H. Bau

Haim H. Bau has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190017084
    Abstract: Disclosed herein are methods for multiple stage isothermal amplification of nucleic acid comprising a first substantially isothermal amplification reaction on the nucleic acid to generate a first amplification product and at least one substantially isothermal amplification reaction on the first amplification product to generate at least one second amplification product in an amount sufficient for recovery, testing, or characterization.
    Type: Application
    Filed: January 13, 2017
    Publication date: January 17, 2019
    Applicant: The Trustees Of The University Of Pennsylvania
    Inventors: Haim H. BAU, Michael G. MAUK, Jinzhao SONG, Changchun LIU
  • Patent number: 9976176
    Abstract: Provided are devices adapted to isolate, amplify, and detect nucleic acids that may be present in a biological sample. The devices can, in some embodiments, isolate, amplify, and detect nucleic acid in a single chamber. In other embodiments, the devices are adapted to isolate and amplify nucleic acids in a reaction chamber, after which the nucleic acids may be communicated to a pervious medium—such as a lateral flow strip—where the user may label and detect the nucleic acids.
    Type: Grant
    Filed: September 8, 2016
    Date of Patent: May 22, 2018
    Assignees: The Trustees of the University of Pennsylvania, New York University
    Inventors: Haim H. Bau, William R. Abrams, Eran Geva, Michael G. Mauk, Changchun Liu, Daniel Malamud, Xianbo Qiu
  • Publication number: 20170362669
    Abstract: Provided herein include compositions comprising a primer having the nucleic acid sequence of ACeIN-F3_c, a primer having the nucleic acid sequence of ACeIN-B3_a, a primer having the nucleic acid sequence of ACeIN-B3_b, a primer having the nucleic acid sequence of ACeIN-FIP_e, a primer having the nucleic acid sequence of ACeIN-FIP_f, a primer having the nucleic acid sequence of ACeIN-BIP (or ACeIN-BIP-song), a primer having the nucleic acid sequence of ACeIN-LF; and a primer having the nucleic acid sequence of ACeIN-LB. Also provided are methods of detecting human immunodeficiency virus (HIV) nucleic acids in a sample comprising performing reverse transcription-based loop mediated isothermal amplification (RT-LAMP) on a sample using the previously disclosed compositions.
    Type: Application
    Filed: December 11, 2015
    Publication date: December 21, 2017
    Inventors: Changchun LIU, Scott SHERRIL-MIX, Haim H. BAU, Frederic D. BUSHMAN, Karen E. OCWIEJA
  • Publication number: 20170343533
    Abstract: The present disclosure provides devices and methods using Plasma coil r separating a fluid—e.g., plasma or serum—from whole blood. In some embodiments, the devices and methods use hydrophobic or superhydrophobic surfaces to encourage whole blood to contact a selective membrane that extracts the desired fluid component from the blood.
    Type: Application
    Filed: November 9, 2015
    Publication date: November 30, 2017
    Inventors: Changchun LIU, Haim H. BAU, Michael G. MAUK
  • Publication number: 20170128947
    Abstract: Provided herein are devices for monitoring nucleic acid amplification, nucleic acid amplification monitors, methods of quantifying nucleic acid amplification, methods of identifying an unknown nucleic acid molecule, and systems for monitoring nucleic acid amplification. The disclosed devices, methods, and systems comprise at least one nuclemeter, comprising at least one sample chamber and at least one reaction-diffusion conduit in fluid communication with the chamber.
    Type: Application
    Filed: July 1, 2015
    Publication date: May 11, 2017
    Inventors: Changchun LIU, Haim H. BAU
  • Publication number: 20170096702
    Abstract: Provided are devices adapted to isolate, amplify, and detect nucleic acids that may be present in a biological sample. The devices can, in some embodiments, isolate, amplify, and detect nucleic acid in a single chamber. In other embodiments, the devices are adapted to isolate and amplify nucleic acids in a reaction chamber, after which the nucleic acids may be communicated to a pervious medium—such as a lateral flow strip—where the user may label and detect the nucleic acids.
    Type: Application
    Filed: September 8, 2016
    Publication date: April 6, 2017
    Inventors: Haim H. Bau, William R. Abrams, Eran Geva, Michael G. Mauk, Changchun Liu, Daniel Malamud, Xianbo Qiu
  • Publication number: 20160310904
    Abstract: A plasma separator includes a vertical chamber with a membrane or membranes partially or fully covering the internal chamber walls and forming an inner cavity to accommodate whole blood. The plasma separator further includes a plasma collection space separated from the inner cavity with one or more membranes and a plasma removal port.
    Type: Application
    Filed: December 18, 2014
    Publication date: October 27, 2016
    Inventors: Changchun LIU, Haim H. BAU, Michael G. MAUK
  • Patent number: 9476102
    Abstract: Provided are devices adapted to isolate, amplify, and detect nucleic acids that may be present in a biological sample. The devices can, in some embodiments, isolate, amplify, and detect nucleic acid in a single chamber. In other embodiments, the devices are adapted to isolate and amplify nucleic acids in a reaction chamber, after which the nucleic acids may be communicated to a pervious medium—such as a lateral flow strip—where the user may label and detect the nucleic acids.
    Type: Grant
    Filed: February 15, 2012
    Date of Patent: October 25, 2016
    Assignee: The Trustees Of The University Of Pennsylvania
    Inventors: Haim H. Bau, William R. Abrams, Eran Geva, Michael G. Mauk, Changchun Liu, Daneil Malamud, Xianbo Ceiu
  • Patent number: 9409166
    Abstract: Disclosed are integrated devices capable of performing a polymerase chain reaction within a single vessel. Also disclosed are related methods of sample analysis.
    Type: Grant
    Filed: December 10, 2008
    Date of Patent: August 9, 2016
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Michael G Mauk, Haim H Bau, Daniel Malamud, William Abrams
  • Patent number: 9233368
    Abstract: Provided are disposable, moisture-activated, self-heating cartridges useful for, e.g., isothermal nucleic acid amplification, incubation, and thermal actuation, and visual fluorescent detection of the amplification products. These devices may be self-contained and do not require any special instruments to operate.
    Type: Grant
    Filed: May 22, 2012
    Date of Patent: January 12, 2016
    Assignee: The Trustees Of The University Of Pennsylvania
    Inventors: Haim H. Bau, Changchun Liu, Michael G. Mauk, Robert W. Hart, Xianbo Qiu
  • Patent number: 9196457
    Abstract: Provided are flow cell devices—referred to as nanoaquariums—that are microfabricated devices featuring a sample chamber having a controllable height in the range of nanometers to micrometers. The cells are sealed so as to withstand the vacuum environment of an electron microscope without fluid loss. The cells allow for the concurrent flow of multiple sample streams and may be equipped with electrodes, heaters, and thermistors for measurement and other analysis devices.
    Type: Grant
    Filed: May 23, 2012
    Date of Patent: November 24, 2015
    Assignee: The Trustees Of The University Of Pennsylvania
    Inventors: Joseph M Grogan, Haim H Bau
  • Patent number: 8911938
    Abstract: Disclosed are preloaded analysis modules comprising reagents disposed within a barrier material capable of liberating the reagents, at a time advantageous to a reaction scheme, when exposed to certain activation conditions or reagents. Also disclosed are related methods for analyzing samples with such modules.
    Type: Grant
    Filed: December 10, 2008
    Date of Patent: December 16, 2014
    Assignee: The Trustees Of The University Of Pennsylvania
    Inventors: Michael G. Mauk, Haim H. Bau, Amanda W. Dyson, Sudhir Ramprasad, Dafeng Chen, Do Young Byun
  • Patent number: 8877518
    Abstract: Provided are nanoscale devices suitable for multiplexed, parallel detection of multiple analytes and methods for fabricating such devices.
    Type: Grant
    Filed: February 4, 2008
    Date of Patent: November 4, 2014
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Haim H. Bau, Michael Schrlau
  • Publication number: 20140162244
    Abstract: Provided are devices adapted to isolate, amplify, and detect nucleic acids that may be present in a biological sample. The devices can, in some embodiments, isolate, amplify, and detect nucleic acid in a single chamber. In other embodiments, the devices are adapted to isolate and amplify nucleic acids in a reaction chamber, after which the nucleic acids may be communicated to a pervious medium—such as a lateral flow strip—where the user may label and detect the nucleic acids.
    Type: Application
    Filed: February 15, 2012
    Publication date: June 12, 2014
    Inventors: Haim H. Bau, William R. Abrams, Eran Geva, Michael G. Mauk, Changchun Liu, Daniel Malamud, Xianbo Ceiu
  • Patent number: 8702927
    Abstract: Provided are probes featuring multiple electrodes, which probes have diameters in the nanometer range and may be inserted into cells or other subjects so as to monitor an electrical characteristic of the subject. The probes may also include a conductive coating on at least one probe element to improve the probes' performance. The probes may also be used to inject a fluid or other agent into the subject and simultaneously monitor changes in the subject's electrical characteristics in response to the injection. Related methods of fabricating and of using the inventive probes are also provided.
    Type: Grant
    Filed: April 23, 2010
    Date of Patent: April 22, 2014
    Assignee: The Trustees Of The University Of Pennsylvania
    Inventors: Haim H. Bau, Michael G. Schrlau, Rui Zhang
  • Patent number: 8697007
    Abstract: Provided are analysis cassettes that include removable sealing layers and deformable connector layers that place various channels, chambers, and reservoirs on the cassettes into fluid communication with one another. The cassettes are suitable for use in self-contained, immunoassay devices that may be operated in an automated fashion. Also disclosed are methods for analyzing samples by use of the disclosed cassettes.
    Type: Grant
    Filed: August 5, 2009
    Date of Patent: April 15, 2014
    Assignee: The Trustees Of The University Of Pennsylvania
    Inventors: Haim H. Bau, Changchun Liu, Xianbo Qiu
  • Patent number: 8691592
    Abstract: Disclosed are mechanically-actuated devices for transporting fluids within a microfluidic circuit and performing diagnostic operations on a sample. Also disclosed are related methods for performing sample analysis effected by the motion of an actuator proximate to a microfluidic system.
    Type: Grant
    Filed: December 14, 2007
    Date of Patent: April 8, 2014
    Assignee: The Trustees Of The University Of Pennsylvania
    Inventors: Zongyuan Chen, Haim H. Bau, Michael Mauk, Xianbo Qiu, Jason Kwa
  • Publication number: 20140023520
    Abstract: The present invention relates to controlled, magnetohydrodynamically-driven, fluidic networks containing a plurality of individually controlled branches. The branches consist of conduits equipped with pairs of electrodes that are controlled by electrode controllers. In operation, the network is placed within a magnetic field and potentials or currents are applied across electrode pairs within the various branches of the network in specifically determined magnitudes and polarities for specifically determined time intervals in accordance with an activation sequence that may be determined by an algorithm. Placed within a temperature gradient, at least a part of the network can act as a thermal cycler for use in biological interactions that employ temperature variations.
    Type: Application
    Filed: September 23, 2013
    Publication date: January 23, 2014
    Inventor: Haim H. Bau
  • Patent number: 8562305
    Abstract: Provided are magnetohydrodynamic stirrers comprising a conduit or cavity having at least two electrodes disposed in such an orientation that, upon the application of a potential or current across the electrode pair within a magnetic field, secondary flows such as chaotic advection is generated.
    Type: Grant
    Filed: April 3, 2008
    Date of Patent: October 22, 2013
    Assignee: The Trustees Of The University Of Pennsylvania
    Inventor: Haim H. Bau
  • Publication number: 20130037423
    Abstract: Provided are devices and methods for performing multi-point analysis on biological materials, such as cells. In one embodiment, the devices simultaneously collect information related to a characteristic of a cell membrane and a characteristic of the interior of the cell.
    Type: Application
    Filed: March 16, 2012
    Publication date: February 14, 2013
    Inventors: Michael G. Schrlau, Eugen Brailoiu, Nae J. Dun, Haim H. Bau