Abstract: The present disclosure relates to bicyclic heterocycles of Formula (I), and pharmaceutical compositions of the same, that are modulators, antagonists, or inhibitors of the G protein-coupled receptor MRGPRX2 and are useful in the treatment of MRGPRX2 dependent conditions such as inflammatory diseases.

Abstract: A hydroxamic acid-metal hydroxide coordination complex and preparation and application thereof are disclosed. The hydroxamic acid-metal hydroxide coordination complex is formed by a coordination of hydroxamic acid with divalent or higher valent metal ions under an alkaline condition. The hydroxamic acid-metal hydroxide coordination complex has a strong selectivity and a strong collection ability for metal oxide minerals such as tungsten-containing minerals, ilmenite, rutile, cassiterite, and rare earth. The preparation method is simple and low in costs, and is beneficial to industrialized production.

Abstract: A method for preparing high-purity metallic arsenic from arsenic-containing solid waste through a short flow process is provided. The method includes: performing oxidative alkaline leaching on nonferrous metallurgy arsenic-containing solid waste to obtain an arsenic-containing alkaline leaching solution; sequentially adding a mixed ammonium magnesium reagent consisting of a carboxyl and/or hydroxy-containing water-soluble macromolecular organic matter, a magnesium compound and an ammonium compound, and a hydrophobic macromolecular organic matter having a periodic geometric structure into the arsenic-containing alkaline leaching solution, and taking a reaction under stirring to obtain complex arsenate crystals cladded with an organic matter; and roasting the complex arsenate crystals cladded with the organic matter, then mixing the roasted complex arsenate crystals cladded with the organic matter with carbon powder, performing reduction roasting, and recycling metallic arsenic from smoke through condensation.

Abstract: Coarse particle flotation equipment and method based on coupled fluidization of cyclone and damping are provided. The flotation equipment includes a flotation column. A raw ore feed pipe is provided in an upper part of the flotation column. The flotation column is sequentially divided into a mine tailing bottom launder area, a cyclone mineralization area and a static separation area from bottom to top. A plurality of water-gas mixing jet pipes which are obliquely arranged inwardly and upwardly and communicated with an inner cavity of the flotation column being provided at a side wall of the cyclone mineralization area, jet directions of the plurality of water-gas mixing jet pipes are distributed clockwise or anticlockwise around an axis of the flotation column, and a damping element for reducing turbulence of a water flow is further provided between the cyclone mineralization area and the static separation area.

Abstract: Disclosed are a slow-release inhibitor for high-magnesium sulfide mineral flotation and an application thereof, where the inhibitor is a nano colloidal particle of an alkaline earth fluoride such as CaF2 and BaF2 or a highly-reactive natural alkaline earth metal mineral powder. When applied to the flotation separation of a high-magnesium sulfide ore, the inhibitor can slowly release F ions to preferentially form a MgF2 layer on the magnesium-containing mineral surface, which provides a structure similar to MgF2 on a surface of oxidized gangue minerals such as magnesium oxide, changing surface electrical property of the magnesium-containing mineral, inhibiting heterogeneous coagulation of magnesium-containing minerals and sulfide ores due to electrostatic attraction and reducing entrainment, enveloping and agglomeration of gangue minerals to efficiently inhibit the flotation of oxidized gangue minerals such as magnesium oxide.

Abstract: A hydroximic acid-metal hydroxide coordination complex and preparation and application thereof are disclosed. The hydroximic acid-metal hydroxide coordination complex is formed by a coordination of hydroximic acid with divalent or higher valent metal ions under an alkaline condition. The hydroximic acid-metal hydroxide coordination complex has a strong selectivity and a strong collection ability for metal oxide minerals such as tungsten-containing minerals, ilmenite, rutile, cassiterite, and rare earth. The preparation method is simple and low in costs, and is beneficial to industrialized production.

Abstract: Disclosed are a slow-release inhibitor for high-magnesium sulfide mineral flotation and an application thereof, where the inhibitor is a nano colloidal particle of an alkaline earth fluoride such as CaF2 and BaF2 or a highly-reactive natural alkaline earth metal mineral powder. When applied to the flotation separation of a high-magnesium sulfide ore, the inhibitor can slowly release F ions to preferentially form a MgF2 layer on the magnesium-containing mineral surface, which provides a structure similar to MgF2 on a surface of oxidized gangue minerals such as magnesium oxide, changing surface electrical property of the magnesium-containing mineral, inhibiting heterogeneous coagulation of magnesium-containing minerals and sulfide ores due to electrostatic attraction and reducing entrainment, enveloping and agglomeration of gangue minerals to efficiently inhibit the flotation of oxidized gangue minerals such as magnesium oxide.