Patents by Inventor Hajime Hiramatsu

Hajime Hiramatsu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7846933
    Abstract: The present invention relates to a compound of the formula [I]: wherein G1 is an alkyl which is substituted by a halogen atom or an alkoxy, or a group of the formula: wherein ring B is benzene ring which may be substituted, etc., Q1 and Q2 may be the same or different, and each is hydrogen atom, a halogen atom or an alkyl, n is 0, 1, 2, 3 or 4, R1 is hydrogen atom, an alkyl which may be substituted, a cycloalkyl which may be substituted, a phenyl which may be substituted, etc., Z1, Z2, Z3 and Z4 may be the same or different, and each is CH or N, provided that 3 or more of Z1, Z2, Z3 and Z4 should not be N at the same time, G2 is hydrogen atom, —NR3R4, —OR5, etc., where R3 to R8 each is independently hydrogen atom, an alkyl which may be substituted, an alkenyl, an alkynyl, etc., or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: November 13, 2008
    Date of Patent: December 7, 2010
    Assignee: Mitsubishi Tanabe Pharma Corporation
    Inventors: Akira Kubo, Ritsuo Imashiro, Hiroaki Sakurai, Hidetaka Miyoshi, Akihito Ogasawara, Hajime Hiramatsu, Tatsuo Nakajima, Tetsu Nakane
  • Publication number: 20090088422
    Abstract: The present invention relates to a compound of the formula [I]: wherein G1 is an alkyl which is substituted by a halogen atom or an alkoxy, or a group of the formula: wherein ring B is benzene ring which may be substituted, etc., Q1 and Q2 may be the same or different, and each is hydrogen atom, a halogen atom or an alkyl, n is 0, 1, 2, 3 or 4, R1 is hydrogen atom, an alkyl which may be substituted, a cycloalkyl which may be substituted, a phenyl which may be substituted, etc., Z1, Z2, Z3 and Z4 may be the same or different, and each is CH or N, provided that 3 or more of Z1, Z2, Z3 and Z4 should not be N at the same time, G2 is hydrogen atom, —NR3R4, —OR5, etc., where R3 to R8 each is independently hydrogen atom, an alkyl which may be substituted, an alkenyl, an alkynyl, etc., or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: November 13, 2008
    Publication date: April 2, 2009
    Inventors: Akira Kubo, Ritsuo Imashiro, Hiroaki Sakurai, Hidetaka Miyoshi, Akihito Ogasawara, Hajime Hiramatsu, Tatsuo Nakajima, Tetsu Nakane
  • Patent number: 7498157
    Abstract: A crystal of a dipeptidyl peptidase IV; a three-dimensional structural coordinate of the dipeptidyl peptidase IV; a method for obtaining a three-dimensional coordinate of a homolog protein of the dipeptidyl peptidase IV; a method for obtaining a three-dimensional structural coordinate of a crystal of a complex of the dipeptidyl peptidase IV and an effector of the dipeptidyl peptidase IV; a method for identifying pharmacophore of the effector of the dipeptidyl peptidase IV; a method for designing, identifying, evaluating or searching; the effector; and a program and a medium therefor for use of the three-dimensional structural coordinate.
    Type: Grant
    Filed: July 28, 2003
    Date of Patent: March 3, 2009
    Assignee: Mitsubishi Tanabe Pharma Corporation
    Inventors: Hajime Hiramatsu, Kiyoshi Kyono, Hideaki Shima, Shigeru Sugiyama
  • Patent number: 7473695
    Abstract: The present invention relates to a compound of the formula [I]: wherein G1 is an alkyl which is substituted by a halogen atom or an alkoxy, or a group of the formula: wherein ring B is benzene ring which may be substituted, etc., Q1 and Q2 maybe the same or different, and each is hydrogen atom, a halogen atom or an alkyl, n is 0, 1, 2, 3 or 4, R1 is hydrogen atom, an alkyl which may be substituted, a cycloalkyl which may be substituted, a phenyl which may be substituted, etc., Z1, Z2, Z3 and Z4 may be the same or different, and each is CH or N, provided that 3 or more of Z1, Z2, Z3 and Z4 should not be N at the same time, G2 is hydrogen atom, —NR3R4, —OR5, etc., where R3 to R8 each is independently hydrogen atom, an alkyl which may be substituted, an alkenyl, an alkynyl, etc., or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: April 20, 2004
    Date of Patent: January 6, 2009
    Assignee: Mitsubishi Tanabe Pharma Corporation
    Inventors: Akira Kubo, Ritsuo Imashiro, Hiroaki Sakurai, Hidetaka Miyoshi, Akihito Ogasawara, Hajime Hiramatsu, Tatsuo Nakajima, Tetsu Nakane
  • Publication number: 20050260732
    Abstract: A crystal of a dipeptidyl peptidase IV; a three-dimensional structural coordinate of the dipeptidyl peptidase IV; a method for obtaining a three-dimensional coordinate of a homolog protein of the dipeptidyl peptidase IV; a method for obtaining a three-dimensional structural coordinate of a crystal of a complex of the dipeptidyl peptidase IV and a effector of the dipeptidyl peptidase IV; a method for identifying pharmacophore of the effector of the dipeptidyl peptidase IV; a method for designing, identifying, evaluating or searching; the effector; and a program and a medium therefor for use of the three-dimensional structural coordinate.
    Type: Application
    Filed: July 28, 2003
    Publication date: November 24, 2005
    Inventors: Hajime Hiramatsu, Kiyoshi Kyono, Hideaki Shima, Shigeru Sugiyama
  • Publication number: 20040204426
    Abstract: The present invention relates to a compound of the formula [I]: 1
    Type: Application
    Filed: April 20, 2004
    Publication date: October 14, 2004
    Inventors: Akira Kubo, Ritsuo Imashiro, Hiroaki Sakurai, Hidetaka Miyoshi, Akihito Ogasawara, Hajime Hiramatsu, Tatsuo Nakajima, Tetsu Nakane
  • Patent number: 4834550
    Abstract: An apparatus for testing a heat-insulating tubular member having at least one tubular portion comprising a combustion chamber connected to the tubular portion, a burner mounted in each combustion chamber, and an air line and a fuel supply line both connected to the burner. It may further comprise an air line for increasing exhaust gas pressure which opens on the inner wall of the combustion chamber near the burner.
    Type: Grant
    Filed: August 5, 1987
    Date of Patent: May 30, 1989
    Assignees: Hitachi Metals, Ltd., Shoei Manufacturing Co., Ltd., San-In Sanso Co., Ltd.
    Inventors: Mitsuru Yano, Hajime Hiramatsu, Hiroshi Takaki