Patents by Inventor Hak-Joon Sung

Hak-Joon Sung has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11628235
    Abstract: The present invention relates to a photo-cross-linkable shape-memory polymer and a preparation method therefor. The shape-memory polymer according to one embodiment of the present invention comprises a photo-cross-linkable functional group, and thus a shape-memory polymer having a melting point suitable for a physiological or medical application device can be provided. Particularly, a method for preparing the shape-memory polymer, according to one embodiment of the present invention, uses a catalyst for inducing the simultaneous ring-opening polymerization of two monomers (CL, GMA) during synthesis of the shape-memory polymer, thereby enabling the synthesis time of the shape-memory polymer to be reduced, and shape-memory polymers having various melting points can be readily prepared by controlling the introduction amounts of CL and GMA.
    Type: Grant
    Filed: January 26, 2018
    Date of Patent: April 18, 2023
    Assignee: TMD LAB CO. LTD
    Inventors: Hak-Joon Sung, Yun Ki Lee
  • Publication number: 20220290098
    Abstract: The present invention relates to a method for diagnosing and treating atherosclerosis by using nanovesicle targeting a site of change in blood flow, and more specifically, the present invention provides a stem cell-derived nanovesicle, which is an anti-atherosclerosis diagnosis and treatment platform using a peptide capable of targeting a disturbed blood flow, wherein the nanovesicle provides strong anti-inflammatory and pre-endothelial recovery effects similar to that of a mesenchymal stem cell, and thus it can be used as a new diagnosis and treatment agent capable of preventing the onset of atherosclerosis.
    Type: Application
    Filed: August 28, 2020
    Publication date: September 15, 2022
    Applicant: NUMAIS CO., LTD.
    Inventors: Hak Joon SUNG, Jeong Kee YOON
  • Publication number: 20220000481
    Abstract: The present invention relates to an artificial blood vessel comprising a shape-memory polymer, and a vascular anastomotic member formed of a shape-memory polymer. An artificial blood vessel according to an embodiment of the present invention comprises a shape-memory polymer including photo-crosslinkable functional groups, the artificial blood vessel thus provided having a fusion point suitable for in vivo transplantation. Also, provided is a vascular anastomotic member which comprises a shape-memory polymer including photo-crosslinkable functional groups, and thus has a fusion point suitable for in vivo transplantation.
    Type: Application
    Filed: October 2, 2019
    Publication date: January 6, 2022
    Inventors: Hak-Joon SUNG, Young Min SHIN, Jung Bok LEE
  • Publication number: 20210369920
    Abstract: The present invention relates to a nasolacrimal duct insertion member comprising a shape memory polymer for treatment of nasolacrimal duct obstruction/stenosis, wherein the shape memory polymer comprises a crosslinkable functional group, such that the nasolacrimal duct insertion member has a melting point suitable for implantation into a living body.
    Type: Application
    Filed: October 1, 2019
    Publication date: December 2, 2021
    Inventors: Hak-Joon SUNG, Jin Sook YOON, Jung Bok LEE, Jae Sang KO, Woo Beom SHIN
  • Publication number: 20210102023
    Abstract: The present invention relates to a photo-cross-linkable shape-memory polymer and a preparation method therefor. The shape-memory polymer according to one embodiment of the present invention comprises a photo-cross-linkable functional group, and thus a shape-memory polymer having a melting point suitable for a physiological or medical application device can be provided. Particularly, a method for preparing the shape-memory polymer, according to one embodiment of the present invention, uses a catalyst for inducing the simultaneous ring-opening polymerization of two monomers (CL, GMA) during synthesis of the shape-memory polymer, thereby enabling the synthesis time of the shape-memory polymer to be reduced, and shape-memory polymers having various melting points can be readily prepared by controlling the introduction amounts of CL and GMA.
    Type: Application
    Filed: January 26, 2018
    Publication date: April 8, 2021
    Inventors: Hak-Joon Sung, Yun Ki Lee
  • Patent number: 10532125
    Abstract: The presently-disclosed subject matter includes a compound comprising a first monomer, which is allyl-functionalized and crosslinkable, and a second monomer, which is not crosslinkable. In some embodiments the compounds are photocrosslinkable, and in certain embodiments are photocrosslinkable by ultraviolet light. Also provided are shape memory vascular grafts comprised the of present compounds that can transition from a temporary shape to an original shape when heated above a melting temperature of the graft. Still further provided are methods for treating vascular conditions that utilize embodiments of the present grafts.
    Type: Grant
    Filed: June 27, 2014
    Date of Patent: January 14, 2020
    Assignee: Vanderbilt University
    Inventors: Hak-Joon Sung, Timothy C. Boire, Mukesh K. Gupta, Angela L. Zachman, Sue Hyun-Lee, Colleen M. Brophy
  • Publication number: 20180126046
    Abstract: The presently-disclosed subject matter includes a compound comprising a first monomer, which is allyl-functionalized and crosslinkable, and a second monomer, which is not crosslinkable. In some embodiments the compounds are photocrosslinkable, and in certain embodiments are photocrosslinkable by ultraviolet light. Also provided are shape memory vascular grafts comprised the of present compounds that can transition from a temporary shape to an original shape when heated above a melting temperature of the graft. Still further provided are methods for treating vascular conditions that utilize embodiments of the present grafts.
    Type: Application
    Filed: April 15, 2016
    Publication date: May 10, 2018
    Inventors: Hak-Joon Sung, Timothy C. Boire, Colleen Brophy
  • Publication number: 20160024249
    Abstract: Embodiments of the invention include polymeric compounds that comprise a co-polymer microgel at least one bioactive agent, pharmaceutical compounds comprising compounds of the present invention, and methods for treating damaged tissue to a patient in need thereof by administering by injection an effect amount of the composition.
    Type: Application
    Filed: July 22, 2015
    Publication date: January 28, 2016
    Inventors: Hak-Joon Sung, Xintong Wang, Mukesh K. Gupta, Timothy C. Boire
  • Patent number: 9012596
    Abstract: Copolymers, such as block copolymers, having at least one block that is a random copolymer of ?-caprolactone and ?-carboxy-?-caprolactone are described. Also described are methods of using such copolymers, such as, for example, in medical devices.
    Type: Grant
    Filed: June 16, 2011
    Date of Patent: April 21, 2015
    Assignee: Vanderbilt University
    Inventors: Hak-Joon Sung, Lucas L. Hofmeister, Mukesh Kumer Gupta, Spencer W. Crowder, Shann S. Yu, Angela L. Zachman, Dae Kwang Jung
  • Publication number: 20140107292
    Abstract: Copolymers, such as block copolymers, having at least one block that is a random copolymer of ?-caprolactone and a-carboxy-s-caprolactone are disclosed. Also described are methods of using such copolymers, such as, for example, in medical devices.
    Type: Application
    Filed: June 16, 2011
    Publication date: April 17, 2014
    Applicant: VANDERBILT UNIVERSITY
    Inventors: Hak-Joon Sung, Lucas L. Hofmeister, Mukesh Kumer Gupta, Spencer W. Crowder, Shann S. Yu, Angela L. Zachman, Dae Kwang Jung