Patents by Inventor Hamed Amini

Hamed Amini has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230151417
    Abstract: Aspects of the invention include methods for preparing sequencing libraries, performing sequencing procedures that can correct for process-related errors, and identifying rare variants that are or may be indicative of cancer.
    Type: Application
    Filed: January 23, 2023
    Publication date: May 18, 2023
    Applicant: GRAIL, LLC
    Inventors: Arash JAMSHIDI, Gordon CANN, Hamed AMINI, Alex ARAVANIS
  • Patent number: 11584958
    Abstract: Aspects of the invention include methods for preparing sequencing libraries, performing sequencing procedures that can correct for process-related errors, and identifying rare variants that are or may be indicative of cancer.
    Type: Grant
    Filed: March 30, 2018
    Date of Patent: February 21, 2023
    Assignee: GRAIL, LLC
    Inventors: Arash Jamshidi, Gordon Cann, Hamed Amini, Alex Aravanis
  • Patent number: 11123733
    Abstract: Described are microfluidic devices and methods for providing a predetermined number of microspheres or beads, together with a cell, within a fluid droplet being processed. The system may provide each droplet with a single bead and a single cell, and the bead may contain DNA or other reagents for later identifying the specific cell associated with that bead.
    Type: Grant
    Filed: November 21, 2019
    Date of Patent: September 21, 2021
    Assignee: Illumina, Inc.
    Inventors: Hamed Amini, Arash Jamshidi, Tarun Kumar Khurana, Foad Mashayekhi, Yir-Shyuan Wu
  • Publication number: 20210277457
    Abstract: Described herein are methods and systems for quantifying low molecular weight nucleic acid molecules in a biological sample amongst a background of high molecular weight contamination.
    Type: Application
    Filed: August 11, 2017
    Publication date: September 9, 2021
    Inventors: Hamed AMINI, Sudha NAGARAJU, Alex ARAVANIS, Arash JAMSHIDI
  • Patent number: 10822651
    Abstract: Aspects of the invention relate to methods and compositions for preparing and analyzing a single-stranded sequencing library from a double-stranded DNA (e.g., double-stranded cfDNA) sample. In some embodiments, the sample includes double-stranded DNA (dsDNA) molecules, and damaged dsDNA (e.g., nicked dsDNA) molecules. In some embodiments, the sample includes single-stranded DNA (ssDNA) molecules. The subject methods facilitate the collection of information, including strand-pairing and connectivity information, from dsDNA, ssDNA and damaged DNA (e.g., nicked DNA) molecules in a sample, thereby providing enhanced diagnostic information as compared to sequencing libraries that are prepared using conventional methods.
    Type: Grant
    Filed: October 27, 2017
    Date of Patent: November 3, 2020
    Assignee: GRAIL, Inc.
    Inventors: Arash Jamshidi, Hamed Amini
  • Publication number: 20200086322
    Abstract: Described are microfluidic devices and methods for providing a predetermined number of microspheres or beads, together with a cell, within a fluid droplet being processed. The system may provide each droplet with a single bead and a single cell, and the bead may contain DNA or other reagents for later identifying the specific cell associated with that bead.
    Type: Application
    Filed: November 21, 2019
    Publication date: March 19, 2020
    Inventors: Hamed Amini, Arash Jamshidi, Tarun Kumar Khurana, Foad Mashayekhi, Yir-Shyuan Wu
  • Publication number: 20190219078
    Abstract: A microfluidic platform is disclosed that uses obstacles placed at particular location(s) within the channel cross-section to turn and stretch fluid. The asymmetric flow behavior upstream and downstream of the obstacle(s) due to fluid inertia manifests itself as a total deformation of the topology of streamlines that effectively creates a tunable net secondary flow. The system and methods passively creates strong secondary flows at moderate to high flow rates in microchannels. These flows can be accurately controlled by the numbers and particular geometric placement of the obstacle(s) within the channel.
    Type: Application
    Filed: March 22, 2019
    Publication date: July 18, 2019
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFONIA
    Inventors: Dino Di Carlo, Hamed Amini, Elodie Sollier
  • Publication number: 20180291438
    Abstract: Aspects of the invention include methods for preparing sequencing libraries, performing sequencing procedures that can correct for process-related errors, and identifying rare variants that are or may be indicative of cancer.
    Type: Application
    Filed: March 30, 2018
    Publication date: October 11, 2018
    Inventors: Arash Jamshidi, Gordon Cann, Hamed Amini, Alex Aravanis
  • Publication number: 20180119216
    Abstract: Aspects of the invention relate to methods and compositions for preparing and analyzing a single-stranded sequencing library from a double-stranded DNA (e.g., double-stranded cfDNA) sample. In some embodiments, the sample includes double-stranded DNA (dsDNA) molecules, and damaged dsDNA (e.g., nicked dsDNA) molecules. In some embodiments, the sample includes single-stranded DNA (ssDNA) molecules. The subject methods facilitate the collection of information, including strand-pairing and connectivity information, from dsDNA, ssDNA and damaged DNA (e.g., nicked DNA) molecules in a sample, thereby providing enhanced diagnostic information as compared to sequencing libraries that are prepared using conventional methods.
    Type: Application
    Filed: October 27, 2017
    Publication date: May 3, 2018
    Inventors: Arash Jamshidi, Hamed Amini
  • Publication number: 20170128940
    Abstract: Described are microfluidic devices and methods for providing a predetermined number of microspheres or beads, together with a cell, within a fluid droplet being processed. The system may provide each droplet with a single bead and a single cell, and the bead may contain DNA or other reagents for later identifying the specific cell associated with that bead.
    Type: Application
    Filed: November 9, 2016
    Publication date: May 11, 2017
    Inventors: Hamed Amini, Arash Jamshidi, Tarun Kumar Khurana, Foad Mashayekhi, Yir-Shyuan Wu
  • Publication number: 20160199832
    Abstract: Provided herein is a droplet actuator including (a) first and second substrates separated by a droplet-operations gap, the first and second substrates including respective hydrophobic surfaces that face the droplet-operations gap; (b) a plurality of electrodes coupled to at least one of the first substrate and the second substrate, the electrodes arranged along the droplet-operations gap to control movement of a droplet along the hydrophobic surfaces within the droplet-operations gap; and (c) a hydrophilic or variegated-hydrophilic surface exposed to the droplet-operations gap, the hydrophilic or variegated-hydrophilic surface being positioned to contact the droplet when the droplet is at a select position within the droplet-operations gap.
    Type: Application
    Filed: August 29, 2014
    Publication date: July 14, 2016
    Applicant: Advanced Liquid Logic France SAS
    Inventors: Arash Jamshidi, Yan-You Lin, Alex Aravanis, Cyril Delattre, Arnaud Rival, Jennifer Foley, Poorya Sabounchi, Tarun Khurana, Majid Babazadeh, Hamed Amini, Bala Murali Venkatesan, M. Shane Bowen, Steven M. Barnard, Maria Candelaria Rogert Bacigalupo, Dietrich Dehlinger
  • Publication number: 20140230909
    Abstract: A microfluidic platform is disclosed that uses obstacles placed at particular location(s) within the channel cross-section to turn and stretch fluid. The asymmetric flow behavior upstream and downstream of the obstacle(s) due to fluid inertia manifests itself as a total deformation of the topology of streamlines that effectively creates a tunable net secondary flow. The system and methods passively creates strong secondary flows at moderate to high flow rates in microchannels. These flows can be accurately controlled by the numbers and particular geometric placement of the obstacle(s) within the channel.
    Type: Application
    Filed: September 27, 2012
    Publication date: August 21, 2014
    Inventors: Dino Di Carlo, Hamed Amini, Elodie Sollier