Patents by Inventor Han-Cheng Zhang

Han-Cheng Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted pyrroline kinase inhibitors
    Publication number: 20060205762
    Abstract: The present invention is directed to novel substituted pyrroline compounds useful as kinase inhibitors and methods for treating or ameliorating a kinase mediated disorder.
    Type: Application
    Filed: May 17, 2006
    Publication date: September 14, 2006
    Inventors: Han-Cheng Zhang, Gee-Hong Kuo, Bruce Maryanoff, Hong Ye, David O'Neill, Lan Shen, Keith Demarest, Bruce Conway, David McComsey
  • Novel indazole peptidomimetics as thrombin receptor antagonists
    Publication number: 20060166897
    Abstract: The invention is directed to novel indazole peptidomimetic compounds which are useful as thrombin receptor antagonists for the treatment of diseases associated with thrombosis, restenosis, hypertension, heart failure, arrhythmia, inflammation, angina, stroke, atherosclerosis, ischemic conditions, Angiogenesis related disorders, cancer, and neurodegenerative disorders. Pharmaceutical compositions comprising the substituted indazole peptidomimetics of the present invention and methods of treating conditions mediated by the thrombin receptor are also disclosed.
    Type: Application
    Filed: March 30, 2006
    Publication date: July 27, 2006
    Inventors: Han-Cheng Zhang, Bruce Maryanoff, Anjali Pandey, Robert Scarborough
  • Novel indazole peptidomimetics as thrombin receptor antagonists
    Publication number: 20060166896
    Abstract: The invention is directed to novel indazole peptidomimetic compounds which are useful as thrombin receptor antagonists for the treatment of diseases associated with thrombosis, restenosis, hypertension, heart failure, arrhythmia, inflammation, angina, stroke, atherosclerosis, ischemic conditions, Angiogenesis related disorders, cancer, and neurodegenerative disorders. Pharmaceutical compositions comprising the substituted indazole peptidomimetics of the present invention and methods of treating conditions mediated by the thrombin receptor are also disclosed.
    Type: Application
    Filed: March 30, 2006
    Publication date: July 27, 2006
    Inventors: Han-Cheng Zhang, Bruce Maryanoff, Anjali Pandey, Robert Scarborough
  • Indazole peptidomimetics as thrombin receptor antagonists
    Patent number: 7049297
    Abstract: The invention is directed to novel indazole peptidomimetic compounds which are useful as thrombin receptor antagonists for the treatment of diseases associated with thrombosis, restenosis, hypertension, heart failure, arrhythmia, inflammation, angina, stroke, atherosclerosis, ischemic conditions, Angiogenesis related disorders, cancer, and neurodegenerative disorders. Pharmaceutical compositions comprising the substituted indazole peptidomimetics of the present invention and methods of treating conditions mediated by the thrombin receptor are also disclosed.
    Type: Grant
    Filed: March 31, 2003
    Date of Patent: May 23, 2006
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Han-Cheng Zhang, Bruce E. Maryanoff, Anjali Pandey, Robert M. Scarborough
  • Substituted pyrrolines as kinase inhibitors
    Patent number: 6987110
    Abstract: The present invention is directed to novel substituted pyrroline compounds useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.
    Type: Grant
    Filed: June 4, 2003
    Date of Patent: January 17, 2006
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Han-Cheng Zhang, Bruce E. Maryanoff, Hong Ye, Bruce R. Conway, Keith Demarest
  • Novel heteroaryl peptidomimetics as thrombin receptor antagonists
    Publication number: 20060009396
    Abstract: The invention is directed to novel heteroaryl peptidomimetic compounds which are useful as thrombin receptor antagonists for the treatment of diseases associated with thrombosis, restenosis, hypertension, heart failure, arrhythmia, inflammation, angina, stroke, atherosclerosis, ischemic conditions, angiogenesis and related disorders, cancer, and neurodegenerative disorders. Pharmaceutical compositions comprising the substituted heteroaryl peptidomimetics of the present invention and methods of treating conditions mediated by the thrombin receptor are also disclosed.
    Type: Application
    Filed: September 15, 2005
    Publication date: January 12, 2006
    Inventors: Han-Cheng Zhang, Bruce Maryanoff, William Hoekstra, Kimberly White
  • Benzimidazolone peptidomimetics as thrombin receptor antagonists
    Patent number: 6943149
    Abstract: The invention is directed to novel benzimidazolone peptidomimetic compounds which are useful as thrombin receptor antagonists for the treatment of diseases associated with thrombosis, restenosis, hypertension, heart failure, arrhythmia, inflammation, angina, stroke, atherosclerosis, ischemic conditions, Angiogenesis related disorders, cancer, and neurodegenerative disorders. Pharmaceutical compositions comprising the substituted benzimidazolone peptidomimetics of the present invention and methods of treating conditions mediated by the thrombin receptor are also disclosed.
    Type: Grant
    Filed: March 17, 2003
    Date of Patent: September 13, 2005
    Assignees: Ortho McNeil Pharmaceutical, Inc., Millennium Pharmaceuticals, Inc.
    Inventors: Han-Cheng Zhang, Bruce E. Maryanoff, David F. McComsey, Kimberly B. White
  • Indole peptidomimetics as thrombin receptor antagonists
    Patent number: 6858577
    Abstract: The invention is directed to novel indole peptidomimetic compounds which are useful as thrombin receptor antagonists for the treatment of diseases associated with thrombosis, restenosis, hypertension, heart failure, arrhythmia, inflammation, angina, stroke, atherosclerosis, ischemic conditions, Angiogenesis related disorders, cancer, and neurodegenerative disorders. Pharmaceutical compositions comprising the substituted indole peptidomimetics of the present invention and methods of treating conditions mediated by the thrombin receptor are also disclosed.
    Type: Grant
    Filed: June 26, 2000
    Date of Patent: February 22, 2005
    Assignees: Ortho-McNeil Pharmaceutical, Inc., Millennium Pharmaceuticals, Inc.
    Inventors: Han-Cheng Zhang, William J. Hoekstra, Bruce E. Maryanoff, David F. McComsey
  • Indazolyl-substituted pyrroline compounds as kinase inhibitors
    Patent number: 6849643
    Abstract: The present invention is directed to novel indazolyl-substituted pyrroline compounds of Formula (I): useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.
    Type: Grant
    Filed: December 6, 2001
    Date of Patent: February 1, 2005
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Han-Cheng Zhang, Bruce Maryanoff, Bruce Conway, Kimberly White, Hong Ye, Leonard Robert Hecker, David F. McComsey
  • Substituted indazolyl(indolyl)maleimide derivatives as kinase inhibitors
    Publication number: 20050004201
    Abstract: The present invention is directed to novel indazolyl-substituted pyrroline compounds of Formula (I): R2 is selected from the group consisting of —C1-8alkyl-Z, —C2-8alkenyl-Z and —C2-8alkynyl-Z; wherein the —C1-8alkyl-Z, —C2-8alkenyl-Z and —C2-8alkynyl-Z and Z is a 5 to 6 member aromatic monocyclic heteroaryl ring having from 2 to 4 heteroatoms. These compounds are useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.
    Type: Application
    Filed: June 1, 2004
    Publication date: January 6, 2005
    Inventors: Han-Cheng Zhang, Bruce Maryanoff, Hong Ye
  • Indazolyl-substituted pyrroline compounds as kinase inhibitors
    Publication number: 20050004202
    Abstract: The present invention is directed to novel indazolyl-substituted pyrroline compounds of Formula (I): useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.
    Type: Application
    Filed: August 2, 2004
    Publication date: January 6, 2005
    Inventors: Han-Cheng Zhang, Bruce Maryanoff, Bruce Conway, Kimberly White, Hong Ye, Leonard Hecker, David McComsey
  • Indazolyl-substituted pyrroline compounds as kinase inhibitors
    Publication number: 20040259928
    Abstract: The present invention is directed to novel indazolyl-substituted pyrroline compounds of Formula (I): 1
    Type: Application
    Filed: July 6, 2004
    Publication date: December 23, 2004
    Inventors: Han-Cheng Zhang, Bruce Maryanoff, Bruce Conway, Kimberly White, Hong Ye, Leonard Robert Hecker, David F. McComsey
  • Macroheterocylic compounds useful as kinase inhibitors
    Patent number: 6828327
    Abstract: This invention is directed to macroheterocyclic compounds useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.
    Type: Grant
    Filed: December 6, 2001
    Date of Patent: December 7, 2004
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Gee-Hong Kuo, Han-Cheng Zhang, Catherine Prouty, Alan DeAngelis, Peter Connolly, William V. Murray, Lan Shen, Bruce Conway, Keith Demarest, Chandra R. Shah, Bruce E. Maryanoff, Kimberly B. White
  • Substituted pyrroline kinase inhibitors
    Publication number: 20040192718
    Abstract: The present invention is directed to novel substituted pyrroline compounds useful as kinase or dual-kinase inhibitors and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.
    Type: Application
    Filed: March 3, 2004
    Publication date: September 30, 2004
    Inventors: Han-Cheng Zhang, Bruce E. Maryanoff, Hong Ye
  • Novel heteroaryl peptidomimetics as thrombin receptor antagonists
    Publication number: 20040138141
    Abstract: The invention is directed to novel heteroaryl peptidomimetic compounds which are useful as thrombin receptor antagonists for the treatment of diseases associated with thrombosis, restenosis, hypertension, heart failure, arrhythmia, inflammation, angina, stroke, atherosclerosis, ischemic conditions, angiogenesis and related disorders, cancer, and neurodegenerative disorders. Pharmaceutical compositions comprising the substituted heteroaryl peptidomimetics of the present invention and methods of treating conditions mediated by the thrombin receptor are also disclosed.
    Type: Application
    Filed: December 10, 2003
    Publication date: July 15, 2004
    Inventors: Han-Cheng Zhang, Bruce E. Maryanoff, William J. Hoekstra, Kimberly White
  • Aminomethyl-pyrroloquinazoline compounds as thrombin receptor antagonists
    Patent number: 6740657
    Abstract: The invention is directed to novel aminomethyl-pyrroloquinazoline compounds and pharmaceutical compositions thereof which are useful thrombin receptor or PAR-1 antagonists, methods for production thereof and methods for treating thrombin or PAR-1 mediated disorders.
    Type: Grant
    Filed: January 29, 2002
    Date of Patent: May 25, 2004
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Bruce E. Maryanoff, Han-Cheng Zhang, David F. McComsey
  • Novel benzimidazolone peptidomimetics as thrombin receptor antagonists
    Publication number: 20040063642
    Abstract: The invention is directed to novel benzimidazolone peptidomimetic compounds which are useful as thrombin receptor antagonists for the treatment of diseases associated with thrombosis, restenosis, hypertension, heart failure, arrhythmia, inflammation, angina, stroke, atherosclerosis, ischemic conditions, Angiogenesis related disorders, cancer, and neurodegenerative disorders. Pharmaceutical compositions comprising the substituted benzimidazolone peptidomimetics of the present invention and methods of treating conditions mediated by the thrombin receptor are also disclosed.
    Type: Application
    Filed: March 17, 2003
    Publication date: April 1, 2004
    Inventors: Han-Cheng Zhang, Bruce E. Maryanoff, David F. McComsey, Kimberly B. White
  • Substituted pyrrolines as kinase inhibitors
    Publication number: 20040059113
    Abstract: The present invention is directed to novel substituted pyrroline compounds useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.
    Type: Application
    Filed: June 4, 2003
    Publication date: March 25, 2004
    Inventors: Han-Cheng Zhang, Bruce E. Maryanoff, Hong Ye, Bruce R. Conway, Keith Demarest
  • Substituted pyrrolines as kinase inhibitors
    Publication number: 20040054180
    Abstract: The present invention is directed to novel substituted pyrroline compounds useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.
    Type: Application
    Filed: June 4, 2003
    Publication date: March 18, 2004
    Inventors: Han Cheng Zhang, Bruce E. Maryanoff, David F. McComsey, Kimberly White, Hong Ye, Leonard R. Hecker, Bruce Conway, Keith Demarest
  • Substituted pyrroline kinase inhibitors
    Publication number: 20040006095
    Abstract: The present invention is directed to novel substituted pyrroline compounds useful as kinase inhibitors and methods for treating or ameliorating a kinase mediated disorder.
    Type: Application
    Filed: May 6, 2003
    Publication date: January 8, 2004
    Inventors: Han-Cheng Zhang, Gee-Hong Kuo, Bruce E. Maryanoff, Hong Ye, David O'Neill, Lan Shen, Keith Demarest, Bruce R. Conway, David F. McComsey