Abstract: This disclosure provides compositions, systems, and methods for the delivery of therapeutic oligonucleotides to a tumor. The oligonucleotide is conjugated to a dendron comprising an end group, a phosphate group, and/or a hydrophobic chain.

Abstract: This disclosure provides compositions, systems, and methods for the delivery of therapeutic oligonucleotides to the lung. The oligonucleotide is conjugated to a dendron comprising a hydrophilic end group, a phosphate group, and/or a hydrophobic chain.

Abstract: This disclosure provides compositions, systems, and methods for the delivery of therapeutic oligonucleotides to the brain. The oligonucleotide is conjugated to a dendron comprising a hydrophilic end group, a phosphate group, and/or a hydrophobic chain.

Abstract: This disclosure provides compositions, systems, and methods for the delivery of therapeutic oligonucleotides to the skin. The oligonucleotide is conjugated to a dendron comprising a hydrophilic end group, a phosphate group, and/or a hydrophobic chain.

Abstract: This disclosure provides compositions, systems, and methods for the topical delivery of therapeutic oligonucleotides with microneedle particles.

Abstract: It is provided the synthesis of an aptamer-like encoded oligomer (ALEnOmer), method of producing same and method of preparing a library of ALEnOmes. More particularly, the method of preparing ALEnOmer comprises coupling at least one phosphoramidite monomer with an orthogonal protecting group, and the ALEnOmer produces comprises a DNA coding strand covalently attached to an oligomer through a branching unit, wherein the oligomer has a degree of polymerization at least 5 and is an aptamer.

Abstract: Block copolymers labelled with molecular recognition units and comprising a hydrophobic block and a luminescent block are presented. A method of detecting biomolecules using such block copolymers is also presented. More specifically, the block copolymers of the present invention have the following Formula (I): wherein “A” is a hydrophobic block; “B” is a luminescent block; “C” is a hydrophilic block; “D” is a molecular recognition unit; “n” and “m” are integers ranging from 1 to 75; “x” is either 0 or an integer ranging from 1 to 75; and “Y” is either 0 or 1.

Abstract: Block copolymers labelled with molecular recognition units and comprising a hydrophobic block and a luminescent block are presented. A method of detecting biomolecules using such block copolymers is also presented. More specifically, the block copolymers of the present invention have the following Formula (I): wherein “A” is a hydrophobic block; “B” is a luminescent block; “C” is a hydrophilic block; “D” is a molecular recognition unit; “n” and “m” are integers ranging from 1 to 75; “x” is either 0 or an integer ranging from 1 to 75; and “Y” is either 0 or 1.