Abstract: The present invention pertains to a process for the preparation of a fast-disintegrating tablet (30) containing a medicinal substance, comprising the steps of providing a fluid formulation comprising the medicinal substance, providing a solid element (100) having formed therein at least one cavity, (101) cooling the solid element (100) to a temperature below a freezing temperature of the formulation, filling the cavity with the fluid formulation, solidifying the formulation while present in the cavity (101) to form a solid pellet comprising the medicinal substance without actively shaping the entire surface of the pellet, taking the pellet out of the cavity and drying the pellet in a vacuum to obtain the tablet. The invention also pertains to a system for performing such a process and a package containing the resulting tablet.

Abstract: The present invention pertains to a process for the preparation of an orally disintegrating tablet for administration to a human subject, the tablet containing a medicinal substance to treat a disorder of the human subject, comprising the steps of providing a fluid formulation comprising the medicinal substance, providing a solid element having formed therein at least one cavity, cooling the solid element to a temperature below a freezing temperature of the formulation, filling the cavity with the fluid formulation, solidifying the formulation while present in the cavity by extracting heat from the formulation through a cavity wall by conduction, to form a solid pellet comprising the medicinal substance without actively shaping the entire surface of the pellet, taking the pellet out of the cavity, and drying the pellet in a vacuum to obtain the tablet. The invention also pertains to the tablet itself and a package comprising such a tablet.

Abstract: A method for fastening a thread (24) to a tampon (10), in particular a veterinary tampon, comprising the steps of passing the thread through the tampon by means of a needle (12, 14), and knotting the loose ends of the thread, wherein that the step of passing the thread through the tampon comprises: -piercing the tampon (10) with two hollow needles (12, 14), -inserting the distal ends of the needles into a mould (20) that forms a passage (16) interconnecting the open ends of the hollow needles, feeding the thread (24) to the proximal end of one (12) of the two needles, -applying a suction pressure to the proximal end of the other (14) of the two needles, -opening the mould (20), and -withdrawing the needles (12, 14) from the tampon (10).

Abstract: A tube weld seam test method and device for testing a tube weld seam (32) of a flexible tube (18) for leaks having: a first pinching device (10) and a second pinching device (12) for pinching closed the flexible tube (18) at a first position (A) and at a second position (B), the weld seam to be tested being arranged between the first and second positions (A; B); a compressing mechanism arranged for partly compressing a tube section enclosed between the first and second pinching devices (10; 12); and a pressure test device (14) arranged for testing an internal pressure of said tube section in order to test the tube weld seam for leaks.

Abstract: The present invention pertains to a method for lyophilizing particles comprising frozen liquid having a pharmaceutical compound contained therein, comprising providing a heat conducting container having a bottom and side walls, filling the container with a bed of the particles, the bed comprising multiple layers of the particles and having an aspect ratio of not less than 1, providing a heat source above a top layer of the particles, the heat source having a surface directed to a top layer of the bed, which surface has an emissivity coefficient of at least 0.4, subjecting the particles filled in the container to a reduced pressure, heating at least the bottom of the container and the said surface to provide heat to the particles to support sublimation of the frozen liquid at the reduced pressure, and after the frozen liquid is sublimated, stopping the provision of heat to the particles.

Abstract: The present invention pertains to a method for dosing a fluid formulation containing a medicinal substance into a mould to form a pharmaceutical unit with a volume of 1000 ?I or less, using a peristaltic pump comprising a flexible tube for guiding the fluid formulation to the mould and at least one roller to compress the tube to induce a flow of the fluid formulation through the tube, the method comprising placing a spout of the tube adjacent the mould, displacing the roller over a predetermined length of the tube to dose the fluid formulation in the mould, positioning the spout such that when the dosing is finished, at least the open end of the spout is present in the dosed unit, and after dosing, retracting the spout end out of the dosed unit.

Abstract: A tool for manipulating a solid object (12) in a cavity (16) of a human or animal body, comprising a longitudinal rod member (14) adapted for insertion into said body cavity (16), a first coupling member (26) connected to one of the rod member (14) and the object (12) through a flexible filament (28), and a second coupling member (24) connected to the other of the rod member and the object, said first and second coupling members being arranged for being mechanically coupled together through magnetic attraction, wherein one of the first and second coupling members forms a recess (30), the other of the first and second coupling members is configured as a key member (26), and magnetic poles of at least one of the first and second coupling members are arranged for drawing the key member into the recess along a direction perpendicular to the longitudinal direction of the rod member, wherein the key member and recess are constituted such that when the key member is drawn into the recess, an operative contact surfac

Abstract: A tube weld seam test method and device for testing a tube weld seam (32) of a flexible tube (18) for leaks having: a first pinching device (10) and a second pinching device (12) for pinching closed the flexible tube (18) at a first position (A) and at a second position (B), the weld seam to be tested being arranged between the first and second positions (A; B); a compressing mechanism arranged for partly compressing a tube section enclosed between the first and second pinching devices (10; 12); and a pressure test device (14) arranged for testing an internal pressure of said tube section in order to test the tube weld seam for leaks.

Abstract: A method for fastening a thread (24) to a tampon (10), in particular a veterinary tampon, comprising the steps of passing the thread through the tampon by means of a needle (12, 14), and knotting the loose ends of the thread, wherein that the step of passing the thread through the tampon comprises: -piercing the tampon (10) with two hollow needles (12, 14), -inserting the distal ends of the needles into a mould (20) that forms a passage (16) interconnecting the open ends of the hollow needles, feeding the thread (24) to the proximal end of one (12) of the two needles, -applying a suction pressure to the proximal end of the other (14) of the two needles, -opening the mould (20), and -withdrawing the needles (12, 14) from the tampon (10).

Abstract: The present invention pertains to a process for the preparation of an orally disintegrating tablet for administration to a human subject, the tablet containing a medicinal substance to treat a disorder of the human subject, comprising the steps of providing a fluid formulation comprising the medicinal substance, providing a solid element having formed therein at least one cavity, cooling the solid element to a temperature below a freezing temperature of the formulation, filling the cavity with the fluid formulation, solidifying the formulation while present in the cavity by extracting heat from the formulation through a cavity wall by conduction, to form a solid pellet comprising the medicinal substance without actively shaping the entire surface of the pellet, taking the pellet out of the cavity, and drying the pellet in a vacuum to obtain the tablet. The invention also pertains to the tablet itself and a package comprising such a tablet.

Abstract: The present invention pertains to a method for lyophilising particles comprising frozen liquid having a pharmaceutical compound contained therein, comprising providing a heat conducting container having a bottom and side walls, filling the container with a bed of the particles, the bed comprising multiple layers of the particles and having an aspect ratio of not less than 1, providing a heat source above a top layer of the particles, the heat source having a surface directed to a top layer of the bed, which surface has an emissivity coefficient of at least 0.4, subjecting the particles filled in the container to a reduced pressure, heating at least the bottom of the container and the said surface to provide heat to the particles to support sublimation of the frozen liquid at the reduced pressure, and after the frozen liquid is sublimated, stopping the provision of heat to the particles.

Abstract: The invention relates to a device for delivering a biologically active composition comprising a nozzle head provided with at least one opening, and a pump for pumping the biologically active composition through the at least one opening so as to obtain a spray of droplets of said composition, to a plate for use in such a device, to a kit comprising a biologically active composition and such a plate, to the use of such a device for delivering a biologically active composition and to methods of making droplets comprising a biologically active composition through such a device.

Abstract: The present invention relates to a vaccine container that contains one or more freeze-dried vaccine components. The vaccine component or components are present in two or more freeze-dried bodies, at least one of which is a lyosphere.Furthermore, the invention relates to methods for the preparation of such a vaccine container.Also, the invention relates to a vaccine pack, comprising the vaccine container.

Abstract: The present invention relates to a vaccine container that contains one or more freeze-dried vaccine components. The vaccine component or components are present in two or more freeze-dried bodies, at least one of which is a lyosphere.Furthermore, the invention relates to methods for the preparation of such a vaccine container.Also, the invention relates to a vaccine pack, comprising the vaccine container.