Patents by Inventor Hans De Winter

Hans De Winter has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Macrocycle derivatives useful as inhibitors of ?-secretase (BACE)
    Patent number: 7932261
    Abstract: The present invention is directed to macrocycle derivatives, pharmaceutical compositions containing them and their use in the treatment of Alzheimer's disease (AD) and related disorders. The compounds of the invention are inhibitors of ?-secretase, also known as ?-site cleaving enzyme and BACE, BACE1, Asp2 and memapsin2.
    Type: Grant
    Filed: February 6, 2007
    Date of Patent: April 26, 2011
    Assignee: Janssen Pharmaceutica NV
    Inventors: Ellen W. Baxter, François P. Bischoff, Hans De Winter, Chih Yung Ho, Yifang Huang, Michael H. Parker, Allen B. Reitz, Charles H. Reynolds, Eric D. Strobel
  • Sulfonyl-Derivatives as Novel Inhibitors or Histone Deacetylase
    Publication number: 20080108601
    Abstract: This invention comprises the novel compounds of formula (I) wherein n, m, t, R1, R2, R3, R4, L, Q, X, Y, Z and have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.
    Type: Application
    Filed: October 29, 2007
    Publication date: May 8, 2008
    Inventors: Kristof Van Emelen, Janine Arts, Leo-Jacobus Backx, Hans De Winter, Sven Van Brandt, Marc Verdonck, Lieven Meerpoel, Isabelle Pilatte, Virginie Poncelet, Alexey Dyatkin, Jimmy Van heusden
  • TRIPEPTIDYL PEPTIDASE INHIBITORS
    Publication number: 20080108653
    Abstract: The present invention is concerned with novel compounds of formula (I) which are inhibitors of a membrane tripeptidyl peptidase responsible for the inactivation of endogenous neuropeptides such as cholecystokinis (CCKs). The invention further relates to methods for preparing such compounds, pharmaceutical compositions comprising said compounds as well as the use as a medicine of said compounds.
    Type: Application
    Filed: October 30, 2007
    Publication date: May 8, 2008
    Inventors: Henry Breslin, Hans De Winter, Michael Kukla
  • SULFONYL-DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE
    Publication number: 20070142393
    Abstract: This invention comprises the novel compounds of formula (I) wherein n, m, t, R1, R2, R3, R4, L, Q, X, Y, Z and have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.
    Type: Application
    Filed: January 30, 2007
    Publication date: June 21, 2007
    Inventors: Kristof Emelen, Janine Arts, Leo Backx, Hans De Winter, Sven Van Brandt, Marc Verdonck, Lieven Meerpoel, Isabelle Pilatte, Virginie Poncelet, Alexey Dyatkin, Jimmy Van heusden
  • Tripeptidyl peptidase inhibitors
    Publication number: 20060276509
    Abstract: The present invention is concerned with novel compounds of formula (I) which are inhibitors of a membrane tripeptidyl peptidase responsible for the inactivation of endogenous neuropeptides such as cholecystokinis (CCKs). The invention further relates to methods for preparing such compounds, pharmaceutical compositions comprising said compounds as well as the use as a medicine of said compounds.
    Type: Application
    Filed: August 7, 2006
    Publication date: December 7, 2006
    Inventors: Henry Breslin, Hans De Winter, Michael Kukla
  • Novel 2-amino-quinazoline derivatives useful as inhibitors of beta-secretase (BACE)
    Publication number: 20060079687
    Abstract: The present invention is directed to novel 2-amino-3,4-dihydro-quinazoline derivatives, pharmaceutical compositions containing them and their use in the treatment of Alzheimer's disease (AD) and related disorders. The compounds of the invention are inhibitors of ?-secretase, also known as ?-site cleaving enzyme and BACE.
    Type: Application
    Filed: August 4, 2005
    Publication date: April 13, 2006
    Inventors: Ellen Baxter, Francois Bischoff, Robert Boyd, Mirielle Braeken, Steve Coats, Yifang Huang, Alfonzo Jordan, Chi Luo, Marc Mercken, Serge Maria Pieters, Allen Reitz, Charles Reynolds, Tina Ross, Brett Tounge, Mark Schulz, Hans De Winter
  • Sulfonylamino-derivatives as novel inhibitors of histone deacetylase
    Publication number: 20050171347
    Abstract: This invention comprises the novel compounds of formula (I) wherein n, m, t, R1, R2, R3, R4, R5, L, Q, X, Y, Z and have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.
    Type: Application
    Filed: March 11, 2003
    Publication date: August 4, 2005
    Inventors: Kristof Emelen, Leo Backx, Sven Van Brandt, Patrick Angibaud, Isabelle Noelle Pilatte, Marc Gustaaf Verdonck, Hans De Winter
  • Sulfonyl-Derivatives as novel inhibitors of histone deacetylase
    Publication number: 20050113373
    Abstract: This invention comprises the novel compounds of formula (I) wherein n, m, t, R1, R2, R3, R4, L, Q, X, Y, Z and have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.
    Type: Application
    Filed: March 11, 2003
    Publication date: May 26, 2005
    Inventors: Kristof Van Emelen, Janine Arts, Leo Backx, Hans De Winter, Sven Van Brandt, Marc Verdonck, Lieven Meerpoel, Isabelle Pilatte, Virginie Poncelet, Alexey Dyatkin