Abstract: A complex comprising at least one target protein and at least one binding molecule having a binding affinity for said target protein, wherein said molecule having a binding affinity is covalently or non-covalently bound to at least one water-soluble polymer

Abstract: Supravalent peptide compounds depicting enhanced efficacy, and which comprise at least bivalent peptide units that bind to a receptor target and are connected to a polymeric carrier unit are disclosed herein.

Abstract: Use of an activated solid phase and a peptide-conjugated anchoring part for solid phase peptide synthesis, wherein the anchoring part is coordinatively and reversibly attached to the activated solid phase.

Abstract: The present disclosure relates to modified EPO mimetic peptides having specific properties.

Abstract: Peptides, methods for the preparation thereof, medicaments containing the peptides, and their use in selected indications, such as the treatment of various forms of anemia and stroke.

Abstract: The invention relates to supravalent peptide compounds depicting an enhanced efficacy. Supravalent compounds comprise several at least bivalent peptide units that bind to a receptor target and are connected to a large polymeric carrier unit.

Abstract: A method of assessing the titre of fertility-relevant autoantibodies of a mammalian female, wherein said method comprises: the presentation of a defined single molecule capable of binding to the idiotype of the fertility-relevant autoantibody, and determining the amount of autoantibody being bound by said molecule from a sample of a body fluid of said mammalian female.

Abstract: The present invention therefore presents modules from which helical constraints can be built by very flexible strategies. The peptide bonds involved partially compensate the hydrophobic nature of the disulfide bonds, which are also included into the constraint strategy. Thus, the invention presents solutions, by means of which peptide bonds or closure of disulfide bridges can be used alternatively for closure of the constraint. This offers greater synthetic flexibility. Moreover, the peptide bonds are more hydrophilic than disulfide bridges alone and offer the advantage of better solubility of the product in an aqueous surrounding. It is possible to attach solvation tags like glycosyl moieties, polyethylenglycol or other suitable extensions or appendices to the helical constraint structure. Usually, such a hydrophilic helical constraint structure replaces two hydrophobic amino acid side chains and thus improves pharmacologic properties of the molecule.

Abstract: The invention pertains to binding molecules consisting of a carrier structure of at least one cyclic molecular subunit and at least two side chain subunits, wherein the side chain subunits are polypeptide chains consisting of natural and/or unnatural D- and/or L-amino acids and the side chain subunits are covalently bonded to the support structure.

Abstract: Use of an activated solid phase and an anchoring part which is attached to a peptide for solid phase peptide synthesis, wherein the anchoring part is coordinatively and reversibly attached to the activated solid phase. Furthermore provided is a process for competitively detachment of said anchoring part, for purification and refolding of said peptides. Provided are peptides with an anchoring part for coordinative and reversible attachment of said peptides to an activated solid phase.

Abstract: Peptides, methods for the preparation thereof, medicaments containing the peptides, and their use in selected indications, such as the treatment of various forms of anemia and stroke.

Abstract: A method for the preparation of specific monoclonal immunological binding molecules having binding capacity to mammal epitopes, comprising the following steps: a) isolation of structures containing said epitopes to obtain an epitope preparation; b) immunization of non-mammals with the epitope preparation to obtain an immune response; c) immortalization of the immune response to obtain a library of immunological binding molecules; d) selection of the immunological binding molecules by means of the epitopes to obtain specific monoclonal immunological binding molecules. The specific monoclonal immunological binding molecules obtained can be used for identifying, in a library of low molecular weight substances, those having a high binding affinity, thus mimicking the epitopes of mammals.

Abstract: A protein which is homologous with chicken VL or VH to at least 80% and inhibits syncytial fusion, as well as fragments having at least 12 continuous amino acids from the sequence of chicken VL or VH.

Abstract: A method for the preparation of specific monoclonal immunological binding molecules having binding capacity to mammal epitopes, comprising the following steps: