Patents by Inventor Hans H. Sedlacek

Hans H. Sedlacek has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20020068056
    Abstract: The invention relates to murine monoclonal antibodies (MAbs), A, B, C and D, which are directed against tumor-associated antigens. The nearly complete nucleotide sequences of the V genes of these MAbs are described, so that the relevant variable domains can be put together to give chimeric MAbs, or “humanized” MAbs are obtained by inserting the hypervariable regions (complementarity determining regions=CDR) into a human MAb framework. Antibody constructs of this type can be employed in human therapy and in vivo diagnosis without the disadvantages observed with murine MAbs.
    Type: Application
    Filed: December 13, 1994
    Publication date: June 6, 2002
  • Patent number: 5561119
    Abstract: Glycosylated prodrugs, a preparation method therefor, and their use with tumor-specific immunoenzymatic conjugates for the treatment of cancer, are described. These anthracycline prodrugs have formula (I).
    Type: Grant
    Filed: May 27, 1994
    Date of Patent: October 1, 1996
    Assignees: Laboratoires Hoechst, Behringwerke A.G.
    Inventors: Jean-Claude Jacquesy, Jean-Pierre Gesson, Claude Monneret, Martine Mondon, Brigitte Renoux, Jean-Claude Florent, Michel Koch, Fran.cedilla.ois Tillequin, Hans H. Sedlacek, Manfred Gerken, Cenek Kolar, Gilbert Gaudel, Klaus Bosslet, J org Czech, Dieter Hoffman, Gerhard Seemann, Hans-Ulrich Schorlemmer, Gerhard Dickneite
  • Patent number: 5284856
    Abstract: Compounds of the formula I ##STR1## in which the substituents R.sub.1 -R.sub.5 and n and m are as defined are suitable for controlling tumors.
    Type: Grant
    Filed: July 24, 1992
    Date of Patent: February 8, 1994
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Ramchandra G. Naik, Bansi Lal, Richard H. Rupp, Hans H. Sedlacek, Gerhard Dickneite
  • Patent number: 5189065
    Abstract: The use of products of formula (I) is described, wherein X and Y represent hydrogen, hydroxy or alkoxy; and R.sub.1 and R.sub.2 represent H, alkyl, alkenyl or alkynyl, arylalkyl, acyl or R.sub.1 and R.sub.2 together with nitrogen form a heterocycle for preparing an antitumoral drug.
    Type: Grant
    Filed: October 17, 1991
    Date of Patent: February 23, 1993
    Assignee: Roussel Uclaf
    Inventors: Jorg Czech, Hans H. Sedlacek, Lucien Nedelec, Jacques Guillaume, Christian Marchandeau
  • Patent number: 5079263
    Abstract: R.sup.2 is H or OH;R.sup.3 is H, OH, OCH.sub.3, CH.sub.3 or NH.sub.2 ;Rhu 4 is H, OH, OCH.sub.3, NH.sub.2 or ##STR2## The compounds of the formula I are prepared by fermentation of the strain Streptomyces parvulus DSM 40722 in the presence of substituted benzoic acids of the general formula II ##STR3## where R.sup.1 is H or OH;R.sup.2 is H or OH;R.sup.3 is H, OH, OCH.sub.3, CH.sub.3 or NH.sub.2 ;R.sup.4 is H, OH, OCH.sub.3 or NH.sub.2,and they inhibit Leukocyte elastase and can be used as pharmaceuticals.
    Type: Grant
    Filed: December 2, 1988
    Date of Patent: January 7, 1992
    Assignee: Behringwerke Aktiengesellschaft
    Inventors: Axel Zeeck, Ralf Thiericke, Hans Zahner, Gerhard Dickneite, Hans H. Sedlacek
  • Patent number: 5006515
    Abstract: Pharmaceuticals containing or composed of at least one compound of the formula I and/or one of its physiologically tolerated salts where appropriate, where the compounds of the formula I can, where appropriate, be in the form of pure stereoisomers or mixtures thereof; formula I is: ##STR1## in which R.sup.1 =organic radical or halogen,A=C,C single or C,C double bond,n=0, 1 or 2, and ##STR2## R.sup.2 and R.sup.3 =H or optionally substituted aliphatic radical. The pharmaceuticals are suitable for the prophylaxis and/or treatment of diseases of the immune system, especially of tumors, infections and/or autoimmune diseases of the human or animal body and for use as adjuvants for vaccines.Some of the compounds of the formula I are new; the compounds can be prepared by special processes.
    Type: Grant
    Filed: October 26, 1988
    Date of Patent: April 9, 1991
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Wilfried Schwab, Robert R. Bartlett, Ulrich Gebert, Hans U. Schorlemmer, Gerhard Dickneite, Hans H. Sedlacek
  • Patent number: 4963577
    Abstract: The use of the thiazole derivative tiprotimod for the preparation of a pharmaceutical for the therapy of virus infections is described.
    Type: Grant
    Filed: May 12, 1989
    Date of Patent: October 16, 1990
    Assignee: Behringwerke Aktiengesellschaft
    Inventors: Hans U. Schorlemmer, Hans H. Sedlacek, Joachim Hilfenhaus
  • Patent number: 4847299
    Abstract: The use of 15-deoxyspergualine for the preparation of a pharmaceutical for the therapy of degenerative diseases is claimed.
    Type: Grant
    Filed: July 31, 1987
    Date of Patent: July 11, 1989
    Assignee: Behringwerke Aktiengesellschaft
    Inventors: Gerhard Dickneite, Hans-Ulrich Schorlemmer, Hans P. Kraemer, Hans H. Sedlacek
  • Patent number: 4801455
    Abstract: A pharmaceutical formulation for the parenteral, in particular intravenous, administration of sparingly soluble substances is obtained when the very finely ground substance, with a maximum particle diameter of 3 .mu.m, is dispersed in an oil phase which contains emulsifier, and this mixture is emulsified with water for injection, is rendered isotonic and is homogenized using a high-pressure homogenizer, so that the resultant product is a solid/liquid/liquid disperse system.
    Type: Grant
    Filed: July 9, 1987
    Date of Patent: January 31, 1989
    Assignee: Behringwerke Aktiengesellschaft
    Inventors: Paul H. List, Peter C. Schmidt, Klaus-Jurgen Steffens, Harald Perschbacher, Hans P. Kraemer, Hans H. Sedlacek
  • Patent number: 4239743
    Abstract: A fission product of an immunoglobulin having an immunologically functioning Fc-portion is bound to a carrier by adhesion or a chemical reaction. It can be used in an immunological analytic process for the determination of Fc-reactants in aqueous solutions.
    Type: Grant
    Filed: July 13, 1978
    Date of Patent: December 16, 1980
    Assignee: Behringwerke Aktiengesellschaft
    Inventors: Hans H. Sedlacek, Friedrich R. Seiler