Patents by Inventor Hans Hofmann

Hans Hofmann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210009588
    Abstract: The present invention encompasses compounds of formula (1) wherein the groups R1 to R4, A and p have the meanings given in the claims and specification, their use as inhibitors of SOS1, pharmaceutical compositions which contain compounds of this kind and their use as medicaments/medical uses, especially as agents for treatment and/or prevention of oncological diseases.
    Type: Application
    Filed: September 24, 2020
    Publication date: January 14, 2021
    Inventors: Juergen RAMHARTER, Christiane KOFINK, Heinz STADTMUELLER, Tobias WUNBERG, Marco Hans HOFMANN, Anke BAUM, Michael GMACHL, Dorothea Ingrid RUDOLPH, Fabio SAVARESE, Markus OSTERMEIER, Markus FRANK, Annika GILLE, Stefan GOEPPER, Marco SANTAGOSTINO, Julian WIPPICH
  • Publication number: 20190290637
    Abstract: The present invention encompasses compounds of formula (I) wherein the groups R2 to R5, A, X and q have the meanings given in the claims and specification, their use as inhibitors of CDK8/19, pharmaceutical compositions which contain compounds of this kind and their use as medicaments, especially as agents for treatment and/or prevention of oncological diseases.
    Type: Application
    Filed: May 19, 2017
    Publication date: September 26, 2019
    Inventors: Harald ENGELHARDT, Heribert ARNHOF, Sebastian CAROTTA, Marco Hans HOFMANN, Marc KERENYI, Dirk SCHARN
  • Publication number: 20190194192
    Abstract: The present invention encompasses compounds of formula (I) wherein the groups R1 to R4, A and p have the meanings given in the claims and specification, their use as inhibitors of SOS1, pharmaceutical compositions which contain compounds of this kind and their use as medicaments/medical uses, especially as agents for treatment and/or prevention of oncological diseases.
    Type: Application
    Filed: December 20, 2018
    Publication date: June 27, 2019
    Inventors: Juergen RAMHARTER, Christiane KOFINK, Heinz STADTMUELLER, Tobias WUNBERG, Marco Hans HOFMANN, Anke BAUM, Michael GMACHL, Dorothea Ingrid RUDOLPH, Fabio SAVARESE, Markus OSTERMEIER, Markus FRANK, Annika GILLE, Stefan GOEPPER, Marco SANTAGOSTINO, Julian WIPPICH
  • Publication number: 20180346559
    Abstract: The invention relates to the combined use of certain bispecific, VEGF and Ang2 binding molecules with PD1 antagonists for the treatment of cancer. It further relates to pharmaceutical compositions and kits comprising such binding molecules and antagonists.
    Type: Application
    Filed: June 1, 2018
    Publication date: December 6, 2018
    Inventors: Frank Hilberg, Marco Hans Hofmann, Markus Reschke, Flavio Solca
  • Publication number: 20090326239
    Abstract: The invention relates to a new process for concentrating epothilones in culture media, a new process for the production of epothilones, a new process for separating epothilones A and B and a new strain obtained by mutagenesis for the production of epothilones, as well as aspects related thereto. New crystal forms of epothilone B are also described.
    Type: Application
    Filed: March 4, 2009
    Publication date: December 31, 2009
    Inventors: Hans Hofmann, Marion Mahnke, Klaus Memmert, Frank Petersen, Thomas Schupp, Ernst Kusters, Michael Mutz
  • Patent number: 7314539
    Abstract: The invention discloses a pressure electrolyzer comprising a pressure vessel (2) and an electrolytic-cell block (3) arranged in the pressure vessel (2) and containing a plurality of electrolytic cells (4) combined in the form of a stack. The electrolytic cells (4) in each case contain anodes (11) and cathodes (12), and an electrolyte-circuit system is provided for supplying an anolyte to the anodes (11) and for supplying a catholyte to the cathodes (12), and wherein the electrolytic-cell block (3) comprises a housing (5) which is sealed relative to the interior of the pressure vessel (2). The invention provides that the housing (5) of the electrolytic-cell block (3), together with the pressure vessel (2), forms at least two chambers (7, 8) separated from each other, which constitute a part of the electrolyte-circuit system and which are defined relative to the electrolytic cells (4) by the housing (5) and relative to the atmosphere by the pressure vessel (2).
    Type: Grant
    Filed: October 12, 2002
    Date of Patent: January 1, 2008
    Assignee: Gesellschaft fuer Hochleistungselektrolyseure zur Wasserstofferzeugung mbH
    Inventors: Rolf August Brand, Pietro d'Erasmo, Hans Hofmann, Marko Raemisch
  • Publication number: 20070197611
    Abstract: The invention relates to a new process for concentrating epothilones in culture media, a new process for the production of epothilones, a new process for separating epothilones A and B and a new strain obtained by mutagenesis for the production of epothilones, as well as aspects related thereto, New crystal forms of epothilone B are also described,
    Type: Application
    Filed: February 5, 2007
    Publication date: August 23, 2007
    Inventors: Hans Hofmann, Marion Mahnke, Klaus Memmert, Frank Petersen, Thomas Schupp, Ernst Kusters, Michael Mutz
  • Publication number: 20060230478
    Abstract: A new and distinct Malus domestica Borkh. plant that produces apples having an excellent sugar-acid balance and keeping quality, suitable for use as a table and dessert fruit.
    Type: Application
    Filed: April 6, 2005
    Publication date: October 12, 2006
    Inventor: Hans Hofmann
  • Patent number: 7101702
    Abstract: The invention relates to a new process for concentrating epothilones in culture media, a new process for the production of epothilones, a new process for separating epothilones A and B and a new strain obtained by mutagenesis for the production of epothilones, as well as aspects related thereto. New crystal forms of epothilone B are also described.
    Type: Grant
    Filed: June 12, 2003
    Date of Patent: September 5, 2006
    Assignee: Novartis AG
    Inventors: Hans Hofmann, Marion Mahnke, Klaus Memmert, Frank Petersen, Thomas Schupp, Ernst Kusters, Michael Mutz
  • Publication number: 20050077174
    Abstract: The invention discloses a pressure electrolyzer comprising a pressure vessel (2) and an electrolytic-cell block (3) arranged in the pressure vessel (2) and containing a plurality of electrolytic cells (4) combined in the form of a stack. The electrolytic cells (4) in each case contain anodes (11) and cathodes (12), and an electrolyte-circuit system is provided for supplying an anolyte to the anodes (11) and for supplying a catholyte to the cathodes (12), and wherein the electrolytic-cell block (3) comprises a housing (5) which is sealed relative to the interior of the pressure vessel (2). The invention provides that the housing (5) of the electrolytic-cell block (3), together with the pressure vessel (2), forms at least two chambers (7, 8) separated from each other, which constitute a part of the electrolyte-circuit system and which are defined relative to the electrolytic cells (4) by the housing (5) and relative to the atmosphere by the pressure vessel (2).
    Type: Application
    Filed: October 12, 2002
    Publication date: April 14, 2005
    Inventors: Rolf Brand, Pietro d'Erasmo, Hans Hofmann, Marko Raemisch
  • Publication number: 20040142990
    Abstract: The invention relates to a new process for concentrating epothilones in culture media, a new process for the production of epothilones, a new process for separating epothilones A and B and a new strain obtained by mutagenesis for the production of epothilones, as well as aspects related thereto. New crystal forms of epothilone B are also described.
    Type: Application
    Filed: January 8, 2004
    Publication date: July 22, 2004
    Inventors: Hans Hofmann, Marion Mahnke, Klaus Memmert, Frank Petersen, Thomas Schupp, Ernst Kusters, Michael Mutz
  • Patent number: 6656711
    Abstract: The invention relates to a new process for concentrating epothilones in culture media, a new process for the production of epothilones, a new process for separating epothilones A and B and a new strain obtained by mutagenesis for the production of epothilones, as well as aspects related thereto. New crystal forms of epothilone B are also described.
    Type: Grant
    Filed: January 29, 2002
    Date of Patent: December 2, 2003
    Assignee: Novartis AG
    Inventors: Hans Hofmann, Marion Mahnke, Klaus Memmert, Frank Petersen, Thomas Schupp, Ernst Küsters, Michael Mutz
  • Publication number: 20030220379
    Abstract: The invention relates to a new process for concentrating epothilones in culture media, a new process for the production of epothilones, a new process for separating epothilones A and B and a new strain obtained by mutagenesis for the production of epothilones, as well as aspects related thereto. New crystal forms of epothilone B are also described.
    Type: Application
    Filed: June 12, 2003
    Publication date: November 27, 2003
    Inventors: Hans Hofmann, Marion Mahnke, Klaus Memmert, Frank Petersen, Thomas Schupp, Ernst Kusters, Michael Mutz
  • Publication number: 20030194787
    Abstract: The invention relates to a new process for concentrating epothilones in culture media, a new process for the production of epothilones, a new process for separating epothilones A and B and a new strain obtained by mutagenesis for the production of epothilones, as well as aspects related thereto. New crystal forms of epothilone B are also described.
    Type: Application
    Filed: January 8, 2003
    Publication date: October 16, 2003
    Inventors: Hans Hofmann, Marion Mahnke, Klaus Memmert, Frank Petersen, Thomas Schupp, Ernst Kusters, Michael Mutz
  • Publication number: 20020165256
    Abstract: The invention relates to a new process for concentrating epothilones in culture media, a new process for the production of epothilones, a new process for separating epothilones A and B and a new strain obtained by mutagenesis for the production of epothilones, as well as aspects related thereto. New crystal forms of epothilone B are also described.
    Type: Application
    Filed: January 29, 2002
    Publication date: November 7, 2002
    Inventors: Hans Hofmann, Marion Mahnke, Klaus Memmert, Frank Petersen, Thomas Schupp, Ernst Kusters, Michael Mutz
  • Patent number: 6455450
    Abstract: A paper machine felt having at least one nonwoven layer made of plastic fibers, wherein there is present in the nonwoven layer or in at least one of the nonwoven layers a fiber combination in which a portion of the plastic fibers is made of a material A that has a water uptake of more than 10 wt % (saturation value, 23° C.) and in which the majority of the plastic fibers is made of a material B that has a water uptake of no more than 10 wt % (saturation value, 23° C.).
    Type: Grant
    Filed: June 21, 2000
    Date of Patent: September 24, 2002
    Assignee: Thomas Josef Heimbach Gesellschaft mit beschrankter Haftung & Co.
    Inventor: Hans Hofmann
  • Patent number: 6267133
    Abstract: A steering valve (1) for power-steering gears contains two valve elements (4, 8), which are rotatable relative to each other. A corresponding centering unit (16) contains two centering elements (17, 18), which are rotation-fixed relative to the valve elements (4, 8) and which—together with the valve elements (4, 8)—are rotatable and axially displaceable relative to each other. Both centering elements (17, 18) feature radially aligned grooves, between which anti-friction elements (26) are inserted. Assembly is broken down into the following stages: The two valve elements (4, 8)—without centering unit (16)—are centrally aligned and linked via torsion bar spring (12). Separate from the steering valve (1), the two centering elements (17, 18) are pre-assembled in an assembly fixture and aligned in their mechanical center together with the anti-friction elements (26).
    Type: Grant
    Filed: March 9, 2000
    Date of Patent: July 31, 2001
    Assignee: ZF Friedrichshafen AG
    Inventors: Hans Hofmann, Andreas Kruttschnitt, Wolfgang Walter
  • Patent number: 6194181
    Abstract: The invention relates to a new process for concentrating epothilones in culture media, a new process for the production of epothilones, a new process for separating epothilones A and B and a new strain obtained by mutagenesis for the production of epothilones, as well as aspects related thereto. New crystal forms of epothilone B are also described.
    Type: Grant
    Filed: February 12, 1999
    Date of Patent: February 27, 2001
    Assignee: Novartis AG
    Inventors: Hans Hofmann, Marion Mahnke, Klaus Memmert, Frank Petersen, Thomas Schupp, Ernst Küsters, Michael Mutz
  • Patent number: 6153083
    Abstract: The invention relates to an electrolyzer for the electrolysis of water in hydrogen and oxygen with a number of electrolytic cells, each containing an anode and a cathode, connected in series in a cell block surrounded by a pressure vessel. At one end of the cell block is a first electrode, and at the opposite end of the cell block is a second electrode. Both are connected with leading-in cables, which run through the pressure vessel and conduct the electric current to the cell block, the interior of the pressure vessel being filled with pressurized water surrounding the cell block. In accordance with the invention, it is envisaged that the first electrode is placed inside the cell block so as to be electrically isolated, by encapsulation, with respect to the pressurized water, and that there is a channel, sealed against the pressurized water, that leads from the cell block through the pressurized vessel to the outside.
    Type: Grant
    Filed: August 19, 1999
    Date of Patent: November 28, 2000
    Assignee: MTU Motoren-und Turbinen-Union Friedrichshafen GmbH
    Inventors: Hans Hofmann, Lutz Mueller-Froelich
  • Patent number: PP17672
    Abstract: A new and distinct Malus domestica Borkh. plant that produces apples having an excellent sugar-acid balance and keeping quality, suitable for use as a table and dessert fruit.
    Type: Grant
    Filed: April 6, 2005
    Date of Patent: May 1, 2007
    Inventor: Hans Hofmann