Patents by Inventor Hans-Joachim Knolker

Hans-Joachim Knolker has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230265052
    Abstract: The present invention relates to oxygenated amino and ammonium-containing sulfonic acid, phosphonic acid and carboxylic acid derivatives, in particular the compounds of formula 1, 2, 3, 4, 5 or 6, and their medical use, including their use in the treatment, prevention or amelioration of an inflammatory, autoimmune and/or allergic disorder, or a proliferative, neoplastic or dysplastic disease or disorder.
    Type: Application
    Filed: September 26, 2022
    Publication date: August 24, 2023
    Inventors: Georg SCHLECHTINGEN, Hans-Joachim KNOLKER, Tim FRIEDRICHSON, Gary JENNINGS, Tobias BRAXMEIER
  • Patent number: 11564895
    Abstract: The present invention relates to hydroxy-substituted amino and ammonium derivatives, in particular the compounds of formula 1 or 2, and their medical use, including their use in the treatment, prevention or amelioration of an inflammatory, autoimmune and/or allergic disorder, or a proliferative, neoplastic or dysplastic disease or disorder.
    Type: Grant
    Filed: March 19, 2021
    Date of Patent: January 31, 2023
    Assignee: GRI BIO, INC.
    Inventors: Georg Schlechtingen, Hans-Joachim Knolker, Tim Friedrichson, Gary Jennings, Tobias Braxmeier
  • Patent number: 11453642
    Abstract: The present invention relates to oxygenated amino and ammonium-containing sulfonic acid, phosphonic acid and carboxylic acid derivatives, in particular the compounds of formula 1, 2, 3, 4, 5 or 6, and their medical use, including their use in the treatment, prevention or amelioration of an inflammatory, autoimmune and/or allergic disorder, or a proliferative, neoplastic or dysplastic disease or disorder.
    Type: Grant
    Filed: October 26, 2020
    Date of Patent: September 27, 2022
    Assignee: GRI Bio, Inc.
    Inventors: Georg Schlechtingen, Hans-Joachim Knolker, Tim Friedrichson, Gary Jennings, Tobias Braxmeier
  • Publication number: 20210228510
    Abstract: The present invention relates to hydroxy-substituted amino and ammonium derivatives, in particular the compounds of formula 1 or 2, and their medical use, including their use in the treatment, prevention or amelioration of an inflammatory, autoimmune and/or allergic disorder, or a proliferative, neoplastic or dysplastic disease or disorder.
    Type: Application
    Filed: March 19, 2021
    Publication date: July 29, 2021
    Inventors: Georg Schlechtingen, Hans-Joachim Knolker, Tim Friedrichson, Gary Jennings, Tobias Braxmeier
  • Publication number: 20210114979
    Abstract: The present invention relates to oxygenated amino and ammonium-containing sulfonic acid, phosphonic acid and carboxylic acid derivatives, in particular the compounds of formula 1, 2, 3, 4, 5 or 6, and their medical use, including their use in the treatment, prevention or amelioration of an inflammatory, autoimmune and/or allergic disorder, or a proliferative, neoplastic or dysplastic disease or disorder.
    Type: Application
    Filed: October 26, 2020
    Publication date: April 22, 2021
    Inventors: Georg Schlechtingen, Hans-Joachim Knolker, Tim Friedrichson, Gary Jennings, Tobias Braxmeier
  • Patent number: 10952977
    Abstract: The present invention relates to hydroxy-substituted amino and ammonium derivatives, in particular the compounds of formula (1) or (2), and their medical use, including their use in the treatment, prevention or amelioration of an inflammatory, autoimmune and/or allergic disorder, or a proliferative, neoplastic or dysplastic disease or disorder.
    Type: Grant
    Filed: December 3, 2018
    Date of Patent: March 23, 2021
    Assignee: GRI BIO, INC.
    Inventors: Georg Schlechtingen, Hans-Joachim Knolker, Tim Friedrichson, Gary Jennings, Tobias Braxmeier
  • Patent number: 10829506
    Abstract: The present invention relates to amino- or ammonium-containing sulfonic acid, phosphonic acid and carboxylic acid derivatives, in particular the compounds of formula 1, 2, 3, 4, 5 or 6 and their medical use, including their use in treatment, prevention or amelioration of an inflammatory, autoimmune and/or allergic disorder.
    Type: Grant
    Filed: December 21, 2017
    Date of Patent: November 10, 2020
    Assignee: GRI Bio, Inc.
    Inventors: Georg Schlechtingen, Hans-Joachim Knölker, Tim Friedrichson, Gary Jennings, Tobias Braxmeier
  • Patent number: 10815195
    Abstract: The present invention relates to oxygenated amino or ammonium-containing sulfonic acid, phosphoric acid and carboxylic acid derivatives, in particular the compounds of formula 1, 2, 3, 4, 5 or 6, and their medical use, including their use in the treatment, prevention or amelioration of an inflammatory, autoimmune and/or allergic disorder, or a proliferative, neoplastic or dysplastic disease or disorder.
    Type: Grant
    Filed: September 1, 2017
    Date of Patent: October 27, 2020
    Assignee: GRI Bio, Inc.
    Inventors: Georg Schlechtingen, Hans-Joachim Knolker, Tim Friedrichson, Gary Jennings, Tobias Braxmeier
  • Publication number: 20190175529
    Abstract: The present invention relates to hydroxy-substituted amino and ammonium derivatives, in particular the compounds of formula (1) or (2), and their medical use, including their use in the treatment, prevention or amelioration of an inflammatory, autoimmune and/or allergic disorder, or a proliferative, neoplastic or dysplastic disease or disorder.
    Type: Application
    Filed: December 3, 2018
    Publication date: June 13, 2019
    Inventors: Georg Schlechtingen, Hans-Joachim Knolker, Tim Friedrichson, Gary Jennings, Tobias Braxmeier
  • Patent number: 10143668
    Abstract: The present invention relates to hydroxy-substituted amino and ammonium derivatives, in particular the compounds of formula (1) or (2), and their medical use, including their use in the treatment, prevention or amelioration of an inflammatory, autoimmune and/or allergic disorder, or a proliferative, neoplastic or dysplastic disease or disorder.
    Type: Grant
    Filed: February 17, 2017
    Date of Patent: December 4, 2018
    Assignee: GRI BIO, INC.
    Inventors: Georg Schlechtingen, Hans-Joachim Knolker, Tim Friedrichson, Gary Jennings, Tobias Braxmeier
  • Publication number: 20180244703
    Abstract: The present invention relates to amino- or ammonium-containing sulfonic acid, phosphonic acid and carboxylic acid derivatives, in particular the compounds of formula 1, 2, 3, 4, 5 or 6 and their medical use, including their use in treatment, prevention or amelioration of an inflammatory, autoimmune and/or allergic disorder.
    Type: Application
    Filed: December 21, 2017
    Publication date: August 30, 2018
    Inventors: Georg Schlechtingen, Hans-Joachim Knölker, Tim Friedrichson, Gary Jennings, Tobias Braxmeier
  • Publication number: 20170369430
    Abstract: The present invention relates to oxygenated amino or ammonium-containing sulfonic acid, phosphoric acid and carboxylic acid derivatives, in particular the compounds of formula 1, 2, 3, 4, 5 or 6, and their medical use, including their use in the treatment, prevention or amelioration of an inflammatory, autoimmune and/or allergic disorder, or a proliferative, neoplastic or dys-plastic disease or disorder.
    Type: Application
    Filed: September 1, 2017
    Publication date: December 28, 2017
    Inventors: Georg Schlechtingen, Hans-Joachim Knolker, Tim Friedrichson, Gary Jennings, Tobias Braxmeier
  • Patent number: 9850265
    Abstract: The present invention relates to amino- or ammonium-containing sulfonic acid, phosphonic acid and carboxylic acid derivatives, in particular the compounds of formula 1, 2, 3, 4, 5 or 6, and their medical use, including their use in the treatment, prevention or amelioration of an inflammatory, autoimmune and/or allergic disorder.
    Type: Grant
    Filed: May 25, 2012
    Date of Patent: December 26, 2017
    Assignee: GRI BIO, INC.
    Inventors: Georg Schlechtingen, Hans-Joachim Knölker, Tim Friedrichson, Gary Jennings, Tobias Braxmeier
  • Patent number: 9751834
    Abstract: The present invention relates to oxygenated amino or ammonium-containing sulfonic acid, phosphonic acid and carboxylic acid derivatives, in particular the compounds of formula 1, 2, 3, 4, 5 or 6, and their medical use, including their use in the treatment, prevention or amelioration of an inflammatory, autoimmune and/or allergic disorder, or a proliferative, neoplastic or dysplastic disease or disorder.
    Type: Grant
    Filed: May 25, 2012
    Date of Patent: September 5, 2017
    Assignee: GRI BIO, INC.
    Inventors: Georg Schlechtingen, Hans-Joachim Knölker, Tim Friedrichson, Gary Jennings, Tobias Braxmeier
  • Publication number: 20170157070
    Abstract: The present invention relates to hydroxy-substituted amino and ammonium derivatives, in particular the compounds of formula (1) or (2), and their medical use, including their use in the treatment, prevention or amelioration of an inflammatory, autoimmune and/or allergic disorder, or a proliferative, neoplastic or dysplastic disease or disorder.
    Type: Application
    Filed: February 17, 2017
    Publication date: June 8, 2017
    Inventors: Georg Schlechtingen, Hans-Joachim Knolker, Tim Friedrichson, Gary Jennings, Tobias Braxmeier
  • Patent number: 9573886
    Abstract: The present invention relates to hydroxy-substituted amino and ammonium derivatives, in particular the compounds of formula (1) or (2), and their medical use, including their use in the treatment, prevention or amelioration of an inflammatory, autoimmune and/or allergic disorder, or a proliferative, neoplastic or dysplastic disease or disorder.
    Type: Grant
    Filed: May 25, 2012
    Date of Patent: February 21, 2017
    Assignee: Glycoregimmune, Inc.
    Inventors: Georg Schlechtingen, Hans-Joachim Knolker, Tim Friedrichson, Gary Jennings, Tobias Braxmeier
  • Publication number: 20160016981
    Abstract: The present invention relates to amino- or ammonium-containing sulfonic acid, phosphonic acid and carboxylic acid derivatives, in particular the compounds of formula 1, 2, 3, 4, 5 or 6, and their medical use, including their use in the treatment, prevention or amelioration of an inflammatory, autoimmune and/or allergic disorder.
    Type: Application
    Filed: May 25, 2012
    Publication date: January 21, 2016
    Applicant: GLYCOREGIMMUNE, INC.
    Inventors: Georg Schlechtingen, Hans-Joachim Knölker, Tim Friedrichson, Gary Jennings, Tobias Braxmeier
  • Publication number: 20150284320
    Abstract: The present invention relates to oxygenated amino or ammonium-containing sulfonic acid, phosphonic acid and carboxylic acid derivatives, in particular the compounds of formula 1, 2, 3, 4, 5 or 6, and their medical use, including their use in the treatment, prevention or amelioration of an inflammatory, autoimmune and/or allergic disorder, or a proliferative, neoplastic or dysplastic disease or disorder.
    Type: Application
    Filed: May 25, 2012
    Publication date: October 8, 2015
    Applicant: GLYCOREGIMMUNE, INC.
    Inventors: Georg Schlechtingen, Hans-Joachim Knölker, Tim Friedrichson, Gary Jennings, Tobias Braxmeier
  • Publication number: 20150232418
    Abstract: The present invention relates to hydroxy-substituted amino and ammonium derivatives, in particular the compounds of formula (1) or (2), and their medical use, including their use in the treatment, prevention or amelioration of an inflammatory, autoimmune and/or allergic disorder, or a proliferative, neoplastic or dysplastic disease or disorder.
    Type: Application
    Filed: May 25, 2012
    Publication date: August 20, 2015
    Applicant: GLYCOREGIMMUNE, INC.
    Inventors: Georg Schlechtingen, Hans-Joachim Knolker, Tim Friedrichson, Gary Jennings, Tobias Braxmeier
  • Publication number: 20110105554
    Abstract: The present invention provides a method of designing a modulator of a myosin, the method comprising molecular modeling of a compound such that the modeled compound interacts with at least three amino acid residues of said myosin, said residues being selected from (a) ranges K265-V268, V411-L441, N588-Q593, D614-T629, and V630-E646 of SEQ ID NO: 2, said myosin comprising or consisting of (i) the sequence of SEQ ID NO: 2; (ii) the sequence encoded by the sequence of SEQ ID NO: 1; (iii) a sequence being at least 40% identical to the sequence of SEQ ID NO: 2 or to the sequence encoded by the sequence of SEQ ID NO: 1; or (iv) a sequence encoded by a sequence being at least 40% identical to the sequence of SEQ ID NO: 1; wherein said sequence of (iii) or (iv) comprises said three amino acid residues, and wherein said residues comprise K265; or (b) ranges of any one of SEQ ID NOs: 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, 38, 40, 42, 44, 46, 48, 50, 52, 54, 56, 58, 60, 62, 64, 66, 68, 70, 72, 7
    Type: Application
    Filed: November 21, 2008
    Publication date: May 5, 2011
    Applicant: KINARIS BIOMEDICALS GMBH
    Inventors: Dietmar Manstein, Roman Fedorov, Georgios Tsiavaliaris, Hans-Joachim Knölker, René Martin, Juliane Kirst, Herwig Gutzeit, Markus Böhl