Patents by Inventor Hao Hong

Hao Hong has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10865225
    Abstract: Provided is a gene encoding alanyl-glutamine dipeptide biosynthetic enzyme and the application thereof. The nucleotide sequence of said gene is shown in SEQ ID NO: 1. Further, provided is an amino acid sequence encoded by the gene, and provided recombinant vector, recombinant E. coli, recombinant S. cerevisiae, and a self-flocculating recombinant S. cerevisiae containing the gene. Furthermore, provided is a method for carrying out bioconversion to synthesize alanyl-glutamine dipeptide by using said recombinant microorganisms. The application of the gene and recombinant batteries has the characteristics of high molar conversion rate, fast production rate and repeated recycling of the bacteria. It is a good choice for efficient, environmentally friendly and economical production of alanyl-glutamine dipeptide. In addition, through the recycling process, it is expected to reduce the cost of industrial production, solve the problems of difficult enzyme recovery, low utilization rate and unstable enzyme activity.
    Type: Grant
    Filed: June 27, 2019
    Date of Patent: December 15, 2020
    Assignee: INNOBIO CORPORATION LIMITED
    Inventors: Wenjie Yuan, Chao Fan, Yimin Li, Hao Hong, Wenzhong Wu
  • Patent number: 10861721
    Abstract: A method includes delivering a wafer into a process chamber, applying a thermal energy to the wafer by a heat source, and moving the heat source substantially along a longitudinal direction of the heat source with respect to the wafer. An apparatus that performs the method is also disclosed.
    Type: Grant
    Filed: February 1, 2019
    Date of Patent: December 8, 2020
    Assignee: TAIWAN SEMICONDUCTOR MANUFACTURING CO., LTD.
    Inventors: You-Hua Chou, Min-Hao Hong, Kuan-Chung Chen
  • Publication number: 20200362318
    Abstract: The present application relates to the technical field of genetic engineering, and provides a monooxygenase mutant, a preparation method and application thereof. The monooxygenase mutant has any one of the amino acid sequences shown in (I) and (II): (I) an amino acid sequence having at least 80% identity with the amino acid sequence shown in SEQ ID NO. 1; and (II) an amino acid sequence obtained by modifying, substituting, deleting, or adding one or several amino acids to the amino acids at 23 to 508 positions of the amino acid sequence shown in SEQ ID NO. 1, the substituting referring to a substitution of 1 to 34 amino acids, wherein the mutant has the activity of monooxygenase.
    Type: Application
    Filed: February 8, 2018
    Publication date: November 19, 2020
    Inventors: Hao HONG, James GAGE, Jiangping LU, Xuecheng JIAO, Na ZHANG, Rui LI, Kejian ZHANG, Yu ZHANG
  • Publication number: 20200354694
    Abstract: A ketoreductase mutant and use thereof are provided. The amino acid sequence of the ketoreductase mutant is an amino acid sequence obtained by mutation of the amino acid sequence shown in SEQ ID NO: 1, wherein the mutation at least comprises one of the following mutation sites: position 6, position 94, position 96, position 117, position 144, position 156, position 193, position 205, position 224, position 176, position 85 and position 108; alternatively, the amino acid sequence of the ketoreductase mutant has a mutation site in a mutated amino acid sequence and an amino acid sequence having 80% or more homology with the mutated amino acid sequence.
    Type: Application
    Filed: January 22, 2018
    Publication date: November 12, 2020
    Inventors: Hao HONG, Gage JAMES, Jiangping LU, Xingfu XU, Wenyan YU, Na ZHANG, Yulei MA, Yibing CHENG, Huiyan MU
  • Publication number: 20200239895
    Abstract: A transaminase mutant and use hereof, the amino acid sequence of the transaminase mutant is an amino acid sequence in which the amino acid sequence as represented by SEQ ID NO: 1 is mutated, the mutated amino acid position being one or more selected from among F89, K193, P243, V234, I262, Q280, V379, R416, A417 and C418. The enzymatic activity and/or stability of the transaminase mutant is improved.
    Type: Application
    Filed: November 15, 2017
    Publication date: July 30, 2020
    Applicant: Asymchem Life Science (Tianjin) Co., Ltd
    Inventors: Hao HONG, Gage JAMES, Jiangping LU, Xingfu XU, Wenyan YU, Xin HUANG, Yulei MA, Yibing CHENG
  • Publication number: 20200199544
    Abstract: Provided are a proline hydroxylase and uses thereof. The proline hydroxylase comprises (a) a protein having the amino acid sequence as shown in SEQ ID NO: 2; (b) a protein having an amino acid sequence of SEQ HD NO: 2 with a mutation of one or more amino acids and having a proline hydroxylase activity; or (c) a protein retaining the mutation of one or more amino acids as in (b), and having the proline hydroxylase activity and having at least 78% homology with the amino acid sequence of the protein in (b). Protein having the amino acid sequence as shown in SEQ HD NO: 2 and mutants obtained by genetically engineering have higher catalytic specificity or significantly increased catalytic activity when compared to proline hydroxylases in prior art.
    Type: Application
    Filed: November 4, 2016
    Publication date: June 25, 2020
    Inventors: Hao HONG, Gage JAMES, Jiangping LU, Na ZHANG, Wenyan YU, Fang LIU, Yanjun LI, Xin HUANG, Juan GAO, Kejian ZHANG, Yulei MA, Junlu WEI
  • Publication number: 20200171537
    Abstract: The present invention provides a slow-start photocuring device, comprising: a housing, an ultraviolet (UV) light-emitting diode (LED) module, and a switch control module. The housing has an inner side provided with an internal cavity, wherein the inner side of the housing is further provided with one or a plurality of openings on one or two sides of the internal cavity. The UV LED module is provided around the internal cavity, wherein the UV LED module has a light-emitting side facing the internal cavity. The switch control module is connected to the UV LED module, wherein the switch control module includes a signal modulator, the signal modulator activates a buffer mode when receiving a trigger signal, and the UV LED module in the buffer mode outputs light of a plurality of brightness levels sequentially according to an output signal of the signal modulator.
    Type: Application
    Filed: November 1, 2019
    Publication date: June 4, 2020
    Inventors: Wan Chieh HSIEH, Hao-Hong CIOU, Lin-Yu SIA, Chun Ching LIU
  • Patent number: 10544119
    Abstract: The present invention relates to a preparation method for a chiral intermediate for use in statins, acquired with chloroacetic acid and benzyl alcohol as starting materials via a series of reactions, namely etherification, condensation, substitution, and asymmetric reduction. The preparation method provided in the present invention has a novel route of synthesis, allows an intermediate compound to be introduced conveniently into the chiral center of a glycol via enzyme reduction, and not only is low in costs, but also is reliable in quality. The route of synthesis provided in the present invention uses raw materials of low costs, has an easy to operate process, and provides a final product of great purity and high yield.
    Type: Grant
    Filed: August 4, 2014
    Date of Patent: January 28, 2020
    Assignees: Asymchem Laboratories (Tianjin) Co., Ltd., Asymchem Life Science (Tianjin) Co. Ltd., Tianjin Asymchem Pharmaceutical Co., Ltd., Asymchem Laboratories (Fuxin) Co., Ltd., Jilin Asymchem Laboratories Co., Ltd.
    Inventors: Hao Hong, Chaoyong Chen, Jiuyuan Li, Litao Shen, Lina Guo, Hongying Tian
  • Patent number: 10492258
    Abstract: The present invention is to provide a slow-start photocuring device, comprising: a housing, one or a plurality of UV LED modules, and a switch control module connected to the one or the plurality of UV LED modules. The housing has an inner side provided with an internal cavity, wherein the inner side of the housing is further provided with one or a plurality of openings in one or two sides of the internal cavity. The one or the plurality of UV LED modules provided around the internal cavity, wherein each of the one or the plurality of UV LED modules has a light-emitting side facing the internal cavity. The switch control module comprises a signal modulator, and the signal modulator activates a power buffer mode when receiving a trigger signal, in order to modulate an irradiation power of the one or the plurality of UV LED modules gradually from a first level to a second level.
    Type: Grant
    Filed: April 13, 2018
    Date of Patent: November 26, 2019
    Assignee: Cosmex Co., Ltd.
    Inventors: Wan Chieh Hsieh, Hao-Hong Ciou, Lin-Yu Sia, Chun Ching Liu
  • Patent number: 10480629
    Abstract: A ball screw with a dustproof member includes: a screw, a nut and the dustproof member. The dustproof member is inserted along the axis into the annular receiving groove and sleeved onto the screw, and includes an annular first dustproof portion and an arc-shaped second dustproof portion. The annular first dustproof portion includes a dustproof hole for insertion of the screw, the dustproof hole has a dustproof inner surface defining an clearance relative to the circumferential surface of the screw, the arc-shaped second dustproof portion protrudes from the dustproof inner surface, and includes an arc-shaped dustproof section contacting the outer helical groove. Such arrangements provide a dustproof effect and prevent overstress on the screw, consequently decreasing friction resistance, thus making the assembly easier and reducing the required starting torque.
    Type: Grant
    Filed: July 21, 2017
    Date of Patent: November 19, 2019
    Assignee: Hiwin Technologies Corp.
    Inventors: Wei-Lun Liu, Sheng-Hao Hong
  • Publication number: 20190337116
    Abstract: A method of using a polishing system includes securing a wafer to a support, wherein the wafer has a first diameter. The method further includes polishing the wafer using a first polishing pad rotating about a first axis, wherein the first polishing pad has a second diameter greater than the first diameter. The method further includes rotating the support about a second axis perpendicular to the first axis after polishing the wafer using the first polishing pad. The method further includes polishing the wafer using a second polishing pad after rotating the support, wherein the second polishing pad has a third diameter less than the first diameter. The method further includes releasing the wafer from the support following polishing the wafer using the second polishing pad.
    Type: Application
    Filed: July 18, 2019
    Publication date: November 7, 2019
    Inventors: Shih-Chi LIN, Kun-Tai WU, You-Hua CHOU, Chih-Tsung LEE, Min Hao HONG, Chih-Jen WU, Chen-Ming HUANG, Soon-Kang HUANG, Chin-Hsiang CHANG, Chih-Yuan YANG
  • Publication number: 20190315801
    Abstract: Provided is a gene encoding alanyl-glutamine dipeptide biosynthetic enzyme and the application thereof. The nucleotide sequence of said gene is shown in SEQ ID NO: 1. Further, provided is an amino acid sequence encoded by the gene, and provided recombinant vector, recombinant E. coli, recombinant S. cerevisiae, and a self-flocculating recombinant S. cerevisiae containing the gene. Furthermore, provided is a method for carrying out bioconversion to synthesize alanyl-glutamine dipeptide by using said recombinant microorganisms. The application of the gene and recombinant batteries has the characteristics of high molar conversion rate, fast production rate and repeated recycling of the bacteria. It is a good choice for efficient, environmentally friendly and economical production of alanyl-glutamine dipeptide. In addition, through the recycling process, it is expected to reduce the cost of industrial production, solve the problems of difficult enzyme recovery, low utilization rate and unstable enzyme activity.
    Type: Application
    Filed: June 27, 2019
    Publication date: October 17, 2019
    Inventors: Wenjie YUAN, Chao FAN, Yimin LI, Hao HONG, Wenzhong WU
  • Patent number: 10428930
    Abstract: A ball screw with a cooling passage includes a ball screw, a nut and a sealing unit. The nut is provided with the input and output cooling holes parallel to the axis, and the flat surface is provided with the guide groove. A first hole and a second hole are disposed between the guide groove and the input cooling hole and the output cooling hole, respectively, and then a sealing unit seals the guide groove, so as to form the cooling passage. The guide groove, the first hole and the second hole all extend along the axial direction of the nut, and the cooling passage can be formed simply by sealing the guide groove with the sealing unit, which effectively reduces the assembling steps and time, consequently decreasing the assembling cost.
    Type: Grant
    Filed: October 17, 2017
    Date of Patent: October 1, 2019
    Assignee: Hiwin Technologies Corp.
    Inventors: You-Xin Fang, Yu-Wei Chuang, Sheng-Hao Hong
  • Patent number: 10399071
    Abstract: A polymer containing a carboxyl group, a preparation method and an application thereof, a supported catalyst and a preparation method thereof and preparation methods of penem antibiotic intermediate are disclosed. The polymer has high rigidity and hardness, thus the mechanical properties of the polymer is effectively improved. Meanwhile, in the polymer, the carboxyl group is used as a main functional group, and is used as a carrier to prepare, by means of a coordination reaction between the carboxyl group and a heavy metal, a supported metal catalyst which has better connection stability between the metal and the polymer. The above two factors can improve the stability of the supported metal catalyst, such that the catalyst can be recycled without losing the catalytic activity. Meanwhile, loss of a heavy metal active ingredient and production cost can be reduced.
    Type: Grant
    Filed: September 10, 2014
    Date of Patent: September 3, 2019
    Inventors: Hao Hong, Jiuyuan Li, Changming Dong, Xin Zhang, Gage James
  • Patent number: 10357867
    Abstract: A polishing system includes a wafer support that holds a wafer, the wafer having a first diameter. The polishing system further includes a first polishing pad that polishes a first region of the wafer, the first polishing pad having a second diameter greater than the first diameter. The polishing system further includes an auxiliary polishing system comprising at least one second polishing pad that polishes a second region of the wafer, wherein the second polishing pad has a third diameter less than the first diameter, and the wafer support is configured to support the wafer during use of the first polishing pad and the auxiliary polishing system.
    Type: Grant
    Filed: July 18, 2017
    Date of Patent: July 23, 2019
    Assignee: TAIWAN SEMICONDUCTOR MANUFACTURING COMPANY, LTD.
    Inventors: Shih-Chi Lin, Kun-Tai Wu, You-Hua Chou, Chih-Tsung Lee, Min Hao Hong, Chih-Jen Wu, Chen-Ming Huang, Soon-Kang Huang, Chin-Hsiang Chang, Chih-Yuan Yang
  • Publication number: 20190172735
    Abstract: A method includes delivering a wafer into a process chamber, applying a thermal energy to the wafer by a heat source, and moving the heat source substantially along a longitudinal direction of the heat source with respect to the wafer. An apparatus that performs the method is also disclosed.
    Type: Application
    Filed: February 1, 2019
    Publication date: June 6, 2019
    Applicant: TAIWAN SEMICONDUCTOR MANUFACTURING CO., LTD.
    Inventors: You-Hua CHOU, Min-Hao HONG, Kuan-Chung CHEN
  • Publication number: 20190173299
    Abstract: The present invention provides a mobile charging device capable of battery replacement, comprising a demountable casing, a control module, and a replaceable battery pack. The demountable casing is demounted or mounted by a demountable means. The control module is disposed in the demountable casing. The replaceable battery pack is disposed in the demountable casing, electrically connected to the control module, controlled by the control module to perform charging or discharging, and is changeable when the demountable casing is demounted. The mobile charging device of the present invention can be directly replaced the battery when the mobile power source is exhausted or insufficient, which enhances practicability.
    Type: Application
    Filed: August 17, 2018
    Publication date: June 6, 2019
    Inventors: Wan Chieh HSIEH, Hao-Hong CIOU, Lin-Yu SIA, Chun Ching LIU
  • Publication number: 20190113129
    Abstract: A ball screw with a cooling passage includes a ball screw, a nut and a sealing unit. The nut is provided with the input and output cooling holes parallel to the axis, and the axial flat surface is provided with the guide groove. A first radial hole and a second radial hole are disposed between the guide groove and the input cooling hole and the output cooling hole, respectively, and then a sealing unit seals the guide groove, so as to form the cooling passage. The guide groove, the first radial hole and the second radial hole all extend along the axial direction of the nut, and the cooling passage can be formed simply by sealing the guide groove with the sealing unit, which effectively reduces the assembling steps and time, consequently decreasing the assembling cost.
    Type: Application
    Filed: October 17, 2017
    Publication date: April 18, 2019
    Inventors: YOU-XIN FANG, YU-WEI CHUANG, SHENG-HAO HONG
  • Patent number: D875318
    Type: Grant
    Filed: March 20, 2018
    Date of Patent: February 11, 2020
    Assignee: COSMEX CO. LTD.
    Inventors: Wan Chieh Hsieh, Hao-Hong Ciou, Lin-Yu Sia, Chun Ching Liu
  • Patent number: D890431
    Type: Grant
    Filed: July 27, 2018
    Date of Patent: July 14, 2020
    Assignee: COSMEX CO. LTD.
    Inventors: Wan Chieh Hsieh, Pai Yao Hsieh, Hung Wei Chang, Hao-Hong Ciou