Patents by Inventor Haris Vikalo

Haris Vikalo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11447816
    Abstract: This invention provides methods and systems for measuring the concentration of multiple nucleic acid sequences in a sample. The nucleic acid sequences in the sample are simultaneously amplified, for example, using polymerase chain reaction (PCR) in the presence of an array of nucleic acid probes. The amount of amplicon corresponding to the multiple nucleic acid sequences can be measured in real-time during or after each cycle using a real-time microarray. The measured amount of amplicon produced can be used to determine the original amount of the nucleic acid sequences in the sample.
    Type: Grant
    Filed: August 29, 2016
    Date of Patent: September 20, 2022
    Assignee: California Institute of Technology
    Inventors: Arjang Hassibi, Babak Hassibi, Haris Vikalo
  • Publication number: 20220195506
    Abstract: This present disclosure provides methods and systems for measuring the concentration of multiple nucleic acid sequences in a sample. The nucleic acid sequences in the sample are simultaneously amplified, for example, using polymerase chain reaction (PCR) in the presence of an array of nucleic acid probes. The amount of amplicon corresponding to the multiple nucleic acid sequences can be measured in real-time during or after each cycle using a real-time microarray. The measured amount of amplicon produced can be used to determine the original amount of the nucleic acid sequences in the sample. Also provided herein are biosensor arrays, systems and methods for affinity based assays that are able to simultaneously obtain high quality measurements of the binding characteristics of multiple analytes, and that are able to determine the amounts of those analytes in solution. The present disclosure also provides a fully integrated bioarray for detecting real-time characteristics of affinity based assays.
    Type: Application
    Filed: July 22, 2021
    Publication date: June 23, 2022
    Applicant: California Institute of Technology
    Inventors: Arjang Hassibi, Babak Hassibi, Haris Vikalo, Jose Luis Riechmann
  • Patent number: 11098345
    Abstract: This present disclosure provides methods and systems for measuring the concentration of multiple nucleic acid sequences in a sample. The nucleic acid sequences in the sample are simultaneously amplified, for example, using polymerase chain reaction (PCR) in the presence of an array of nucleic acid probes. The amount of amplicon corresponding to the multiple nucleic acid sequences can be measured in real-time during or after each cycle using a real-time microarray. The measured amount of amplicon produced can be used to determine the original amount of the nucleic acid sequences in the sample. Also provided herein are biosensor arrays, systems and methods for affinity based assays that are able to simultaneously obtain high quality measurements of the binding characteristics of multiple analytes, and that are able to determine the amounts of those analytes in solution. The present disclosure also provides a fully integrated bioarray for detecting real-time characteristics of affinity based assays.
    Type: Grant
    Filed: April 10, 2019
    Date of Patent: August 24, 2021
    Assignee: California Institute of Technology
    Inventors: Arjang Hassibi, Babak Hassibi, Haris Vikalo, Jose Luis Riechmann
  • Patent number: 11001881
    Abstract: This invention provides methods and systems for measuring the concentration of multiple nucleic acid sequences in a sample. The nucleic acid sequences in the sample are simultaneously amplified, for example, using polymerase chain reaction (PCR) in the presence of an array of nucleic acid probes. The amount of amplicon corresponding to the multiple nucleic acid sequences can be measured in real-time during or after each cycle using a real-time microarray. The measured amount of amplicon produced can be used to determine the original amount of the nucleic acid sequences in the sample. Also provided herein are biosensor arrays, systems and methods for affinity based assays that are able to simultaneously obtain high quality measurements of the binding characteristics of multiple analytes, and that are able to determine the amounts of those analytes in solution. The invention also provides a fully integrated bioarray for detecting real-time characteristics of affinity based assays.
    Type: Grant
    Filed: August 29, 2017
    Date of Patent: May 11, 2021
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Arjang Hassibi, Babak Hassibi, Haris Vikalo
  • Publication number: 20190323070
    Abstract: This present disclosure provides methods and systems for measuring the concentration of multiple nucleic acid sequences in a sample. The nucleic acid sequences in the sample are simultaneously amplified, for example, using polymerase chain reaction (PCR) in the presence of an array of nucleic acid probes. The amount of amplicon corresponding to the multiple nucleic acid sequences can be measured in real-time during or after each cycle using a real-time microarray. The measured amount of amplicon produced can be used to determine the original amount of the nucleic acid sequences in the sample. Also provided herein are biosensor arrays, systems and methods for affinity based assays that are able to simultaneously obtain high quality measurements of the binding characteristics of multiple analytes, and that are able to determine the amounts of those analytes in solution. The present disclosure also provides a fully integrated bioarray for detecting real-time characteristics of affinity based assays.
    Type: Application
    Filed: April 10, 2019
    Publication date: October 24, 2019
    Inventors: Arjang HASSIBI, Babak HASSIBI, Haris VIKALO, Jose Luis RIECHMANN
  • Publication number: 20180251828
    Abstract: This invention provides methods and systems for measuring the concentration of multiple nucleic acid sequences in a sample. The nucleic acid sequences in the sample are simultaneously amplified, for example, using polymerase chain reaction (PCR) in the presence of an array of nucleic acid probes. The amount of amplicon corresponding to the multiple nucleic acid sequences can be measured in real-time during or after each cycle using a real-time microarray. The measured amount of amplicon produced can be used to determine the original amount of the nucleic acid sequences in the sample. Also provided herein are biosensor arrays, systems and methods for affinity based assays that are able to simultaneously obtain high quality measurements of the binding characteristics of multiple analytes, and that are able to determine the amounts of those analytes in solution. The invention also provides a fully integrated bioarray for detecting real-time characteristics of affinity based assays.
    Type: Application
    Filed: May 7, 2018
    Publication date: September 6, 2018
    Inventors: Arjang Hassibi, Babak Hassibi, Haris Vikalo
  • Publication number: 20180251829
    Abstract: This invention provides methods and systems for measuring the concentration of multiple nucleic acid sequences in a sample. The nucleic acid sequences in the sample are simultaneously amplified, for example, using polymerase chain reaction (PCR) in the presence of an array of nucleic acid probes. The amount of amplicon corresponding to the multiple nucleic acid sequences can be measured in real-time during or after each cycle using a real-time microarray. The measured amount of amplicon produced can be used to determine the original amount of the nucleic acid sequences in the sample. Also provided herein are biosensor arrays, systems and methods for affinity based assays that are able to simultaneously obtain high quality measurements of the binding characteristics of multiple analytes, and that are able to determine the amounts of those analytes in solution. The invention also provides a fully integrated bioarray for detecting real-time characteristics of affinity based assays.
    Type: Application
    Filed: May 7, 2018
    Publication date: September 6, 2018
    Inventors: Arjang Hassibi, Babak Hassibi, Haris Vikalo
  • Publication number: 20170362648
    Abstract: This invention provides methods and systems for measuring the concentration of multiple nucleic acid sequences in a sample. The nucleic acid sequences in the sample are simultaneously amplified, for example, using polymerase chain reaction (PCR) in the presence of an array of nucleic acid probes. The amount of amplicon corresponding to the multiple nucleic acid sequences can be measured in real-time during or after each cycle using a real-time microarray. The measured amount of amplicon produced can be used to determine the original amount of the nucleic acid sequences in the sample. Also provided herein are biosensor arrays, systems and methods for affinity based assays that are able to simultaneously obtain high quality measurements of the binding characteristics of multiple analytes, and that are able to determine the amounts of those analytes in solution. The invention also provides a fully integrated bioarray for detecting real-time characteristics of affinity based assays.
    Type: Application
    Filed: August 29, 2017
    Publication date: December 21, 2017
    Inventors: Arjang HASSIBI, Babak Hassibi, Haris Vikalo
  • Publication number: 20170081714
    Abstract: This invention provides methods and systems for measuring the concentration of multiple nucleic acid sequences in a sample. The nucleic acid sequences in the sample are simultaneously amplified, for example, using polymerase chain reaction (PCR) in the presence of an array of nucleic acid probes. The amount of amplicon corresponding to the multiple nucleic acid sequences can be measured in real-time during or after each cycle using a real-time microarray. The measured amount of amplicon produced can be used to determine the original amount of the nucleic acid sequences in the sample.
    Type: Application
    Filed: August 29, 2016
    Publication date: March 23, 2017
    Inventors: Arjang Hassibi, Babak Hassibi, Haris Vikalo
  • Patent number: 9458497
    Abstract: This invention provides methods and systems for measuring the concentration of multiple nucleic acid sequences in a sample. The nucleic acid sequences in the sample are simultaneously amplified, for example, using polymerase chain reaction (PCR) in the presence of an array of nucleic acid probes. The amount of amplicon corresponding to the multiple nucleic acid sequences can be measured in real-time during or after each cycle using a real-time microarray. The measured amount of amplicon produced can be used to determine the original amount of the nucleic acid sequences in the sample.
    Type: Grant
    Filed: September 22, 2011
    Date of Patent: October 4, 2016
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Arjang Hassibi, Babak Hassibi, Haris Vikalo
  • Publication number: 20160160271
    Abstract: This invention provides methods and systems for measuring the binding of analytes in solution to probes bound to surfaces in real-time.
    Type: Application
    Filed: August 10, 2015
    Publication date: June 9, 2016
    Inventors: Arjang Hassibi, Babak Hassibi, Haris Vikalo, Jose Luis Riechmann
  • Patent number: 9223929
    Abstract: The disclosure provides methods, device, and systems for analyzing biological array data. In particular, the disclosure provides methods and computer implemented techniques for reducing interference in microarray data, and exploiting it to obtain more accurate readouts.
    Type: Grant
    Filed: March 14, 2006
    Date of Patent: December 29, 2015
    Assignee: The California Institute of Technology
    Inventors: Babak Hassibi, Haris Vikalo, Arjang Hassibi
  • Patent number: 9133504
    Abstract: This invention provides methods and systems for measuring the binding of analytes in solution to probes bound to surfaces in real-time. The method involves contacting a fluid volume having a plurality of different analytes with a solid substrate having a plurality of different probes. The probes are capable of specifically binding to the analytes. The method also involves measuring signals at multiple time points while the fluid volume is in contact with the substrate. The signals measured at multiple time points can be correlated with the amount of binding of the analytes with the probes. The method eliminates the need to wash the probes before measuring the binding characteristics.
    Type: Grant
    Filed: June 5, 2007
    Date of Patent: September 15, 2015
    Assignee: California Institute of Technology
    Inventors: Arjang Hassibi, Babak Hassibi, Haris Vikalo, Jose Luis Riechmann
  • Publication number: 20120077692
    Abstract: This invention provides methods and systems for measuring the concentration of multiple nucleic acid sequences in a sample. The nucleic acid sequences in the sample are simultaneously amplified, for example, using polymerase chain reaction (PCR) in the presence of an array of nucleic acid probes. The amount of amplicon corresponding to the multiple nucleic acid sequences can be measured in real-time during or after each cycle using a real-time microarray. The measured amount of amplicon produced can be used to determine the original amount of the nucleic acid sequences in the sample.
    Type: Application
    Filed: September 22, 2011
    Publication date: March 29, 2012
    Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Arjang Hassibi, Babak Hassibi, Haris Vikalo
  • Patent number: 8048626
    Abstract: This invention provides methods and systems for measuring the concentration of multiple nucleic acid sequences in a sample. The nucleic acid sequences in the sample are simultaneously amplified, for example, using polymerase chain reaction (PCR) in the presence of an array of nucleic acid probes. The amount of amplicon corresponding to the multiple nucleic acid sequences can be measured in real-time during or after each cycle using a real-time microarray. The measured amount of amplicon produced can be used to determine the original amount of the nucleic acid sequences in the sample.
    Type: Grant
    Filed: July 27, 2007
    Date of Patent: November 1, 2011
    Assignee: California Institute of Technology
    Inventors: Arjang Hassibi, Babak Hassibi, Haris Vikalo
  • Publication number: 20080176757
    Abstract: This invention provides methods and systems for measuring the concentration of multiple nucleic acid sequences in a sample. The nucleic acid sequences in the sample are simultaneously amplified, for example, using polymerase chain reaction (PCR) in the presence of an array of nucleic acid probes. The amount of amplicon corresponding to the multiple nucleic acid sequences can be measured in real-time during or after each cycle using a real-time microarray. The measured amount of amplicon produced can be used to determine the original amount of the nucleic acid sequences in the sample.
    Type: Application
    Filed: July 27, 2007
    Publication date: July 24, 2008
    Inventors: Arjang Hassibi, Babak Hassibi, Haris Vikalo
  • Publication number: 20080039339
    Abstract: This invention provides methods and systems for measuring the binding of analytes in solution to probes bound to surfaces in real-time.
    Type: Application
    Filed: June 5, 2007
    Publication date: February 14, 2008
    Inventors: Arjang Hassibi, Babak Hassibi, Haris Vikalo, Jose Riechmann
  • Publication number: 20070099198
    Abstract: The disclosure provides methods, device, and systems for analyzing biological array data.
    Type: Application
    Filed: March 14, 2006
    Publication date: May 3, 2007
    Applicant: California Institute of Technology
    Inventors: Babak Hassibi, Haris Vikalo, Arjang Hassibi