Abstract: The disclosed subject matter provides systems and methods for identifying bioactivities of biopolymers from sequence data of the biopolymers. The disclosed system can include a processor configured to receive the input data and a storage medium including instructions operable when executed by the processors. The instructions can cause the system to obtain the input data and generate an evaluative model configured to acquire a biophysical model parameter, a model interaction parameter, a count table parameter, or combinations thereof utilizing the input data. The evaluative model can be configured to simultaneously use multiple biophysical models to represent one or more sequence recognition modes of the biopolymers, evaluate the biopolymers using the evaluative model, and generate a value using the evaluating model that corresponds to the bioactivity of each biopolymer.