Patents by Inventor Harold R. Garner

Harold R. Garner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20150337388
    Abstract: The disclosure provides methods and systems for assessing microsatellites, for identifying informative microsatellite loci, and for using microsatellite data. Microsatellite information has numerous uses including, for example, to characterize disease risk, to predict responsiveness to therapy, and to non-invasively diagnose subjects.
    Type: Application
    Filed: December 17, 2013
    Publication date: November 26, 2015
    Inventors: Harold R. Garner, JR., Lauren J. McIver, Hongseok Tae
  • Publication number: 20140235456
    Abstract: The disclosure provides methods and systems for assessing microsatellites, for identifying informative microsatellite loci, and for using microsatellite data. Microsatellite information has numerous uses including, for example, to characterize disease risk, to predict responsiveness to therapy, and to non-invasively diagnose subjects.
    Type: Application
    Filed: December 17, 2013
    Publication date: August 21, 2014
    Applicant: VIRGINIA TECH INTELLECTUAL PROPERTIES, INC.
    Inventors: Harold R. Garner, JR., Lauren J. McIver, Hongseok Tae
  • Patent number: 8415101
    Abstract: An apparatus and method for catalyzing a reaction on a substrate (24) comprising, a light source (12), a micromirror (16) positioned to redirect light (14) from the light source (12) toward a substrate (24) wherein the redirected light (14) catalyzes a chemical reaction proximate a substrate (24), is disclosed. A computer (18) is connected to, and controls, the positioning of mirrors within the micromirror (16) to specifically redirect light to specific portions of a substrate. The substrate (24) can be placed in a reaction chamber (50), wherein the light (14) that is redirected by the micromirror (16) catalyzes a chemical reaction proximate a substrate (24).
    Type: Grant
    Filed: September 28, 2011
    Date of Patent: April 9, 2013
    Assignee: Roche Nimblegen, Inc.
    Inventor: Harold R. Garner
  • Publication number: 20120015305
    Abstract: An apparatus and method for catalyzing a reaction on a substrate (24) comprising, a light source (12), a micromirror (16) positioned to redirect light (14) from the light source (12) toward a substrate (24) wherein the redirected light (14) catalyzes a chemical reaction proximate a substrate (24), is disclosed. A computer (18) is connected to, and controls, the positioning of mirrors within the micromirror (16) to specifically redirect light to specific portions of a substrate. The substrate (24) can be placed in a reaction chamber (50), wherein the light (14) that is redirected by the micromirror (16) catalyzes a chemical reaction proximate a substrate (24).
    Type: Application
    Filed: September 28, 2011
    Publication date: January 19, 2012
    Inventor: Harold R. Garner
  • Patent number: 8030056
    Abstract: An apparatus and method for catalyzing a reaction on a substrate (24) comprising, a light source (12), a micromirror (16) positioned to redirect light (14) from the light source (12) toward a substrate (24) wherein the redirected light (14) catalyzes a chemical reaction proximate a substrate (24), is disclosed. A computer (18) is connected to; and controls, the positioning of mirrors within the micromirror (16) to specifically redirect light to specific portions of a substrate. The substrate (24) can be placed in a reaction chamber (50), wherein the light (14) that is redirected by the micromirror (16) catalyzes a chemical reaction proximate a substrate (24).
    Type: Grant
    Filed: August 27, 2010
    Date of Patent: October 4, 2011
    Assignee: Roche Nimblegen, Inc.
    Inventor: Harold R. Garner
  • Patent number: 7859653
    Abstract: A method, computer program product and system for analyzing multispectral images from a plurality of regions of birefringent material, such as a polymer film, using polarized light and a corresponding polar analyzer to identify differential strain in the birefringent material. For example, the birefringement material may be low-density polyethylene (LDPE), high-density polyethylene (HDPE), polypropylene, polyethylene terephthalate (PET), polyvinyl chloride (PVC), polyvinylidene chloride, polyester, nylon, or cellophane film. Optionally, the method includes generating a real-time quantitative strain map.
    Type: Grant
    Filed: August 31, 2007
    Date of Patent: December 28, 2010
    Assignee: Lynntech, Inc.
    Inventors: Anthony J. Ragucci, Alan J. Cisar, Michael L. Huebschman, Harold R. Garner
  • Publication number: 20100323300
    Abstract: An apparatus and method for catalyzing a reaction on a substrate (24) comprising, a light source (12), a micromirror (16) positioned to redirect light (14) from the light source (12) toward a substrate (24) wherein the redirected light (14) catalyzes a chemical reaction proximate a substrate (24), is disclosed. A computer (18) is connected to; and controls, the positioning of mirrors within the micromirror (16) to specifically redirect light to specific portions of a substrate. The substrate (24) can be placed in a reaction chamber (50), wherein the light (14) that is redirected by the micromirror (16) catalyzes a chemical reaction proximate a substrate (24).
    Type: Application
    Filed: August 27, 2010
    Publication date: December 23, 2010
    Inventor: Harold R. Garner
  • Publication number: 20100317534
    Abstract: The present invention includes a method of identifying an increase in microsatellite DNA from a genomic nucleic acid sample comprising: obtaining a microsatellite profile from a sample suspected of comprising cancer cells; comparing the microsatellite profile to a reference microsatellite profile from a reference genome; and determining in increase in the number of microsatellite DNAs from the sample as compared to the reference genome, wherein an increase in microsatellite DNA indicates a pre-disposition to cancer and the microsatellites are upstream from the estrogen receptor-related gamma gene (ESRRG).
    Type: Application
    Filed: June 11, 2010
    Publication date: December 16, 2010
    Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventor: Harold R. Garner
  • Patent number: 7785863
    Abstract: An apparatus and method for catalyzing a reaction on a substrate (24) comprising, a light source (12), a micromirror (16) positioned to redirect light (14) from the light source (12) toward a substrate (24) wherein the redirected light (14) catalyzes a chemical reaction proximate a substrate (24), is disclosed. A computer (18) is connected to, and controls, the positioning of mirrors within the micromirror (16) to specifically redirect light to specific portions of a substrate. The substrate (24) can be placed in a reaction chamber (50), wherein the light (14) that is redirected by the micromirror (16) catalyzes a chemical reaction proximate a substrate (24).
    Type: Grant
    Filed: February 9, 2007
    Date of Patent: August 31, 2010
    Assignee: Roche Nimblegen, Inc.
    Inventor: Harold R. Garner
  • Patent number: 7738151
    Abstract: A projection device having a coherent light beam-generator that generates a light beam and a beam expander disposed to receive the light beam and to emit an expanded light beam. The projection device also includes a digital micro-mirror device disposed to receive a holographic transform of an original image and to display the holographic transform for illumination by the expanded light beam into a holographic light beam with a convergent or focusing lens disposed to receive and modulate the holographic light beam and a liquid crystal plate volumetric image reconstructor that receives the focused holographic light beam and emits a 3-dimensional holographic image of the original image.
    Type: Grant
    Filed: April 7, 2005
    Date of Patent: June 15, 2010
    Assignee: Board of Regents, The University of Texas System
    Inventors: Harold R. Garner, Bala Nagendra Raja Munjuluri, Michael L. Huebschman
  • Publication number: 20080305186
    Abstract: The present invention includes compositions and methods treat a patient suffering from one or more symptoms of cardiac hypertrophy, hypertension and/or ischemia by administering a pharmaceutically effective amount of a pharmaceutical composition having an anti-epileptic drug and an antibiotic to the patient, for example, the anti-epileptic drug may be carbamazepine and the antibiotic may be doxycycline.
    Type: Application
    Filed: June 11, 2007
    Publication date: December 11, 2008
    Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Harold R. Garner, Mounir Errami
  • Patent number: 7065451
    Abstract: The invention relates to computer-based systems and methods for the design, comparison and analysis of genetic and proteomic databases. In a particular embodiment, the recited systems and methods have been implemented in a computer tool called ARROGANT. ARROGANT, in the analysis mode, is a comprehensive tool for providing annotation to large gene and protein collections. ARROGANT takes in a large collection of sequence identifiers and associates it with other information collected from many sources like sequence annotations, pathways, homology, polymorphisms, artifacts, etc. The simultaneous annotation for a large assembly of genes makes the collection of genomic/EST sequences truly informative.
    Type: Grant
    Filed: May 24, 2001
    Date of Patent: June 20, 2006
    Assignee: Board of Regents, The University of Texas System
    Inventors: Harold R. Garner, Amit Kulkarni
  • Patent number: 6819807
    Abstract: An optical correlator (10) that uses a spatial light modulator (11) to illuminate a pattern of on and off pixels into a length of an optical fiber (12). The spatial light modulator (11) is optically coupled to the length of fiber (12) so that the illumination enters the fiber along that length. The optical fiber (12) also carries light representing a bitstream of data. At the optical fiber, the illumination from the spatial light modulator interacts with the illumination of the optical bitstream. A detector (14) is optically coupled to the same length of fiber (12) and detects the resulting optical response to determine if a correlation exists.
    Type: Grant
    Filed: August 20, 2001
    Date of Patent: November 16, 2004
    Assignees: Board of Regents, The University of Texas System, Texas Instruments Incorporated
    Inventors: Harold R. Garner, Richard O. Gale
  • Publication number: 20040093331
    Abstract: The present invention is a system, method for accessing domains of information to identify heretofore unknown relationships between disparate sources of data to seek and obtain knowledge, the invention includes a source of data with one or more domains of information, an Object-Relationship Database for integrating objects from one or more domains of information and a knowledge discovery engine where relationships between two or more objects are identified, retrieved, grouped, ranked, filtered and numerically evaluated.
    Type: Application
    Filed: September 19, 2003
    Publication date: May 13, 2004
    Applicant: Board of Regents, University of Texas System
    Inventors: Harold R. Garner, Jonathan D. Wren
  • Patent number: 6657758
    Abstract: An apparatus and method for regulating the behavior of an atomic, molecular or cellular target is disclosed that includes a light source positioned to redirect light from the light source toward the target site. The light source may be, e.g., a combination of a light and a micromirror array or a liquid crystal display. A computer connected to, and controlling, the light source and a variable spectrum generator is placed in the path of light produced by the light source, wherein the light that is passed through said variable spectrum generator is of one or more wavelengths of light and may be used for, e.g., microscopy or image scanning.
    Type: Grant
    Filed: April 28, 2000
    Date of Patent: December 2, 2003
    Assignee: Board of Regents, The University of Texas System
    Inventor: Harold R. Garner
  • Patent number: 6646773
    Abstract: The present invention relates to a method and apparatus for display of three-dimensional images and production of mega-channel phase-encoded optical communications. In certain embodiments, the device of the present invention allows for the creation and display of real-time, three-dimensional moving holograms. In the present invention, a computed image or virtual model of a real object is stored in a computer or dedicated digital signal processor (DSP). The stored image or model is then converted by the computer or DSP into its Fourier, or holographic, transform. The holographic transform is displayed on a light modulation device that is illuminated by a one portion of a laser emission. The remaining portion of the same laser emission is combined with the holographic transform at a plane to create a three-dimensional image.
    Type: Grant
    Filed: May 23, 2001
    Date of Patent: November 11, 2003
    Assignee: Board of Regents, The University of Texas System
    Inventor: Harold R. Garner
  • Publication number: 20030152950
    Abstract: The present invention provides a high-throughput method for the parallel analysis of many potential sites of chemical modification (e.g., methylation) in DNA. It makes use of chemical treatment of the DNA to alter its sequence in a way that depends upon the modification of interest and subsequent analysis of the resulting sequence by hybridization to an array of probes. A device, comprising the array of probes, is provided by the invention, and principles and methods for its design and fabrication are also provided.
    Type: Application
    Filed: June 27, 2002
    Publication date: August 14, 2003
    Inventors: Harold R. Garner, John D. Minna, Kevin J. Luebke, Robert P. Balog
  • Publication number: 20030138778
    Abstract: An apparatus, system and method for predicting single nucleotide polymorphisms (SNPs) is disclosed. The present invention generally includes steps for obtaining a variation predictiveness matrix and predicting one or more single nucleotide variations of a nucleic acid sequence based on the variation predictiveness matrix. The variation predictiveness matrix may be made by calculating the variation frequency from a first base to a second base in a dataset of two or more bases and determining a variation predictiveness value from the calculated variation frequency.
    Type: Application
    Filed: November 30, 2001
    Publication date: July 24, 2003
    Inventors: Harold R. Garner, Monica M. Horvath, John W. Fondon, Alexander Pertsemlidis
  • Publication number: 20030066025
    Abstract: The present invention is directed toward an improved method of mining data. The method uses a query composed of natural language text that may be expanded to include related terms and concepts. The query is parsed into a variety of textual elements that may be keywords, phrases, or concepts, and compared with one or more databases to determine what, if any, information units in the database are related to textual elements that have been culled from the query.
    Type: Application
    Filed: July 15, 2002
    Publication date: April 3, 2003
    Inventors: Harold R. Garner, Alexander Pertsemlidis
  • Publication number: 20030054388
    Abstract: An apparatus and method for comparative genomic mapping of a sample and a reference is disclosed that includes an array of oligonucleotides having a surface derived from a selected portion of a genome. A reader capable of producing a signal disposed to detect events that occur at the surface of the array of oligonucleotides and a computer attached to the reader, wherein the computer processes a signal from the reader to determine the relative intensity produced at the array surface and capable of comparing the intensity of the signal from the array to provide map with a resolution of about 20, 30, 50, 100, 200, 500, 1,000, 2,000, 5,000, 20,000, 50,000, 100,000, 200,000, 500,000, 1,000,000, 2,000,000 basepairs.
    Type: Application
    Filed: June 27, 2002
    Publication date: March 20, 2003
    Inventors: Harold R. Garner, Kevin J. Luebke, Robert P. Balog