Patents by Inventor Harry R. Beller

Harry R. Beller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11078499
    Abstract: The present invention provides for a genetically modified host cell comprising a first polypeptide comprising a sequence having at least 70% amino acid sequence identity with a phenylacetate decarboxylase, and having an enzymatic activity to decarboxylate a phenylacetic acid into a toluene and a carbon dioxide, and a second polypeptide comprising a sequence having at least 70% amino acid sequence identity with a phenylacetate decarboxylase activating enzyme, and having an enzymatic activity to cleave a S-adenosylmethionine (SAM) to form a methionine and a 5?-deoxyadenosyl radical.
    Type: Grant
    Filed: February 26, 2019
    Date of Patent: August 3, 2021
    Assignee: The Regents of the University of California
    Inventors: Harry R. Beller, Andria V. Rodrigues, Kamrun Zargar
  • Patent number: 10913935
    Abstract: The present invention provides for a genetically modified host cell or bacterium capable of producing an organic molecule, wherein the bacterium is capable of using hydrogen sulfide as an electron donor, carbon dioxide (CO2) as a carbon source, and/or nitrate as an electron acceptor. The present invention is useful in the wastewater treatment industry, in particular in municipal wastewater treatment plants (WWTP).
    Type: Grant
    Filed: March 17, 2014
    Date of Patent: February 9, 2021
    Assignee: The Regents of the University of California
    Inventor: Harry R. Beller
  • Publication number: 20210002671
    Abstract: The present invention provides for a genetically modified host cell comprising a first polypeptide comprising a sequence having at least 70% amino acid sequence identity with a phenylacetate decarboxylase, and having an enzymatic activity to decarboxylate a phenylacetic acid into a toluene and a carbon dioxide, and a second polypeptide comprising a sequence having at least 70% amino acid sequence identity with a phenylacetate decarboxylase activating enzyme, and having an enzymatic activity to cleave a S-adenosylmethionine (SAM) to form a methionine and a 5?-deoxyadenosyl radical.
    Type: Application
    Filed: February 26, 2019
    Publication date: January 7, 2021
    Applicant: The Regents of the University of California
    Inventors: Harry R. Beller, Andria V. Rodrigues, Kamrun Zargar
  • Publication number: 20200270642
    Abstract: The present invention provides for a genetically modified host cell comprising a first polypeptide comprising a sequence having at least 70% amino acid sequence identity with a phenylacetate decarboxylase, and having an enzymatic activity to decarboxylate a phenylacetic acid into a toluene and a carbon dioxide, and a second polypeptide comprising a sequence having at least 70% amino acid sequence identity with a phenylacetate decarboxylase activating enzyme, and having an enzymatic activity to cleave a S-adenosylmethionine (SAM) to form a methionine and a 5?-deoxyadenosyl radical.
    Type: Application
    Filed: February 26, 2019
    Publication date: August 27, 2020
    Applicant: The Regents of the University of California
    Inventors: Harry R. Beller, Andria V. Rodrigues, Kamrun Zargar
  • Patent number: 9777300
    Abstract: The present invention provides for a system for converting CO2 and H2 to one or more biologically derived compounds. In some embodiments, the system comprises a host cell comprising one or more nucleic acids encoding genes for a recombinant surface display protein which is capable of tethering an electrocatalyst molecule, such as a cobalt(II) complex supported by tetradentate polypyridyl ligand 2-bis(2-pyridyl)(methoxy)methyl-6-pyridylpyridine (PY4), and enzymes for synthesizing a biologically derived compound, such as an alkane, alcohol, fatty acid, ester, or isoprenoid.
    Type: Grant
    Filed: May 8, 2014
    Date of Patent: October 3, 2017
    Assignee: The Regents of the University of California
    Inventors: Yi-Chun Yeh, Steven W. Singer, Swapnil R. Chhabra, Harry R. Beller, Jana Mueller
  • Patent number: 9556458
    Abstract: The present invention relates to methods and compositions for increasing production of methyl ketones in a genetically modified host cell that overproduces ?-ketoacyl-CoAs through a re-engineered ?-oxidation pathway and overexpresses FadM.
    Type: Grant
    Filed: October 26, 2012
    Date of Patent: January 31, 2017
    Assignee: The Regents of the University of California
    Inventors: Harry R. Beller, Ee-Been Goh
  • Publication number: 20150184133
    Abstract: The present invention provides for a genetically modified host cell or bacterium capable of producing an organic molecule, wherein the bacterium is capable of using hydrogen sulfide as an electron donor, carbon dioxide (CO2) as a carbon source, and/or nitrate as an electron acceptor. The present invention is useful in the wastewater treatment industry, in particular in municipal wastewater treatment plants (WWTP).
    Type: Application
    Filed: March 17, 2014
    Publication date: July 2, 2015
    Applicant: The Regents of the University of California
    Inventor: Harry R. Beller
  • Publication number: 20140370560
    Abstract: The present invention relates to methods and compositions for increasing production of methyl ketones in a genetically modified host cell that overproduces ?-ketoacyl-CoAs through a re-engineered ?-oxidation pathway and overexpresses FadM.
    Type: Application
    Filed: October 26, 2012
    Publication date: December 18, 2014
    Inventors: Harry R. Beller, Ee-Been Goh
  • Publication number: 20140242649
    Abstract: The present invention provides for a system for converting CO2 and H2 to one or more biologically derived compounds. In some embodiments, the system comprises a host cell comprising one or more nucleic acids encoding genes for a recombinant surface display protein which is capable of tethering an electrocatalyst molecule, such as a cobalt(II) complex supported by tetradentate polypyridyl ligand 2-bis(2-pyridyl)(methoxy)methyl-6-pyridylpyridine (PY4), and enzymes for synthesizing a biologically derived compound, such as an alkane, alcohol, fatty acid, ester, or isoprenoid.
    Type: Application
    Filed: May 8, 2014
    Publication date: August 28, 2014
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Yi-Chun Yeh, Steven W. Singer, Swapnil R. Chhabra, Harry R. Beller, Jana Mueller