Patents by Inventor Harvey B. Pollard
Harvey B. Pollard has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11085934Abstract: The invention relates to methods of determining if a subject is at risk of developing post-traumatic stress disorder (PTSD).Type: GrantFiled: October 6, 2016Date of Patent: August 10, 2021Assignee: The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.Inventors: Harvey B. Pollard, Clifton L. Dalgard
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Patent number: 10358679Abstract: Methods of detecting or diagnosing posttraumatic stress disorder (PTSD) in a human subject are disclosed. In addition, methods of monitoring the progression of PTSD in a human subject, methods of treating a patient with PTSD, kits for diagnosing PTSD in a human subject suspected of having PTSD, and methods of detecting a microRA (miRNA) or plurality of miRNAs in a biological sample from a human subject are also disclosed.Type: GrantFiled: September 25, 2015Date of Patent: July 23, 2019Assignee: The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.Inventors: Harvey B. Pollard, Roopa Biswas
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Publication number: 20190113526Abstract: The invention relates to methods of determining if a subject is at risk of developing post-traumatic stress disorder (PTSD).Type: ApplicationFiled: October 6, 2016Publication date: April 18, 2019Applicant: The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.Inventors: Harvey B. POLLARD, Clifton L. DALGARD
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Publication number: 20170247761Abstract: Methods of detecting or diagnosing posttraumatic stress disorder (PTSD) in a human subject are disclosed. In addition, methods of monitoring the progression of PTSD in a human subject, methods of treating a patient with PTSD, kits for diagnosing PTSD in a human subject suspected of having PTSD, and methods of detecting a microRA (miRNA) or plurality of miRNAs in a biological sample from a human subject are also disclosed.Type: ApplicationFiled: September 25, 2015Publication date: August 31, 2017Inventors: Harvey B. Pollard, Roopa Biswas
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Patent number: 7893094Abstract: The present invention is directed to the amphiphilic pyridinium compounds, such as for suppressing IL-8 secretion and production. The present invention further provides methods of making and using such compounds for the treatment of the IL-8 related diseases, such as cystic fibrosis.Type: GrantFiled: June 28, 2004Date of Patent: February 22, 2011Assignees: The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., National Institutes of Health (NIH)Inventors: Harvey B. Pollard, Kenneth Jacobson
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Patent number: 7504223Abstract: This invention provides methods, including a method of assessing the prognosis of a breast cancer patient, comprising assaying for loss of heterozygosity at the 10q21 region of the genome of the patient, a method of identifying a probability that a patient with breast cancer has metastasized breast cancer, a method of determining a survival probability of a patient with breast cancer, and a method of identifying a probability that a patient with prostate cancer has a severe form of prostate cancer. This invention also provides assay complexes, including assay complexes which comprise at least one prostate tissue sample or tissue sample extract, an antibody that specifically binds ANX7, and a label, or which comprise at least one breast tissue sample or tissue sample extract, an antibody that specifically binds ANX7, and a label.Type: GrantFiled: December 22, 2004Date of Patent: March 17, 2009Assignee: Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.Inventors: Meera Srivastava, Harvey B. Pollard
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Patent number: 6747187Abstract: A knockout transgenic mouse containing a nonfunctional allele of the tumor suppressing gene, annexin VII. This mouse is used as a screening model for potential therapeutic agents useful in the treatment of tumors resulting from an annexin tumor suppressor disease.Type: GrantFiled: August 4, 2000Date of Patent: June 8, 2004Assignee: Henry M. Jackson Foundation for The Advancement of Military MedicineInventors: Meera Srivastava, Harvey B. Pollard
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Publication number: 20030114375Abstract: The present invention provides a method of identifying CFTR-binding compounds for treating cells having a reduced apical Cl− conductance, such as cystic fibrosis cells. This identification method involves the use of polypeptide I&agr;, which constitutes a portion of the CFTR protein. The present invention also provides a method of treating CF cells by contacting cells having a reduced apical Cl− conductance with a therapeutically effective quantity of a compound selected by the present inventive identification method. Preferred compounds for such treatment have little or no affinity for adenosine cell receptors. The present invention provides novel compounds useful in practicing the present inventive method, as well as pharmaceutical compositions containing such compounds.Type: ApplicationFiled: July 3, 2002Publication date: June 19, 2003Applicant: The Government of the USA, Dept of Health and Human Services, The National Institutes of HealthInventors: Harvey B. Pollard, Kenneth A. Jacobson
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Patent number: 6491655Abstract: The present invention provides a method for treating Hemophilia A or B which comprises implanting in fluid communication with the bloodstream of a mammal in need of such treatment a permeable membrane having one or more walls, a hollow chamber therewithin, a plurality of holes extending through the walls of the membrane and permitting fluid to enter and exit the chamber of the membrane, each of the holes being sized so that it is large enough to permit inactive Factor VII to enter the chamber of the membrane and activated Factor VIIa to exit the chamber of the membrane but small enough to prevent fibrinogen from entering the chamber of the membrane, a plurality of supports being disposed within the chamber, and an effective amount of a Factor VII activator or a source of the activator being bound to the supports, wherein inactive factor VII in blood passing through the membrane becomes activated into Factor VIIa upon contact with the activator within the chamber.Type: GrantFiled: March 1, 2000Date of Patent: December 10, 2002Inventors: Harvey B. Pollard, Bette S. Pollard
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Patent number: 6174299Abstract: The present invention provides a method for treating Hemophilia A or B which comprises implanting in fluid communication with the bloodstream of a mammal in need of such treatment a permeable membrane having one or more walls, a hollow chamber therewithin, a plurality of holes extending through the walls of the membrane and permitting fluid to enter and exit the chamber of the membrane, each of the holes being sized so that it is large enough to permit inactive Factor VII to enter the chamber of the membrane and activated Factor VIIa to exit the chamber of the membrane but small enough to prevent fibrinogen from entering the chamber of the membrane, a plurality of supports being disposed within the chamber, and an effective amount of a Factor VII activator or a source of the activator being bound to the supports, wherein inactive Factor VII in blood passing through the membrane becomes activated into Factor VIIa upon contact with the activator within the chamber.Type: GrantFiled: December 4, 1998Date of Patent: January 16, 2001Inventors: Harvey B. Pollard, Bette S. Pollard
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Patent number: 6083954Abstract: The present invention provides a method of identifying CFTR-binding compounds for treating cells having a reduced apical Cl.sup.- conductance, such as cystic fibrosis cells. This identification method involves the use of polypeptide I.alpha., which constitutes a portion of the CFTR protein. The present invention also provides a method of treating CF cells by contacting cells having a reduced apical Cl.sup.- conductance with a therapeutically effective quantity of a compound selected by the present inventive identification method. Preferred compounds for such treatment have little or no affinity for adenosine cell receptors. The present invention provides novel compounds useful in practicing the present inventive method, as well as pharmaceutical compositions containing such compounds.Type: GrantFiled: July 13, 1998Date of Patent: July 4, 2000Inventors: Harvey B. Pollard, Kenneth A. Jacobson
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Patent number: 5908399Abstract: The present invention provides a method for treating Hemophilia A or B which comprises implanting in fluid communication with the bloodstream of a mammal in need of such treatment a permeable membrane having one or more walls, a hollow chamber therewithin, a plurality of holes extending through the walls of the membrane and permitting fluid to enter and exit the chamber of the membrane, each of the holes being sized so that it is large enough to permit inactive Factor VII to enter the chamber of the membrane and activated Factor VIIa to exit the chamber of the membrane but small enough to prevent fibrinogen from entering the chamber of the membrane, a plurality of supports being disposed within the chamber, and an effective amount of a Factor VII activator or a source of the activator being bound to the supports, wherein inactive Factor VII in blood passing through the membrane becomes activated into Factor VIIa upon contact with the activator within the chamber.Type: GrantFiled: September 26, 1996Date of Patent: June 1, 1999Inventor: Harvey B. Pollard
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Patent number: 5877179Abstract: The present invention provides novel compounds and pharmaceutical compositions comprising such compounds useful for treating cystic fibrosis cells, wherein such compounds have the formula ##STR1## wherein (a) R.sub.1 and R.sub.3 are methyl, R.sub.7 is ethyl or cyclopropylmethyl, and R.sub.8 is cyclohexyl; (b) R.sub.1 and R.sub.3 are allyl, R.sub.7 is hydrogen and R.sub.8 is cyclohexyl, cyclohexylmethyl, or cycloheptyl; (c) R.sub.1 is allyl and R.sub.3 is methyl, R.sub.7 is hydrogen, and R.sub.8 is cyclohexyl; or (d) R.sub.1 is methyl, R.sub.3 is allyl, R.sub.7 is cyclopropylmethyl or ethyl, and R.sub.8 is cyclohexyl.Type: GrantFiled: November 22, 1994Date of Patent: March 2, 1999Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: Harvey B. Pollard, Kenneth A. Jacobson
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Patent number: 5366977Abstract: A method of treating cells having a reduced apical Cl.sup.- conductance, such as that characteristic of cystic fibrosis cells, by contacting cells having a reduced apical Cl.sup.- conductance with a therapeutically effective quantity of a compound that antagonizes the A.sub.1 -adenosine cell receptor and does not antagonize the A.sub.2 -adenosine cell receptor. Suitable compounds include 8-cyclopentyl-1,3-dipropylxanthine (CPX), xanthine amino congener (XAC), and therapeutically effective derivatives thereof.Type: GrantFiled: September 29, 1992Date of Patent: November 22, 1994Assignee: The United States of America, as represented by the Department of Health and Human ServicesInventors: Harvey B. Pollard, Philip J. M. van Galen, Kenneth A. Jacobson
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Patent number: 5112957Abstract: A method is described for safely and effectively washing solid gels or films containing biological macromolecules such as proteins or nucleic acids. The method involves placing the gels in an open plastic container and decanting a wash solution horizontally so as to leave the gel at the bottom of the container without using external means to hold the gel down. The undamaged gel can then be safely removed and detection experiments can thus be carried out. A preferred apparatus for carrying out this method is also described and consists of an elongated open-topped side spouted tray.Type: GrantFiled: December 19, 1985Date of Patent: May 12, 1992Inventor: Harvey B. Pollard
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Patent number: 4753635Abstract: A method of inducing analgesia or reducing pain is described. The method involves implanting in the central nervous system of a host susceptible to pain, living material capable of releasing effective amount of analgesic substance when interacted with a stimulus which induces said material to release analgesic amount of said substance. The procedure described herein reduces sensitivity to intractable pain.Type: GrantFiled: May 23, 1986Date of Patent: June 28, 1988Inventors: Jacqueline Sagen, Mark Perlow, George D. Pappas, Harvey B. Pollard
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Patent number: 4670394Abstract: The present invention discloses a new line of endothelial cell of adrenal medullary origin capable of producing blood clotting Factor VIII:C. A method of isolating and culturing said cell line has also been disclosed. Factor VIII:C is useful in treating hemophilia.Type: GrantFiled: November 16, 1984Date of Patent: June 2, 1987Assignee: The United States of America as represented by the Secretary of the Department of Health and Human ServicesInventors: Harvey B. Pollard, Richard Ornberg, Dipak Banerjee, Moussa Youdim, Peter Lelkes, Eli Heldman