Patents by Inventor Heather Shih

Heather Shih has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7763441
    Abstract: The present invention provides methods of affecting gluconeogenesis by altering the levels or activity of DUSP4 and/or EGR1. Pharmaceutical compositions comprising or encoding modulators of gluconeogenesis are also disclosed.
    Type: Grant
    Filed: March 13, 2007
    Date of Patent: July 27, 2010
    Assignee: Wyeth
    Inventors: Stephen Berasi, Christine Huard, Dongmei Li, Heather Shih, Ying Sun, Janet Paulsen, Eugene L. Brown, Ruth Gimeno, Robert Martinez
  • Publication number: 20070274987
    Abstract: The present invention provides isolated and purified polynucleotides, polypeptides, and antibodies related to mammalian (e.g., mouse and human) legumain and the novel legumain splice variant, ZB-1. The invention further relates to the use of these isolated and purified polynucleotides, polypeptides, and antibodies, as well as other legumain and ZB-1 agonists and antagonists, in modulating legumain and/or ZB-1 activity, expression, and/or secretion in a cell or cell population, e.g., monocytes, macrophages, foam cells, vascular endothelial cells, kidney proximal tubule cells, arterial endothelial cells, sites of inflammatory cell invasion into a vessel intima, and neointimal lesional areas of an artery. The invention also provides legumain and ZB-1 antagonists, e.g., antagonistic small molecules, antibodies and antibody fragments to legumain and ZB-1, legumain and ZB-1 inhibitory polypeptides, and legumain and ZB-1 inhibitory polynucleotides.
    Type: Application
    Filed: May 25, 2007
    Publication date: November 29, 2007
    Inventors: Valerie Clerin, Heather Shih, Kathleen Shields, Jeffrey Feldman, Gustave Hebert, Debra Pittman, Nanhua Deng
  • Publication number: 20070270331
    Abstract: The present invention provides methods of affecting gluconeogenesis by altering the levels or activity of DUSP4 and/or EGR1. Pharmaceutical compositions comprising or encoding modulators of gluconeogenesis are also disclosed.
    Type: Application
    Filed: March 13, 2007
    Publication date: November 22, 2007
    Inventors: Stephen Berasi, Christine Huard, Dongmei Li, Heather Shih, Ying Sun, Janet Paulsen, Eugene Brown, Ruth Gimeno, Robert Martinez