Patents by Inventor Heidi Lopez de Diego

Heidi Lopez de Diego has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 1-[2-(2,4-dimethylphenylsulfanyl)-phenyl] piperazine as a compound with combined serotonin reuptake, 5-HT3 and 5-HT1A activity for the treatment of cognitive impairment
    Patent number: 8722684
    Abstract: 1-[2-(2,4-dimethylphenylsulphanyl)phenyl]piperazine exhibits potent activity on SERT, 5-HT3 and 5-HT1A and may as such be useful for the treatment of cognitive impairment, especially in depressed patients.
    Type: Grant
    Filed: June 15, 2007
    Date of Patent: May 13, 2014
    Assignee: H. Lundbeck A/S
    Inventors: Benny Bang-Andersen, Andre Faldt, Arne Mork, Heidi Lopez de Diego, Rene Holm, Tine Bryan Stensbol, Nicholas Moore
  • NALMEFENE HYDROCHLORIDE DIHYDRATE
    Publication number: 20130338365
    Abstract: The present invention relates to the Nalmefene hydrochloride dihydrate, methods of manufacturing Nalmefene hydrochloride dihydrate, a pharmaceutical composition comprising Nalmefene hydrochloride dihydrate and a method of treatment comprising administering Nalmefene hydrochloride dehydrate.
    Type: Application
    Filed: June 25, 2013
    Publication date: December 19, 2013
    Inventors: Heidi Lopez de DIEGO, Carla de FAVERI, Florian Anton Martin HUBER
  • Purification of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine
    Patent number: 8598348
    Abstract: The present invention concerns a process for the manufacture of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine.
    Type: Grant
    Filed: February 16, 2010
    Date of Patent: December 3, 2013
    Assignee: H. Lundbeck A/S
    Inventors: Henrik Vigan Nicolajsen, Heidi Lopez de Diego, Michael Harold Rock
  • Nalmefene hydrochloride dihydrate
    Patent number: 8530495
    Abstract: The present invention relates to the Nalmefene hydrochloride dihydrate, methods of manufacturing Nalmefene hydrochloride dihydrate, a pharmaceutical composition comprising Nalmefene hydrochloride dihydrate and a method of treatment comprising administering Nalmefene hydrochloride dihydrate.
    Type: Grant
    Filed: December 4, 2009
    Date of Patent: September 10, 2013
    Assignees: H. Lundbeck A/S, Bioei Therapies Corp
    Inventors: Heidi Lopez de Diego, Carla de Faveri, Florian Anton Martin Huber
  • Crystalline base of trans-1-((1R,3S)-6-chloro-3-phenylindan-1-yl)-3,3-dimethylpiperazine
    Patent number: 8450324
    Abstract: Crystalline base of compound trans-1-((1R,3S)-6-chloro-3-phenylindan-1-yl)-3,3-dimethylpiperazine, processes for the preparation of purified free base or salts of this compound, pharmaceutical compositions comprising the base and medical use thereof, including for treatment of schizophrenia and other psychotic disorders.
    Type: Grant
    Filed: December 1, 2009
    Date of Patent: May 28, 2013
    Assignee: H. Lunbeck A/S
    Inventors: Benny Bang-Andersen, Heidi Lopez de Diego
  • Crystalline forms of 4-[2-(4-methylphenylsulfanyl)-phenyl] piperidine with combined serotonin and norepinephrine reuptake inhibition and uses thereof
    Patent number: 8299095
    Abstract: Crystalline forms of 4-[2-(4-methylphenylsulfanyl)-phenyl]piperidine and salts thereof are provided e.g. for the treatment of neuropathic pain.
    Type: Grant
    Filed: June 15, 2007
    Date of Patent: October 30, 2012
    Assignee: H. Lundbeck A/S
    Inventors: Benny Bang-Andersen, Andre Faldt, Tine Bryan Stensbol, Silke Miller, Heidi Lopez De Diego
  • Processes for 4-((1R,35)-6-Chloro-3-phenylindan-1-yl)-1,2,2-trimethylpiperazine or a salt thereof
    Patent number: 8227607
    Abstract: Methods for the preparation of 4-((1R,3S)-6-Chloro-3-phenylindan-1-yl)-1,2,2-trimethylpiperazine and salts thereof are described.
    Type: Grant
    Filed: June 22, 2010
    Date of Patent: July 24, 2012
    Assignee: H. Lundbeck A/S
    Inventors: Heidi Lopez de Diego, Ole Nielsen, Lone Munch Ringgard, Henrik Svane, Allan Carsten Dahl, Mark Howells, Benny Bang-Andersen, Lars Ole Lyngsø, Sherry Lynn Collier
  • Stable forms of N-(2,6-Dimethyl-4-morpholin-4-yl-phenyl)-3,3-dimethyl-butyramide
    Publication number: 20120165325
    Abstract: Polymorphic forms of N-(2,6-dimethyl-4-morpholin-4-yl-phenyl)-3,3-dimethyl-butyramide are provided together with a process for the manufacture of said compound.
    Type: Application
    Filed: March 2, 2012
    Publication date: June 28, 2012
    Applicant: H. Lundbeck A/S
    Inventors: Svend Treppendahl, Karin Liltorp, Heidi Lopez de Diego
  • LIQUID FORMULATIONS OF SALTS OF 1-[2-(2,4-DIMETHYLPHENYLSULFANYL)PHENYL]-PIPERAZINE
    Publication number: 20120035188
    Abstract: Liquid formulations of lactic acid addition salts of 1-[2-(2,4-dimethylphenylsulfanyl)-phenyl]piperazine are provided.
    Type: Application
    Filed: April 16, 2010
    Publication date: February 9, 2012
    Applicant: H. LUNDBECK A/S
    Inventors: Svend Treppendahl, Heidi Lopez De Diego
  • Purification of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine
    Publication number: 20120004409
    Abstract: The present invention concerns a process for the manufacture of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine.
    Type: Application
    Filed: February 16, 2010
    Publication date: January 5, 2012
    Applicant: H. LUNDBECK A/S
    Inventors: Henrik Vigan Nicolajsen, Heidi Lopez de Diego, Michael Harold Rock
  • Malonate salt of 4-((1R,3S)-6-chloro-3-phenylindan-1-yl)-1,2,2-trimethylpiperazine and uses of same
    Patent number: 8076342
    Abstract: 4-((1R,3S)-6-Chloro-3-phenylindan-1-yl)-1,2,2-trimethylpiperazine hydrogen malonate salt and pharmaceutical comprising and uses of the same, including for the treatment of schizophrenia and other psychotic disorders are described.
    Type: Grant
    Filed: November 4, 2010
    Date of Patent: December 13, 2011
    Inventors: Heidi Lopez de Diego, Ole Nielsen, Lone Munch Ringgard, Henrik Svane, Allan Carsten Dahl, Mark Howells, Benny Bang-Andersen, Lars Ole Lyngso
  • Crystalline forms of a pharmaceutical compound
    Patent number: 8076320
    Abstract: Described are crystalline forms of the pharmaceutical compound “[9S-(9?,10?,12?)]-5,16-Bis[(ethylthio)methyl]-2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-9, 12-epoxy-1H-diindolo[1,2,3-fg:3?,2?,1?-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid methyl ester”, as well as methods for their use and preparation.
    Type: Grant
    Filed: February 24, 2005
    Date of Patent: December 13, 2011
    Assignee: Cephalon, Inc.
    Inventors: Michael Harold Rock, Heidi Lopez De Diego, Kim Lasse Christensen, Ole Nielsen, Anders Buur, Mark Howells
  • NALMEFENE HYDROCHLORIDE DIHYDRATE
    Publication number: 20110251228
    Abstract: The present invention relates to the Nalmefene hydrochloride dihydrate, methods of manufacturing Nalmefene hydrochloride dihydrate, a pharmaceutical composition comprising Nalmefene hydrochloride dihydrate and a method of treatment comprising administering Nalmefene hydrochloride dehydrate.
    Type: Application
    Filed: December 4, 2009
    Publication date: October 13, 2011
    Applicants: Biotie Therapies Corp., H. Lundbeck A/S
    Inventors: Heidi Lopez de Diego, Carla de Faveri, Florian Anton Martin Huber
  • Crystalline Forms of a Pharmaceutical Compound
    Publication number: 20110124629
    Abstract: Described are crystalline forms of the pharmaceutical compound “[9S-(9?,10?,12?)]-5,16-Bis[(ethylthio)methyl]-2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3 -fg:3?,2?,1?-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid methyl ester”, as well as methods for their use and preparation.
    Type: Application
    Filed: January 3, 2011
    Publication date: May 26, 2011
    Applicant: CEPHALON, INC.
    Inventors: Michael Harold Rock, Heidi Lopez De Diego, Kim Lasse Christensen, Ole Nielsen, Anders Buur, Mark Howells
  • MALONATE SALT OF 4-((1R,3S)-6-CHLORO-3-PHENYLINDAN-1-YL)-1,2,2-TRIMETHYLPIPERAZINE AND USES OF SAME
    Publication number: 20110053957
    Abstract: 4-((1R,35)-6-Chloro-3 -phenylindan-1-yl)-1,2,2-trimethylpiperazine hydrogen malonate salt and pharmaceutical comprising and uses of the same, including for the treatment of schizophrenia and other psychotic disorders are described.
    Type: Application
    Filed: November 4, 2010
    Publication date: March 3, 2011
    Applicant: H. LUNDBECK A/S
    Inventors: Heidi Lopez de Diego, Ole Nielsen, Lone Munch Ringgard, Henrik Svane, Allan Carsten Dahl, Mark Howells, Benny Bang-Andersen, Lars Ole Lyngsø
  • PROCESSES FOR 4-((1R,3S)-6-CHLORO-3-PHENYLINDAN-1-YL)-1,2,2-TRIMETHYLPIPERAZINE OR A SALT THEREOF
    Publication number: 20100324291
    Abstract: Methods for the preparation of 4-((1R,3S)-6-Chloro-3-phenylindan-1-yl)-1,2,2-trimethylpiperazine and salts thereof are described.
    Type: Application
    Filed: June 22, 2010
    Publication date: December 23, 2010
    Applicant: H. LUNDBECK A/S
    Inventors: Heidi Lopez de Diego, Ole Nielsen, Lone Munch Ringgard, Henrik Svane, Allan Carsten Dahl, Mark Howells, Benny Bang-Andersen, Lars Ole Lyngsø, Sherry Lynn Collier
  • 1- [2- (2,4-DIMETHYLPHENYLSULFANYL)-PHENYL] PIPERAZINE AS A COMPOUND WITH COMBINED SEROTONIN REUPTAKE, 5-HT3 AND 5-HT1A ACTIVITY FOR THE TREATMENT OF COGNITIVE IMPAIRMENT
    Publication number: 20100297240
    Abstract: 1-[2-(2,4-dimethylphenylsulphanyl)phenyl]piperazine exhibits potent activity on SERT, 5-HT3 and 5-HT1A and may as such be useful for the treatment of cognitive impairment, especially in depressed patients.
    Type: Application
    Filed: June 15, 2007
    Publication date: November 25, 2010
    Applicant: H. Lundbeck A/S
    Inventors: Benny Bang-Andersen, Andre Faldt, Arne Mork, Heidi Lopez De Diego, Rene Holm, Tine Bryan Stensbol, Lone Munch Ringgaard, Michael J. Mealy, Michael Harold Rock, Jorgen Brodersen, Morten Jorgensen, Nicholas Moore
  • Stable forms of N-(2,6-Dimethyl-4-morpholin-4-yl-phenyl)-3,3-dimethyl-butyramide
    Publication number: 20100286138
    Abstract: Polymorphic forms of N-(2,6-dimethyl-4-morpholin-4-yl-phenyl)-3,3-dimethyl-butyramide are provided together with a process for the manufacture of said compound.
    Type: Application
    Filed: May 11, 2010
    Publication date: November 11, 2010
    Applicant: H. LUNDBECK A/S
    Inventors: Svend Treppendahl, Karin Liltorp, Heidi Lopez de Diego
  • Hydrogen succinate salts of trans-4-((1R, 3S)-6-chloro-3-phenylindan-1-YL)-1,2,2-trimethylpiperazine and the use as a medicament
    Patent number: 7767683
    Abstract: 4-((1R,3S)-6-Chloro-3-phenylindan-1-yl)-1,2,2-trimethylpiperazine hydrogen succinate, pharmaceutical compositions containing the salt and the medical use thereof, including for the treatment of schizophrenia and other psychotic disorders. Also described are methods for the preparation of 4-((1R,3S)-6-Chloro-3-phenylindan-1-yl)-1,2,2-trimethylpiperazine and medical uses thereof.
    Type: Grant
    Filed: August 18, 2004
    Date of Patent: August 3, 2010
    Assignee: H. Lundbeck A/S
    Inventors: Heidi Lopez de Diego, Ole Nielsen, Lone Munch Ringgard, Henrik Svane, Allan Carsten Dahl, Mark Howells, Benny Bang-Andersen, Lars Ole Lyngso, Sherry Lynn Collier
  • CRYSTALLINE BASE OF TRANS-1-((1R,3S)-6-CHLORO-3-PHENYLINDAN-1-YL)-3,3-DIMETHYLPIPERAZINE
    Publication number: 20100105699
    Abstract: Crystalline base of compound trans-1-(1R,3S)-6-chloro-3-phenylindan-1-yl)-3,3-dimethylpiperazine, processes for the preparation of purified free base or salts of this compound, pharmaceutical compositions comprising the base and medical use thereof, including for treatment of schizophrenia and other psychotic disorders.
    Type: Application
    Filed: December 1, 2009
    Publication date: April 29, 2010
    Applicant: H. Lundbeck A/S
    Inventors: Benny Bang-Andersen, Heidi Lopez de Diego